Vicugna pacos (alpaca): 102537530 Help Entry 102537530         CDS       T08098                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism vpc  Vicugna pacos (alpaca) Pathway vpc04020   Calcium signaling pathway vpc04024   cAMP signaling pathway vpc04260   Cardiac muscle contraction vpc04261   Adrenergic signaling in cardiomyocytes vpc04371   Apelin signaling pathway vpc04713   Circadian entrainment vpc04911   Insulin secretion vpc04921   Oxytocin signaling pathway vpc04972   Pancreatic secretion vpc05020   Prion disease vpc05022   Pathways of neurodegeneration - multiple diseases vpc05410   Hypertrophic cardiomyopathy vpc05412   Arrhythmogenic right ventricular cardiomyopathy vpc05414   Dilated cardiomyopathy vpc05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:vpc00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102537530 (RYR2)    04020 Calcium signaling pathway     102537530 (RYR2)    04024 cAMP signaling pathway     102537530 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     102537530 (RYR2)    04921 Oxytocin signaling pathway     102537530 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     102537530 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102537530 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     102537530 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     102537530 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     102537530 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     102537530 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     102537530 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     102537530 (RYR2)    05414 Dilated cardiomyopathy     102537530 (RYR2)    05415 Diabetic cardiomyopathy     102537530 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:vpc04040]     102537530 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:vpc04990]     102537530 (RYR2) Ion channels [BR:vpc04040]  Voltage-gated cation channels   Ryanodine receptor    102537530 (RYR2) Domain-containing proteins not elsewhere classified [BR:vpc04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102537530 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  102537530 NCBI-ProteinID:  XP_031527799 UniProt:  A0A6J3A276 LinkDB All DBs Position Unknown AA seq 5300 aa AA seqDB search MTYLGKVRNVKGIKQLSKNTNILRCLQEKAGLPLTNQTSPRGHLTADPRSHWRTLPPSGR RRGARLRCGKTEKARPDLGSARILTGLPPARPVGLAVSGSVAAVVDTHFPQVNGEGGDGA EARSGGLGSTDVNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKT AQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHP ASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAA QGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAW SGSHIRWGQPFRLRHVTTGKYLSLLEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRK EVDGMGTSEIKYGDSVCYIQHINSGLWLTYQSVDVKSVRMGSVQRKAIMHHEGHMDDGLN LSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFH PPEEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGE SWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPE ALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLL QTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYS PYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTEDVISCCLDLSAP SISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYE AVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREK LAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSRLPEQERNYNLQMSLETLKTLL ALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAH NVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYSL EAPDQDHAARAEVCSGTGERFRIFRAEKTYAVRAGRWYFEFEAVTAGDMRVGWSRPGCQP DQELGSDEHAFAFDGFKAQRWHQGSEHYGRPWQAGDVVGCMADVTERTMVFTLNGEILLD DSGSELAFKDFDVADGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTN RDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRL SMPVECAEVFSKTAAGGIPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKE AAKPECNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTS TYYYSVRIFPGQDPANVWVGWITSDFHQYDTAFDLDRVRTVTVTLGDEKGKVHESIKRSN CYMVCAGESMSPGQGRNSNGLEIGCVVDAASGLLTFTANSKELSTYYQVEPSTKLFPAVF AQATSPHVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFL KVDVSRISERQGWLVQCVEPLQFMSLHIPEENRSVDILELTEQEDLLKFHYHTLRLYSAV CALGNHRVAHALCSHVDEPQLLYAIESKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSE FIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQVSSPSFVSISHESYQYSPEFPL DVLKAKTIQMLTEAVREGSLHARDPVGGTTEFLLVPLIKLFYTLLIMGVFHSRDLKHVLQ LIEPSVFKEAAAPDEESEVLEGESCTEDPKPDGATEEEAKGGKRPKEGLLQMKLPEPVKL QMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKE FRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLT IRGRLLSLVEKVTYLKKKQAEKPVESAAKKSSTLQQLISETMVRWAQESVIEDPELVRAM FVLLHRQYDGIGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIR GLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFC RISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEK VVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLL IRRPECFGPALRGEGGDGLLAAMEEAIKIAGDPSRDGPSPTSGSSKTLDPEEEEDTIHTG NAVMTFYSALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTV AKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTA ALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQ RDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPG GWGSFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNY VSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFISKYAEHSHDKWSMDKLANGWIYGE IYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTR RISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNTWAKKKKLELEAKGG GNHPLLVPYDTLTAKEKAKDREKAQDILKFLQISGYAVSRGFKDLELDTPSIEKRFAYSF LQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSA ASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTV MKTGLESVKSALRAFLDSAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPML SSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGA FPVAFLETHLDKHNVYSIYNTKSSRERAALSLPANVEDVCPNIPSLEKLMEEIVELAESG IRYTQMPHVMEVILPMLCSYMSRWWEHGPENHPGRADTCCTALSSEHMNTLLGNILKIIY NNLGVDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEAR GDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNAEAEDLFRMVAEVFIY WSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRRGDRYSMQTSL