Xiphophorus hellerii (green swordtail): 116727252 Help Entry 116727252         CDS       T07363                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism xhe  Xiphophorus hellerii (green swordtail) Pathway xhe04020   Calcium signaling pathway xhe04260   Cardiac muscle contraction xhe04261   Adrenergic signaling in cardiomyocytes xhe04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:xhe00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116727252 (ryr2)    04020 Calcium signaling pathway     116727252 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     116727252 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     116727252 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:xhe04040]     116727252 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:xhe04990]     116727252 (ryr2) Ion channels [BR:xhe04040]  Voltage-gated cation channels   Ryanodine receptor    116727252 (ryr2) Domain-containing proteins not elsewhere classified [BR:xhe04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    116727252 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  116727252 NCBI-ProteinID:  XP_032430464 LinkDB All DBs Position 10:25075912..25236855 Genome browser AA seq 4973 aa AA seqDB search MADLGEGEDEIQFLRTDDEVVLQCSATIQKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLASTEEKAEGAAQGGGHRTLLYGHAVLLRHSYSGMFLCC LSTSRSSTDKLAFDVGLQEETTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLQVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GEEQRRSVHYEGGAVSSHARSLWRLETLRVMWSGSHIRWGQPFRLRHVTTGKYLSLTEDK SLLLMDKEKADVRSTAFCFRLSKEKLDPGVRKEVDGMGTPDIKYGDSVCYIQHVNTSLWL TYQTIDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNIFIRG LDTVRKKGKSSTLDLPIDSVSLSLQDLIGYFQPPEDHLDHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFAEVVGREAAEAWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQHLICDNLLPGRDLLLQTRLTNHVSSMRPNIFLGVSDGSAQYRK WYYELIVDQTVPFVTSEPTHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVTSPNQHLLRSEDVVSCCLDLSIPSISFRINGQPVQGMFENFNSEGLFFPVA SFSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLKLEASQDQTVARDLLGPTVT LSQAAFTPTPVDTSQIVLPSHLERIREKLAENIHELWVMNKIELGWTYGVVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKVKGMKLSPTYELSSGY KPAPLDLGHIKLTPTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYM LLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDVSNVSAERFRIFRAEKTYCV NTGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAW QTGDVVGCMVDLNEHTMMFTMNGEVLLDDSGSELAFKDFEVAEGFIPVCSLGMCQVGRMD FGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIEVTRMDGT VESCPCLKVTQRSFGSQNSYNDITFYRLSMPIECAESRSPSYGSLFSPKRELEDFETVSD FEVLLKSSHGPNGPSGHDRDEFNNHKDYTQEKPSKLKQRFTLKKNKPDNSCPSSARLSEE VAVDDREGYEVLMQASTYYYSVRIFPGQEPSSVWVGWVTSDFHQYDPSFELSKVRTVTVT LGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLSFTANGKELS MYYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSERKNPAPQCPPRLHV QFLTPVLWSRVPNHFLKVSASRVNDRHGWQVQCSDPLQFMSLHIPEENRSVDILELSEQK