KEGG   Vicugna pacos (alpaca): 102524821
Entry
102524821         CDS       T08098                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
vpc  Vicugna pacos (alpaca)
Pathway
vpc00562  Inositol phosphate metabolism
vpc01100  Metabolic pathways
vpc01521  EGFR tyrosine kinase inhibitor resistance
vpc01522  Endocrine resistance
vpc01524  Platinum drug resistance
vpc04012  ErbB signaling pathway
vpc04014  Ras signaling pathway
vpc04015  Rap1 signaling pathway
vpc04024  cAMP signaling pathway
vpc04062  Chemokine signaling pathway
vpc04066  HIF-1 signaling pathway
vpc04068  FoxO signaling pathway
vpc04070  Phosphatidylinositol signaling system
vpc04071  Sphingolipid signaling pathway
vpc04072  Phospholipase D signaling pathway
vpc04081  Hormone signaling
vpc04140  Autophagy - animal
vpc04150  mTOR signaling pathway
vpc04151  PI3K-Akt signaling pathway
vpc04152  AMPK signaling pathway
vpc04210  Apoptosis
vpc04211  Longevity regulating pathway
vpc04213  Longevity regulating pathway - multiple species
vpc04218  Cellular senescence
vpc04360  Axon guidance
vpc04370  VEGF signaling pathway
vpc04380  Osteoclast differentiation
vpc04510  Focal adhesion
vpc04550  Signaling pathways regulating pluripotency of stem cells
vpc04611  Platelet activation
vpc04613  Neutrophil extracellular trap formation
vpc04620  Toll-like receptor signaling pathway
vpc04625  C-type lectin receptor signaling pathway
vpc04630  JAK-STAT signaling pathway
vpc04650  Natural killer cell mediated cytotoxicity
vpc04660  T cell receptor signaling pathway
vpc04662  B cell receptor signaling pathway
vpc04664  Fc epsilon RI signaling pathway
vpc04666  Fc gamma R-mediated phagocytosis
vpc04668  TNF signaling pathway
vpc04670  Leukocyte transendothelial migration
vpc04722  Neurotrophin signaling pathway
vpc04725  Cholinergic synapse
vpc04750  Inflammatory mediator regulation of TRP channels
vpc04810  Regulation of actin cytoskeleton
vpc04910  Insulin signaling pathway
vpc04914  Progesterone-mediated oocyte maturation
vpc04915  Estrogen signaling pathway
vpc04917  Prolactin signaling pathway
vpc04919  Thyroid hormone signaling pathway
vpc04923  Regulation of lipolysis in adipocytes
vpc04926  Relaxin signaling pathway
vpc04929  GnRH secretion
vpc04930  Type II diabetes mellitus
vpc04931  Insulin resistance
vpc04932  Non-alcoholic fatty liver disease
vpc04933  AGE-RAGE signaling pathway in diabetic complications
vpc04935  Growth hormone synthesis, secretion and action
vpc04960  Aldosterone-regulated sodium reabsorption
vpc04973  Carbohydrate digestion and absorption
vpc05010  Alzheimer disease
vpc05017  Spinocerebellar ataxia
vpc05020  Prion disease
vpc05100  Bacterial invasion of epithelial cells
vpc05132  Salmonella infection
vpc05135  Yersinia infection
vpc05142  Chagas disease
vpc05146  Amoebiasis
vpc05160  Hepatitis C
vpc05161  Hepatitis B
vpc05162  Measles
vpc05163  Human cytomegalovirus infection
vpc05164  Influenza A
vpc05165  Human papillomavirus infection
vpc05166  Human T-cell leukemia virus 1 infection
vpc05167  Kaposi sarcoma-associated herpesvirus infection
vpc05168  Herpes simplex virus 1 infection
vpc05169  Epstein-Barr virus infection
vpc05170  Human immunodeficiency virus 1 infection
vpc05171  Coronavirus disease - COVID-19
vpc05200  Pathways in cancer
vpc05203  Viral carcinogenesis
vpc05205  Proteoglycans in cancer
vpc05206  MicroRNAs in cancer
vpc05207  Chemical carcinogenesis - receptor activation
vpc05208  Chemical carcinogenesis - reactive oxygen species
vpc05210  Colorectal cancer
vpc05211  Renal cell carcinoma
vpc05212  Pancreatic cancer
vpc05213  Endometrial cancer
vpc05214  Glioma
vpc05215  Prostate cancer
vpc05218  Melanoma
vpc05220  Chronic myeloid leukemia
vpc05221  Acute myeloid leukemia
vpc05222  Small cell lung cancer
vpc05223  Non-small cell lung cancer
vpc05224  Breast cancer
vpc05225  Hepatocellular carcinoma
vpc05226  Gastric cancer
vpc05230  Central carbon metabolism in cancer
vpc05231  Choline metabolism in cancer
vpc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vpc05415  Diabetic cardiomyopathy
vpc05417  Lipid and atherosclerosis
vpc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vpc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102524821 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102524821 (PIK3CD)
   04014 Ras signaling pathway
    102524821 (PIK3CD)
   04015 Rap1 signaling pathway
    102524821 (PIK3CD)
   04370 VEGF signaling pathway
    102524821 (PIK3CD)
   04630 JAK-STAT signaling pathway
    102524821 (PIK3CD)
   04668 TNF signaling pathway
    102524821 (PIK3CD)
   04066 HIF-1 signaling pathway
    102524821 (PIK3CD)
   04068 FoxO signaling pathway
    102524821 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    102524821 (PIK3CD)
   04072 Phospholipase D signaling pathway
    102524821 (PIK3CD)
   04071 Sphingolipid signaling pathway
    102524821 (PIK3CD)
   04024 cAMP signaling pathway
