KEGG   Vicugna pacos (alpaca): 102530118
Entry
102530118         CDS       T08098                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
vpc  Vicugna pacos (alpaca)
Pathway
vpc01521  EGFR tyrosine kinase inhibitor resistance
vpc01522  Endocrine resistance
vpc04010  MAPK signaling pathway
vpc04012  ErbB signaling pathway
vpc04014  Ras signaling pathway
vpc04015  Rap1 signaling pathway
vpc04022  cGMP-PKG signaling pathway
vpc04024  cAMP signaling pathway
vpc04062  Chemokine signaling pathway
vpc04066  HIF-1 signaling pathway
vpc04068  FoxO signaling pathway
vpc04071  Sphingolipid signaling pathway
vpc04072  Phospholipase D signaling pathway
vpc04114  Oocyte meiosis
vpc04140  Autophagy - animal
vpc04148  Efferocytosis
vpc04150  mTOR signaling pathway
vpc04151  PI3K-Akt signaling pathway
vpc04210  Apoptosis
vpc04218  Cellular senescence
vpc04270  Vascular smooth muscle contraction
vpc04370  VEGF signaling pathway
vpc04371  Apelin signaling pathway
vpc04380  Osteoclast differentiation
vpc04510  Focal adhesion
vpc04540  Gap junction
vpc04550  Signaling pathways regulating pluripotency of stem cells
vpc04613  Neutrophil extracellular trap formation
vpc04620  Toll-like receptor signaling pathway
vpc04650  Natural killer cell mediated cytotoxicity
vpc04660  T cell receptor signaling pathway
vpc04662  B cell receptor signaling pathway
vpc04664  Fc epsilon RI signaling pathway
vpc04666  Fc gamma R-mediated phagocytosis
vpc04668  TNF signaling pathway
vpc04720  Long-term potentiation
vpc04722  Neurotrophin signaling pathway
vpc04725  Cholinergic synapse
vpc04726  Serotonergic synapse
vpc04730  Long-term depression
vpc04810  Regulation of actin cytoskeleton
vpc04910  Insulin signaling pathway
vpc04912  GnRH signaling pathway
vpc04914  Progesterone-mediated oocyte maturation
vpc04915  Estrogen signaling pathway
vpc04916  Melanogenesis
vpc04917  Prolactin signaling pathway
vpc04919  Thyroid hormone signaling pathway
vpc04921  Oxytocin signaling pathway
vpc04926  Relaxin signaling pathway
vpc04928  Parathyroid hormone synthesis, secretion and action
vpc04929  GnRH secretion
vpc04934  Cushing syndrome
vpc04935  Growth hormone synthesis, secretion and action
vpc05010  Alzheimer disease
vpc05022  Pathways of neurodegeneration - multiple diseases
vpc05034  Alcoholism
vpc05132  Salmonella infection
vpc05135  Yersinia infection
vpc05160  Hepatitis C
vpc05161  Hepatitis B
vpc05163  Human cytomegalovirus infection
vpc05164  Influenza A
vpc05165  Human papillomavirus infection
vpc05166  Human T-cell leukemia virus 1 infection
vpc05167  Kaposi sarcoma-associated herpesvirus infection
vpc05170  Human immunodeficiency virus 1 infection
vpc05200  Pathways in cancer
vpc05205  Proteoglycans in cancer
vpc05206  MicroRNAs in cancer
vpc05207  Chemical carcinogenesis - receptor activation
vpc05208  Chemical carcinogenesis - reactive oxygen species
vpc05210  Colorectal cancer
vpc05211  Renal cell carcinoma
vpc05212  Pancreatic cancer
vpc05213  Endometrial cancer
vpc05214  Glioma
vpc05215  Prostate cancer
vpc05216  Thyroid cancer
vpc05218  Melanoma
vpc05219  Bladder cancer
vpc05220  Chronic myeloid leukemia
vpc05221  Acute myeloid leukemia
vpc05223  Non-small cell lung cancer
vpc05224  Breast cancer
vpc05225  Hepatocellular carcinoma
vpc05226  Gastric cancer
vpc05230  Central carbon metabolism in cancer
vpc05231  Choline metabolism in cancer
vpc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:vpc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102530118 (MAP2K1)
   04012 ErbB signaling pathway
    102530118 (MAP2K1)
   04014 Ras signaling pathway
    102530118 (MAP2K1)
   04015 Rap1 signaling pathway
    102530118 (MAP2K1)
   04370 VEGF signaling pathway
    102530118 (MAP2K1)
   04371 Apelin signaling pathway
    102530118 (MAP2K1)
   04668 TNF signaling pathway
    102530118 (MAP2K1)
   04066 HIF-1 signaling pathway
    102530118 (MAP2K1)
   04068 FoxO signaling pathway
    102530118 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102530118 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102530118 (MAP2K1)
   04024 cAMP signaling pathway
    102530118 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102530118 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102530118 (MAP2K1)
   04150 mTOR signaling pathway
    102530118 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102530118 (MAP2K1)
   04148 Efferocytosis
    102530118 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102530118 (MAP2K1)
   04210 Apoptosis
    102530118 (MAP2K1)
   04218 Cellular senescence
    102530118 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102530118 (MAP2K1)
   04540 Gap junction
    102530118 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102530118 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102530118 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102530118 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102530118 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102530118 (MAP2K1)
   04660 T cell receptor signaling pathway
    102530118 (MAP2K1)
   04662 B cell receptor signaling pathway
    102530118 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102530118 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102530118 (MAP2K1)
