KEGG   Vicugna pacos (alpaca): 102529339
Entry
102529339         CDS       T08098                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
vpc  Vicugna pacos (alpaca)
Pathway
vpc01521  EGFR tyrosine kinase inhibitor resistance
vpc01522  Endocrine resistance
vpc04010  MAPK signaling pathway
vpc04012  ErbB signaling pathway
vpc04068  FoxO signaling pathway
vpc04270  Vascular smooth muscle contraction
vpc04650  Natural killer cell mediated cytotoxicity
vpc04720  Long-term potentiation
vpc04726  Serotonergic synapse
vpc04730  Long-term depression
vpc04810  Regulation of actin cytoskeleton
vpc04910  Insulin signaling pathway
vpc04914  Progesterone-mediated oocyte maturation
vpc04928  Parathyroid hormone synthesis, secretion and action
vpc05010  Alzheimer disease
vpc05022  Pathways of neurodegeneration - multiple diseases
vpc05034  Alcoholism
vpc05160  Hepatitis C
vpc05161  Hepatitis B
vpc05200  Pathways in cancer
vpc05205  Proteoglycans in cancer
vpc05208  Chemical carcinogenesis - reactive oxygen species
vpc05210  Colorectal cancer
vpc05211  Renal cell carcinoma
vpc05212  Pancreatic cancer
vpc05213  Endometrial cancer
vpc05214  Glioma
vpc05215  Prostate cancer
vpc05218  Melanoma
vpc05219  Bladder cancer
vpc05220  Chronic myeloid leukemia
vpc05221  Acute myeloid leukemia
vpc05223  Non-small cell lung cancer
vpc05224  Breast cancer
vpc05225  Hepatocellular carcinoma
vpc05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:vpc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102529339 (ARAF)
   04012 ErbB signaling pathway
    102529339 (ARAF)
   04068 FoxO signaling pathway
    102529339 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102529339 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102529339 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102529339 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    102529339 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    102529339 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102529339 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    102529339 (ARAF)
   04720 Long-term potentiation
    102529339 (ARAF)
   04730 Long-term depression
    102529339 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102529339 (ARAF)
   05205 Proteoglycans in cancer
    102529339 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    102529339 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102529339 (ARAF)
   05212 Pancreatic cancer
    102529339 (ARAF)
   05225 Hepatocellular carcinoma
    102529339 (ARAF)
   05226 Gastric cancer
    102529339 (ARAF)
   05214 Glioma
    102529339 (ARAF)
   05221 Acute myeloid leukemia
    102529339 (ARAF)
   05220 Chronic myeloid leukemia
    102529339 (ARAF)
   05218 Melanoma
    102529339 (ARAF)
   05211 Renal cell carcinoma
    102529339 (ARAF)
   05219 Bladder cancer
    102529339 (ARAF)
   05215 Prostate cancer
    102529339 (ARAF)
   05213 Endometrial cancer
    102529339 (ARAF)
   05224 Breast cancer
    102529339 (ARAF)
   05223 Non-small cell lung cancer
    102529339 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102529339 (ARAF)
   05160 Hepatitis C
    102529339 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102529339 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    102529339 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    102529339 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102529339 (ARAF)
   01522 Endocrine resistance
    102529339 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:vpc01001]
    102529339 (ARAF)
Enzymes [BR:vpc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102529339 (ARAF)
Protein kinases [BR:vpc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102529339 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal C1_2 TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 102529339
NCBI-ProteinID: XP_006213489
UniProt: A0A6J3A620
LinkDB
Position
Unknown
AA seq 611 aa
MEPSRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCRKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHETPSSRPLNEPL
TPQGPSLSPASSCTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLIQLT
AQSFNTDAAGNRGGGDGAPRGSPGPASVSSGRKSPHSKSPSEQRERKPLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLVP
NT seq 1836 nt   +upstreamnt  +downstreamnt
atggagccatcgcggggcccccctgccaacggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtttacgactctctagacaaggccctcaaggtgcggggtctcaatcaggattgctgtgtg
gtctaccggctcatcaaggggcgaaagacagtcactgcctgggacacggccattgccccc
ctggatggcgaggagctcatcgtggaggtcctcgaagacgtcccgctgaccatgcacaat
tttgtacggaagacattcttcagcctggcattttgtgacttctgccgtaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgagactccctcgagccgccccctgaatgagccgcta
acccctcagggtcccagcctttcccccgccagctcctgcacccagcaccgcgaccccgag
cacttccccttccctgccccggccaacgctcccctccagcgcatccgctccacgtccacc
cccaacgtccatatggtcagcaccacagcccccatggactccagcctcatccagctcact
gcccagagtttcaacaccgatgctgctggtaatagaggtggtggcgatggagctccccgg
gggagccctggcccggccagcgtgtcctcggggaggaagtccccacattccaagtcccct
tcagagcagcgggaacggaaacccttggccgacgacaagaagaaagtgaagaatctcggg
taccgggactcgggctattactgggaggtgccacccagtgaggtgcagctgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggtgatgtggccgtg
aaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaacgagatg
caggtgctcaggaagacgcggcacgtcaacatcttgctgttcatgggcttcatgacccgg
ccgggatttgccatcatcacacagtggtgcgagggctccagtctctaccaccacctgcat
gtggccgacacgcgctttgacatggtccagctcattgatgtggcccggcagacggcccag
ggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatc
ttcctacacgaggggctcacggtgaagatcggagactttggcttggccacagtgaagacg
cggtggagcggggcccagcccttggagcagccctcgggctcggtgctgtggatggcagct
gaggtgatccgtatgcaggacccaaacccctacagcttccagtcggatgtctacgcctat
ggggttgtgctctacgaactcatgactggctcactgccttacagccacattggcagccgt
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaactgccccaaggccatgcggcgcctgctgtctgattgcctcaagttccaacgggag
gagcggcctctcttcccccagatcctggccacgattgagctgctgcagcggtcactcccc
aagattgagcggagtgcctccgaaccctccttgcaccgtacccaggctgatgagttgcct
gcctgcctactcagcgcagcccgccttgtgccttag

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