Xiphias gladius (swordfish): 120787404 Help Entry 120787404         CDS       T07311                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism xgl  Xiphias gladius (swordfish) Pathway xgl04020   Calcium signaling pathway xgl04260   Cardiac muscle contraction xgl04261   Adrenergic signaling in cardiomyocytes xgl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:xgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120787404 (ryr2a)    04020 Calcium signaling pathway     120787404 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     120787404 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     120787404 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:xgl04040]     120787404 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:xgl04990]     120787404 (ryr2a) Ion channels [BR:xgl04040]  Voltage-gated cation channels   Ryanodine receptor    120787404 (ryr2a) Domain-containing proteins not elsewhere classified [BR:xgl04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120787404 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120787404 NCBI-ProteinID:  XP_039978966 LinkDB All DBs Position Unknown AA seq 4957 aa AA seqDB search DDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPPDLSICTFVLEQSLSVR ALQEMLANTEEKAEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCCLSTSRSSTDKLAFDVG LQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQ QTLWSVAPICSGSEVAQGLSLYILPGFLIGGDVLRLLHGHMDECLTVPSGEHGDEQRRTV HYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLIEDKYLLLMDKE KADVKSTAFCFRSSKEKLDPVVKKEVDGMGVPDIKYGDSVCYIQHVNTCLWLTYQTVDAK CARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNLFIRGLDTLRKKG KTSTLDLPIDSVSLNLQDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEEGMISLVLE CIDRLHVYSSAAHFAEAVGREAGEAWSSILNSLYQLLAALIRGNRKNCAQFSGSLDWLIS RLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVC HGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMHPNIFLGVSDGSAQYRKWYYELIVD QVLPFITAEATHLRVGWASTSGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHLWSGCIART VSSPNQHLLRSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVASFSAGVKM RFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQDQTAARDILGPTVSLSQAAFTP TPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVREDNKRQHPCLVEFSKL PEQERSYNLQMSLETLKTLLALGCHVGVGDEHAVEKVKSMKLSPTYELSSGYKPAPLDLS HIKLTSTQEAMVDKLAENAHNVWARDRIHQGWTYGIQQDVKNHRNPRLVPYTLLDERTKK SNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDFNNMSAEKFRIFRAEKTYCVNTGKWYFE LEVLTAGETRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAWQTGDVVGC MVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEAGEGFIPVCSLGVCQVGRMNFGKDVSTL KYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIEVTRIDGTVESCPCLK VTQRSFGSQNSYTDITFYRLSMPIDCAESFTRRNGGLFSPKRELEDFETVSDFEVLMKSS HGHCGPNGSERDEFNNHKDYNQEKPSKLKQRFMLKRNKQDNSCPSSPRLSDEGMTDDRDD YEFLMQAATQYYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFELDKVQTVTVTLGDEKGKV HESIKRSNCYMVWAGESSSPGQGRNNNGFEIGCLVDTTNGLLTFTANGKELSTYYQVEPS TKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSERRNPVPQCPPRLHVQFLTPVLW SRVPNHFLKVSASRVNDRHGWLVQCNEPLQFMSLHIPEENRSVDILELSEQRDLLKFHYH