Vicugna pacos (alpaca): 102529827 Help Entry 102529827         CDS       T08098                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism vpc  Vicugna pacos (alpaca) Pathway vpc04020   Calcium signaling pathway vpc04371   Apelin signaling pathway vpc04713   Circadian entrainment vpc04921   Oxytocin signaling pathway vpc04970   Salivary secretion vpc05010   Alzheimer disease vpc05012   Parkinson disease vpc05020   Prion disease vpc05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:vpc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102529827 (RYR3)    04020 Calcium signaling pathway     102529827 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102529827 (RYR3)   09154 Digestive system    04970 Salivary secretion     102529827 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     102529827 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102529827 (RYR3)    05012 Parkinson disease     102529827 (RYR3)    05020 Prion disease     102529827 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     102529827 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vpc04040]     102529827 (RYR3) Ion channels [BR:vpc04040]  Voltage-gated cation channels   Ryanodine receptor    102529827 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  102529827 NCBI-ProteinID:  XP_031528832 UniProt:  A0A6J3A6E5 LinkDB All DBs Position Unknown AA seq 4716 aa AA seqDB search MLANTGENGGEGFQRKAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDV GLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGNIQVDASF MQTLWNVHPTCSGSSVEEGYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRRVFYEAGGAG TRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRGKSDTKSTA FSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKTSRLG PLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRNTTALFSQFVSGNTRTTAPVTLPIE EVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNS IAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSG ILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQN LICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEP THLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLR SDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFLMGGRHGE FKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGTTQFLSQASFIPCPIDTS QVVLPPHLEKVRDKLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKLPETEKN YNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLP PQEILVDKLAENAHNVWAKDRLKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSL REAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGG DMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDA SMIFTLNGELLITNKGSELAFADYEIHNGFVPICSLGLSQIGRMNLGTDASTFKFYTMCG LQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRIDGTMDSPPCLKVTHKTFG TQNSNATMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEILSHATTQCYYAIRIFAG QDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVA TSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLF QFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSE RHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYHTLRLYSAVCALGNSRVA YALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKERKLMMKNEYIIPITGTT RKIRLYPDASKRHGLPGVGPRTCLKPGFRFSTPCFVVTSEEHQKQSPEIPLELLKTKALS MLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDEDVRQILLLIDPSVFGE HSAEMEEGAEKEEVTQVEEKAVEAGEKASKEAGKEAPVKGLLQTRLPESVKLQMCELLSY LCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTREFRSPPQEQ INMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEEDASWTGRFRALVYK IKGLPKPEKEQPSEEEERSPTTLKELVSQTMIRWAQEDQIQDAELVRMMFTLLRRQYDSI GELLQALRKTYTISQASVSDTIGLLAALGQIRCLLSVRMGKEEELLMINGLGDIMNNKVF YQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFE HLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQS CPMLLARGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALR GEGGNGLLAAMQGAIKISESPALDLPSQVYKREVSTEGGGDEEEIVHMGNAIMSFYSALI DLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVYEPDM AANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVALSTTEAALAL NRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEQCLLAI CNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEE ELHLTEKLFWGIFDSLSHKRYDSDLFRMALPCLSAIAGALPPDYLDTRMSATLEKQVSVD ADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKYGISLDENVKTHPL IRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQASQG NSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLT AKEKFRDREKAQDLFKFLQVNGVVVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQE FIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYAS HKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILAQTLDTRTVVKSGSELAKAGL RAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQF GVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNR YNPLSVFNTKTPRERAILGMPDTVEEMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEV ILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVVLGNILKIINNNLGIDEASWMK RIAVFAQPIISKARPDLLRSHFIPTLEKLKKKAIKTVQEEEQLKADSKGDTQEAELLILD EFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQ NFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGNLYSIQTSLIVAALKK MLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYK DVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRM APLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKLEEEEEEETEKQPDPL HQIILHFSRNALTERSKLENDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEEKEMEKQK TLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNASVQQKMLDYLKE KKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTR DLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDI IDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMK LSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDM FNYIDFMDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLEPAESVLNYFEPYLGRIE IMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTI FEMQLASQISESDSADRPEEEEEDEEDAPYTLEMEGEEEDDKTFECASAFAVACASVRRN VANFLRRATLKNLRKQYRKVKKMSLKELVKVFFSFFWMLFMGFFRLVFAILGGIFQILWS TVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALEAERAEGPELGITTELIPFVKGEK GDADVMSDLFGFHPKKEGGVKHGPEVGLGDLSEIIGKDEPPTLESAVRRKRKAQAAEMKT