IVAALKRLLPIGLNICAPGDQELIALAKNRFSLVRVLSLLVDVTTPPPHGLRSVSGDQGD TCVSVVGKALARGGFCIPAFTIVWKCFTLENELLPASQGQGISGFGLWVMIRRCAVLGKS LWIDSSEGGLRSVRCNPVFSELFSLFVLQLEDPAIRWQMALYKDLPNRTEDTSDPERTVE RVLDIANVLFHLEQKSTSMRRRYYNLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLY NLPRSESLCCLWCSCSAPSQVRAVCVPDSDFETLQSCVQFQTLSSQNFAAFQAFRKYTQA SFEKYLSLSPLNRTFSEGLARALFQGRTGDYAAPLRSSICPHTDLWWVLAAPAASSVPLP GVKALRGPPPLLSSAARSVYVLVVFAGLSPQAAARRQRCRAWSWSAGPPPCSPLNTRCST VLGACLCRELEHGGASSLDVYHMVDPESTLCPFYFKTDFFLVFHSKLEEDFLYMAYADIM AKSCHDEEEDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTVSAS KGETGPMVAATLRLGIAVLNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNA FERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTT VNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGP CTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLE GNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRD FHKAMESHKHYTPSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSE HMPNDSRLQTFLELAESVLSYFQPFLGRIEVMGSAKRIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSASKEESEKERPE EPGPRMGFFSLGTVRAALLALRYNVLALMRMLSLKSLRKQVKRVKKMTVKDMVTAVFTSY WAVFLSLLHFVASVFRGFSRILCSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGE DAERKATEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMS SPVPIPEVQEKFQEQVPKEEEKEEKEESRSEPEKAEGEDGEKEDKAREDKGKPRPRQLHT HRYGEPEAPESAFWKKIIASQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSV VEGREPPPRSSGENTRGSSLDGGSPRVIAVHYVLEESSGYMEPTLRILAVLHTVIAFFCI IGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDK FVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLSSVDVKYQM WKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQL VLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGI GDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK CFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQER CWEFFPAGDCFRKQYEDQLN NT seq 15903 nt NT seq  +upstreamnt  +downstreamnt atgacatatttgggaaaagtaaggaatgtaaaaggaataaagcagttgtcaaaaaacaca aacatcctccgctgccttcaggagaaggcgggccttcccttaaccaatcagacgagtcct cgcggtcacctgacagcagacccgcgttctcattggcggactctgccgccgtctggccgc cggcgcggtgcgcgcctcagatgtggaaagaccgagaaggcgcgtcccgacctggggagc gcgcggattctgacgggactgccgcccgcgcggcctgtgggactcgcagtctctggcagt gtggccgcagtcgtggatacgcattttcctcaggttaacggtgagggcggtgacggggca gaggcgaggagcggtggtctgggctctacagatgtgaatgttcccccagacctctccatc tgcacctttgtgctggaacaatccctctccgtccgggccctgcaggagatgctggctaac actgtggagaaatcagaagggaaagttgatgtggaaaaatggaaattcatgatgaagact gctcaaggtggtggccaccgaacactcctgtacggacatgccatattgctgcgccattcc tacagcggcatgtacctgtgttgcctgtccacctcccggtcttcaactgacaagctggcc tttgatgttggcttgcaagaggacacaacaggtgaggcctgttggtggactatacatcct gcctccaagcagcgctcagaaggagagaaagtacgagtcggagatgacctcatcttagtt agtgtgtcctctgaaaggtacttgcacttgtcctacggcaatggcagcttgcacgtggac gccgccttccagcagaccctctggagcgtggcccccatcagctcaggaagcgaagcagcc caagggtatctcatcggcggtgacgtcctcaggttgcttcatggacacatggacgagtgc ctcacggtcccctcaggagaacacggtgaagagcagcggagaactgttcactacgaaggt ggtgctgtatctgttcacgcacgttccctgtggaggctggagacactgagggttgcgtgg agtgggagccacataagatggggccagcctttccgactccgccacgtcacaacagggaaa