DLLKFHYHTLRLYSAICALGNNRVAHALCSHIDEAQLLQAIENKYMPGLLRAGYYDLLID IHLRSYATARLMMNNEYIVPMTHETKSITLFPDDLKKHGLPGIGLSTSLRPRMHFSCPSF IRVTESSCHDNGNSGPGSCFQYSPEFPLDILKVKTIEMLTEAVREGSMHVRDPVGGSTEL LFVPLIKLVYTMLIMGIFQNGDLKNILQLIEPSVFSEPRDEQEELPRELEMLKNVETAGR GEDGGRNLPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQDNQ RFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDDKQECPCPEYIREQLLDFH EDLMRHCELDEERGIDGDSDFTIRGRLMSLVEKVSYLKKKMGSLPKEKKDRKPSTLQQLI SDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKAYTINSVSIEDTINLLAA LGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGG DSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDV AAASVMDNNELALALREPELEKVVQYLAGCGLQSCVMLVHKGYPDIGWNPVEGERYLDFL RFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIRISQDPCRDGP SPVSESSRTLSDMLDEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEALRIR AILRSLIPIDDLVGVISIPFSMPNLAKDGIVVEPDMSAGFCPDHKAAMVLFLDRVYGIED QNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEP FASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLN EHTKMPLKLLTNHYERCWKYYCLSGGWGSFGVASDEELHLSRKLFWGIFDALSCKRYDQE LFKLALPCLSAVAGALPPDYMESNYMSLMEKQSSMDSEGNFNPQPADTTNVTVPEKLDYF ITRYAEHNHERWCIEKFSHGWTYEEHLCESSKTHPLLKPYKALSEKDKEAYCWSVRESLK TMLSWGWSIDRNREGDTASLHNKSRRISMASQLSFEGTPAFSPRPVDMSNVTLSRDMQSM AELLAENYHNIWARQKKMELEAKGGGRHPLLVPYDTLTAKEKSKDREKAQDILKFLQING YIVSRGKKSPELDTPAIEKRFAYTFLQKLITYVDQAHQHMMEFDVGAKLKGGKIPHEQQI KFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVLVRHRIS LFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDSVAEDLEKTQENLKLGQF THSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLMLDEVQVSCYRILNSLYFL GTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPQLNKFNSFSIYNNKASKDRTALGLPGP VGEVCRLVPNLEKSLEEIMELAESGMKYTQMPHVMEVVLPMLCSYMSHWWEHGPESNPDE DDSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKAQLLQTHFL PLMDKLKKKAAVVLMDEEQSRAEGRGEMSETELLIMDQFTILVRDLYAFYPLLIRFVDYN RGRWLKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLISDTKCKMS KGIVSDQERKKMKRKGDRYSTQTSLIVATLKRLLPVGLNICAPGEQELIALAKNRFTQKD TEDEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPYHYEDTSDPEKTVKRVLDIAHVLFH LDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAE EHYFEDKLIEDLAVRYCAFKVKQKAGEREPSEEEEGIKHIDPLHQLIQLFSRTALTEKCK LDEDNLYMAYADIMAKSCHDEEDEEGEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQT ISASKGVMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVL DLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKD MVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDGFKEYDP DGKGVISKRDFHKAMESHKHYTQSETDFLLSCAETDENELLDYEEFVMRFHEPAKDIGFN VAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKE ESEREKCDEENPDMGFFSVSTVRLALIALRYNVMLLIKVLSMKSLKKQMKKIKNMTLKDL VTTLVSFYWSVLLSLLHVTFSVARGFCRIFYNTFMGGNLVEGAKAVKVSELLATMPDPTQ DEVRSEGDEREKRLSERSSPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPN ATLTELLNSPVAPSAPPPASQPELRQRHQSKSGPSEKKEEIPEAEPEKMSEEEHVVKQEK QVKNEKMKSKVRKHHNSKSDEPDLQESAFLKKILAYQRKLLNYFARNFYNMRMLALFVAF