Xiphias gladius (swordfish): 120796349 Help Entry 120796349         CDS       T07311                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism xgl  Xiphias gladius (swordfish) Pathway xgl04020   Calcium signaling pathway xgl04260   Cardiac muscle contraction xgl04261   Adrenergic signaling in cardiomyocytes xgl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:xgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120796349 (ryr2b)    04020 Calcium signaling pathway     120796349 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     120796349 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     120796349 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:xgl04040]     120796349 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:xgl04990]     120796349 (ryr2b) Ion channels [BR:xgl04040]  Voltage-gated cation channels   Ryanodine receptor    120796349 (ryr2b) Domain-containing proteins not elsewhere classified [BR:xgl04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120796349 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_6 RRN3 Motif Other DBs NCBI-GeneID:  120796349 NCBI-ProteinID:  XP_039995017 LinkDB All DBs Position LG11:9874790..9942779 Genome browser AA seq 4986 aa AA seqDB search MMTDTGEGDDEFQFLRTGDEVVLQSTFTSQEEHVKLCLAAEGFGSRLCRLESTSNYKNVP PDLSVCGFVLAQCLSVRALQEMLAHSLPLAAEVGAGGSHRTLLYGQAVLFLHSYSGMYLS CLSSSQSSTDKLAFDVGLKEDKAGEACWWTVHPASRQRSEGEKVRVRDDLILVNVSSERY LHLSFGTVFDNKSVSDGLIVNAAFQQTLWSVAPICSGGGVVQGYLKGGDTLRLLHSHSDA CLTIPSTEQGEELQRLMHYEIGSVCSYARSLWRLEILHVVWSGRHTCWGQPFRLCHVTTG RYLGLTEEKGLHLVDRDKADINTTSFCFRSSKEKHDTGTKTAVDAMGIPEIKYGDSICYV QHAESGLWLTYQATDAKSSLMGGSQRKAILHSEGHMDDGLTLSRSQREESHTARLIRSAV LLFTRFIRKLDSFSQQGNLPSVSLPMEMVTCSLQDLIKYFQPPLEGLGHEAKQNSKKALK NRQNMFQEEGVIDLVLDCIDHVHQYSSASHFAEAAQSETGEEWETILNCLYELLAALIRG NRVNCAHFSGSLDWLISRLDRLEASSGVLEVLHCILVESPEALNVIKEGHIHSIISFLDK HGCNHKVVFQVLEVLCSLCVCNGVAVRSNQNHICDSLLPDRDLLLQTRLVNQVISMRPNI FLAVGEDTAQHRRWYYELVVDHVNPFLTSEPTHLRVGWACTEGYHPRPTGGEGWGGNGVG DDLCSYGFDGLHLWSGCVGRRVSSPFPHLLKNDDVVSCCLDVSAPCISFRVNGLPVQGML ENFSADGLLYPVVSFSAGVRVRFLFGGRHGEFRFLPPPGFAPCSEALLPRVKLKVEPCQT YILDHGEGKQELIGPLVPVNPVTFTPTPVDISKVVLPSQLEDIREKMAENIHELWVMDKT DLGWTHGPVRDEIKRQDPCLVEFSKLPEQERNQNLQVAQDTLRTLLALGFYICLTDDRAA EKVKYMRLATKYEQPSGYRPAPVDLSRVYLSPVYEEVINLLAENDHNVWARERIKLGWTY GAQQDVKVKRSPYLVPYNLLDERSRRVGRESVREAVCTLLAYGYSLEPLNQERTMSSNAC LFSTEKCRVFRPDKSYAVTQGKWYFEFEILTTGPMRVGWARPGCTPDKELGSDDQAYVFD GFEGQWYHQGGEPLGRPWQRGNVVGCLVDMAECTMVITLNGEVLFNDRGSELAAKDFDIR DGLLPVVSVGVNQVGRINLGRQVDSLQYFTVCGLQEGYEPFAVNMARDPSLWMSWKQPQF TSILPDDNNLQVTKISGSTDSSSSLRVSQRLFAHHGGGSEMGFYRLSMSIECAAILTSPA GGVLPVASNTLSPGRKEQEEVDSDFEMLMKSAHSFAGSRDELNHKDHNQDKTSRLKQRFM LKRTKPDLVSSISSARLLEDVVVDKDNYDHLIQSSRYYYSVRVLPGQEPFNVWVGWVTSD