    102524821 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    102524821 (PIK3CD)
   04152 AMPK signaling pathway
    102524821 (PIK3CD)
   04150 mTOR signaling pathway
    102524821 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102524821 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102524821 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    102524821 (PIK3CD)
   04218 Cellular senescence
    102524821 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102524821 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    102524821 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102524821 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102524821 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    102524821 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    102524821 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    102524821 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    102524821 (PIK3CD)
   04660 T cell receptor signaling pathway
    102524821 (PIK3CD)
   04662 B cell receptor signaling pathway
    102524821 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    102524821 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    102524821 (PIK3CD)
   04670 Leukocyte transendothelial migration
    102524821 (PIK3CD)
   04062 Chemokine signaling pathway
    102524821 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102524821 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    102524821 (PIK3CD)
   04929 GnRH secretion
    102524821 (PIK3CD)
   04915 Estrogen signaling pathway
    102524821 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    102524821 (PIK3CD)
   04917 Prolactin signaling pathway
    102524821 (PIK3CD)
   04926 Relaxin signaling pathway
    102524821 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    102524821 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    102524821 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102524821 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102524821 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    102524821 (PIK3CD)
   04722 Neurotrophin signaling pathway
    102524821 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102524821 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    102524821 (PIK3CD)
   04380 Osteoclast differentiation
    102524821 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    102524821 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    102524821 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102524821 (PIK3CD)
   05206 MicroRNAs in cancer
    102524821 (PIK3CD)
   05205 Proteoglycans in cancer
    102524821 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    102524821 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    102524821 (PIK3CD)
   05203 Viral carcinogenesis
    102524821 (PIK3CD)
   05230 Central carbon metabolism in cancer
    102524821 (PIK3CD)
   05231 Choline metabolism in cancer
    102524821 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102524821 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102524821 (PIK3CD)
   05212 Pancreatic cancer
    102524821 (PIK3CD)
   05225 Hepatocellular carcinoma
    102524821 (PIK3CD)
   05226 Gastric cancer
    102524821 (PIK3CD)
   05214 Glioma
    102524821 (PIK3CD)
   05221 Acute myeloid leukemia
    102524821 (PIK3CD)
   05220 Chronic myeloid leukemia
    102524821 (PIK3CD)
   05218 Melanoma
    102524821 (PIK3CD)
   05211 Renal cell carcinoma
    102524821 (PIK3CD)
   05215 Prostate cancer
    102524821 (PIK3CD)
   05213 Endometrial cancer
    102524821 (PIK3CD)
   05224 Breast cancer
    102524821 (PIK3CD)
   05222 Small cell lung cancer
    102524821 (PIK3CD)
   05223 Non-small cell lung cancer
    102524821 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102524821 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    102524821 (PIK3CD)
   05161 Hepatitis B
    102524821 (PIK3CD)
   05160 Hepatitis C
    102524821 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    102524821 (PIK3CD)
   05164 Influenza A
    102524821 (PIK3CD)
   05162 Measles
    102524821 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    102524821 (PIK3CD)
   05163 Human cytomegalovirus infection
    102524821 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102524821 (PIK3CD)
   05169 Epstein-Barr virus infection
    102524821 (PIK3CD)
   05165 Human papillomavirus infection
    102524821 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102524821 (PIK3CD)
   05135 Yersinia infection
    102524821 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    102524821 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102524821 (PIK3CD)
   05142 Chagas disease
    102524821 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102524821 (PIK3CD)
   05017 Spinocerebellar ataxia
    102524821 (PIK3CD)
   05020 Prion disease
