Vicugna pacos (alpaca): 102541197
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Entry
102541197 CDS
T08098
Symbol
LRRK2
Name
(RefSeq) LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
vpc
Vicugna pacos (alpaca)
Pathway
vpc05012
Parkinson disease
vpc05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
vpc00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
102541197 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
102541197 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
vpc01001
]
102541197 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
vpc04131
]
102541197 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
vpc04147
]
102541197 (LRRK2)
Enzymes [BR:
vpc01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
102541197 (LRRK2)
Protein kinases [BR:
vpc01001
]
Serine/threonine kinases: TKL group
LRRK family
102541197 (LRRK2)
Membrane trafficking [BR:
vpc04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
102541197 (LRRK2)
Exosome [BR:
vpc04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
102541197 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR-B
COR-A
Ras
LRR_14
LRR_9
WDR55
LRR_13
Beta-prop_RSE1_2nd
Beta-prop_WDR36-Utp21_1st
Arf
Beta-prop_EML_2
WD40_CDC20-Fz
G-alpha
WD40_Prp19
Beta-prop_BBS7
Ank_2
Beta-prop_THOC3
Kdo
GTP_EFTU
Beta-prop_WDR5
LRR_NXF1-5
Beta-prop_RIG_2nd
MobB
Beta-prop_EML
MMR_HSR1
LRR_6
nSTAND3
T2SSE
PduV-EutP
TniB
Motif
Other DBs
NCBI-GeneID:
102541197
NCBI-ProteinID:
XP_006202920
LinkDB
All DBs
Position
12
AA seq
2544 aa
AA seq
DB search
MASGSCQGCEEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVLTYADYASKLFQDK
NVHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGNDWEVLGVHQLI
LKMLTVHNASVTLSAVGLKTLDLLLTSGKITLLILEEEHDIFLLIFDAMRTFSANDEVQK
LGCKALHVLFERVSEEQLTEFVENKDYMILLSALNNFKDEEEIVLHVLHCLHSLAIPCNN
VEVLMSGNVRCYNIVVEAMKAFPINEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKA
VQRYSKNADLQIAALSCLALLTETIFLNQDLEEKNEHQENEEEEEEEKLFWLEACYKALT
WHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQAS
ANALSTLLEQNVNFRKILLSKGIYLNVLELMQXXXXXXXXXKHIHSPEVAESGCKMLNHL
FEGSNTSLDTMAAVAPKIITVMKSHQTSLSVQLEALRAILHFIVPDLPEESTEDCEYQHK
LNMVKKQCFRNDIHKLVLAAVNRFIGNPGIQKCGLKVISSIARFPDALEVLTLEGAVDSV
LHTLQMYPDDQEIQYLGLSLIGCLVTKKNLYTGTGHLLAKILISSLQRFKDIGEVQIKGF
QAIFTILELSVSFSKLLLQHSFDSVIFHQMSSGVLEQKDQQFLSLCCKCFAKLALDDELK
SVMLERACDQNNSIMVECLLLLGADANRTKEATSLICQVCEKASSPKLVELLLDSGSREQ
DVRRALTVSIGKGDSRIISLLLRRLALDLANNSICLGGFCLGKIEPSWLGPLFPDKTSQL
RKETNMGSILARMVLRYQMKSAVEEGAASGSNGNLSEEIMDKLDEWTFIPESYMDSVFGQ
SDDLDSEGSEGSFLVKKKSNSISVGEFYRDPALQRCSPNLQRHSSSLVSYIVKIVIKCLN
LNDLLIFSFVCLFVTKGTSKLQSHVRHSDSVSSLASERDCITSLDLSANELRDIDALSQK
SCISGHLEHLEKLELHQNALTSFPQQLCETLKCLTHLDLHSNKFTSFPPYLLKMNCIANL
DVSRNDIGPSVVLDPAVKCPTLKQLNLSYNQLSSLPENLGDVVEKLEQLILEGNKISEIC
SPLSLKELKILNLSKNHISSLSEDFLETCPKVESLSARMNFLVSMPFLPSSMTSLKLSQN
RFTCVPEAILNLPHLRSLDMSSNDIQYLPGPVHWRSLNLRELLFSHNRISVLDLSEKACA
WSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELH
LNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTESGKTTLLQQLMKIKKSDLG
MQGATVGIDVKDWPIQIRGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSK
GQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACIGKITKELLNKRGFPAIR
DYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPI
EFPVIDRKRLLQLVEDHQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPRWL
CKVMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPNG
EENLLVPSSLSDQRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGR
EQALRPNRMYWRQGIYLIWSPEAYCLVGSEVLDNHGESFLKITVPSCRKGCILLGQVVDH
IDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLINP
DQPRLTIPISQIAPDLILADLPRSIMLNNDELEFEQAPEFLLGDGSFGSVYRATYEGEEV
AVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDK
ASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQY
CCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEF
DELAIQGKLPDPVKEYGCAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRR
ISIPKNFTVECMVASNHISKNASIWLGCGHTDKGQLSLLDLNTERYISEEVTDSRILCLA
LVHLPVEKESWIVSGTQSGTLLVINTEDERRRHTLEKMTDSVTCLYCHSFSKQSKQKNFL
LVGTADGNLAIFEDKTVKCKGAAPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKL
FSFSDDFTIQKLIESRTNQLFSYASYSDSNIIAVVVDTVLYVAKKDSPFVEVWDKKTEKL
CELIDCVHFLKEELVKLNKESKHKMSYSGRVKTLSLQKNTALWIGTGGGHILLLDLSTRR
IIRIIHNFCDSVRVMMTAQLGNLKNVMLVLGYNRKNTEGMQHQKEIQSCLSVWDINLPHE
VQNLEKHIEVRKELAEKMRRISVE
NT seq
7635 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgccagggctgcgaggaggaggaggacgaggaaactctgaagaag
ttgatagtcaggctgaacaatgtccaggaaggaaagcagatagagacgctggtccaaatc
ctggaggatatgctcgtgctcacttatgccgactacgcctccaagttatttcaagacaaa
aatgtccacgtgcctctgttgatcgtcttggactcgtatatgagagtcgctagcgtgcag
caggtgggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcaaagc
ttaatgggaccccaggatattggaaacgattgggaagtccttggggttcaccaactgatt
cttaaaatgctaacagttcataatgccagtgtcaccctgtcagcggttggattgaagacc
ttagatctccttctaacatcaggtaaaatcactttgctgatattggaggaagaacatgat
attttcttgttaattttcgatgccatgcgcacattttcagccaacgatgaagtccagaaa
cttggatgcaaagctttacatgtgctgtttgaaagagtttcagaggagcaactgactgaa
tttgtcgaaaataaagattatatgatactgctaagtgcgttaaacaattttaaggatgaa
gaggaaattgtgctgcatgtattgcactgtttacattccctagcgattccttgcaataat
gttgaagtcctcatgagtggcaatgtcagatgttataatattgtggtagaagccatgaaa
gcattccctatcaatgaaaaaattcaagaagtgagttgctgcttgctccataggcttaca
ttaggtaatttttttaatatcctggtgttaaatgaggtgcatgagttcgtggtaaaagcc
gtgcagcgatattcaaagaacgcagacttacagatcgcggcactcagctgtttggcgctc
ctcactgagaccattttcttaaatcaagacttagaggaaaagaatgagcatcaggagaat
gaggaggaggaagaagaagaaaagttgttttggctggaagcctgttacaaagcattaaca
tggcacagaaagaacaagcatgtgcaggaggccgcatgctgggccctgaacaatctcctc
atgtatcaaaacagtttacacgagaagattggagatgaagatggccagttcccggctcac
agggaagtgatgctgtccatgctgatgcattcttcttcaaaagaagtcttccaggcatct
gcaaatgcgttgtcgactctgttagaacaaaatgttaatttcagaaaaatcctgttgtca
aaaggaatatatctgaatgtattggaattaatgcagnnnnnnnnnnnnnnnnnnnnnnnn
nnnaaacatatacattctcctgaagtggctgaaagtggctgtaaaatgctaaatcatctt
tttgaaggaagtaacacctccctggatacaatggcagcagtggcccccaaaataataaca
gttatgaaaagtcatcagacatcgttatcagtgcagctggaggcacttcgagctatttta
cattttatagttccagacctcccagaagaatccacggaagactgtgaatatcaacataag
ctaaatatggttaaaaaacaatgtttcaggaatgatattcacaaactggtcctagcggcc
gtgaacaggttcattggaaatcctgggattcagaaatgtggattaaaagtaatttcttct