FHQYEMTFDTDYVNTVTVTLGDDSGKVQESVKRCNCYMVCAGEATGLSQSRRSSGLEIGC LIDSATGLLTFTSSGVEMATFYQVEASTKLFPAVFVKPTTSIMFQFELGHVKNVMPLSAG LLRSQRRNATPQCPPRFQVQHLSPVSWTRVPDHALKVLVDRPDECHGWRVQCSDPLLVMT LQIPDENRCVDILELSELDDLLTFHRHTLLLYCSLCTLGNTRVCHALCSHVDQSQLLHAI QNPHLPGPLRSAFYQLLTQVHLSSHTTACLMMNHEYIVPMTDQTKEITLYPSSANGGSGQ PPEANPSTSLSTSLKPRMHFSSPCFVRSDGIEADGAVEIACTDSPEIPLDILKKLTVEML TAGVLAAGQGVRDPVGGSIELLLVPLIRLFYTLLVMGVFRGEDLGKVLRLIDPGVFSIDA ETAEEREQEEEEEEEEEDDDDDDDDDDDDDDDDDDDDEEERKEGNKKENDTPKQGLLQMK LPEAVKLELCHLLSYLCDSQVRHRVEAAVAFSDNFAGQLQENQRFRYNQVMQALNMSAAL TARKTKEFRSPPQDQINMLLSFREDEQLENCPCPVELQQLLKHFHNLLNRHCGIELDSDS EVEEDAEMSVKDRLLSLVARVCGLRKKPIAVVECRPQSAKSLKKLISETMVRWAQESEME DPELVRAVFSLLYRQYQGLGGQMAGPLCRAYTISQASVEDTMTLLSSLGQIRSLLSVRMG KEEERLMIRRLGDIMNNKIFYQHPNLMRALGMHETVMEVMVNVLGEGESKEITFPKMVAS CCRFLCYFCRISRHNQGALFDHLSYLLENSSVGLASPSMRGATPLDVAAASVMDNNELAL ALKEPDLEKVVQYLAGCGLQSCPMLVAKGYPDVGWNPVEGERYLDFLRFAVFCNGESVEE NAYLVLKLLIRRPECFGPALRGDGGNGLLAAMEEAIRISEDPSMDGPCTMYQDVVQDHDD DFIHMGHAIMTFYSALIDLLGRCAPEKHLIQGGKGEAIRIRAILRSLIPIQDLEGVISIS FQIPSVSEDGHVVEPDLSTVFCPDHKAAMVLFLDRVYGIENQKFFLHLLEVGFLPDLQAA VSLDTAHLGSTDMALALNRYLCTAVLPLLTKCSAFFCGLADHTLLVDSLIQAVYSLSGAL SLTKAQRDTIGDCLLAVCSELQPSMMQPLLRRLVFDVPHLTDYSKMPLKLLTSHYEQRWK YYLLTGVQSDQGLASEEELHLSRKLFWGVFKALAKKPYEPQLFQLCVQCLAAVAKALPPD HMDSSSASKMEKKTSMDTDGHFDPQPVDTSNVSVPERLEFVVNKYAEHTHEKWSLDKFAN GWVHGEQLCENTKVHPLLKPYRTLAEKEKEAYRWAIKESIKSMLAFGWTIERTKEGDAFG MHTCTRRVSQSGQLSFEGASTFSPKPMDMSNITLSWEQCATAEQLAENYHNAWAKRKKSE LESKGGCGHSMIVPYDTLTAKEKTKFRERAQDILKFLRLNGYTVWRDRKTVEMDFPATAN CFSYILLHRLLSHTEEAQEHMLELEVMQARGQMSKGERVPHQHFFPKVILPLLEQYVKSH HLYFLSISLCSSGNRTHASKKEKEMIACLFCKLATLVRHRISFFGSEASSVASCLHVLAQ ALDARTLMKLAPESIQASLHSFFEAAAADLEMTVENLSVTLVSLPQSRSQQARGFAKVLS YTTSILLPTLTSLFQHLGNQNYGVDLLVGGIQVSCYRILNSLYSLGNSSSIFMEGQRPAA GACLAALTGAFPVCFLEPALNHNNPYSIYNTLSATEREDLGLPDQVEDMCLLLPSLEQAL GEVEELAGTGAGARQAHYIRVTDVTLPMLCSYMCRWWHWGPEGQPASPICTSVITQHVSD LLGHILRIIHNHVGASQGDWMKQLAVFSQPIIFKAHTELLKSHFLPLMEKLRKRAESVLM EEEQMKAEGCCASEAELQIQEKFTVLVRDLYAFYPLLIPFVDFNRASWLKESNPEAEQLF SMVAEVFIFWAKSHNFKWEEQNFVVQNETNNLSFLVNNDKMSKFNHEKRRMRRKGDRYST HTSLIVASVKRLLPVGLRVCFPNNQSLIMLAKNSFAQKKTEDEIRERVLHGLVHLQSQAS NCLKQETRYAEHASQPGAITDPERTVDRIVGIGQVLYYLDQVEHPQRSKKSALHKVLSKQ RKRAVVACLRMAPLYNLPRHRAVNLFLQGYNKSWISAEDHGFEEKLVEDLAKGGVIELCG GDRGEEKDVEEGTKPIDPLLQLITLFSRSALTERSKLGNDSLYKSYAAILAKSCQREEDD SEEQEVESFEEKEMEKQKLLYQQARLHLRGASEMVLQTISASKGIMGCMIAPTLKLGIAV LNGGNATVQQKMLDYLREKRDVGFFQSMAGLMRSCSVLDLNAFERQNKAEGLGLAMDESS GEKVLSDKDLTCDLFRFLQLLCEGHNSDFQNYLRTQSGNNTTVNIIISTVDYLLRVQESI SDFYWYYSGKDVIDIHGQHNFSKAIEVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVV GFLHIFAHMQMKLSQDSRQIELLKELMDLHKDMVVFLLSMLEGNVVNGTIGKQMVDMLVE SSGNVEMILRFFDMFLKLKDLTSSDSFREYDPDRKGCISRKDFQKAMENCKRFSQAESNF