   04062 Chemokine signaling pathway
    102530118 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102530118 (MAP2K1)
   04929 GnRH secretion
    102530118 (MAP2K1)
   04912 GnRH signaling pathway
    102530118 (MAP2K1)
   04915 Estrogen signaling pathway
    102530118 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102530118 (MAP2K1)
   04917 Prolactin signaling pathway
    102530118 (MAP2K1)
   04921 Oxytocin signaling pathway
    102530118 (MAP2K1)
   04926 Relaxin signaling pathway
    102530118 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102530118 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102530118 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102530118 (MAP2K1)
   04916 Melanogenesis
    102530118 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102530118 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102530118 (MAP2K1)
   04726 Serotonergic synapse
    102530118 (MAP2K1)
   04720 Long-term potentiation
    102530118 (MAP2K1)
   04730 Long-term depression
    102530118 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102530118 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102530118 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102530118 (MAP2K1)
   05206 MicroRNAs in cancer
    102530118 (MAP2K1)
   05205 Proteoglycans in cancer
    102530118 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    102530118 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102530118 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102530118 (MAP2K1)
   05231 Choline metabolism in cancer
    102530118 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102530118 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102530118 (MAP2K1)
   05212 Pancreatic cancer
    102530118 (MAP2K1)
   05225 Hepatocellular carcinoma
    102530118 (MAP2K1)
   05226 Gastric cancer
    102530118 (MAP2K1)
   05214 Glioma
    102530118 (MAP2K1)
   05216 Thyroid cancer
    102530118 (MAP2K1)
   05221 Acute myeloid leukemia
    102530118 (MAP2K1)
   05220 Chronic myeloid leukemia
    102530118 (MAP2K1)
   05218 Melanoma
    102530118 (MAP2K1)
   05211 Renal cell carcinoma
    102530118 (MAP2K1)
   05219 Bladder cancer
    102530118 (MAP2K1)
   05215 Prostate cancer
    102530118 (MAP2K1)
   05213 Endometrial cancer
    102530118 (MAP2K1)
   05224 Breast cancer
    102530118 (MAP2K1)
   05223 Non-small cell lung cancer
    102530118 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102530118 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102530118 (MAP2K1)
   05161 Hepatitis B
    102530118 (MAP2K1)
   05160 Hepatitis C
    102530118 (MAP2K1)
   05164 Influenza A
    102530118 (MAP2K1)
   05163 Human cytomegalovirus infection
    102530118 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102530118 (MAP2K1)
   05165 Human papillomavirus infection
    102530118 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102530118 (MAP2K1)
   05135 Yersinia infection
    102530118 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102530118 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102530118 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102530118 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102530118 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102530118 (MAP2K1)
   01522 Endocrine resistance
    102530118 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:vpc01001]
    102530118 (MAP2K1)
Enzymes [BR:vpc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102530118 (MAP2K1)
Protein kinases [BR:vpc01001]
 Serine/threonine kinases: STE group
  STE7 family
   102530118 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 102530118
NCBI-ProteinID: XP_015099359
UniProt: A0A6J0AP43
LinkDB
Position
6
AA seq 371 aa
MKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP
IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP
PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
QPSTPTHAAGV
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgaagctggagcggaccaatctggaggccttgcagaagaagctggaggagctggagctg
gatgaacagcagcggaagcgcctcgaggcctttcttacccagaagcagaaggtgggggaa
ctgaaggatgacgactttgagaagatcagtgagctgggcgccggcaatggtggtgtggtg
ttcaaggtctcccacaagccatccggcctcgtcatggccagaaagctaattcacctggag
atcaagcctgcaatccggaaccagatcataagggagcttcaggttctgcatgagtgcaac
tccccgtacatcgtgggcttttatggtgcgttctacagcgacggcgagatcagcatctgc
atggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaagaattcct
gaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacgtacctgagagag
aagcacaagattatgcacagagatgtcaaaccttccaacatcctagtgaactcccgtggg
gagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggccaactcc
ttcgtgggcacgaggtcctacatgtcgccagaaaggctccaagggactcattactcggtg
cagtcggacatctggagcatggggctctctctggttgagatggcggtcgggaggtatccc
atccctcctccagatgccaaggagctggagctgatgtttggatgccaggtggagggagat
gcggctgagaccccacccaggccacggacccctgggaggcccctcagctcttatggaatg
gacagccggcctcctatggcaatcttcgagttgttggattacatagtcaatgagcctcca
ccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaatgctta
ataaaaaaccccgccgagagagcagatttgaagcaactcatggttcacgctttcatcaag
agatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggccttaac
cagcccagcacgcccacccacgcagctggcgtctaa

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