AHEAEGRVESEKADIEDGEKEDAAKEEEQPEALWADMTKRKKRRCGQKAEKPEAFMANFF KGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDIANLWNSF NDEDEEEAMVFFVLQESTGYMAPALRALAVIHTIISLVCVVGYYCLKVPLVVFKREKEIA RKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIA ELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMS VLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDDEEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDIT FFFFVIVILLAIIQGMVASSLVCTGLSQLLLFFLHL NT seq 14151 nt NT seq  +upstreamnt  +downstreamnt atgcttgccaacactggtgaaaatggcggcgaagggtttcaaaggaaggcagcacaaggc ggtggccacaggaccctgctatacggccacgcgattctcctgcggcactctttcagcgga atgtatctaacatgcttgactacatcaagatcccagacagataaacttgcctttgatgta ggtctacgcgaacatgccacaggtgaagcctgttggtggaccatacatcctgcttccaag cagaggtctgagggagaaaaggttcgaattggcgatgacctcatccttgtcagcgtgtcc tctgaaagataccttcatctctcaatatccaatggtaacatacaagtggatgcctccttc atgcaaaccctctggaacgtacatcctacgtgctcaggaagtagcgtagaagaaggatac ctgcttggtgggcacgtagtacgtctcttccatggtcatgatgagtgtttgacgataccg tctacagaccagaatgattcccagcacaggagggtattctatgaagccgggggagctggc acgagagctagatctctgtggagagtggaaccccttcggataagctggagtggcagtaac atcagatggggccaggctttccgacttcggcacctcaccacaggccactacctggccttg acagaggaccaaggccttatactgcaagaccggggaaaatcagacaccaagtccacagcc ttctctttccgggcatcaaaggaaatcaaggagaaattggattccagccacaagcgagat atagaaggcatgggagtcccggaaatcaagtatggagattccgtctgctttgtccagcac gtagccagtggtctgtgggtgacctacaaagcacaggatgccaagacatcccgccttgga cctctgaaaagaaaggtcatactccatcaggaaggccacatggatgacggcttaaccctg cagagatgccagcaggaggagtcccaggctgctcggatcatccggaacacgacagccttg ttcagccagttcgtcagtggaaacactcgcacaactgcccctgtcaccctgccgatagaa gaggtcctacagaccttgcaggacttgattgcctacttccagcccccggaggaggagatg cagcatgaagacaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaag gaagagggaatgttggcccttgtgttaaactgcattgatcgcttaaatatctacaatagc atcgctcacttcgcagggattgccagggaggagagtggcatggcctggaaagaaattctg aaccttctgtacaaactgctggctgctctcatccgtggaaacagaaacaattgcgctcaa ttctccaataaccttgattggctaatcagcaaactggacagactagaatcctcctcaggt atcttggaagtactgcactgcattctgatcgaaagcccagaagccttgaatctgatagca gagggtcacatcaagtctatcatctccctgttggataagcacgggcggaatcacaaggtg ctggatgtgctgtgctccctctgtctctgcaacggggtcgcagtgagagccaaccagaac ctgatctgcgacaacttgctgccccggagaaatctgctcctgcagacgcggctgattaac gatgtgacaagtattcggccaaacatcttcctgggagtcgctgagggctcagcgcagtac aagaagtggtacttcgagctgatcatcgaccaggtggaccccttcctcacagcagagccc acacacctgcgggtgggctgggcctcttcctcaggctatgctccgtaccccggaggtggg gaaggatggggaggcaacggtgttggcgacgacctgtactcctatggctttgacgggctg cacctttggtcaggccgcataccccgagccgtggcctccatcaaccagcacctcctccgg tcggacgacgtggtgagctgttgcctggaccttggagcgcccagcatctctttccgcatc aacgggcagcctgtccaggggatgtttgagaacttcaacacagatgggctcttcttccct gtggtgagcttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagaa tttaagttcctgcctccctccggctatgccccttgctatgaagccttgcttccaaaagaa aagatgagattggagcctgtcaaagagtataaacgagatgccgaaggcgtcagagatctg ttggggaccacccagtttctgtcccaagcctctttcatcccgtgccccatagacaccagt caggtggttttgccaccgcacctagagaaggtccgggacaagctggcagaaaacatccac