AINFILLFYKVSTSSSLVEEKEAVHTSSHPDSSVQWDPLLGERLESNERVSGETGEPLKP VSVRFVLEESSGYMEPMLRILAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDG LYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGLDK AALDFSDAHKKRKPRKDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHY NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYN KSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFV IVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNEYFDTVPHGFETHTLQEHN LANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14922 nt NT seq  +upstreamnt  +downstreamnt atggctgacctgggagaaggagaggatgagatccagttcctgcgaacagatgatgaagtg gttctacagtgctcagctacaattcaaaaagagcagcagaagctctgcctggcagctgaa ggcttcggaaacagactctgcttcctggagtccatctccaactccaagaatgttcctcca gatctttccatctgtacctttgtgctggagcagtccctatctgtccgagcccttcaggag atgctggccagcacagaggagaaggctgaaggggcagcccagggtggtggacatcgcact ctgctgtatggacacgctgttttactacgacactcctacagcggaatgttcttgtgctgt ctgtccacctcacggtcgtctacagacaaactggcttttgacgtgggactgcaggaggaa acgacaggtgaggcatgctggtggaccatccatccagcatcaaagcagcgttcagaggga gagaaggttagagtgggagatgatctcatcctggtcagcgtctcctctgaaagatatctg catctgtcctatgggaatggcagcctgcaggtagatgcagcctttcagcagacactatgg agtgtggctcccatctgttctggcagtgaagtagcacaaggtttcctaataggaggggat gttttgcggctcctccatggacatatggatgaatgtctgactgttccatctggagaacat ggagaggaacaaagaaggtcagtgcactatgaaggaggagcagtttcgagtcatgctagg tccctgtggagactggagacgctgcgcgtcatgtggagtgggagtcatatccgttggggt cagcctttcagactcagacatgtaactacagggaaatatctgagtctgactgaagataag tctcttcttctgatggacaaagagaaagccgatgtgaggtccactgccttctgcttcagg ttgtccaaggaaaagctggaccctggagtgaggaaggaggtggatgggatgggtacacca gacattaagtatggtgactctgtgtgctatattcaacatgtcaacacctccctgtggctt acataccaaactattgatgcaaagtgtgcgcgcatgggtggagtacagagaaaggccatc atgcaccatgaaggtcacatggacgatgggctcactctgtctcggtcacaacatgaggag agccggactgccagggtcatccgcagtaccgtctttctcttcaacattttcatcagaggt ctggacacagtgagaaaaaaaggaaaaagttctactttagatcttccaatagactcagtc agtctcagtctacaagatctgattggctacttccaaccacctgaagatcacctggaccat gaagacaagcagaaccggctgagagctctaaaaaacagacagaacctcttccaagaggag gggatgatcagcctggtgctggagtgtattgatcgtctccatgtgtacagcagcgcagct cactttgctgaggtggttggaagggaggctgcagaggcctggagctccatcctgaactct ttgtatcaactgctggctgcattgatccggggaaacaggaaaaactgtgctcagttttcc ggctctctcgactggctgataagcagactggagcgactggaagcttcttcaggtatcttg gaggtgcttcattgtgtgctggtggaaagcccagaagccctaaacataatcaaagaagga cacatcaaatctatcatttctcttctggacaagcatggacgcaaccataaggtcctagac gtgttgtgttcactgtgtgtctgtaatggcgtggcggtgcgctccaaccagcacctgatc tgtgataacctgctgccaggaagagatctgctgctgcagacccgcctcaccaaccacgta agcagtatgcgcccaaacatcttcctgggtgtcagtgatggctctgcccagtacagaaaa tggtactatgaacttattgtggatcagacggtgccatttgtcacgtcagaacccactcac ctcagggttggctgggccaacaccagtggctatgcgccgtaccccagtggaggggagggc tggggaggcaatggagtgggtgatgatctctactcctacggcttcgatggacttcacctg tggtcaggctgcattgcacggactgttacatcacccaatcagcacctgctgcgttcagaa gatgtggtgagctgctgcctggacctgagcattcccagcatctccttcaggatcaacggc cagcctgttcagggcatgttcgagaacttcaactcagagggccttttctttcctgtggcc