tacttgagtctcctggaggacaaaagccttctactcatggacaaggaaaaagctgacgtc aagtcgacagcatttaccttccgatcttccaaggaaaaattagatgtaggggtgaggaaa gaagttgatggcatgggaacgtcggaaataaagtacggggactcggtgtgctacatacag cacataaacagtggcctgtggctcacctaccagtctgtggatgtgaaatctgtgaggatg ggatccgtacagcgtaaggctattatgcaccacgaaggtcacatggacgatggcctaaat ttatccagatctcaacatgaagaatcacggacagcacgtgtcatccgaagcacagtcttt ctcttcaatagatttattaggggccttgatgctctcagcaaaaaagtgaaagcttccaca gtagacttacctatcgagtccgtgagtctaagtctgcaggacctgatcggttacttccac ccaccagaggagcacttagagcatgaagacaaacagaacagattacgagctctgaagaac cggcagaatctcttccaggaagagggaatgatcaacctcgtgctggaatgcatagacagg ctgcatgtctacagcagtgccgctcactttgctgacgttgccggcagagaagccggggag tcgtggaaatcaattctgaattctctgtacgagttgctggcggctctaattagaggaaat cgtaaaaactgtgctcagttttctggctccctcgactggttgatcagccgattggaaaga ctggaagcttcttccggtattcttgaagttttacactgtgtgttagtagaaagtccagaa gctctaaatattattaaagaagggcatattaaatccattatctcacttctagacaagcat ggaagaaatcacaaggtccttgatgtcttatgctctctctgtgtttgccatggggtagca gtccgttctaaccagcatctcatctgtgacaatctcctgccaggaagagacctgctgttg cagacccgcctcgtgaaccatgtcagcagcatgaggcccaatattttcctgggtgtcagt gaagggtctgcccagtataagaagtggtactatgagttgatggtcgaccacaccgagccg ttcgtgaccgctgaagccacccatctgcgagtgggctgggcgtccacggaaggctactcc ccctaccctggagggggcgaagagtggggaggcaatggtgttggagatgatctcttttcc tatggatttgatggccttcacctctggtcagggtgtattgctcgcactgtcagctcacca aaccagcatctgctgagaactgaggacgtcatcagttgctgtttagatctaagtgcccca agcatctcatttcgaattaacggacagcctgttcaaggaatgtttgagaatttcaacatt gatggactcttctttccagttgtcagtttctctgcaggaataaaggtacgcttcctgctt ggggggagacatggagaatttaaatttctccccccacctggctacgctccgtgttatgaa gctgttctgccaaaagaaaagttgaaagtggaacacagccgagagtataagcaagagaga acttacacacgggacctgttgggccccacggtctccctgacacaagccgccttcaccccg atccctgtggataccagccagatcgtgttgcctccccatctagagaggataagagaaaaa ctggcggagaatatccacgaactctgggtcatgaataagattgaactcggttggcagtat ggcccggttagagacgacaataagagacagcacccgtgtctggtggagttctccaggctg cctgaacaggaacgcaattacaatttacagatgtcacttgagaccctgaagaccttgttg gcattaggatgtcacgtgggcatatcagatgaacatgctgaagaaaaggtgaaaaaaatg aagctgcccaagaattaccagctgacgagtgggtacaagcctgccccgatggacctgagc tttatcaaactcaccccatctcaggaagcgatggtggacaagttggcggaaaatgctcat aacgtgtgggcccgggatcgaatccgccagggctggacctacggcatccagcaggacgta aagaacagaagaaacccgcgcctcgttccctacgcccttctagacgaccgaaccaagaaa tcaaacaaggacagcctccgcgaggcggtgcgcacgctgctggggtacggctacagcctg gaggcgcccgatcaagaccacgccgccagggcagaggtgtgcagcggcaccggggagcgg ttccggatcttccgggccgagaaaacttacgccgtgagggccggaaggtggtatttcgag ttcgaggctgtcactgctggagacatgcgagtgggctggagccggccaggctgccagcct gatcaggagctgggctcggatgaacatgcctttgcttttgatggcttcaaggcccagcgc tggcaccagggcagcgagcactacgggcggccctggcaggcgggcgacgtggtgggctgc atggccgacgtgaccgagcgcaccatggtgttcacgctcaacggcgagatcctgctcgac gactcgggctccgagctggccttcaaggacttcgacgtcgctgacgggttcataccagtg tgtagcctcggagtggctcaagtgggcaggatgaacttcggaaaggatgtcagcaccttg aaatacttcaccatctgcggcttacaggagggctatgaaccatttgccgttaatacaaac agggatattaccatgtggctgagcaagaggctccctcagtttctccaggttccatcaaac cacgaacacattgaggtgaccaggatagatggcaccatagacagctccccgtgtttaaag