gagctttggggaatgaataagatagagctgggctggactttcggcaagatacgggatgac aataaaagacaacacccctgccttgtcgagttttcaaagctgcccgaaactgagaagaat tataacctacaaatgtcaaccgaaactctaaagaccctcctggccctggggtgtcacatc gctcacgttaacccggctgccgaagaggatctaaagaaggtcaaattgcccaaaaactac atgatgtccaacggctataagcctgcccctttggatttgtctgatgtgaagctgctacct cctcaagaaattctagtcgataagcttgcagaaaatgcacacaacgtttgggcaaaagac aggctaaaacaaggatggacctatggcattcaacaggatttaaagaacaaaagaaacccc cgcctggtaccatatgcgctactggatgagcgtaccaagaagtccaacagagacagcctt cgtgaagctgttcggacgtttgtcggttatggctataacattgagccatcagaccaagaa ctggccgacccagctgtggagaaagtcagcatagacaagatccggtttttccgagtagag cggtcgtatgccgtgagatctggaaagtggtattttgagtttgaggtggtgaccggagga gacatgcgcgtcggctgggccaggccaggctgtcggccggacgttgagctgggggccgat gaccaagcctttgtgtttgaaggcagcaggggccagcgctggcatcaagggagtgggtat tttggacggacctggcagccaggagacgtggttggatgtatgattaacctggatgatgct tcgatgatcttcacactgaacggggagctgctgatcaccaacaaaggctctgaacttgcc ttcgctgactatgagattcacaacggctttgtgcccatctgctccctgggactctctcag atcgggcgcatgaatctcgggacagatgccagcaccttcaagttttataccatgtgtggc ctccaagagggctttgaaccttttgctgtcaacatgaaccgagacgtggccatgtggttc agcaagcggctcccgacatttgtcaatgtgccaaaggaccatccacagatagaggtcgtg aggatcgacggcaccatggacagccctccgtgcctcaaggtgacccacaagacgttcggt acccaaaacagcaatgccaccatgatctactgccgcctgagcatgcctgtcgagtgccac tcttccttcagtcacagcccctgtctggacagtgaggctttccagaaaaggaaacagatg caagaaatactctctcacgcaaccacacagtgctactatgcaatccgcatctttgctggg caggacccttcctgcgtctgggtcggatgggtgactccggactatcacttgtacagtgag aagttcgacctgagtaaaaactgtaccgtgactgttactctgggggatgaaagaggccga gtccatgaaagtgtgaagcgcagcaactgctacatggtctggggcggggacattgtggcc acgtcccaaagggcgagtcgcagcaacgtggacctggagatcggctgcctcgtggacctg gccatgggcatgttgtccttctcggccaacgggagagaactcggcacctgctaccaggtg gagcccaataccaaagtgtttccagcggtcttcctgcaacctacaagcacctctttgttt cagtttgaacttgggaagctgaagaacgcgatgcccctgtctgcggccatatttaagagt gaagagaagaacccagtgccacagtgcccgccccggctggacgtccaaaccatccagccc gtgctctggagccgcatgcccaacagcttcctgaaggtggagacggagcgggtgagcgag cgccacggctgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatcccc gaggagaacaggtgtgtggacatcctggagctgtgtgagcaggaggacctgatgcagttc cactaccacacgctgagactctacagcgctgtgtgtgccctgggaaacagccgggtggcc tacgccctgtgcagccacgtggacctctcccagctcttctacgccattgacaacaagtac ctccccggcctcctgcgctctggcttctatgacctgctcatcagcatccacctggccagc gcgaaggagaggaagctgatgatgaagaatgagtacatcatccccatcaccggcaccacc cggaaaatccgcctgtaccccgacgcgtccaagaggcacgggctccctggggtgggccca agaacgtgcctcaagccagggttcaggttctccaccccgtgcttcgtcgtgaccagcgag gagcaccagaagcagagccccgagatccccttggagctcctcaagacgaaggcgctgagc atgctgacggaggctgtgcagtgcagcggggctcacatccgggaccccgtcggcgggtct gtggagttccagtttgtgccggtgctgaaactcattggaactctgctggtcatgggggta tttgacgatgaagacgttcggcagatcctcctcctcatcgacccctccgtgtttggggaa cacagtgcagagatggaggagggggcagagaaggaggaggtgacacaggtggaggagaag gctgtggaggctggggaaaaggccagcaaggaggccggcaaggaggctcccgtcaaaggc ttgctgcagacccggttaccggagtctgtcaagctgcagatgtgtgagctcctcagctat ctctgtgactgtgagctgcagcaccgagtggaggccattgtggcatttggcgacatttat gtctccaagctccaggcaaatcagaagttccgctacaatgagctcatgcaagccctgaac