    102524821 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102524821 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    102524821 (PIK3CD)
   05415 Diabetic cardiomyopathy
    102524821 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102524821 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    102524821 (PIK3CD)
   04931 Insulin resistance
    102524821 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102524821 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102524821 (PIK3CD)
   01524 Platinum drug resistance
    102524821 (PIK3CD)
   01522 Endocrine resistance
    102524821 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vpc04131]
    102524821 (PIK3CD)
Enzymes [BR:vpc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102524821 (PIK3CD)
Membrane trafficking [BR:vpc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102524821 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 102524821
NCBI-ProteinID: XP_006196689
UniProt: A0A6I9HUP6
LinkDB
Position
13
AA seq 1044 aa
MPPGVDCPMEFWTKEENQDVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLQDPEVNDFRAKMRQFCEEAAARRQQLSWEAWLQYSFPLQLEPSARSWGP
GTLRVPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LRVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPASQVQKPR
TKPPPIPMKKPSSVSLWSLEQPFCIELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERRLYMWPSVPDEKGELLNPSGTVRSNPNTESAAALVIFLPEVAP
HPVYYPALDKILELGRHGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEIQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTPKPQTKELMHVCMR
QETYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDILWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
VRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYSILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcaggacgtg
gcagttgacttcttgctgcccacgggggtctatctgaacttccctgtgtcccgaaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccgctcttccac
atgctcagtgaccccgaggcctatgtgttcacctgcgtcaaccagactgcggagcagcag
gagctggaggacgagcagcggcggctgtgcgacatccagccctttctgcccgttctgcgc
ctggtggcccgcgagggggacagagtgaagaagctcatcaactcccagatcagcctgctc
attggcaaaggcctccacgaatttgactccttgcaagacccggaggtgaatgactttcga
gccaagatgcgccagttctgcgaggaggcggctgcgcggagacagcagctgagctgggag
gcctggctgcagtacagcttcccgctgcagctggagccttcagcacggagctggggacca
ggcaccctgcgcgtccccaaccgggccctcctggtcaatgtcaagttcgagggtagtgag
gagagcttcaccttccaggtgtccaccaaggatgtgcccctggcactgatggcctgcgcc
ctccggaagaaggccacagtgttccggcagccactggtggagcagcccgaggactacaca
ctgcgagtgaacgggaggcatgagtacctgtacggcagctaccccctctgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccgcacctgaccatggtgcactcctcc
tccatcctcgctatgcgggacgaacagagcaaccccgcctcccaagtccaaaaaccacgc
accaagccgccccccattcccatgaagaagccttcctcagtgtctctgtggtccctggag
cagcctttctgcatcgagctgatccagggcagcaaagtgaatgcagatgagcggatgaag
ctggtggtgcaggccgggctcttccatggcaacgagacactgtgcaagacggtgtccagc
tcagaggtgagcgtgtgctcagagcccgtgtggaagcaacggctggagtttgacatcaat
gtgtgcgacctgccgcgcatggcccgcctctgctttgcactttacgccgtgattgagaag
gccaagaaggcgcgctctaccaagaagaagtccaagaaggcggactgccctatcgcgtgg
gccaacctcatgttgtttgactacaaggaccagctcaagaccggcgagcgccgcctctac
atgtggccctccgtcccagatgagaaaggggagctgctgaacccctcgggaactgtgcgg
agtaatcccaacactgagagtgcagccgctctggtcatctttctccctgaggtggccccc
caccctgtgtactaccctgccctggacaagatcctggagctggggcggcacggggagcat
gggcgcttcacggaggaggagcagctgcagctgcgggaaatcctggagcggcggggatcc
ggggagctgtatgagcacgaaaaggacctggtgtggaagatgcggcatgagatccaggag
cacttccccgaggcgctggcccggctgctgctggtcaccaagtggaacaaacatgaggac
gtggcccagatgctctacctgctgtgctcctggcctgagctgcctgtcctgagtgccctg
gagctgctggacttcagcttccccgaccgccacgtgggctccttcgccatcaagtccctg
cggaaactgacggacgacgagcttttccagtacctactgcagctggtgcaggtgctcaag
tacgagtcctacctcgactgcgaactgaccaaattcctgctggaccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccgtctgtg
gccctgcgcttcggcctcatcatggaggcctactgccggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagctctgagcaaactgaaggccctgaacgactttgtcaaa
gtgagctcccagaagacccccaagccgcagaccaaggagctgatgcacgtgtgcatgcgc
caggagacctacctggaggccctctcccacctgcagtccccgcttgaccccagcaccctg
ctggctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
gtcatgtacagcaacgaggaggccggcagtgacggcagcgtgggcatcattttcaagaat
ggggatgacctccgccaggacatgctgaccctgcagatgatccagctcatggacattctg
tggaagcaggaggggttggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacaggcctcatcgaggtcgttcttcactcggacaccatcgccaacatccagctgaac
aagagcaacatggcggccacagctgccttcaacaaagatgctctactcaactggctcaag
tccaagaaccctggggaggccctggatcgagccattgaggagttcaccctctcctgtgct
ggctactgcgtggccacatatgtgctgggcatcggtgatcggcacagcgacaacatcatg
gtccgggagaacgggcagcttttccacattgatttcggccactttctggggaatttcaag
accaagtttggaatcaaccgtgagcgagtcccattcatcctcacctatgactttgtccac
gtgatccagcaggggaagacgaataatagtgagaaatttgaaaggttccggggctactgt
gagagggcctactccatcctgcggcggcacgggctgctcttcctccacctcttcgccctc
atgcgggcggcaggcctgcctgagctcagctgctccaaagacatccagtatctcaaggat
tctctggccttgggaaaaacagaggaggaggctctgaagcacttccgagtgaagtttaac
gaagccctccgggagagctggaaaaccaaagtgaactggctggcccacaacgtgtccaaa
gataacaggcaatag

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