gtcactcagaagtcattcggctcccagaacagcagcacggacatcatgttctaccgcctg agcatgcccgtcgagtgcgcagaggtgttctccaagactgcggcgggcggcatcccgggc gccggcctctttgggcccaagaacgacttggaggattatgatgcagattcggacttcgag gttctcatgaagacagctcatggccatctggtgccagatcgagtggacaaagacaaagaa gctgcaaaaccggagtgtaacaaccacaaggattacgctcaggaaaagccctctcgtctg aaacaaagatttctgctcaggaggacaaagccggattacagcacaagccattccgcaaga ctcactgaggacgtccttgccgacgacagggatgactacgactacttgatgcagacgtcc acgtactattactcagtgagaatcttccctggacaagaccccgctaacgtctgggtgggc tggattacgtcagatttccatcagtacgataccgcctttgacctggacagagttcgcaca gtgaccgtgactctaggagatgaaaaaggaaaggtgcacgaaagcatcaaacgcagcaac tgctacatggtgtgtgcgggcgagagcatgagcccggggcaggggcgcaacagtaacggc ctggagatcggctgcgtggtggacgcggccagcgggctgctcaccttcaccgccaacagc aaggagctgagcacctactaccaggtggagccaagtacaaaattatttcctgccgttttt gcacaagctacaagtcctcatgtctttcagtttgagttgggaagaataaagaacgtgatg cctctctcagcgggactgttcaagagcgagcacaaaaacccggtgccgcagtgccccccg cgcctccacgtgcagttcctgtcccacgtcctctggagcaggatgcccaaccagttcttg aaggtcgacgtctctcgaatcagcgagcgccagggctggctggtgcagtgtgtggaaccc ttgcagttcatgtctcttcacatcccggaggagaacaggtctgtggacatcctggagttg accgagcaggaggacctgctgaagttccactaccacacgctccggctgtactcggcggtg tgtgcactggggaaccaccgcgtggcccacgccctgtgcagccatgtggatgagccgcag ctgctctacgccatcgagagcaagtatatgcccggcctgctgcgcgccggctactacgac ctgctgattgacatccacctcagctcctacgccaccgccaggctcatgatgaacagcgag ttcatcgtccccatgacggaggagaccaagagcatcacgctgttcccggacgagaacaag aagcacggcctcccgggcattggcctcagcacctcgctcaggccgcggatgcaggtgtcc tcccccagcttcgtgagcatcagtcacgagagctaccagtacagccccgagttcccgctg gacgtcctcaaggccaagaccatccagatgctgacagaggcagtgcgagagggcagccta cacgcccgggaccccgtagggggcaccaccgagttcctcctcgtgcccctcatcaagctc ttctacaccctgctcatcatgggtgtcttccacagccgggacctcaagcacgtcctgcag ctcatcgagcccagcgtgttcaaggaagctgctgcccctgacgaggagagcgaggtgctg gagggggagtcctgcaccgaagaccccaagcccgacggagccacggaggaagaagccaaa gggggtaagaggcccaaggaaggtctgctccaaatgaaactgcccgagccagttaaattg cagatgtgcctcctacttcagtacctctgtgactgccaggtccggcaccggatagaagcc attgtggccttttctgatgactttgtagccaagctccaggacaaccagcggttccgctat aacgaggtcatgcaagccttaaacatgtcggctgccctcacagccaggaagactaaggag ttccgatcaccacctcaagaacagatcaatatgcttctcaattttaaggatgacaaaagc gaatgtccatgtcctgaagaaatccgagaccagctcttggattttcatgaagatttgatg acgcattgtggaattgagctggatgaagatgggtctctggatggaaacagtgatttaaca attagaggacgcctgctgtccttggtggaaaaggtgacatacctgaagaagaagcaagcc gaaaagccagttgagagtgccgccaagaagtcgtccactctgcagcagctgatatccgag accatggtccgctgggcccaagagtctgtcattgaagaccctgagctggtgagggccatg tttgtgctgctccaccgacagtatgacggcattgggggtctggttcgtgctctgcccaag acctacactatcaacagtgtttccgtcgaggacaccatcaacctgctggcatctcttggt cagattcgctctctgctgagcgtgagaatgggaaaagaagaagagaagctcatgatccgt ggattgggggatatcatgaataataaagtattctaccagcaccctaatctcatgagggcg cttgggatgcacgagacagtgatggaggtcatggtgaacgtccttggaggtggagagtcc aaggaaatcacttttcccaagatggtggccaactgctgccgttttctctgttacttctgt cgtataagcaggcagaatcagaaagccatgtttgatcatctcagttacttactggagaac agcagtgttggtctcgcctcaccagctatgagggggtcaacgccgctggatgtggccgca gcctccgtgatggataataatgagctcgccctggctctgcgggagccagatctggaaaag gtggtccgctatctggctggctgtggactgcagagctgccagatgctggtgtcgaagggc