TLRLYSAICALGNNWVAHALCSHVDEAQLLQAIENKYMPGLLRAGYYNLLIDIHLRSYAT ARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRPRMHFSSPSFVCRTGSSY CNNSNSGSGSGDCFQYSPEFPLDILKIKTIEMLTEAVQEGSMHVRDPIGGSTEFLFVPLI KLFYTMLIMGVFQNGDLKNILRLIEPSVFSERREEQEEIHMELEMVREVVTEGRGEDGRR NMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQDNQRFRYNE VMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEYIREQLLDFHEDLMRH CGIELDEDRGIDGDSDFTIRGRLMSLVEKVSYLKKKMANLPKEKKDKKPSTLQQLISDTM VRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDTINLLAALGQI RSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGDLKE ITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAAS VMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWNPVEGERYLDFLRFAV FCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMKEAIKISQDSSRDGPSPKS ESIKILSDMMEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILR SLIPIEDLVGVISIPFSMPNLAKDGMVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFL LHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASL IDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNEHTK MPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIFDALSYKRYDQELFKL ALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTTNVNVPEKMDYFITRY AEHNHEKWCIEKFSIGWLYGEQICEISKTHPLLKPYKGLSEKDKESYCWSVRESLKTMLS WGWSIDRIREGDPTSLQNKSRRISQASQLSFEGTSAFSPRPIDMSNVTLSRDMQSMAELL AENLHNIWARKKKIELEAKGGGNHPLLVPYDTLTAKEKSRDRGNAQDILKFLQINGYTVT RGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDLGIKPKGEKIPHEQQIKFFG KVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGN NATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDSSAEDLEKTQENLKLGQFTHSR ELPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQVSCYRILNSLYFLGTNK SIYVERQRPALGKCLAAFSAAFPVAFLEPHINKFNIFSIYNSKGTKDRGALGLPGHVGEV CPVIPNLEKSLEEIMDLAESGMRYTQMPHVMEVVLPMLCSYMSHWWEHGPESNADKADSC CTSVNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISRAKAQLLKTHFLPLME KLKKKAAVVLMDEEHSKVEGRGEMSETELLIMDQFTILVRDLYAFYPLLIRFVDYNRARW LKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKCKMSKGIV SDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELIALAKNRFTQKDTEDE VREIIRNNLHLQGKLEDPAIRWQMALYRDLPNHYDDTSDPEKTVERVLDIAHVLFHLDQV EHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEHYF EDKLIEDLAKPGEQEPLEEEEGVKHIDPLHQLIQLFSRTALTENKLDEDNLYMAYADIMA KSCHDEQDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPIVAS TLKLGIAILNGGNSIVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGL GMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDY LLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAH SRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGK QMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISMRDFHKAMESHKH YTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQT FLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVV NEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEESEREKPDEENPEMGFFSVT TVCMALLALRYNIMLLIKVLSMKSLKKQMKKIKNMTVKDMVTTLVSLYWSVLLGLLHVAF SVARGFCRIFHRTFMGGSLVEEAKTIKVSELLANMPDPTQDEVRGEAEDREKRSSDRSSP KEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNASLTELLNSPVPSPNLLTPP TAPPPELRRRHQSKSSSTEEKEETPETECEPKKTSEAGHVEEQEKQQKNEKMKPKVRRHH TSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSS SVAEEREVMYTSSQPDSGVQWDPLGGEAVETEEVMDETGGPLKAVTVRFVLEESSGYMEP MLRILAVLHTVISFFCIIGYYCLKVPLVIFKHEKEVARKLEFDGLYITEQPSEDDIKGQW DRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHKKRKPRR DSSLAAVLSSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGF KTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGELPDMKCDDML TCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDE TEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14874 nt NT seq  +upstreamnt  +downstreamnt gatgatgaggttgtcctacagtgctcagctacaatccataaggagcaacagaaactctgt ctggctgctgaaggctttggaaacagactctgcttccttgaatccatctccaactccaag aatgtgcctccagatctgtccatctgcacctttgtcttggagcagtcactatcagtacga gcccttcaggagatgctggccaacacagaggaaaaggctgaggggacagcccagggtggc ggtcatcgtaccttactgtatggacacgctgtcctgctgcgacactcctacagtggaatg tacctatgctgtctgtcaacgtcccgctcatccacagacaaattggcgtttgatgtggga ctgcaggaagataccacaggtgaggcttgctggtggaccatccatccggcatcaaagcag cgttcagagggagagaaggttagagtgggagatgatctcatcctggtcagcgtttcctct gaaagatatctgcatctatcctatggtaatggcagtctccatgtagatgcagccttccag cagactctttggagcgtggctcctatctgttctggcagtgaagtagcacaaggtctgtct ttatatattttaccaggtttcctgataggaggggacgtcctgcgcctccttcatggtcac atggatgagtgtctaaccgttccatctggggagcatggagatgagcagaggaggacagtg cactatgaggggggagcagtgtccagtcatgccaggtccctgtggaggctggagacactg cgggttgtgtggagtgggagtcatatccgctggggtcagccattcagactgagacatgtg accacagggaaatatctgagtttgatagaagacaaatatctcctgttaatggacaaagag aaagctgatgtcaagtctacagccttctgcttcaggtcctctaaggaaaagttggaccct gttgtgaagaaggaagtggatgggatgggtgttcctgacattaagtatggcgactctgtc tgttacatccaacatgttaatacctgcctgtggctaacataccagactgttgatgccaag tgtgcacgcatgggtggagtacagagaaaggccatcatgcaccatgagggtcacatggac gacgggctgacgctgtctcggtcacaacatgaagagagtcgcactgccagagtcatccgt agtactgtctttctgttcaatctcttcatcaggggtctggacacactaaggaaaaaggga aagacctctactttggatctaccaatagattcagtcagtctgaatctacaggatctgatt ggctacttccaaccacctggagatcacctggaacatgaagacaagcagaaccgactgaga gctctgaagaaccgacagaacctctttcaggaggaggggatgatcagcctggttttggag tgtattgatcggcttcacgtctacagcagtgcagctcattttgctgaggcagtaggaagg gaggcaggagaggcctggagctccatcctcaactccctctaccaactactggctgcactg atcagaggaaacaggaagaactgcgcccagttttctggttcgctggactggctgattagc agactggagcgattggaggcctcttctggtatactagaggtgcttcattgtgtactagtg gagagtcctgaggcactgaacataatcaaagagggacacatcaaatctataatatctctg ctggacaagcatggacgcaaccacaaggttctagatgtgttgtgttcgctgtgtgtatgt cacggtgtagcagtacgctccaaccagcacctgatctgtgacaacctgctgccaggaaga gatctgttactacagactcgcctgatcaaccacgtcagcagcatgcatccaaacatcttc ctgggcgtcagtgatggctccgctcagtacaggaagtggtactacgagctgattgtggat caggtgttgccattcatcacagcagaggccactcacctcagggtgggctgggccagcacc agtggctacgcaccgtaccccagtgggggggagggctggggaggcaacggggtgggtgat gacctctactcctacggctttgatggactccatctttggtcaggctgtattgcacggact gttagctcccccaatcagcatctcttgaggtccgaggatgtggtgagctgctgcctggat ctaagtgtgcccagtatctccttcaggatcaatggccagccagttcagggcatgtttgag aacttcaactctgacggcctcttcttccctgtggccagcttctctgccggggtcaagatg cgttttctcctcggaggtcgccatggggagtttaagttcctccctcctccaggttatgct ccttgctatgaagcagtgttgccaagggagaaactgaagctggaggccagtcaggaccag actgcagccagagacatcctaggaccaactgtttccttgagccaggcagcattcaccccc acacctgtggacaccagtcagattgtgctgcctcctcacttggagaggatcagggagaag