agtttctctgcgggggtcaaggtgcgttttctcctcggggggcgtcatggagagttcaaa ttcctccccccttcaggctacgccccctgctttgaggcagtgttgcccagggagaaactc aaactggaggccagccaggaccagactgtagccagagacctgctgggacccactgtcact ctgagccaggccgcattcacacccacccctgtggacaccagccagattgttctgccatct cacttggagagaatcagggagaaacttgcagaaaacatccatgaactgtgggtgatgaac aagatcgaactgggctggacgtacggtgtggtgcgagacgataacaagcggcagcacccc tgcttagtggagttttcaaagcttcctgaacaggaacgaagctacaacctgcaaatgtct ctggagactctgaaaaccttacttgctttgggatgccatgttggattagcagatgaacat gctgttgaaaaagtaaagggcatgaaactatcaccaacgtatgagttgtccagtggctac aaacctgctcctctggacctgggtcacatcaagctgactcccacacaggaagcaatggtg gacaagctggctgaaaatgcccacaatgtctgggcaagagaccgaatccgtcagggctgg acatatggaatccaacaggatgtgaagaaccggagaaaccctcgccttgttccatacatg ctgcttgatgagagaaccaaaaagtctaataaagacagtctgagagaggctgttaggact ctattgggctatggatacaacctagaagctccagaccaggatcatgctgctcagtctgac gtcagcaatgtgtctgcagagagatttcgcattttcagagcagagaagacctactgcgtt aacactgggaagtggtactttgagctggaggtactgacagctggagaaatgagggtgggc tgggcaaggccaggctgtctaccagaccaggagctgggatctgatgaccaggcctttgtc ttcgatggttttaaggtccagcgctggcatcagggcaatgagcactttggccgtgcctgg cagactggtgatgtagtgggctgcatggtggatctgaacgagcacacaatgatgttcact atgaatggagaagtgctgctggatgattctggatctgagctggccttcaaggattttgaa gttgctgaaggcttcatcccagtctgcagtctgggaatgtgtcaggttgggaggatggat tttggtaaagatgtcagcactctgaagtacttcaccatctgtggcctgcaggaaggctat gagccgttcgccgtcaatatgaaccgagatgtaaccatgtggctcagcaagaggctgcct cagtttgtgcctgttccccccaaccaccaacacattgaggtgaccaggatggatggaaca gtggagtcgtgtccctgccttaaggtcacccagaggtcatttggttcccagaacagttac aatgacatcactttctacaggctgagcatgcctatagagtgcgctgaatccagatccccg tcttatggcagcctgttctcaccgaagagggagctggaggattttgaaactgtgtcagac tttgaagtcttgttgaagtcatctcatggtcccaatggtcccagtggacatgacagagat gaattcaacaaccacaaagactacacccaggagaagccttccaagctaaagcaacggttc acactgaagaaaaacaagccagacaacagctgtccatcatctgctcgcctatcagaggaa gtggcggtcgacgacagagagggctacgaagtcctaatgcaagcttctacttactactac tcagtgcggatcttccctggtcaggagcccagcagtgtgtgggtcggctgggttacctct gactttcatcagtatgacccaagctttgagctgagcaaagtccgaactgtcaccgttacc ctgggagatgagaaaggaaaagttcatgagagcataaagcgcagtaactgctacatggtg tgggctggagagagcagcagcccaggacagggcaggaacaataacggcctggaaatcggc tgcctggtggacacaacaaacggtctgctgtccttcacagccaatgggaaagagctcagc atgtattaccaggtggagcctagtacaaaactgtttccagctgtttttgccaaggccacc agtcccaacgtcttccagtttgaacttggccggattaagaatgtgatgcctctgtcagct ggtttgtttaaaagtgagaggaagaacccagctccccagtgtcccccgcgcctccatgtc cagtttctcactccagtgttatggagccgtgttcccaatcacttcctcaaggtttcagct tccagagtgaatgatcgacacggctggcaggtccagtgtagcgatcccctgcagttcatg tctctccacatacctgaggagaacaggtcggtggatatcctggagctgtcagagcagaag gacttattaaagtttcattaccacactctcagactgtactccgcaatctgcgccttgggg aacaatagagtggctcatgctctatgctctcacatcgatgaggcccagctcctacaggct atagagaacaagtacatgccaggtttgcttcgtgcaggctactatgacctcctcatcgac atccacctgaggagctatgcaacagctcggcttatgatgaataatgagtacattgtgccc atgacacatgaaacaaaaagcatcacactgtttccagacgacctgaagaagcatggcctg ccaggcatcggactcagcacatccctgagacccagaatgcacttctcctgtccaagcttt