LLSCMETAKSDIVDYEAFVDRFHEPAKDIGFSIAVLLTNLSEHMPNDSRLRTFLELAECV LTHFHPYLGRIEILGSGKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEK MEMFVNFCEDTIFEMQLAAKISDSDTGERCAGKEVDEKSWSEEIGLDKKGMFFMYHWWLL LTSLLSVKSLKILMKMTLKDILMSAVFFLRFIFMAQVRCICVVIRSIIYVLYIAFVSGGL IEGAKRMRISDFLSGILEPTLDEVMEVSSGVDRLRKYSASFSSQRELREIGQVAAVTSPR DLDIMSDIFGLKVKKEGGQYRLMTQDLTASLTDLFITTPRRAATADFSEKHHRTQLKAHT ATEEKEDEKKRKEDEKMLELENAKGKESEKKTGKEKAEAGWTAKRCYNKSEELEGPHSAL WEMISTRNKSLLNYFARNFYNMHLLALFVAFAINFILLFYKVASLPASQEEEGVITSVYS KEEDSAAKVDNKGRVYFVLEESSGYMEPSLRFLAVAHTIISFCCIIGYYCLKVPLVIFKR EKEVARRLEFDGLYVTEQPPEEDIKGQWDRLVINTPSFPSNYWDKFVKRKVMDKYGEFYG CEKISELLGLDQAALAFSSGRKEGKWLKKDTAWGALFNSIDMKYQVWKLGVVFTDNSFLY LAWYMAMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDKDTQDMKCNDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDDFEV ERIIFDITFFFFVIIILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSEYFDKV PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQGRCWEFFPVGDCFRKQ YEDQLG NT seq 14961 nt NT seq  +upstreamnt  +downstreamnt atgatgactgacaccggagagggcgacgatgagttccagtttctgcgaacgggagatgaa gtggttttgcagagtaccttcacctcccaggaggaacacgtgaagctctgtcttgccgcg gaaggatttggcagcagactttgcaggcttgagtccacctctaactacaagaatgttcca ccagatttgtctgtatgtggctttgtcctggcccagtgtctctctgtgcgagccttgcag gagatgctggcccacagtctgcccctggctgcggaggtgggagctggaggaagccatcgc acccttctttatggccaggcagtgttgttcctgcactcatacagcggcatgtatctcagc tgcttgtcttcatctcagtcttcaactgacaagctggcttttgatgttggtctgaaagag gataaagcaggtgaggcatgttggtggactgtccacccagcatctagacagaggtcagag ggtgagaaagtgcgtgttagagatgacctcatactggtcaatgtttcctcagagagatat ctgcacctgtcgtttggcacagtgtttgacaacaaaagcgtgagtgacggtctgattgtt aatgcagccttccagcagaccctctggagtgtcgctcccatctgctccggagggggagtg gttcaaggatacctgaaggggggcgacacattgcggctactccacagccatagtgacgca tgtctgacaattccctccacagagcagggagaggagctgcaaaggttaatgcattatgag attggatccgtctgcagctacgcccgttctctctggaggctggagattcttcatgttgtt tggagtggtaggcatacatgctgggggcaacctttcagactgtgccatgtgactactggg aggtatctgggtcttacagaggagaaaggcctgcatctggttgatcgggacaaggctgac atcaacacaacctccttctgtttccgatcctcgaaggaaaagcatgacactggcacaaag actgctgtcgatgccatggggatcccagagatcaagtatggagattccatttgttatgtc cagcatgcagaatctgggctctggctcacctaccaagccactgatgccaagtcttctctc atggggggatctcagcgaaaggccatcttgcacagcgagggtcatatggacgacgggctg acgctgtctcgttctcagagggaagaatctcacactgccagacttatccggagtgctgtt ctcctcttcactcgctttatcaggaaactggacagttttagtcaacaaggaaacctaccc tctgtcagcctgccgatggagatggtgacgtgcagtctgcaggatctaataaagtatttc cagcctccactggaggggctaggccatgaagcgaaacagaacagcaagaaggctctaaag aatcggcagaacatgtttcaagaagagggtgtgatagatttggtcctagactgtattgac catgtgcaccaatatagtagtgcttcacattttgctgaagctgctcagagtgagacggga gaagagtgggagaccatcctcaactgtctctatgagttactagctgctctgatccgggga aaccgtgtgaactgtgcacatttctcaggttctctagactggctgattagcagactagac