cttgcagaaaacatccatgaactgtgggtgatgaacaagatagaactaggctggacctat ggtgcagtgcgagaagataacaagcggcaacacccctgtctggtggagttctccaaactt cctgaacaagagcgaagctacaacctacagatgtcactggagactctcaaaactctcctg gctttgggttgccatgtgggcgtaggagatgaacacgctgtagagaaagtcaagagcatg aaactgtcaccaacctatgagttgtccagtggttataaacctgctcctctggacctgagt cacatcaaactgacctccacccaggaagccatggtggacaaactagctgagaatgcacac aatgtctgggcaagagatcgcatccaccagggctggacctatggaatccaacaggatgtg aagaatcatagaaatcctcgtctggtcccctacactctgctggatgagagaaccaaaaag tccaacaaagacagtttgagagaggctgtcaggactcttttgggatatggatacaacctg gaagctcctgaccaggaccatgcagctcaatctgacttcaacaacatgtctgctgagaag ttccgtattttcagagcagaaaaaacctactgtgttaatactgggaagtggtactttgaa ctggaggtactgacagcaggagagacgagggtgggctgggccaggccaggatgcctccca gaccaggagctgggatctgatgaccaggcctttgtatttgatggcttcaaggtccagcgc tggcaccagggcaacgagcactttgggcgtgcctggcagacgggggacgtggtgggatgc atggtggatctgaacgaacacaccatgatgttcacacttaatggagaagtgctgctggat gattctggctctgagctggccttcaaggactttgaagctggtgaaggttttatcccagtg tgcagtctgggtgtatgtcaggtggggcggatgaactttggtaaagatgtcagcactctg aagtacttcaccatctgtggcctgcaggaaggctacgagccgtttgctgtcaacatgaac cgagatgtaaccatgtggctcagcaagaggctgcctcagtttgtacctgtcccccccaac caccagcatatagaggtgacaaggattgatgggacagtggagtcgtgtccatgcctaaag gtcacccagaggtcatttggctcccagaatagttacactgacattacgttctacagactg agcatgcccatagactgtgcagaatccttcaccaggcgtaatggcggcctcttctcgcca aagagggagctggaggactttgaaactgtatcagactttgaggtcctgatgaagtcgtct catggtcactgtggtcccaacggatccgagagagatgaattcaacaaccacaaagattat aaccaggagaagccatctaagctcaaacaacggttcatgttgaagagaaacaaacaagac aacagctgcccctcatctcctcgactgtcagatgaggggatgactgatgacagagatgac tatgaattcctcatgcaagccgccactcagtactattcagtgcggatcttccctggtcag gagcccagcagtgtgtgggtaggctgggtaacctctgacttccatcagtatgacccaggg tttgagctggacaaggtccaaactgtcactgttaccctgggagatgagaaaggcaaggtt catgagagtataaagcgcagtaactgttacatggtgtgggctggagagagcagcagtcct ggtcaggggaggaacaacaacggtttcgagattggctgtctagtcgacacgacaaatggt ctgctgaccttcactgccaacggcaaagagctcagcacatattaccaggtggagcccagc actaagcttttccctgcagtctttgccaaggccacaagccccaatgtcttccagtttgaa ctggggcgaataaagaatgtgatgcctctgtcagctggtctgtttaagagcgaaagaagg aacccagtacctcagtgtcctccacggcttcatgtccagtttctcactcctgttttatgg agtcgtgttcccaaccacttcctcaaggtgtcagcatccagagtgaatgatagacatggc tggctggtccagtgtaatgaacctctgcaattcatgtctctgcacatacctgaggagaac aggtcggtggatatcctggagctgtcagagcagagggacttattaaagtttcactaccat acgctcagactgtactcggcaatttgtgctctgggaaacaattgggtggcacatgccctc tgctcccatgtagacgaagcacagctcctacaggctatagagaataagtacatgccaggt ttgcttcgtgcgggctattacaacctccttattgacatccacctgaggagctatgccacg gctcgccttatgatgaacaatgagtacatcgttcccatgacggatgaaacaaagagcatc acgctgtttcctgatgagaagaagaaacatggcctgccaggcatcggcctcagcacctcc ctgagacccagaatgcacttctcatctccgagctttgtctgcaggaccggatcatcttat tgtaacaacagcaacagcggatcaggatcaggagactgtttccagtatagccctgaattc cccttagatatactgaaaattaaaaccattgagatgcttacagaggcagtgcaggaagga agcatgcatgtacgggatccaataggaggcagcactgagtttctctttgtccccctcatc aagctcttctacaccatgctcatcatgggagttttccaaaatggagatctgaagaacatc ctccgactaattgaaccatctgtgttctctgaaagacgagaagagcaggaggagattcac atggagctggagatggtgagggaagtggtgactgaaggaagaggggaagatggaaggagg aacatgccaaaagaaggactgttacagatgaaactgccagagcctgtaaaactccagatg tgtcatgtgctgcagtacctgtgtgactgtcaggtgcgtcatcgtatagaggcagtggtg