atacgtgtgactgagtcctcatgccatgacaacggaaacagtggaccaggaagttgtttc cagtacagccccgagttccctttagatattttaaaagtgaaaactatcgagatgctgaca gaggcagtgcgggagggaagcatgcatgttcgggatccagtagggggaagcacagagttg ctattcgtccctcttatcaagctggtctacaccatgctcatcatgggaattttccaaaat ggagatctgaagaacattctccaactcattgaaccatctgtgttctctgaaccaagagac gagcaggaagagcttcccagagagctggagatgctgaagaacgtggaaacagccggaaga ggagaggatggagggaggaacctgccaaaggaggggctgctgcagatgaagctgccagag cccgttaaactgcagatgtgccatgtgttgcagtacctgtgtgactgccaggtgcgccat cgtatcgaggcggtggtggccttctccgatgactttgttgcttgtctccaagacaaccag cgctttcgctacaatgaagtgatgctggctctgaacatgtctgctgcactcactgccaag aaaaccaaagagttcagatctcccccacaggaacagatcaacatgctgctgaacttcaag gatgacaagcaggaatgtccctgtccggaatatatccgggagcagctactggacttccat gaagatctgatgagacactgtgagctggacgaggagagaggaatagatggggacagtgac ttcaccattcgaggtcgtctcatgtcgctggtggagaaggtgtcctacctgaagaagaag atgggcagcctgcccaaggaaaaaaaggacaggaagcccagtaccttacaacagcttatc tctgatacgatggtccgctgggctcaggagtctgttatagaggatccagagctagtgaga gccatgtttgtccttctgcaccgccagtatgatggcattggaggacaggttcgagctctt cctaaagcctacactatcaactccgtatccatagaggacaccatcaacctgctggctgcc ctgggtcagatccgctctctgctgagcgtccggatgggcagagaggaggagaagctgatg atcagagggcttggtgatatcatgaacaacaaggtgttctaccagcatcccaacctgatg agggctctgggcatgcatgagacggtcatggaggtcatggttaacgttctcagtggagga gactccaaggaaatcaccttccctaaaatggtggccaactgttgtcggtttctgtgctac ttctgccgaatcagtcgccagaaccagaaggccatgtttgaccatctgagctacctgctg gagaacagcagcgtaggccttgcctctccttccatgcgtggatccactcctctggacgtg gctgcagcatcagtcatggataacaatgaactggctctggctctaagagaaccagagctg gaaaaggtggtgcagtatctggctggctgtgggctgcagagctgtgtaatgctggtgcat aagggatacccagacatcggctggaaccctgtggagggggagcgctacctggactttctg cgttttgctgtcttctgcaatggggagagcgtggaagagaacgccaacgttgtggtgagg cttcttattcgccggcctgaatgttttggccccgctcttcgaggtgaaggcggtgatggc ttgcttgcagcaatggaggaagccatcagaatctctcaggatccttgcagagacgggccg tctccggtgtctgagagcagcagaacactcagtgacatgctggatgaagaggaggatgat accatccacatgggcaatgccattatgaccttctactctgcacttattgatctgctgggt cgctgtgctccagagatgcatctgatccatgctggtaaaggtgaagccctccgcatcaga gccattttaaggtctctgattcccatcgacgacctggtgggagtcatcagcatccccttc tccatgcccaacctggctaaagatgggatagttgtggagccagacatgtcagcaggtttc tgtccagaccataaagcagccatggtccttttcctggaccgggtctatggtatagaagac cagaatttcctcctccaccttcttgaggttggattcctgccagatctcagagctgctgcc tctctggacactgctgccctcagtgccacagatatggctctggccctcaacaggtacctg tgtacagcggtgctgcccctcctgaccaaatgtgctcctctgtttgcggggaccgagccg ttcgcctctctgatcgactccctcctccacacggtgtaccggctgtccaaaggctgctgc cttaccaaagctcagagggacgctatagaggagtgtctgctggctgtttgtggtaagctg aggccttcaatgatgcagcacctgctgaggaggctggtgttcgacgttcccctgctgaat gaacacaccaagatgcctctgaagctgctgaccaatcactatgagcgctgctggaagtat tactgcctgtccggaggctggggcagctttggagtggcttcagatgaagagcttcacctc tccaggaaactgttctggggaatatttgatgctctgtcctgcaagcgttatgatcaggag ctgtttaagctggcactgccgtgtctgagcgcggtggcaggcgctcttcctccagactac atggagtccaactacatgtccctgatggagaaacagtcctccatggattcagagggaaac ttcaacccacaacctgcagacaccactaatgtaactgttcctgaaaagctggactatttt ataaccagatatgccgagcataaccatgagaggtggtgcatagagaagttttcccatggc