tatccagacatcggctggaatcctgtcgaaggagagagatacctcgactttctcagattt gctgtgttctgtaacggggagagtgtggaggagaacgccaacgtcgtggtcagactgctc atccggaggcctgagtgcttcggccccgccctgcggggggaaggtggggacggtctgctt gcagccatggaagaggccatcaagatagccggagacccttctcgcgatggtccctccccg accagcggctccagcaaaacccttgacccagaggaggaggaggacacaatccacacgggg aatgccgtcatgaccttctactcggctctgatcgacctgttggggcgctgtgcccccgag atgcacctgattcatgctgctaagggagaggccatcaggatcaggtctattttgagatcc ctgattccactgggagacttggtgggagtgatcagcatcgctttccagatgccaaccgta gccaaagatgggaatgtggtggagcctgacatgtctgcggggttttgcccagatcacaag gcagccatggttttgttccttgacagggtctatggaattgaggttcaagacttcctcctc caccttcttgaggttggctttctgccagatctccgggctgctgcttctttagacacggct gccctgagcgccacagacatggccctggccctcaatcggtacctctgcacggctgtgctg cccttgttgaccaggtgcgctcctctgtttgcgggcaccgagcaccacgcttcgctcatc gactccttacttcacacagtgtacagactctctaagggctgttcacttaccaaagctcag cgggactccatcgaagtgtgtctgctctccatttgtggccaactgagaccttctatgatg cagcacttgctcagaagattagtgtttgatgttccactattaaatgaacatgcaaagatg cctcttaagctgctgacaaatcattatgaaagatgctggaaatattactgcctgcctgga gggtggggaagctttggagctgcctcagaagaagaacttcatttatcaagaaagttgttc tggggcatttttgacgcgctgtctcaaaagaaatatgaacaagaacttttcaaactggca ctgccttgcctgagcgcagttgcaggagctttgcccccagactacatggagtcaaattat gtcagtatgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaacct gttgatacctcaaatatcacaattcctgagaagttggagtacttcattagcaaatatgca gagcattcccatgacaaatggtcgatggacaagttggcaaatggatggatttatggagaa atatattcagactcatctaaagttcagccattaatgaagccatataagctgttatctgaa aaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaaactatgctggcttgg gggtggaggattgaaaggacacgagagggagacagcatggccctttacaaccggactcgt cgcatttctcagacaagccaggtttctgtggatgccgcccatgggtacagcccccgagcc atcgacatgagcaatgttacactgtctcgagatctgcatgcgatggcagaaatgatggct gaaaactaccataatacatgggcgaagaaaaagaagctggagctggaggccaaaggaggt ggaaatcatccactgctggttccctatgacacactgacagccaaagagaaagccaaggac agggagaaagcacaggacatcctcaagttcctgcagatcagcgggtatgctgtgtccaga ggcttcaaggacctggaattggacacaccttctattgagaaacgatttgcctatagtttc cttcagcaactgattcgctatgtggatgaagcccatcagtatatcctggagttcgatggt ggcagcagaagcaaaggagaacatttcccttatgagcaagaaatcaagttctttgctaaa gtcgttcttcctttaattgatcagtatttcaaaaaccatcgtttatacttcttatctgca gcaagcagacctctctgttctggaggacatgcttcaaacaaagagaaagaaatggtgact agcctattctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaatgat gcaacatcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggaccgtg atgaagactggcctggagagtgtcaagagcgcactgcgggctttcctggacagtgccgcc gaggatctggagaagacgatggagaacctcaagcagggccagttcacccacacccgaaac cagcccaaaggtgttactcagattatcaattataccacggtggcactgctgccaatgctg tcgtccctatttgagcatattggccagcatcagttcggagaagatctgatattggaagat gtgcaggtgtcatgctatagaattctgactagcttgtatgctttgggaactagcaagagt atctatgtggaaaggcaacgttctgcattaggagaatgcctggctgcctttgctggtgcg tttcctgtagcctttttggaaactcatctggacaaacacaacgtttactcaatctacaat acaaagtcttcacgagagagagcagctctcagtttgccagctaacgtggaagacgtttgt ccaaatataccgtctctggagaagctcatggaagaaatcgtggagctggctgagtccggg atccgctacactcagatgccacatgtgatggaggtcatcctgcccatgctctgcagctac atgtcccgctggtgggagcacggccctgagaatcacccggggagggcagacacgtgctgc