gccttctctgatgactttgtggcctgtctccaagacaatcagcggttccgctacaacgag gtaatgctggcactcaacatgtctgcagctctcaccgccaagaagaccaaagagttcaga tcacctccacaggaacagatcaacatgttgctgaactttaaggatgagaagcaggagtgt ccctgtcctgaatacatccgagaacagctgctcgacttccatgaagatctgatgagacac tgtggtatagagttggatgaggacagagggatagacggtgacagtgacttcaccatccgc ggtcgactcatgtcgttggtggagaaagtctcttatctgaagaagaagatggccaacctg ccaaaggagaaaaaagacaagaaacccagtacgttacagcagcttatctcagatacgatg gtccgctgggctcaagagtcagttattgaggatccagagctggtcagagccatgtttgtc ctgctgcaccgccagtatgatggcatcggaggacaggtgcgggctctcccgaagacctac actataaattcagtatccatcgaggacaccatcaacctgttggctgctctgggtcagatc agatctctgctgagtgtacgcatgggaagagaggaggagaaactaatgattcgagggctg ggtgatatcatgaacaacaaggtgttttaccagcatcctaacctgatgagagctctgggg atgcacgagactgtcatggaggtcatggtcaatgtgctcagtggaggagacttgaaggaa ataaccttccctaaaatggtggccaactgttgtcgctttctctgttatttttgtcgaatc agtcgtcagaaccagaaagccatgtttgaccatctcagctacctgttggagaacagcagt gttggtcttgcatctccatccatgcgaggctctactcctcttgatgtggctgcagcatca gtcatggataataatgagttggccctggctttgagagagccagacctggagaaggttgtg cagtacctggccggctgtgggctgcagagctgtgtgatgctggtgcgtaaaggataccct gacatcggctggaaccctgtggaaggggaacgctaccttgacttcctgcgctttgctgtg ttttgcaatggtgaaagcgtggaggagaatgccaatgttgtggtgaggcttctgattcgc cgaccagaatgttttggccctgctcttcggggagaaggtggtgatgggctgttggcagca atgaaggaagctattaagatctctcaggattcttctagggatggtccttctcctaaatct gagagcattaaaattctcagtgacatgatggaagaagaggaagatgataccatccacatg gggaatgccatcatgaccttctatgctgctctcattgacctgctaggtcgctgtgctcca gagatgcatttgatccatgctggtaaaggtgaagcgatccgtatcagagccattctgagg tctctcattcctattgaagacctggtgggagttatcagcattccattctccatgcccaac ctggctaaagatgggatggtggtggagccagacatgtcagctgggttctgtccagaccat aaagcagccatggtgctgttcctggaccgggtctatggtatcgaagaccagaatttcctg ctccacctgctggaagtcggattcttaccagacctgagagctgctgcctctctggacact gttgctctcagtgccacagacatggcactcgccctcaacaggtatctttgtacagctgtg ttgcctctcctgactaaatgtgcaccactgtttgcggggacagagccgtttgcctcactg attgactccctcctccacacggtttaccggctgtccaaaggctgctgcctcactaaggcc cagagggatgccatagaggagtgtctgctggctgtttgtggtaagctgagaccctcaatg atgcagcatctgctgaggaggctggtgtttgacgttcccctgcttaatgaacacaccaag atgcctctgaagctgttaaccaatcactatgagcggtgctggaagtattactgcctagct ggaggctggggtaactttggagctgcatcagacgaagaacttcacctttccaggaaactg ttctggggaatatttgatgctctatcatataagcggtatgaccaggagctttttaagctg gcgttgccatgtctcagcgctgtggcgggagctcttcctccagactacatggagtctaac tacatggccatgatggagaaacagtcatccatggactcagagggaaactttactccacag cctgcagacactaccaatgtgaatgtccctgagaaaatggactatttcataaccagatat gcagagcacaaccatgaaaagtggtgtatagaaaagttttccattggctggttatatggg gaacagatatgtgaaatcagcaagacccaccctttactgaaaccttacaaaggcctctct gaaaaggataaggagtcatattgctggtcagtcagagagtctctgaaaactatgctctcg tggggctggagcattgacaggatcagagagggagaccccaccagcctccagaacaagtcc aggaggatatcacaggctagccagctgtcttttgaaggaacttcagctttcagcccaaga cccattgatatgagcaatgttacactgtccagagacatgcagtctatggcagagcttctt gcagagaatttgcataatatatgggccaggaaaaagaaaatagagctggaagccaaaggt ggaggaaaccatccccttctggttccttatgatacactgactgccaaagagaaatccaga gacagaggaaatgcacaagacatcctcaagttcctccaaatcaacggttacactgttacc agaggagtgaagtcacaggagctggacactccagctatagagaaacgatttgcctacacc ttcctccagcagcttatcacttatgtagaccaggcccaccaacacatgatggagtttgat