tggacatatgaagaacacctgtgtgagagcagtaagacccatccccttctgaagccatac aaagctctgtctgagaaggacaaggaggcgtactgctggtctgtcagagaatctctgaag acgatgctgtcgtggggctggagcatcgacagaaacagagagggagacacagcctccctc cacaacaaatccagacggatatcaatggccagccagctgtcttttgaaggaactccagct ttcagcccaagacctgttgacatgagcaatgttacactgtccagagatatgcagtctatg gctgagctgcttgctgaaaattatcataatatctgggcaagacaaaagaaaatggagctg gaagctaaaggtggaggaagacatcctcttctagttccctatgacactctgactgccaaa gagaaatccaaagaccgagaaaaagctcaagacattctcaagtttctccagatcaacggt tacatcgtatccagaggaaagaagtctccagagctggacactccagcaatcgagaagagg tttgcctacaccttcctccagaagctcatcacatatgtagaccaggctcatcagcatatg atggagtttgatgtgggagcaaagctgaaaggaggaaagattcctcatgaacagcaaata aagttctttggaaaggttgttttgccgttggtggatcagtactttaaaaaccacaggctg tacttcctgtccacagccattcatccaatcagcagtggaggccatgcctcaaataaggag aaggagatggtgaccagtcttttttgcaaacttggagttcttgtcagacataggatatcc ttgttcgggaacaatgcaacatcaatcgtcaactgtctgcagatactaggacagagccta gatgcgaggacagtaatgaagactgggctggagtcagtgaaggcagctctgcggtcctac tttgatagtgtggcagaagatttggagaaaactcaggagaacctgaagctgggccagttc acccactccagagaacaaccacgtggcgtcactcagatcatcaactacaccaccttcgcc ctgctgccggtgctctcctccctgtttgagcacatcgggcagaacatgtttggagaggac ctcatgttggatgaagtccaggtgtcctgctacagaatactgaatagtctctacttcctg ggaaccaacaaaagtatctatgtggagagacagcggccagctttaggaaagtgtttagct gccttctcagcagccttccctgtcgccttcctggagccacagctcaacaagtttaacagc ttctccatttacaacaacaaagcaagcaaagacagaacagctttgggtctgccagggcca gttggagaggtgtgtcgtttggttccaaacctcgaaaagtctctggaagagatcatggag ctggctgagtctggcatgaagtatactcagatgcctcatgtaatggaggtagtgttaccc atgttgtgcagctatatgtcacactggtgggagcatggaccagaaagcaatcctgacgag gatgacagctgctgcacatctgttacctcggagcacatgaatacactgctgggaaacatt ctgaaaatcatctacaacaacctgggaatcgacgagggggcctggatgaaaagactggct gtcttttcccagccaatcatcagcaaagctaaagcccaactattacagacacacttcctg ccacttatggataaactcaaaaagaaagctgcagtggttctgatggatgaggagcagagc agggctgaagggagaggtgagatgtctgagacagagctcctcatcatggatcagtttacc atactggtcagagacctgtatgccttctaccccctgctcatacgatttgtggactacaac agaggaagatggctaaaagagtccaacccagaggcagaagagctgttcagaatggtggct gaagttttcatattttgggccaagtctcataacttcaagagagaagagcagaattttgtg gtccagaatgaaatcaacaacatgtcattccttatctccgacaccaagtgcaagatgtca aagggtatagtttcagaccaggagaggaagaaaatgaagaggaagggtgatcgatactca actcagaccagtttgatcgtggccacgctaaaacgcctgctgcctgtgggactgaacatc tgtgctccaggagaacaggagctcatcgccctggctaagaaccgattcacacagaaagac acagaggatgaggttcgagagatcatcaggaacaatctccatttacaagggaagctggag gatccagcaattcgctggcagatggctttgtacagagacctgccctaccactatgaggac acatctgacccagaaaagactgtgaaaagagtcctggacattgctcatgtcctcttccac ctagaccaggtagagcatcctcagcgcagcaagaaagctgtatggcacaaactgctgtcc aagcaaagaaagcgagccgtagttgcttgtttcaggatggcacccctctataacctgccg aggcacagagctgtgaacttgttcttgcaaggctatgagaagtcctggatcgaggcagaa gagcattattttgaagacaaactcatcgaggaccttgctgtaagatattgtgcattcaaa gttaagcaaaaagcaggtgaacgagagccatctgaagaagaggagggcataaaacacatc gatcctctccatcaacttatccagctcttcagcagaacagccctcaccgagaaatgtaag ctggatgaagataacctttacatggcgtatgctgacatcatggcaaagagttgtcacgat