atgtctgcagccctgaccgcccggaagaccagggagttccgctcacccccgcaggagcag atcaacatgcttcttaactttcaacttggggagaactgcccgtgcccagaggagatccgg gaggagctctatgacttccacgaggaccttctcattcactgtggggttcccctggaggaa gaggaagaagaggaggaagacgcctcctggacaggaagattccgtgccctggtgtataaa atcaaaggccttcccaagccggagaaggagcagccatcggaggaagaggagagaagccct acgacgctgaaggagctcgtctcccagaccatgatccgctgggcgcaagaggaccagatc caggatgcggagctggtccggatgatgttcacgctcctgcggaggcagtacgacagcatc ggggagctgctacaggcactgcggaagacctacaccatcagccaggcctccgtgagcgac accatcggcctgctagctgccctgggccagattcgctgcctgctcagcgtccggatgggc aaggaggaggagctgctcatgatcaacggtctgggagacataatgaacaacaaggtgttt taccagcaccccaacctcatgcgagtcctcggcatgcacgaaacggtgatggaggtgatg gtgaacgtgctgggtacagagaagtctcagatcgcctttccaaagatggttgctagctgt tgccgcttcctgtgctatttctgccgaattagccgacaaaaccagaaggccatgtttgag catctaagttacctgctggagaatagcagtgttggcctagcctccccgtcgatgagaggg tccaccccgctggatgtggcagcttcctccgtgatggacaacaacgagctggcattgggc ttagaggaaccagaccttgagaaggtggtgacctacttggcaggctgcggcctgcagagc tgccccatgcttctggccagaggatacccggacgtcggctggaaccccattgaaggggag cgctacctgtccttcctgaggtttgccgtcttcgtgaacagtgaaagtgtggaggaaaat gctagtgtcgtggtcaaactgctcatcagacgccccgagtgcttcggcccagccctgcgg ggtgaaggaggaaacggtctgctggcggccatgcaaggcgccattaagatctccgagagc ccagccctcgacctcccctcgcaggtctacaagagagaagtcagcacagagggcggtgga gatgaagaggagattgtgcacatgggcaatgcaattatgtcattttattcggctctgata gacctgctgggccgctgtgctcctgaaatgcatcttatccagacaggaaaaggggaagcc atccggatcaggtccatcctgcgctccctggtccccactgaggacttggtcgggatcatc agcatccccttgaagctgccctccctgaacaaagacgggtcagtctatgagccggatatg gcggccaacttctgccccgaccacaaggcacccatggtgctgttcttggaccgcgtttat ggcatcaaggaccagactttcctgctccacttgctggaggttggatttttacctgactta agagcctctgcctctctagatacggttgccctgagcaccacagaggccgcgctggcgctg aacaggtacctctgctcggccgtgctccccctcctcacacggtgcgccccgctctttgcc ggaacagagcactacacctctttgatcgattctacgctgcagaccatctacaggctttcc aagggccgttccctcaccaaagctcagagggacaccatcgagcaatgtttgcttgccatc tgcaatcacttgaggccttccatgttacagcagctcctgcgacgtctagtttttgatgtg ccgcaactcaacgaatactgcaaaatgcctctgaagcttctgacgaatcactacgagcag tgctggaagtattactgtctgccttcgggctgggggagctacggtctggccgtggaggaa gagctgcacctgacagagaagctcttctgggggatttttgactccctgtcccataagagg tatgactcagatcttttccggatggccctgccttgtctcagcgctattgccggggccttg ccaccggattacttagataccaggatgtcagccactttggagaagcaggtctcggtggat gctgatggcaactttgaccccaaacccatcaacaccgtgaatttctccctgcctgaaaaa ctggaatacatcgtcaccaagtatgcggagcattcacatgataaatgggcctgtgacaag agtcagaatggatggaaatacggcatttccctggacgaaaatgtgaagacacatccattg atcaggcctttcaagacattaacggagaaggagaaggaaatttatcgctggcctgccagg gagtccctgaaaaccatgctggctgtgggctggaccgtggagaggaccaaagagggagaa gccctagttcaacagcgggaaaatgagaagctacgaagcgtgtcccaggccagccagggc aacagctacagccccgctcccctggacctctccaacgttgtgctctccagagagctccag gggatggtggaggtggtagctgagaactatcacaatatctgggccaagaagaagaagctg gaactggagagcaaaggtggcggcagtcaccctcttttggtaccatatgacacgttgact gccaaggaaaagttcagggaccgagagaaggcgcaggacctgtttaaattcctccaagtg aatggcgtcgtggtttctagaggtatgaaggatatggaactggacgcctcctccatggaa aagaggtttgcctataagtttttgaagaagatcctgaaatatgttgattctgctcaagag