cggctggaggcctcctctggagtcttggaggttctgcactgtatcctggtggaaagtcct gaagctctcaatgtcatcaaagaaggacacattcattccatcatctcttttctagacaag catggatgcaaccacaaggttgtgttccaggtactggaggtgctgtgctctctgtgtgtg tgcaatggtgtggcagtgcggtccaatcagaaccacatctgtgacagcctgctgccagac agagacctgctgctccaaacacgtctggttaatcaggtcatcagcatgagaccaaacatc ttcctggcagtgggggaagatacagcccagcatcggaggtggtactatgagctggttgtg gatcatgtcaaccccttcctcacatctgagcccacccacttgcgtgttggctgggcttgc actgagggctaccaccccaggcccacaggaggagagggctgggggggcaacggggtggga gacgacctctgctcctatggctttgatgggcttcacctctggtcaggctgtgtgggccgc agagtgagctctcccttccctcacctactgaaaaatgatgatgtggtcagctgctgtctt gacgtcagtgctccctgcatctctttccgggtcaacggtctacctgtgcagggcatgttg gagaacttcagtgctgacggacttctttatcctgtagtcagcttctctgctggagtcagg gttcgttttctgtttgggggaagacatggagagttccgcttcctaccgccaccaggtttt gctccatgctctgaggcgctgctcccgagagtcaagctgaaggtagagccctgtcagaca tacatcttggatcatggagaagggaaacaagagctcatcggccccttagtacctgtcaat ccagttaccttcactcccacaccagttgacattagcaaggtggtactgccctcacaactt gaggacatccgagaaaaaatggctgaaaatatccatgaactctgggtaatggacaagact gatcttggatggacacatggacctgtgagagatgagattaagaggcaggatccatgtctg gtggagttctccaagctgccagagcaggagaggaaccaaaaccttcaggtggctcaggac accctcaggactctccttgctcttggcttctacatctgtttgactgatgaccgtgctgca gagaaagtcaaatacatgagactagccaccaagtatgagcagcccagtggctatagacct gccccagtagacttgagcagggtttatctaagcccagtctatgaggaagtgattaacttg ctggcagagaatgatcacaacgtatgggccagagagcgcatcaagctgggatggacctac ggagcccaacaggatgtgaaagtgaagcggagcccgtaccttgtgccttacaaccttctg gatgaaaggagtaggagagtgggcagggagagtgtgagagaggccgtctgtaccttgctg gcctacggttacagcttggagcccctcaaccaggagcggaccatgtcatcaaacgcgtgt ctcttctctactgagaagtgtagagtgttcagaccagataaatcatacgctgtgacccag gggaagtggtattttgagtttgaaatactgacaacagggccaatgagagtgggctgggct agaccgggctgtacccctgataaagagctcggctcagatgaccaggcatatgtctttgat ggatttgagggtcagtggtaccatcagggtggtgaacccctgggacgtccgtggcagaga ggcaatgtggtgggttgcttggtggacatggctgaatgcaccatggttatcacactcaat ggagaggtgctgtttaatgacagaggatcagagctggctgccaaggactttgatatcaga gacggcctcttgcctgtggtcagtgttggggtgaaccaggtggggagaattaatctgggc cgccaagtggactctctgcagtacttcactgtgtgtggcctgcaggagggctatgagcca tttgctgtcaacatggccagagatccatccctttggatgagttggaaacagcctcagttt acctccatactacctgatgataacaatttacaggtcactaaaatcagtggctcaacggat tcctcatccagcctgagggtctctcagcgattgtttgcacaccacggtggaggcagtgag atgggcttttaccggctcagcatgtctattgaatgtgctgctatcctcactagccctgca gggggcgtacttccagtggcctccaacactctctctccaggaaggaaagagcaggaggag gtggactctgactttgaaatgctgatgaagtcagcccacagctttgctggctcaagagat gagctcaaccacaaggatcataaccaagacaaaacatcaagattgaaacaacggttcatg ctgaagaggactaaaccagacctagtcagcagcatctcatctgcacggcttctcgaagat gttgtagttgacaaagataactatgatcaccttatccagagctccaggtattactactca gtgagagttcttccaggccaggagccgtttaacgtgtgggtaggctgggtgacctctgac