atagcacgttttcctgatgcattagaggtgttaaccctggaaggtgctgttgattcggtg
cttcacacgctgcagatgtatccggatgaccaagaaattcagtatctgggtttgagtctt
ataggatgcttggttacaaagaagaatttatacacagggactgggcatcttttggcaaaa
attctgatttccagcttacaacgatttaaggatattggtgaagtacagattaaaggattt
caggcaatctttacgatactggagttgtcagtgtctttttccaagctactgctgcagcat
tcctttgattcagtaatattccatcagatgtcttccggtgtcctggaacaaaaggatcag
cagtttctaagcctctgttgcaagtgctttgcgaaactagctctggatgatgaattaaag
agcgtgatgctcgagagggcgtgtgatcagaataacagcatcatggttgaatgcttgctt
ctgttgggagcggatgccaatcgaacaaaagaggcaacctctttaatttgtcaggtgtgt
gaaaaagcgagcagtcccaaactggtggaactgttactggacagtgggtcccgggaacaa
gatgtgcggagagctctgacagtcagcattgggaagggcgacagccggatcatcagcctg
cttttaaggaggcttgccctggatctggccaataatagcatttgccttggaggattttgt
ttgggcaaaattgaaccttcttggctgggtcctttatttccagataagacatctcagtta
aggaaagaaacaaatatgggctccatcctagcaagaatggtgctcagatatcagatgaaa
agtgctgtggaagaaggagcagcctcaggcagcaatgggaatctttctgaagaaataatg
gataaacttgacgaatggaccttcattcctgagtcttacatggacagtgtgtttggtcaa
agtgatgacctggatagtgaaggaagtgaaggctcatttcttgtgaaaaagaaatcaaat
tcaattagcgtaggagaattttaccgagatcctgcgttgcagcgttgctcaccaaatttg
caaagacattccagttcgttggtaagttatattgtgaagattgtgattaaatgtttgaac
ttaaatgacttgctgatattttcattcgtttgtttgtttgtgaccaaaggaacgtcaaaa
ctccagtcacatgtgaggcattcagacagcgtttcttccctggcttctgagagagactgt
attacatcattagacctttcagccaatgaactcagagatattgacgccctgagccagaag
tcctgcataagtggtcatttggagcaccttgaaaagctggagcttcaccagaatgcactc
acgagctttccacaacaactctgtgaaactctgaagtgtttgacccatttggacttgcac
agtaataaatttacatcatttcccccctacttgttgaaaatgaattgtattgccaacctc
gatgtctctcgaaacgacattggaccctcagtagttttggatcctgctgtgaagtgcccg
accttgaaacagcttaacctctcctataatcagctgtcttctcttcctgagaaccttggt
gatgtggtagagaaactggagcagctcattttagaaggaaataaaatatcagaaatatgt
tctcctttgagcctgaaggaactgaagattttaaaccttagtaaaaaccacatttcgtct
ctgtcggaggattttctggagacttgtcctaaagtggagagtttaagtgccaggatgaat
tttcttgtttctatgccttttttgccttcctccatgacaagcctaaaattatctcagaac
agatttacatgtgttccggaagcaattttaaatcttccacacctgcggtccttagatatg
agcagcaatgatattcagtatctgccaggtcctgtgcactggagatctctgaacttacgg
gaactcttatttagccataatcggatcagtgtcttggacttgagtgaaaaagcctgtgcc
tggtctagagtagagaaactacatctttctcataataaactgaaagagattcctcccgag
attggctgtctggaaaacctgacatctcttgatgttagttacaacttggaactgagatct
tttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggacgaactgcat
cttaattttgattttaaacatataggatgtaaagccaaagacatcataaggttccttcag
cagcggttaaaaaaggctgtgccttataaccgaatgaagcttatgattgtgggaaatact
gagagcggtaaaaccaccttattgcagcaattaatgaaaatcaagaaatcagatcttggg
atgcaaggtgccacagttggcatagacgtgaaagactggcccatccaaataagaggcaaa
gggaagaaagaccttattctaaatgtgtgggattttgcaggtcgtgaggagttctacagc
actcatccccacttcatgacccagcgagctctgtatcttgctgtctatgacctcagcaaa
gggcaagctgaagtggacgccatgaagccttggctcttcaatataaaggcgcgtgcttct
tcttcgcccgtgattcttgttggcacacatttggatgtttctgatgagaagcagcgcaaa
gcctgtataggtaaaatcaccaaggagctcttgaacaagcgagggtttcctgccatacgg
gattaccactttgtaaatgccacggaggaatccgatgctttggcaaaacttcggaaaacc
atcataaatgagagcctgaatttcaagatccgagaccagcctgttgttgggcagctgatt
ccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaatgtgccaatt
gaatttcctgtaattgaccggaaacgattattacagctcgtggaagaccatcagctgcag
ttggatgaaaatgagctccctcatgcagttcacttcctaaatgaatcaggggttcttctt
cattttcaagacccagcactgcagttaagtgatttgtattttgtggaacccaggtggctt
tgtaaagtcatggcacagattttgacagtgaaagtggaaggctgtcccaaacatcctaag
ggaattatttcacgtagagatgtggagaagtttctttcgaagaaaaagagatttccaaag
aactacatgtcacagtactttaaactcctagagaaattccagattgccttgccaaacggt
gaagaaaatttgctggtcccaagcagtctgtctgaccaaaggcctgtgatagagctcccg
cactgtgagaactctgaaattatcattcggctctacgaaatgccttattttccaatgggc
ttttggtcgagattaatcaatcgattacttgaaatttcaccttacatgctttcaggaaga
gagcaagcacttcgcccaaacagaatgtactggcgacaaggcatctacctgatctggtct
cctgaagcttactgcctggtaggatctgaagtcttagacaatcacggggagagtttctta
aaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagttgtggaccac
attgattctctcatggaagagtggtttcctgggttattggagattgatatttgtggcgaa
ggagaaactctgttgaagaaatgggccttgtatagttttaatgatggggaagagcatcaa
aaaatcttacttgacgacttgatgaagaaagccgaagaaggagaccttctaataaatcca
gatcaaccaaggctcaccattccaatatctcagattgcccctgacttgattttggctgac
ctgcctagaagcattatgttgaacaatgatgaactggaatttgaacaagctccagagttt
ctcttaggcgatggcagttttggatccgtttatagagcaacctatgaaggagaagaagtg
gctgtgaagatctttaataaacatacatcactcagactgctaagacaagagctggtggtg
ctctgccacctccaccatcccagcttaatatctctgctggcggctgggattcgtcctcga
atgttggtgatggagttggcttccaaggggtccctggatcgcctgcttcagcaagacaaa
gccagcctcaccaggacactgcagcacaggatcgcgctccacgtggctgatggcttgaga
taccttcactcagccatgattatataccgtgacttgaagccccacaacgtgttgctcttc
accctgtatcccaacgctgccatcattgccaagattgctgactacgggattgcccagtac
tgctgtagaatggggataaaaacgtccgagggcacaccagggttccgtgcacctgaagtt
gctagaggaaatgttatttataaccagcaagcagatgtatattcatttggtttgcttctc
tatgacattttgacaactggaggcagaatagcagagggtttgaagtttccaaatgagttt
gatgaattggcaatacaaggaaaattacctgatccagttaaagaatatggttgtgcccca
tggcccatggttgagaagttaattaaaaagtgtttgaaagaaaatcctcaagaaagacct
acttctgcccaggtctttgacattttgaattcagctgagttaatctgtctcatgagacgt
atatcaatacctaaaaacttcactgttgaatgcatggttgcttcaaatcatattagcaag
aatgcaagcatttggctgggctgtgggcacactgacaaaggacagctctcacttcttgac
ttaaatactgaaagatacatttctgaggaagttactgacagcagaatactgtgcctagcc
ttggtgcatcttccagtggaaaaggaaagctggatcgtgtctggaacccagtctggcacg
ctcctcgtcatcaatactgaagacgagagaaggaggcacacccttgaaaagatgactgat
tctgttacttgcttgtattgccattctttctccaagcaaagcaagcaaaaaaatttcctc
ttagtgggaactgctgatggcaacttagcaatttttgaagataaaactgttaagtgtaaa
ggagctgcccctttgaagatactcaatataggaaatgtcagcactcccctgatgtgtcta
agtgaatctatgaattctactgaaaaaaacatcatgtggggaggatgtggtacaaaactt
ttttcattttctgatgatttcaccattcagaaactcattgagagcaggacaaatcagctg
ttttcttatgcatcttatagtgattccaacatcatcgcagtggtggtagacacagttctt
tatgttgctaagaaagatagcccgtttgtggaagtgtgggacaagaagactgaaaaactc
tgcgaactgatagactgtgtgcactttttaaaggaggaactggtaaaactgaacaaggaa
tcgaaacacaaaatgtcttattctgggagagtgaaaactctcagcctgcaaaagaacact
gctctctggataggaaccggagggggccacatcttactccttgatctctcaactcgtcga
attatacgtataattcacaacttttgtgattctgttagagtcatgatgacagcacagcta
ggaaaccttaaaaatgtcatgctggttctgggttataatcggaaaaatactgaaggtatg
caacaccaaaaagagatacagtcttgcttgtctgtttgggacatcaatctgccacatgaa
gtgcaaaatttagagaaacatattgaagtgaggaaagaattagctgaaaaaatgagaaga
atatctgttgaataa
DBGET
integrated database retrieval system
