Vicugna pacos (alpaca): 102544505 Help Entry 102544505         CDS       T08098                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism vpc  Vicugna pacos (alpaca) Pathway vpc01521   EGFR tyrosine kinase inhibitor resistance vpc04151   PI3K-Akt signaling pathway vpc04217   Necroptosis vpc04380   Osteoclast differentiation vpc04550   Signaling pathways regulating pluripotency of stem cells vpc04620   Toll-like receptor signaling pathway vpc04621   NOD-like receptor signaling pathway vpc04630   JAK-STAT signaling pathway vpc04658   Th1 and Th2 cell differentiation vpc04659   Th17 cell differentiation vpc05140   Leishmaniasis vpc05145   Toxoplasmosis vpc05152   Tuberculosis vpc05160   Hepatitis C vpc05161   Hepatitis B vpc05162   Measles vpc05163   Human cytomegalovirus infection vpc05164   Influenza A vpc05165   Human papillomavirus infection vpc05166   Human T-cell leukemia virus 1 infection vpc05167   Kaposi sarcoma-associated herpesvirus infection vpc05168   Herpes simplex virus 1 infection vpc05169   Epstein-Barr virus infection vpc05171   Coronavirus disease vpc05200   Pathways in cancer vpc05203   Viral carcinogenesis vpc05212   Pancreatic cancer vpc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:vpc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102544505 (JAK1)    04151 PI3K-Akt signaling pathway     102544505 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102544505 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102544505 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102544505 (JAK1)    04621 NOD-like receptor signaling pathway     102544505 (JAK1)    04658 Th1 and Th2 cell differentiation     102544505 (JAK1)    04659 Th17 cell differentiation     102544505 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     102544505 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102544505 (JAK1)    05203 Viral carcinogenesis     102544505 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102544505 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     102544505 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102544505 (JAK1)    05161 Hepatitis B     102544505 (JAK1)    05160 Hepatitis C     102544505 (JAK1)    05171 Coronavirus disease     102544505 (JAK1)    05164 Influenza A     102544505 (JAK1)    05162 Measles     102544505 (JAK1)    05168 Herpes simplex virus 1 infection     102544505 (JAK1)    05163 Human cytomegalovirus infection     102544505 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     102544505 (JAK1)    05169 Epstein-Barr virus infection     102544505 (JAK1)    05165 Human papillomavirus infection     102544505 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     102544505 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102544505 (JAK1)    05140 Leishmaniasis     102544505 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102544505 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:vpc01001]     102544505 (JAK1) Enzymes [BR:vpc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102544505 (JAK1) Protein kinases [BR:vpc01001]  Non-receptor tyrosine kinases   JAK family [OT]    102544505 (JAK1) SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 ABC1 SH2 RIO1 FERM_F1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  102544505 NCBI-ProteinID:  XP_031540231 LinkDB All DBs Position 13 AA seq 1045 aa AA seqDB search MRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVK CLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMIKKMQLPELPKDISYKRYIPETLNKS IRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFET SMLLISSENEMNRFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLEN KHKKDEEKNKIREEWNSFSYFPEITHIVIKESVVSVNKQDNKKMELKLSSHEEALSFVSL VDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWS CTDFDNILMTVTCFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQ ILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHL GRGTRTHIYSGTLMDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKH IVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKD LVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKN LSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMN YDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKV ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGG NGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNV LVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGV TLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPEEVYQLMR KCWEFQPSNRTTFQNLIEGFEALLK NT seq 3138 nt NT seq  +upstreamnt  +downstreamnt atgaggttctatttcaccaactggcatgggaccaatgataatgagcagtcagtatggcga cactccccaaagaagcagaagaatggctacgagaaaaaaaaagttccagatgcaacccct ctccttgacgccagctcactggagtatctgtttgctcagggtcagtatgatttggtcaag tgcctggctcccatccgagaccccaagacggagcaggacgggcatgatattgagaacgag tgtttgggaatggccgtcctggctatctcccactacgccatgataaagaagatgcagctg cccgagcttcccaaggatatcagctacaagcgatatattccagaaacactgaataagtcc atcagacagaggaaccttctcaccaggatgcggataaataacgttttcaaggatttccta aaggagtttaacaacaagaccatctgcgacagcagcgtgtccacgcacgacctgaaggtg aagtacctggccaccttggagactctgacaaaacattatggtgctgaaatatttgagacg tccatgctactgatctcgtcagaaaatgagatgaatcggtttcatccaaatgacagtgga aacgttctctactatgaagtgatggtgactggaaatcttggaatccagtggaggcagaaa ccaaatgttgttcctgttgaaaaggaaaaaaataaactgaagcggaaaaaactggaaaat aaacacaagaaggatgaggagaaaaacaaaatccgggaagagtggaacagcttttcttac ttccccgagatcactcacatcgtaatcaaggagtctgtggtcagcgttaataagcaggac aacaagaaaatggaactgaagctctcgtcccacgaggaggccttgtcttttgtgtccctg gtggacggctacttccggctcacggcagatgcccaccattacctctgcaccgacgtggct cccccgctcatcgtccacaacatacagaatggctgtcacgggccaatctgcacagaatat gccatcaacaaattgcggcaagaaggaagcgaggaggggatgtacgtgctgcggtggagc tgcaccgactttgacaacatcctcatgaccgttacctgctttgaaaagtctgaggtgctg ggtggccagaaacagttcaagaactttcagatcgaagtgcagaagggccgctacagcctg catggctcagaccgcagcttccccagcctcggggacctcatgagccacctgaagaagcag atcctgcgcacagacaacatcagcttcgtgctgaagcgctgctgccagcccaagccccga gaaatctccaacctgctggtggccactaagaaagcccaagagtggcagcccgtctacccc atgagccagctgagttttgatcggatcctcaagaaagatattatgcagggcgagcacctt gggagaggcacacggacacacatctactctgggaccctcatggattacaaggatgacgaa ggaactgccgaagagaagagaataaaagtgatcctcaaagtgttagaccccagccacagg gacatttccctggccttctttgaggcagccagcatgatgagacaggtctcccataaacac atcgtgtacctctatggcgtctgtgtccgagacgtggagaatatcatggtggaagagttt gtggagggggggcccctggacctcttcatgcaccggaaaagtgatgtcctcaccacaccc tggaaattcaaagttgccaagcagctggccagcgccctgagttacttggaggataaagac ctggtccacggaaacgtgtgcactaaaaacctcctcctggcccgcgagggcattgacagc gagtgtggcccgtttatcaagctcagtgaccccggcatccccatcacggtgctgtccagg caagagtgcatagaacgaatcccatggattgctcccgagtgtgttgaagactccaagaac ctgagtgtggctgctgacaaatggagctttggaaccacactctgggaaatctgctacaat ggcgagatccccttgaaagacaagacactgattgagaaagagaggttctacgaaagccgg tgcaggccagtgacaccgtcttgtaaggagctggctgaccttatgacccgctgcatgaac tacgaccccaaccagagaccgttcttccgagccatcatgagagacatcaacaagctggag gagcagaatccagacatcgtatcagaaaaaaagccggcaaccgaagtggatcccacacat tttgaaaagcggttcttaaagaggatccgtgacttgggagagggccacttcgggaaggtt gagctctgcagatacgaccccgagggggacaatacaggggagcaggtggctgtcaaatct ctgaagcctgagagcggagggaaccacatagctgatctgaagaaggaaatcgaaatctta agaaacctttatcacgagaacattgtgaagtacaaaggcatctgcaccgaggacggagga aatggtattaagctcatcatggaatttctgccttcgggaagccttaaggaatatcttcca aagaataagaacaaaattaacctcaaacagcagttaaaatatgctgttcagatttgcaag gggatggactacctgggttctcggcagtacgtccaccgggacttagcagcaagaaatgtc cttgttgagagtgaacaccaagtgaaaattggagacttcggtctgaccaaagcaattgaa actgataaggagtattacaccgtcaaggacgaccgggacagccctgtgttctggtatgct ccagaatgtttaattcagtgtaaattttacatcgcctctgatgtctggtcctttggagtg actctgcacgagctgcttacttactgtgattcagactccagtcccatggcattgttcctg aaaatgataggcccaactcatggccagatgacggtaacaagacttgtgaatacattaaaa gaaggaaaacgtttgccttgtccacctaactgtccagaagaggtttatcaactcatgaga aaatgctgggaattccaaccatctaatcggacaacctttcaaaaccttattgaaggattt gaagcacttttaaaataa

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