tttcatcaatatgagatgacatttgacactgactatgtcaacaccgtgactgtcaccctc ggagacgacagcggcaaagtccaggaaagcgtgaagcggtgtaactgttacatggtgtgt gctggagaagcaacaggcctgtctcagagtcgaagaagttcagggctggaaatcggctgt ttgattgacagtgccactgggctgctgacctttacctccagtggagtggagatggccacc ttctaccaagtggaagccagtacaaagctgttccctgctgtttttgtcaagcccaccacc agcatcatgtttcagtttgaactgggacatgttaagaatgtgatgccgctgtcagcaggt ttgcttcgcagccaaagaagaaatgccactcctcagtgtcctccaaggtttcaggtccag catctcagccctgtttcatggaccagagtaccagaccatgcattaaaggtgttggtagat cggccagatgagtgccatggctggagagtccaatgctctgatcccctgctagtcatgacc cttcagatccctgatgaaaacaggtgtgttgacattttggagctgtctgaacttgatgac ctcttgacctttcaccgccacaccctcctcctctactgctctttatgcacccttggaaac accagagtttgccatgccctctgcagtcacgttgaccagtcccagctccttcatgccatt cagaatccccacctccctggcccactccgctctgcattttaccagctacttactcaggtt cacctctccagccacaccacagcatgtctcatgatgaaccatgaatacatagtgcctatg acagaccagaccaaagaaatcaccctttatcccagctctgctaatggggggagtggtcaa cctccagaggccaatcccagcacgagtcttagcacatcccttaaaccacggatgcacttt tcatctccttgttttgtcaggagtgacgggatagaagcagatggtgcagttgaaatagcc tgcacagacagcccagaaatccctctggacatattgaagaaactgactgtagagatgctg actgcaggggtgttggctgcgggtcagggtgtgagggatcctgtaggaggcagcattgag cttctgctggttcccctaattaggctgttctatacgctgctggtaatgggggtgtttagg ggtgaggatctgggcaaagttctgagactgatagacccaggagtcttctccatagatgct gaaaccgctgaagagagagagcaagaggaggaggaggaggaggaggaggaggatgatgat gatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgatgaagaggaa aggaaagagggcaacaaaaaggaaaatgacactcctaaacaaggacttcttcaaatgaag cttccagaagctgtcaaacttgagctctgccatttgctgtcttacctgtgcgacagccag gtgcgccacagggtagaagctgcggttgccttctctgacaactttgctggtcaactgcaa gagaaccaacgctttcgctacaaccaggtcatgcaggcactcaacatgtctgccgcccta actgcccgcaagaccaaggagttccgctcacctccacaggaccagatcaacatgctgctg agcttcagagaagatgagcagctggagaactgtccatgtccagtggaactccaacagctc ctaaaacacttccataacctcctcaacagacactgtggcattgaattggacagtgactca gaggttgaagaggatgctgagatgtctgtaaaagatcgactacttagtctagtggcgaga gtctgtgggctgaggaagaaacccatagcagtagtcgagtgtagaccgcagagtgccaag tccctcaaaaagctgatatctgagacaatggtgcgctgggcccaagagagtgagatggag gatcctgaactggttagagctgtcttctcattgctgtaccgccagtatcagggccttggg ggccaaatggcaggaccactctgcagagcctatacgatcagccaggcttccgtggaggac accatgacactcctgtcctccctgggccaaatccgctcgctccttagtgtccgcatgggg aaagaagaggagaggctgatgatcagaagactaggagacatcatgaataataaaattttc taccaacaccccaacctaatgagggcattggggatgcacgagaccgtgatggaggtgatg gtcaatgttctaggagaaggggaatcaaaggagattacctttcccaagatggtagctagc tgctgtcgattcctgtgttatttttgccgcatcagccgacacaatcagggagcccttttt gaccatctcagctacctgctggagaacagcagtgttggactagcttcaccgtccatgcgt ggagccactcctctagatgtggcagcagcctctgtaatggataataacgaactggcctta gcactgaaggaacctgacctagagaaggtggtgcagtacctcgctggctgtggtctccag agctgtccaatgctagtggcgaaaggctatcctgatgttggatggaaccctgtagagggc gagcgttacctggattttctacgttttgctgtcttctgcaatggtgagagtgtagaggaa