Vicugna pacos (alpaca): 102526461
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Entry
102526461 CDS
T08098
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
vpc
Vicugna pacos (alpaca)
Pathway
vpc00270
Cysteine and methionine metabolism
vpc00480
Glutathione metabolism
vpc01100
Metabolic pathways
vpc01240
Biosynthesis of cofactors
vpc04216
Ferroptosis
Module
vpc_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
vpc00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
102526461 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
102526461 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
102526461 (GCLC)
Enzymes [BR:
vpc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
102526461 (GCLC)
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Paralog
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
102526461
NCBI-ProteinID:
XP_031544502
UniProt:
A0A6J3BGX2
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Position
20
AA seq
636 aa
AA seq
DB search
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVQLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRQEATSLLGDNQAVCTITSFPRLGCPGFTLPEFRPRPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFAEDDEAAKAAKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNSYRISKSRYDSIDSYLSECGEKYNDLDLTIDREIYGHLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
RDRFYFRKDICKGGSAVVDGCGKAAGAEPAAEEYALMTIDTIINGKEGVFPGLIPILNSY
LENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIAKHPDYKQDSVITDEINYSL
LLKCNQIANELCECPELLGPAFRKVKYSGSKTDPSN
NT seq
1911 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccaaggctcaccgctgagctgggaggagacccagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcttgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtgtctttcgatcat
gaaaacaaaaaagtccaattggtcctgtctggagaggaggttcttgaaactctgcaagaa
aaaggggaaaggacaaacccaaaccaccctaccctctggagaccagagtacgggagctac
atgatcgaagggacaccgggccagccgtacggggggaccatgtccgagttcaacaccgtg
gaggacaacatgaggaaacgccgccaggaggcgacgtctctgctgggagacaaccaggct
gtctgcacgataacctcatttcccagattaggctgccctgggttcacgctgcccgagttc
aggccccgcccggtcgaaggaggagcttccaagtccctcttctttcccgacgaagcaatc
aacaagcacccgcgcttcagcaccctaacaaggaacatccggcacaggaggggagagaaa
gtcgtcatcaatgtcccgatatttaaggacaagaacacaccgtctccgtttatagagacg
tttgccgaggatgacgaggcagcgaaggcggctaagccggaccacatttacatggacgcc
atgggcttcgggatgggcaattgctgtctccaggtaacgttccaagcctgcagcatatct
gaggcccgctacctgtatgatcagttggccactatctgcccaattgttatggctttgagc
gctgcgtctcctttttaccgaggctatgtgtcagacattgattgtcgctggggagtgatt
tctgcgtctgtagatgatagaactcgggaggagagaggactggagccgctgaagaacaat
agctataggattagtaaatcccggtacgactccatcgacagttacttgtccgagtgtggg
gagaagtacaacgacctcgacctgaccatagacagggagatctacggccatctgctgcag
gaaggcatcgatcacctcctggcccagcacgtggctcacctcttcatcagagacccgctg
actctgtttgaggagaaaatacacctggacgacgccaacgagtctgaccatttcgagaat
attcagtccacaaattggcagacgatgagatttaagcctcctcccccaaactccgacatt
ggatggagagtggaattccggcccatggaggtgcagttgacagacttcgagaactctgca
tacgtggtgtttgtggtgctgcttaccagggtgatcctgtcctacaaactggacttcctc
attcccctgtcaaaggtggacgagaacatgaaagtggctcagaagcgagatgccgtcctg
cgggacaggttttatttcagaaaagacatctgcaaaggtggcagcgccgtggtggacggc
tgtggcaaggcggcgggcgcggagccggcggccgaggagtacgcgctcatgaccatcgac
accatcatcaacggcaaggaaggcgtgttccccgggctgatccccatcctgaactcttac
ctggagaacatggaggtggatgtggacaccagatgcagtattctcaactacctgaagctg
atcaagaagagagcatccggagaattaatgacagttgccaggtggatgagggagtttatc
gcaaagcatcctgactacaagcaagacagtgtcatcactgacgaaataaactatagcctt
cttttaaagtgtaaccaaattgcaaacgaattatgtgaatgcccagagttacttggacca
gcatttaggaaagtaaaatatagtggaagtaaaaccgacccttccaactag
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