tttattgcccatttggaagccattgtcagcagtgggaaaactgaaaagtctccccatgac caggagatcaaattctttgccaaagttctcctcccgctggttgaccagtacttcaccaat caccgcctctactttctctcgtcccctctgaagccccttagcagcagcgggtatgcctcc cataaggagaaagaaatggtggccagcctgttctgcaaactcgctgctcttgttcggcac aggatttccctcttcgggagtgattctgctacaatggtgagctgtcttcacatcttagca cagacacttgacacaaggactgtcgtgaagtcaggctcagagctggcgaaggctgggcta cgagcattctttgaaaacgccgcagaagatttggagaagacttcggaaaacctgaagctt gggaagtttacccattccaggacgcagatcaaaggcgtttcccagaacattaactacacc acggtggctctgctccctatcctgacatccatctttgagcacgttgctcagcatcagttc ggggtggacttgctcttgggtgacgtgcagatttcatgctaccacatactgtgcagcctc tactccctcgggacgggcaagaacatctatgttgaaaggcaacgtcctgcccttggagaa tgcctggcctctctggcagccgccataccagtggccttcctggaacccacccttaaccgc tacaatccgctctcagtcttcaacaccaaaacccccagggagagggccattctggggatg ccagacacggtggaggagatgtgccccgacatcccccagctggaaggcctgatgaaggaa atcaacgacctggccgagtcgggggcccgatacacggagatgccgcacgtcatcgaggtg atcttgcccatgctctgcaactacctgtcctactggtgggagcgggggcctgagcacctg ccccccagcacaggcccctggtgcaccaaggtcacctctgaacacctcagtgttgtcctg ggcaacattctgaaaatcatcaacaacaacctgggcatcgacgaggcctcgtggatgaag cgcatcgcagtgttcgcccagcccatcatcagcaaagccaggccggacctgctgagaagc cacttcatcccaaccctggagaagctgaagaagaaggccatcaagaccgtgcaggaggag gagcagctgaaagccgacagcaaaggggacactcaggaggcggagctcctcatcctggac gagtttgctgtcctctgcagagacctgtacgccttctaccccatgctgatccgctacgtg gacaacaacaggtctaactggctcaaaagccctgatgctgactctgaccagctcttccgc atggtggcagaggtcttcatcctgtggtgcaaatctcacaacttcaagagggaagagcaa aattttgtgattcagaatgaaattaataacttggcatttttaactggagacagcaaaagc aagatgtcaaaagccatgcaagtaaagtctggaggacaggaccaggaacggaagaagaca aagcggaggggaaacttgtattccatccagacctccctcattgtggctgcgctcaagaag atgctacccattggtttgaatatgtgcaccccaggtgatcaggagctgatctccctcgca aaatcacgatacagctataaagatacagatgaagaggtgaaggaacatctgcggaataac ttgcacttgcaggaaaagtctgatgacccagctgtaaagtggcagctgaacctgtacaaa gatgtcttgaagagtgaagaaccttccaacccagaaaagacagtggagcgtgtgcagaga atttcagcagctgtcttccacctggagcaggtggaacagcctttgaggtccaagaaggca gtctggcacaaactgctgtcaaagcagcggaaacgggcagtggtggcctgtttcaggatg gcccctctctacaacctgcccaggcaccgctctattaacctcttcctccatggctatcag agattttggatagaaacagaggagtattcctttgaagagaaactagtacaggatttggct aaatcccccaagttggaagaggaggaggaggaggagacggaaaagcagccagacccactt catcagatcattctccacttcagccgcaatgctctcacggagaggagcaaactggaaaac gaccctttgtacacgtcctattccagcatgatggccaagagttgtcagagtggggaggac gaagaagaggaggaagacaaggaaaaaacatttgaagagaaagaaatggaaaagcagaaa accctctatcagcaggctcggctgcacgagcgcggagccgcagagatggtccttcagatg atcagcgccagcaaaggtgagatgagccccatggtggttgagacgctgaagctggggatc gccatcctgaatgggggcaacgccagcgtgcagcagaaaatgctagattacctaaaggag aagaaggatgctgggttctttcaaagcctttctggtcttatgcagtcttgcagtgtcctc gatttgaatgcatttgagaggcagaacaaagctgaaggcctggggatggttactgaggaa ggaacactcattgttcgtgagcgtggtgaaaaagtactgcagaatgacgagtttacacgc gatctctttagattcctacagctactttgtgaaggacataacagtgacttccagaacttc ctgcggacgcagatgggcaacaccaccaccgtgaacgtcatcatcagcaccgtggactac cttctgcgcctgcaggaatcaatcagcgatttctactggtattactcagggaaggacatc attgatgaatctggacagcacaatttttctaaagctctggcggtcaccaagcagattttc aattcgcttacagaatacatccagggcccctgcattgggaaccagcagagcctggcccac