aatgcttacttggtgttgaagttgcttattcgtcggcctgagtgttttggccctgccctg cgaggtgatgggggaaatggtctcttggcagccatggaggaagccatcaggatctctgag gacccctctatggacggaccttgcaccatgtaccaagatgttgtccaggaccatgacgat gacttcattcacatggggcacgccatcatgacattctactcggcccttattgacttgctg gggcgctgtgctccagagaagcatttaattcaaggaggcaaaggagaagccatccgcatc cgggccattctgaggtcgctcatccccattcaggatcttgagggagtcatcagcatctca tttcaaatcccttcagtgtctgaagatggtcacgtggttgagcctgacctgtctacagtg ttctgcccggaccacaaggcagctatggttctgttcctagaccgggtttatggcatcgag aaccagaaattttttctccacctcctagaagttggttttctgcctgaccttcaggcagcc gtctcgcttgacactgctcatttgggatccactgacatggccctggccctcaacagatac ttgtgcaccgctgtgcttcccttgctcaccaaatgttcggctttcttctgtggattagca gaccataccttgctggttgattctctcatccaggcagtctacagcctctccggggctctt agcttgaccaaggctcagagagacactatcggagattgtttgttggctgtgtgcagtgaa ctccaaccttctatgatgcagcctcttcttcgtcgtcttgtcttcgatgttccccatctc acggactacagcaagatgccactaaaactcttgaccagtcactatgagcagaggtggaag tactacttgctaactggtgtgcagagtgaccagggtttggcctctgaagaggagctccac ctgtctagaaaattgttctggggagtgtttaaggccttggcaaaaaagccctatgagcct cagttgtttcagctgtgtgtccagtgcctggctgcagtggccaaggccctgcctcccgac cacatggactcaagctctgcgtcaaagatggagaaaaaaacctccatggacacagatgga cactttgacccccagcctgtagatacctccaacgtgtcagtgccagagagactggagttt gtagtgaacaagtatgcagagcatactcacgagaagtggtcacttgacaagtttgccaat ggctgggttcatggggagcagctatgtgagaacaccaaggttcaccctctcctcaagcca tacaggactctggctgagaaggagaaggaggcataccgctgggccattaaagagtcaata aagagtatgctggcctttggatggaccatagagaggactaaagaaggagatgcatttggc atgcatacctgtacacgcagagtctctcagtctggacagctgtcttttgaaggagcttca accttcagccccaaaccaatggacatgagcaacatcactttatcatgggagcagtgtgct acggctgaacaattagctgaaaactatcacaatgcgtgggctaaaaggaagaaatcagaa cttgagagtaaaggaggatgtggccattcaatgattgtaccctatgataccctgactgcc aaggagaagaccaaattcagagaaagagcccaggatatccttaagttccttcggctaaat ggctacactgtgtggagggatcggaagacagtggagatggactttccggccacagccaac tgctttagctacattctccttcaccggctcctgtctcacactgaggaggcccaagagcac atgttggagctggaggtgatgcaagccagaggacagatgtctaaaggagagagagttcca catcagcattttttccctaaggtcatccttcctcttttggaacaatatgtgaaaagccac catctgtacttcttgtccattagtctctgctcaagtggtaacagaacccatgcctcaaaa aaagaaaaggaaatgattgcatgcctcttttgtaagcttgcaaccctagtaagacacaga atctcattctttggaagcgaagcctcgtcagtcgcaagctgcctccatgttttggctcag gctctggatgcaaggacattgatgaagttagccccagagtctatccaagcatccctgcac tcattctttgaggcagctgcagcagatctggagatgactgtggaaaacctttctgttacc ttggtctcgttgccacagagtaggagtcagcaagctaggggatttgccaaggttctcagc tacacaacctccattcttctacccaccctcacttccctcttccagcatcttggcaaccag aactatggcgtggacctcctggtgggtggtatccaggtgtcctgttacaggatcctcaac agcctctactctcttggcaacagtagcagcatcttcatggaggggcaaaggcctgcagca ggtgcttgtctggcagccctgacgggtgcttttcctgtatgtttcctggagccagccctc aaccataacaacccttactccatttacaacaccctgagtgctactgagagagaagacctg