ctgggaataaaaccaaagggagagaagattcctcatgaacagcagattaagttctttgga aaggttgtcttgccattggtggatcagtactttaaaaaccataggctgtacttcctgtcc acagccatccatccaatcagcagtggtggccacgcctccaacaaggaaaaggagatggtg accagtcttttctgcaaactgggagttcttgtcagacataggatatccttgtttggtaac aatgccacatccatagtcaactgtctgcagatactgggacaaagcctggatgccaggaca gtgatgaagactggtttggagtcagtgaaggcggctctacggtcatactttgacagttcg gcagaggatctggagaagacacaggagaacctgaagctaggtcagttcacccacagcaga gagctgccacgaggtgtcacccagatcatcaactataccaccttcgccctgctgcctgtc ctctcctccctgtttgaacacattggacagaacatgtttggagaagacctcatattggat gatgtccaggtctcctgctacaggatcctcaacagcctttactttctgggaaccaacaaa agcatctatgtagaaagacagcgtccagcgttaggaaagtgtctagctgccttctcagca gccttccctgttgcatttcttgagcctcacatcaacaagttcaacatcttctccatctac aacagcaaaggaactaaagatagaggggctttaggtcttccagggcacgttggggaggtt tgtcctgtgatcccaaacttagagaagtctctggaggagatcatggatttggcagaatct ggcatgagatacactcagatgccccatgtcatggaggtggtgttaccaatgttatgcagc tacatgtctcactggtgggaacatggaccagagagcaacgcagacaaagctgacagctgc tgcacctctgtgaactccgaacacatgaacactctgctgggaaacattcttaagattatc tacaacaacctgggaatagatgagggggcttggatgaaaagactggctgttttctctcag ccaattatcagcagggccaaagcccagctgctcaagacccatttcctgcctttgatggag aaactcaaaaaaaaagcagcagttgtgttgatggatgaggaacacagcaaggtggagggg aggggtgagatgtcagagacagagcttctcatcatggaccagttcaccatattggtcaga gacctgtacgccttctaccctctcctcatccgatttgtcgactacaatagggccagatgg ctgaaagagtccaacccagaggctgaggagctgttccgaatggtggctgaggttttcatc ttctgggccaagtctcataacttcaagagggaagaacaaaactttgtggtccaaaatgaa atcaacaacatgtccttcctcatcactgacaccaagtgtaagatgtcaaagggaatagtt tcagaccaggaaaggaaaaagatgaagaggaagggagatcgatattcaatgcagacaagt ttgattgttgctactctgaagcgtctactgcctgttggactcaacatctgtgcccccgga gaacaagagcttatcgcactggctaagaaccgcttcacccagaaggatacagaggatgaa gtccgagagatcatcaggaacaatctccatttacaagggaagctggaggacccagctatt cgttggcagatggctctgtacagggacctccctaatcactatgacgacacctctgaccca gagaagactgtggagagagtcctggacatcgctcatgtcctcttccacctagaccaggtt gagcaccctcagcgaagtaagaaggcagtgtggcacaaacttctgtcaaaacagaggaag agagcagtggtcgcttgcttcaggatggcaccgctctataacctgcccaggcaccgggct gtcaacttgttcctgcagggctatgagaagtcctggattgaggcagaggaacactatttt gaagataaactcatagaggaccttgctaaaccaggtgaacaagagccattagaagaagag gaaggggtgaagcacattgatccactgcatcagcttattcagctgttcagtagaacagcc ctcacagagaataaactggatgaggataatctttacatggcctatgctgacatcatggct aagagttgccatgatgaacaggatgaagacggagaggaagtgaagagttttgaagagaag gagatggagaagcagaagctgttgtatcagcaggctcggctacatgaccgaggagctgct gagatggtgcttcaaaccatcagcgctagcaaaggtgagatgggtcccatagtggcctct actctgaagctgggaatagctattctcaatggaggaaactctattgtacagcagaaaatg ttggattatctgaaagaaaagaaggatgtaggcttttttcagagtttggctggtctgatg cagtcatgcagtgttctggatctaaatgcatttgagaggcagaacaaagcagaaggactg ggaatggtgacagaggagggatcgggtgagaaggtcatgcaggatgatgagttcacctgt gaccttttccgcttcctgcagctgctctgtgagggacacaactcagacttccaaaactac ctaaggacacaaacgggcaacaatacgactgtcaacatcatcatctctactgttgactac ctcctcagagtccaggaatctatcagtgatttctactggtattattctgggaaagatgtt attgacgaacagggccagaggaatttctccaaggcaataaatgtggccaagcaagttttc aatacactgactgagtacatccagggtccatgcactggcaaccagcagagtttggcccat agccgtttgtgggatgctgtggttggttttctccatgtcttcgctcatatgcagatgaaa ctttctcaggactccagtcagattgagttactaaaggaactgatggatctgcagaaagac