agcaggctgtgggacgcggtggtcggcttcctccacgtgtttgctaacatgcagatgaaa ctctctcaggattccagtcagatcgagctgctgaaggaactcttggatctccttcaggac atggtggtgatgcttctgtccctcctggaagggaatgtggtaaatggaactattggcaag cagatggttgacaccctggtagagtcctctaccaatgtagaaatgatcttgaaattcttt gacatgttcttgaaacttaaagacttaaccagctcagacactttcaaagaatatgaccct gatggtaaagggatcatctctaaaaaggaattccagaaggccatggaagggcaaaaacag tacacgcagtcggagattgactttctcctctcgtgcgcagaagctgatgagaatgacatg tttaattacattgattttatggaccggttccatgagccggccaaggacatagggtttaac gtggcagtgttgttgacaaacctctcagagcatatgccgaatgattctcgccttaagtgt ctattggagccagcagaaagtgtactaaactacttcgaaccatacctcggacgcattgag atcatgggtggggccaagaaaattgaacgtgtttactttgagatcagcgagtccagtcga actcagtgggaaaagccccaggtgaaggagtcgaagcgacagttcatctttgacgtcgtc aatgaaggcggagagcaggagaagatggaactgttcgtgaacttctgtgaggataccatc tttgagatgcagttagcatctcagatctctgagtcagactcagctgaccggccagaagag gaggaggaggacgaggaagacgctccgtatacgttggagatggagggtgaagaggaggac gacaagacttttgagtgtgcctctgcatttgccgtggcctgtgcctcggtgaggaggaac gtggccaactttctgaggagggccaccctgaagaacctcaggaagcagtacaggaaggtg aagaagatgagcctcaaggagctggtgaaggtgttcttctctttcttctggatgttgttc atggggttcttccggttggtcttcgccatcttgggaggaatctttcagatcctctggagc acggtgttcggagggggcctcgtggaaggggccaagaacatccgagttaccaagatcctg ggcgacatgcctgacccgacccagtttggtatccacgatgatgctctggaggctgagcgg gcagaggggcctgagctgggcatcaccacggaactcatacccttcgtcaagggggagaag ggcgatgcggatgttatgtcggatctctttggattccaccctaagaaagaaggtggcgta aagcatgggcccgaagtgggtttgggtgacctgtctgagatcatcggcaaggatgagccc cctacgttagagagtgctgtacggaggaaaaggaaagcacaggcagcagagatgaaaaca gctcatgaagcagaaggaagagtggagtctgagaaggcagacatagaagatggggagaaa gaggatgcagccaaggaagaagagcagcccgaggccctctgggcggacatgacaaagagg aagaagcgacggtgtggccagaaagctgagaagcctgaagccttcatggccaatttcttt aaagggctggaaatctatcagaccaagttgctgcactacctggccaggaatttctacaac ctgaggttccttgctctgtttgtagccttcgctatcaacttcatcctgctcttttacaag gtcaccgaggaacctttagaagaagagacagaggacattgcaaacctgtggaattccttt aatgatgaggacgaggaggaagcaatggtgttctttgtcctgcaggagagcacggggtat atggcgccagcactgcgggccctggccgtcatccacaccatcatctctttggtctgcgtg gtgggctactactgcctgaaggtccctctggtggtcttcaaaagagaaaaagaaattgcc aggaagctggagtttgatggcctgtatatcaccgaacagccttctgaagatgacatcaag gggcagtgggatcgcctggtgatcaacaccccatcttttcctaataactactgggacaag tttgtcaagagaaaggtgatcaacaaatacggagacctctatggcgcagaacgcattgca gaactcctgggtttggacaaaaatgcccttgactttagcccagtggaagagaccaaagca gaggcggcctccctggtgtcatggctgagttccatcgacatgaagtaccatatctggaag ctgggagttgtttttaccgacaattccttcctctacctcgcctggtacacgaccatgtca gtcctgggccactacaacaacttcttcttcgctgctcatctgctggacatcgccatgggc ttcaagactctgaggacgatcctgtcatccgtcactcacaacggcaaacagctggtcctg actgtcgggttgctggccgtggtggtctatctctacacggtggtggcgttcaacttcttc cgcaagttctacaacaaaagcgaggatgacgaggagcccgatatgaagtgtgatgacatg atgacgtgttacctgttccacatgtacgtgggcgtgagagctggaggtggcatcggcgat gaaattgaagaccctgccggggacccctacgaaatgtaccgcatcgtctttgacattacc ttcttcttcttcgtcatcgtcatcctgctggccatcatccaaggtatggtagccagctct cttgtatgcacagggctcagtcagcttctcttgttctttctgcatctatga

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