gggctgccagatcaggtggaggacatgtgtcttcttctgccttctctggaacaggctctg ggggaagtggaagagttggcaggcactggtgctggagcgcgccaggcccactacatccgt gtcacggatgtcaccttgcccatgctctgcagctatatgtgccgttggtggcactggggc cctgagggccagccagccagcccaatctgcacctctgtcattacccagcatgttagtgac ctgcttggccacatccttcgtatcatccacaaccatgtgggcgctagccagggggactgg atgaagcaactggcagttttttctcagccaattatatttaaagctcacactgagctgctg aagagccacttcctgccactgatggaaaagttgaggaagagggcagaaagtgtgctgatg gaggaggagcagatgaaagcagaagggtgttgtgcgtctgaagcagagttgcagatacag gagaagttcactgtgctggtgcgagatctctatgccttctatcccctcctcatcccattt gtggattttaatcgagccagctggttgaaagagtcgaaccctgaggctgagcagctgttc agcatggtggcagaggtctttatattctgggccaaatctcataatttcaaatgggaggaa cagaactttgtggtccaaaatgaaaccaacaacttatctttcttggtcaacaacgacaaa atgtccaagttcaaccatgagaagaggaggatgaggaggaagggggatcggtattccacg cacacctctctcattgtggcttccgtgaagaggctgctccctgtgggactcagggtttgt tttccaaacaaccagagccttatcatgttggctaagaacagcttcgctcagaagaaaact gaagatgagattcgagagcgtgtgctccatggccttgtacatcttcagagtcaggcgtca aactgcttgaagcaggaaactcgttacgctgaacatgcgagccagccaggggccatcact gaccctgagagaactgtagacaggattgtgggaataggccaagttctttattacctggac caggtggaacaccctcagagaagtaaaaaatcggcgttgcacaaggtcttgtctaaacag aggaaacgagcagtggtggcctgcctaaggatggctcccctctacaacctacccaggcac agagctgtcaaccttttcctccaaggctacaataaatcctggatatcggctgaggaccac ggctttgaggagaagcttgtggaggatttagctaagggaggagtgatagagctgtgtgga ggtgacagaggggaagaaaaggatgtggaagaaggtaccaaaccaatcgatcccctccta caactcattacactcttcagtcgaagcgccctgacagaaagaagtaagcttggaaatgac agtctctataagtcctacgctgctattttggccaagagctgccagagagaggaggatgac agtgaagaacaggaggtggaaagctttgaggagaaggagatggagaaacagaagttgctg taccagcaggccaggttgcatctgcgtggagcttctgagatggtcttgcaaactatcagt gccagcaaagggatcatgggctgcatgattgcccctacgctgaagctgggtattgctgtt ctcaatggagggaatgccactgttcagcagaaaatgctggattatctgagagagaagcga gatgttggcttctttcagagcatggctggactcatgcggtcatgtagtgttctggatctg aatgcatttgagaggcagaacaaagcagaaggattagggttggccatggacgagagctca ggagagaaggtgttgtctgacaaagatctaacctgtgacctattccggtttctacagctg ctctgtgaaggacacaactcagatttccagaattacctgagaacacagtcaggaaacaac accactgtcaacatcattatttccactgtagactatttactaagagtgcaggaatcgatc agtgacttttactggtactactcagggaaggatgtgattgatatacatggccaacacaac ttctccaaggccattgaagtggccaaacaggtcttcaattcactcactgagtacatacag ggcccatgtactgggaaccaacagagtcttgctcacagtcgtctgtgggacgctgttgtg ggattcctccatatatttgcccacatgcagatgaagctctctcaggattcaaggcaaatc gagcttttgaaagagctgatggatttacataaggacatggttgtgtttttgctttcaatg ctagaaggtaatgttgtcaatggaactattggaaagcagatggtggatatgctggtggaa tcatcaggcaacgtggagatgatcctcaggttttttgacatgttcctcaaactaaaagac ctcacctcctcagattccttccgagaatatgaccccgatcgtaagggctgcatatccagg aaggactttcagaaagccatggaaaattgcaagcgtttctcccaagctgagagtaatttc ctcctctcctgcatggagactgccaaaagtgatattgtggattatgaggcctttgtggat cgcttccatgagccagccaaagacatcggcttcagcatcgccgttctcctcaccaatttg