Vicugna pacos (alpaca): 102544515 Help Entry 102544515         CDS       T08098                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism vpc  Vicugna pacos (alpaca) Pathway vpc01521   EGFR tyrosine kinase inhibitor resistance vpc04062   Chemokine signaling pathway vpc04081   Hormone signaling vpc04148   Efferocytosis vpc04151   PI3K-Akt signaling pathway vpc04217   Necroptosis vpc04550   Signaling pathways regulating pluripotency of stem cells vpc04630   JAK-STAT signaling pathway vpc04658   Th1 and Th2 cell differentiation vpc04659   Th17 cell differentiation vpc04725   Cholinergic synapse vpc04917   Prolactin signaling pathway vpc04920   Adipocytokine signaling pathway vpc04933   AGE-RAGE signaling pathway in diabetic complications vpc04935   Growth hormone synthesis, secretion and action vpc05140   Leishmaniasis vpc05145   Toxoplasmosis vpc05152   Tuberculosis vpc05161   Hepatitis B vpc05164   Influenza A vpc05167   Kaposi sarcoma-associated herpesvirus infection vpc05168   Herpes simplex virus 1 infection vpc05200   Pathways in cancer vpc05207   Chemical carcinogenesis - receptor activation vpc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer vpc05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:vpc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102544515 (JAK2)    04151 PI3K-Akt signaling pathway     102544515 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     102544515 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     102544515 (JAK2)   09143 Cell growth and death    04217 Necroptosis     102544515 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102544515 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102544515 (JAK2)    04659 Th17 cell differentiation     102544515 (JAK2)    04062 Chemokine signaling pathway     102544515 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     102544515 (JAK2)    04917 Prolactin signaling pathway     102544515 (JAK2)    04935 Growth hormone synthesis, secretion and action     102544515 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     102544515 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102544515 (JAK2)    05207 Chemical carcinogenesis - receptor activation     102544515 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102544515 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     102544515 (JAK2)    05164 Influenza A     102544515 (JAK2)    05168 Herpes simplex virus 1 infection     102544515 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     102544515 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     102544515 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102544515 (JAK2)    05140 Leishmaniasis     102544515 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102544515 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102544515 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102544515 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:vpc01001]     102544515 (JAK2) Enzymes [BR:vpc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102544515 (JAK2) Protein kinases [BR:vpc01001]  Non-receptor tyrosine kinases   JAK family [OT]    102544515 (JAK2) SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  102544515 NCBI-ProteinID:  XP_006208204 UniProt:  A0A6J3AJG9 LinkDB All DBs Position 4 AA seq 1130 aa AA seqDB search MACLTMTEMEGTSASPIHQNGDIPGNANSVKQIDPELQVYLYHSLGKAEGEYLQFPPGEY VAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTKHSVLYRIRFYFPY WYCNGSNRTYRHGISRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLGMA VLDMMRIAKEKDQTPLDIYSSVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSH CKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIVITGNGGIQWSRGK HKESETLTEQGLQLYCDFPDIIDVSIKQANQEGSNESRIVTIHKQDGKSLEIELSSLREA LSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKAGNQTGL YVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFNNLKDLLNCYQ METVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDIPTSPTLQRHNNVNQMVFHKIRN EDLMFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKTHRNYSESFFEAASMMS QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMH FLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPE CIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELAN LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPT QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICK GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL KNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAFRVDQIRDNMAG NT seq 3393 nt NT seq  +upstreamnt  +downstreamnt atggcttgccttacaatgacagaaatggaaggaacatctgcatcccctatacatcagaat ggtgatattcctggaaatgctaattctgtgaagcaaatagatcccgaactacaggtgtat ctttatcattcccttgggaaagctgagggagagtatctacagtttccacctggggagtac gttgcagaagaaatttgtgttgctgcttctaaagcttgtggaatcacacctgtgtatcat agtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccatgtcttc catatagatgaatcaaccaagcacagtgtactctacagaatcagattttactttccctac tggtattgtaatggcagcaacagaacctatcggcatggaatatctcgaggtgctgaagct cctcttcttgacgactttgtcatgtcttacctttttgctcagtggcggcatgattttttg catggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttgggatggcg gtgttagatatgatgagaatagctaaagaaaaggatcagactccactggacatctatagc tctgtcagctacaagacattcttaccaaaatgtgtccgagcaaagatccaggactatcat attttgacaaggaagcgaataaggtacagatttcgccgatttattgagcagttcagccat tgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag tctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttcaggtgag gagatttttgcaaccattgtaataactggaaacggtggaattcagtggtcaagagggaaa cataaagaaagtgagacactgacagaacagggtttacagttatattgtgattttcctgat attattgatgtcagtattaaacaagcaaaccaagaaggctcaaatgaaagcagaattgta actattcataagcaagatggtaaaagtctggaaattgaacttagctcattaagagaagct ttgtcttttgtgtctttaattgacggatattatagattaactgcagatgcacatcattat ctttgtaaagaagtagctcctccaatggtacttgaaaatattcaaagcaactgtcatggc ccaatttcaatggattttgctatcagtaaactgaagaaagcaggtaatcagactggactc tatgtacttcgatgcagtcctaaggattttaataaatattttctgacttttgctgttgag cgagaaaatgtcattgaatataagcactgtttgattacaaaaaatgagaatggagaatac aacctcagtggtactaagaagaacttcaataatcttaaagatcttttgaattgctaccag atggaaactgttcgctcagacagtatcatcttccagtttactaaatgctgtcccccaaag ccaaaagataaatcaaaccttctagtcttcagaaccaatggtatttctgatataccaacg tcaccaacattacagagacataataatgtgaaccaaatggtgttccacaaaatcagaaat gaagatttgatgtttaatgaaagccttggccaaggtacttttacaaaaatttttaaaggc gtaagaagggaagtaggagactacggtcaactgcatgaaacagaagttcttttaaaagtt ctggataaaacacatagaaactattcagagtctttctttgaagcagcaagcatgatgagc cagctttctcacaaacatctggttttaaattatggagtgtgtgtctgtggagaggagaat attctggttcaggagtttgtaaaatttggatcactagatacatatctgaaaaagaataaa aattctataaatatattatggaagcttgaagtggctaaacagttggcatgggccatgcat tttctagaagaaaaaacccttattcatggaaatgtgtgtgccaaaaatattcttcttatc agagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcctggcatt agtattacagttttgccaaaggacattctgcaggagagaataccatgggtaccacctgaa tgcattgaaaatcctaaaaatctaaacttagcaacagacaaatggagttttggtaccact ttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaaagaaag ctacaattttatgaagataggcaccaacttcctgcaccaaagtggacagaattagcaaat cttattaataattgtatggattatgaaccagattttagaccttctttcagagccatcatt cgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgacatgtta ccaaatatgaggataggtgccctagggttttctggtgcttttgaagaccgagaccctaca cagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaattttgggagt gtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtagctgttaaa aagctccagcacagtactgaagagcacctgagagactttgaaagggaaattgaaatcctt aaatccttgcagcatgacaacattgtaaagtacaagggagtgtgctacagtgctggccgg cgtaatctaagattaattatggaatatttaccatatggaagtttacgagactatctccaa aaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgcaag ggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaggaatata ttggtggagaatgaaaacagagttaaaataggagattttggtttaaccaaagtcttgcca caagacaaagaatactacaaggtgaaagaacctggtgaaagtcctatattctggtatgca ccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttggagtg gttctgtatgaacttttcacatatattgagaaaagtaaaagcccaccagcggaatttatg cgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaacttctg aagaataatggaagattaccaagaccagatggatgcccagacgagatttacgtaatcatg acagaatgctggaacaataatgtaaatcagcgcccctctttcagagatctagcttttcga gttgatcaaataagggacaacatggctggatga

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