acggcgctgagctcagagcacatgaacacgttgctgggcaacatcctgaagatcatatac aacaacctgggggtggacgagggcgcctggatgaagaggctggcagtgttttcccagccc attataaacaaagtgaaacctcagctgttgaaaactcatttcctgccattaatggagaaa ctcaagaaaaaggcggcgatggtggtatcggaggaggaccacctgaagtccgaggccagg ggggacatgtccgaggcggagctgctcatcctggacgagttcaccacgctggccagggac ctctacgccttctacccgctcctgattcgatttgtggactacaacagggcaaagtggctc aaggagcctaacgcagaagcagaggaccttttccgcatggtcgctgaggtgtttatctac tggtcgaaatcccacaacttcaaaagggaggagcagaacttcgtggtgcagaatgaaatc aacaacatgtcttttctcatcacggacaccaagtcaaagatgtcgaaggcagccgtgtct gaccaggagaggaagaagatgaagcgcagaggggaccggtactccatgcagacatcgctc atcgtggcggcgctgaagcggctgctgcccatcggcctgaacatctgcgcgcccggggac caggagctcatcgctctggccaaaaatcggtttagtctggtaagggtcctgtccctcctg gtggacgtgaccactccccctccacacggtctcagaagcgtgagtggagatcagggcgac acctgtgtttcagtggtgggtaaagcactggccagaggtggcttctgtatcccagcattt accattgtttggaaatgcttcacactggagaatgaactgttgccggcctcacaaggccaa ggcatttctgggtttggtctctgggtgatgatcaggcgctgcgccgtgctcggtaaatct ctgtggatcgactcttcagaagggggtcttcgctctgtacgttgtaacccggtgttttct gaactcttctctctctttgtcctgcagttggaggaccccgccattcggtggcagatggcc ctttacaaagacctaccaaacaggactgaagacacttccgaccccgagaggacagttgag agggtactggacatagcaaacgtgctcttccaccttgagcagaaatctacatcaatgcgc cggagatattacaatctggtggagcatccgcagagatccaagaaggccgtctggcacaag ctgctctccaagcagaggaagcgggcggtggtggcctgcttccggatggcccccttgtac aacctgccgaggtcagagtccctctgctgtttgtggtgcagctgctctgcccctagccag gttagagctgtttgtgtccctgattcagacttcgagacccttcagagctgtgttcagttt caaactctcagtagccagaacttcgctgcctttcaggcttttaggaaatacactcaggca tcatttgagaaatatctaagcctcagcccattgaatcggactttctccgagggcttagca cgggccctgtttcagggccgcacaggtgattatgctgcaccactgaggtcgagcatctgc ccgcacacggatctctggtgggttctggccgctccagccgcatcgtcagttcctctcccc ggtgtcaaggcccttcgggggcctcccccgcttctctcgtcggccgcacggtcggtttac gtgctcgtggtcttcgctggtctctccccgcaggcagccgctcgtcgtcagcgctgcagg gcgtggtcttggagtgcaggcccccccccatgcagtccgctgaacacgcggtgctccaca gtcctcggggcctgtctctgccgagagctggaacacggtggcgcgtcctctcttgatgtt tatcacatggttgatcctgagtcaaccttatgccccttctacttcaaaactgattttttt cttgtttttcatagcaaactggaagaagattttttatatatggcttatgcagatattatg gcaaagagctgtcatgacgaggaggaggatgacggcgaagaggaggtgaagagctttgaa gtcacaggatcgcagcgcagcaaggaaaaggaaatggagaagcagaagcttctgtaccag caagccaggctgcacgaccgcggcgctgccgagatggtgctgcagaccgtcagcgccagc aaaggtgagactggacccatggtggctgctactctgagactcgggattgccgtcttaaat ggcgggaactccacggtgcagcagaaaatgctcgactacctcaaggagaaaaaggacgtg ggcttctttcagagcctggcgggcctgatgcagtcatgcagcgtcctcgacctcaatgca tttgagcgacagaacaaagccgagggactcgggatggtgacggaagaaggatcaggagag aaggttctgcaggatgacgagttcacctgtgacctcttccgcttcttgcagctgctctgt gagggacacaactcagattttcaaaattatctgagaactcagacgggcaacaatacaact gtcaacatcatcatctccacggtggactacctgctgcgagtccaggaatcaatcagtgat ttctattggtattactctgggaaggacgtcatcgatgagcaaggacaaaggaatttctcc aaagcaattcaagtagcaaagcaagtcttcaacactcttacagagtatattcagggccct tgcacggggaaccagcagagcctggcccacagccggctgtgggacgcggtggtgggcttc ctccacgtgtttgcccacatgcagatgaagctgtcccaggactccagtcaaattgagctc ctgaaagagctgatggaccttcagaaggacatggtggtcatgctgctgtccatgctggaa