tccgaacacatgcccaacgattcaagactaaggacattcttggaactggcagagtgtgtc ttgacccacttccacccctatctaggacgcattgagatccttggcagtgggaagcgcatt gaacgtgtttactttgagatcagtgagtctagccgcacacaatgggagaaaccgcaagtc aaagagtccaagagacagttcatttttgatgtggtcaatgagggtggagagaaggaaaaa atggagatgtttgtcaatttctgtgaggacaccatctttgagatgcagcttgcagccaag atatctgactctgacactggagagaggtgtgctggaaaagaagtagatgaaaagagctgg agtgaagaaataggcctggacaaaaagggaatgtttttcatgtatcattggtggctactg ctgacatctctactttctgtgaaaagcctgaagatattaatgaagatgactctgaaggat atcctcatgtcagctgttttcttcctaagattcatttttatggctcaggtccggtgcatt tgtgttgtaattcgcagcatcatatatgtcctgtacatcgcctttgtcagtggtgggctc atagagggagccaaaaggatgaggatatcagactttctcagtggtatccttgagccaact ctagatgaggtcatggaggtgtcaagtggtgtggatcggctgaggaagtactctgccagt ttctcttcccagagagaattgagggagatcgggcaggtggcagctgtgacctcccccagg gacttggatataatgtcagacatattcggcctcaaagtgaagaaggagggaggtcaatac agacttatgacacaagacctcactgctagtctgactgacctgttcatcacaactcccaga agagctgccactgctgatttttctgaaaagcatcataggacgcagcttaaggcccacact gccacagaggaaaaagaagatgagaagaagagaaaagaagatgagaaaatgcttgaatta gagaacgcaaaagggaaggaatctgagaagaaaactgggaaagagaaagcagaagcagga tggacagccaagagatgctataataaatcagaggaactagagggcccacattctgccctc tgggaaatgataagcactcgtaacaagagcctgctgaactactttgcaaggaatttttat aatatgcacttgctggctctcttcgtggcctttgcaatcaacttcatcctcctcttctac aaggtagcatccttgcctgcatcgcaagaagaggaaggagtgataacatctgtttacagc aaagaggaggactctgccgctaaagtcgacaacaagggcagagtttattttgtgctggag gaaagcagtggatacatggagccgtcgctccgcttcctagctgtagcacacaccatcatc tccttttgttgtataattggttactactgcctcaaggtaccactggtgatcttcaaacgt gagaaggaagtggcgcgaaggctggagtttgacgggctgtatgtgacagagcagcctcct gaggaggacatcaaagggcaatgggaccgactggtcattaacacaccgtcatttccaagt aattactgggataaatttgtgaaaagaaaggtgatggataagtatggtgagttttacggc tgtgaaaagatcagtgaactcctaggtctggaccaggctgctttagccttcagctctggg agaaaagaagggaagtggctcaagaaagacactgcctggggtgctctatttaactccatt gacatgaagtaccaggtctggaaactaggagttgtgttcactgacaattccttcttgtac ttggcctggtacatggccatgtcggttctgggtcattataacaacttcttctttgctgcc caccttttggacatcgccatgggctttaagacacttcgtaccatcctttcctctgtcaca cacaatgggaaacagttggtcctgactgttggcctgttggcagttgtcgtgtatctctac accgttgtggccttcaacttcttcaggaagttttacaacaaaagcgaagataaggacacc caagacatgaagtgcaatgacatgcttacttgctacatgttccacatgtatgtgggggtg cgtgcgggtgggggcattggtgacgagattgaggaccctgcaggagatgattttgaggtg gagcgcatcatcttcgacatcacatttttcttcttcgtcatcatcatcctcttggccatc atccaaggcttgatcattgacgcctttggggagcttcgtgaccagcaggaacaggtgaaa gaggatatggagaccaaatgttttatatgtggaataggaagtgaatattttgataaagtc cctcatggctttgagactcacactctacaggagcacaacttggccaactatctatttttt ctgatgtacctcattaacaaggatgaaactgaacacacggggcaggaatcctatgtgtgg aaaatgtaccaggggcgttgctgggagttctttcctgtgggagactgtttccgtaagcaa tatgaggatcaactgggttga

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