atggtggtcatgctgctgtctatgctggagggtaatgtggtgaatgggactattgggaag cagatggtggacatgttggtggagtcttccaacaatgtggagatgatcctcaagtttttt gacatgttcctcaaactgaaagacctgacctcctcagatgccttcaaagaatatgaccct gatggaaaaggtgtcatctccatgagggacttccataaggcaatggagagccacaagcac tacacccagtcggagacagagttcctgctctcctgtgctgagactgatgagaatgaactc ttggactatgaagaatttgtggagcgctttcatgagccagccaaggatattggcttcaat gtggcggttttgctgaccaacctgtcggagcacatgcctcatgacacccggctgcagacc ttcttggaactggcagagagtgtcctcaactacttccaaccctacctgggccggattgag ataatgggcagtgctaagcgaattgagagggtctactttgaaatcagcgagtccagtcga actcagtgggagaaacctcaggtcaaagaatcaaagcgtcagttcatttttgatgtggtg aatgagggaggggagaaggagaagatggagctgtttgtgaatttctgtgaggacaccatc tttgaaatgcagctggcggctcagatgtctgatgctggtgagcgttcagcagtgaaagag gagagtgagcgggagaaaccagatgaggagaatcctgaaatgggcttcttctccgttacc actgtctgcatggctctgttagctctgcgatacaacatcatgctgctgataaaggtgctg tccatgaagagcttgaagaaacagatgaagaagataaaaaacatgacagtgaaggacatg gtgaccaccctggtgtccttatactggtcagtgttgttgggccttctccatgtggcgttc agtgtggctcgaggcttttgccgaatcttccacagaactttcatgggcggcagtctggtt gaggaggccaagaccataaaggtgtcagagctgctggccaacatgcctgaccccacccag gatgaggtgcggggtgaagctgaggacagagagaagagatcatctgaccgcagctccccg aaggaggacctggctgacctggcagtcaacaccagtgagaccgagctgctgtcagacatt tttggtctggacttaagaagggagggtgggcagtacaagatcaccccccataaccccaat gctagcctgaccgaactgctcaactccccagttccctccccaaacctactaaccccacct acagcacccccacctgagctcagacggaggcatcagtctaagagctcttccacagaggag aaggaagaaacaccagagactgaatgtgaacccaagaaaacatcagaggctgggcatgta gaggaacaagagaaacaacagaagaatgagaagatgaagccaaaagttagaaggcatcac acctcaaagtccgatgaaccagatctgcaggagtctgcattcttgaagaagatcatagcc taccagaggaaactactgaactactttgccaggaacttctacaacatgagaatgttggcg ctgtttgttgcctttgcaatcaacttcatcctcttattctataaggtgtctacatcctca tctgtggctgaagaaagggaagtgatgtacaccagcagccaaccagacagtggcgttcag tgggatccactgggtggagaagcagtggagacagaggaggtgatggatgagactgggggg cccctgaaggctgtcacggtccgttttgtcctggaagagagcagtggatacatggagccc atgttacggatcctggccgttcttcacactgttatctccttcttctgtatcattggatac tactgtctcaaggtgccactggtaatttttaagcatgagaaggaggtggccaggaagctg gaatttgacggcctttatatcacagaacaaccatctgaagatgacatcaaaggacagtgg gacagactggtcatcaacacacaatctttccccaacaactactgggataagtttgtgaag aggaaggtgatggataaatatggagagttttacggccatgaccgcatcagtgagctgctg ggaatggacaaggcggcactggacttcagtgatgctcacaaaaagagaaaacccaggaga gacagctcactggctgctgtgctgagctccattgatgtcaagtaccagatctggaagctg ggggttgtatttacagacaattccttcctgtatctggcctggtatatgaccatgtccatc ctgggtcactataacaacttcttctttgctgcccatctacttgacatcgccatgggtttt aagactctacgtacaatcttgtcctcggtcacacacaatggcaaacagctggttttaacg gttggcctcttagcagtggtggtgtacctctacacagtagtggccttcaacttctttagg aagttctacaacaagagtgaagatggagaactgccagacatgaagtgtgacgacatgctg acatgctacatgtttcacatgtatgtaggtgtgagagcaggtggagggattggtgaccag attgaagacccagcaggtgacgagtacgagatctatcgcatcatctttgacatcaccttc ttcttctttgtcattgtaatcctcctggctatcatccaggggttgatcattgatgctttt ggagagctgagggaccagcaggaacaagtgaaagaagatatggagaccaaatgttttatc tgtggaataggtaatgactactttgacacagtgccacatggctttgaaacacatacgcta caggagcacaacttggccaactacctattctttgtgatgtatctcatcaacaaagatgaa acagagcacacaggccaggagtcttatgtatggaagatgtaccaagagcgttgctgggag tttttccctgctggtgactgtttccggaaacagtatgaggatcagctcaactaa

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