ggtaatgttgtgaacggcaccatcggcaaacagatggtggacatgctcgtggagtcttcc aacaacgtggagatgattctcaaattttttgacatgttcctgaaactgaaggacttgacg tcttccgacgccttcaaagagtatgaccccgatggcaagggcgtcatctccaagagggac ttccacaaggcgatggagagccacaagcactacacgccgtccgagaccgagttcctcctg tcctgcgccgagacggacgagaacgaaaccctggactacgaggagttcgtcaagcggttc cacgagcccgccaaggacatcggcttcaacgtggcggtgctgctgacaaacctgtccgag cacatgcccaacgacagccggctgcagaccttcctggagctggccgagagcgtgctcagc tacttccagcccttcctgggccgcatcgaggtcatgggcagcgccaagcgcatcgagagg gtctactttgagatcagcgagtccagccggacccagtgggagaagccccaggtcaaggag tccaagaggcagttcatattcgacgtggtcaacgaggggggtgagaaggagaagatggag ctgttcgtgaacttctgtgaggacaccatcttcgagatgcagctggcggctcagatctca gagtcggacctgaacgagaggtcggcgagcaaggaggagagcgagaaggagcggccggag gaaccgggcccgaggatgggcttcttctccctggggacggtgcgcgcggccctgctcgcc ctgcgctacaacgtcctggccctcatgcggatgctcagcctcaagagcctgaggaagcag gtgaagcgcgtgaagaagatgacggtcaaggacatggtcacggccgtcttcacatcctac tgggccgtcttcctcagcctcctgcactttgtggccagcgtgttcaggggcttctcccgc atcctctgcagcctcctgctggggggcagcttggtggaaggtgccaagaagatccgagtg gccgagctcttggccaacatgccggaccccacgcaggacgaggtcaggggggacggggag gatgcagagaggaaggccacggaagctgccctgccctctgaagacctcacagacctgaaa gagctgacggaggagagcgacctgctctccgacatcttcggcttggacctgaagcgagaa ggaggacagtacaaactcatcccgcataatcccaatgccggcctgagcgacctcatgagc agcccggtccccatccccgaggtgcaggagaagttccaggaacaggtgcccaaagaagag gagaaggaagaaaaagaagagagcagatcagaacccgagaaagccgagggagaagacgga gaaaaagaagacaaagccagagaagacaagggcaagccgaggccgaggcagctgcacaca cacagatacggggagcccgaggctcccgagtcggctttctggaagaagatcatagcctct cagcagaagctgctcaactattttgctcgcaacttttacaacatgaggatgttagccttg tttgtcgcgtttgcaatcaatttcatcttgctcttctacaaggtctccacttcttctgtg gttgaaggaagggagccgcccccacgcagctcaggcgaaaatacccgaggcagcagcctg gacggcggctcgccgcgagtcatcgccgtgcactacgtgctggaggagagcagcggctac atggagcccacgctgcgcatcctggccgtgctgcacacggtcatcgccttcttctgcatc attgggtactactgcctgaaggtcccactggttatttttaagcgagaaaaggaagtagct cgaaaattggaattcgatgggctttatattacggagcagccttcggaagatgacattaaa ggccagtgggatagactcgtaatcaacacacagtcatttcccaataactactgggacaaa tttgttaaaagaaaggttatggataaatacggggaattctatggccgagacagaatcagc gagctgcttggcatggacaaagccgccctggacttcagcgacgcccgggaaaagaagaag ccgaagaaagacagctccctgtcggccgtactgagctctgtcgacgtgaagtatcagatg tggaagctgggagtcgttttcacggacaactccttcctctacctggcctggtacatgacc atgtccgtcctcgggcactacaacaacttcttcttcgctgctcatcttctggacattgcc atggggttcaagaccctaagaaccatcctgtcgtcagtcacgcacaatggcaagcagctt gtgctgaccgtcggcttactggccgtcgtcgtgtacctgtacactgtggtggcgttcaac ttcttccgaaaattctacaacaaaagtgaagatggtgacacaccagatatgaagtgtgat gacatgctgacgtgctacatgttccacatgtatgtcggggtgcgtgctggcgggggtatc ggcgacgagatcgaggaccccgcgggcgacgagtacgagatctaccgcatcatcttcgac atcaccttcttcttcttcgtgatcgtcatcctcttggccatcatccaaggtttgatcatt gatgcgttcggggaactgagagaccagcaggaacaggtcaaggaagacatggagaccaag tgcttcatctgtgggataggcaacgattacttcgacaccgtgccgcacggcttcgagacc cacaccctgcaggagcacaacctggccaattacctgtttttcctgatgtatctcataaac aaagatgaaacagagcacacaggacaggaatcttacgtctggaagatgtaccaggaaagg tgctgggagttcttcccagccggggattgtttccggaaacagtacgaagaccagctgaac tga

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