gaagaggatgaagaaggagaagttaaaagctttgaagagaaggagatggagaagcaaaag ctgctgtatcagcaggcccgactgcacgaccgcggagctgcagagatggtccttcaaacc atcagcgccagcaaaggtgttatgggccctatggttgcatccactctgaaactgggtata gccattctcaatggaggaaactcaactgtacaacagaaaatgttggattatctaaaggaa aagaaggatgtgggcttcttccaaagtctggctggtctaatgcagtcctgcagtgttctg gatctgaatgcatttgagaggcagaacaaagcagaggggctgggcatggtgacagaggag ggatcagtcatcactcatgagcgtggtgagaaggtcatgcaggatgatgagttcacctgt gaccttttccgcttcctgcagctgctttgcgaaggacacaactcagatttccagaactac ttgaggacacaaactgggaacaatacaactgtcaacatcatcatctctactgttgactac ttactcagagtacaggagtctatcagtgacttttactggtattattctgggaaggatgtt attgacgagcagggccagaggaatttctccaaggcaatcaatgtggccaaacaggtgttc aacacgcttacagagtatatccagggaccgtgcacaggcaaccagcagagtttggcacac agtcgcttgtgggatgctgtggttggcttcctgcatgtctttgctcacatgcagatgaaa ttatctcaggactccagtcagattgagttactgaaagagctgatggatctgcagaaagac atggtggttatgttgctgtctatgctagaaggtaatgtagtaaatgggacaattggcaaa caaatggttgatatgttggtggaatcgtccaacaacgtggagatgatcctcaagttcttt gacatgttcctgaaactgaaagacctgacctcctctgatggtttcaaggagtacgacccc gatggaaaaggtgtcatctccaaaagggacttccataaagccatggagagccacaaacac tacacccagtctgaaacagacttcctcctctcctgtgctgagactgatgagaatgaactt ctggactatgaggagtttgtgatgcgttttcatgaaccagccaaggacattggcttcaat gtggcagttttgttgacaaatctgtccgagcacatgcctcatgacacccgcctgcagacc ttcctggagctggccgagagcgtcctcaactacttccagccatatctgggccggattgag atcatgggcagcgccaagcgcattgagcgggtttactttgaaatcagtgagtccagtcgg acacaatgggagaaacctcaggttaaagaatcaaaacgccagttcattttcgatgtggtg aatgaaggtggagagaaagagaagatggagctgtttgtgaatttctgtgaggacaccatc tttgaaatgcagctagcagcgcagatgtccgatgctggcgagcgctcagctgtgaaagaa gagagtgagcgagagaaatgtgatgaggaaaaccctgacatgggcttcttctctgtgtct actgtgcgcttggctttaatcgcccttcgttataacgtcatgttgctcataaaggtgttg tcaatgaagagtctaaagaaacaaatgaagaagatcaagaacatgacactgaaagacctg gtgaccactctggtgtctttctactggtcagtgctgctgagtctcctccatgtgaccttc agtgtggctcgaggattttgcagaatcttctacaataccttcatgggagggaatttagta gagggagccaaagctgtcaaggtgtcagaactgctggccaccatgcctgaccccacccag gacgaggtccgcagtgaaggagatgagagggagaagaggctgtctgagcgcagctccccg aaggaggacctggctgacctagcagttaataccagtgaaactgagctgctgtcggacatt tttggtcttgacttgagaagagaggggggacagtacaaaatcaccccccataaccccaat gctaccctcacagagctcctcaactccccagtggccccctcagctcctcctcctgcttca cagccagaactaagacaaagacaccagtcaaagagtggtccctctgaaaagaaggaagaa ataccagaagctgaacctgaaaaaatgtcagaagaggaacatgtggtgaaacaagagaaa caagtgaagaatgagaagatgaaatcaaaagtgagaaagcatcacaactcaaagtctgat gaaccagacctgcaggagtcggccttcctgaagaaaatcctggcctaccagaggaaactg ctgaactactttgccagaaacttctacaacatgaggatgctggccctgtttgttgcattt gcaattaattttatacttctattctataaggtttctacttcttcatccctggtggaagag aaggaagctgttcacaccagcagccatccagacagcagtgtccagtgggatccactgctt ggagaaaggctggaatcgaacgagcgggtatcgggtgagacgggcgagcctctgaagccg gtctcagtgcgttttgttctggaggaaagcagcggatacatggagcccatgttgcggatc ctggctgttctccatactgtcatttctttcttctgcatcatcggatactactgtctgaag gttccactggtaatcttcaaacgtgaaaaggaagtggccaggaagcttgaatttgatggt ctttacatcacagagcaaccatctgaggacgacattaaaggacagtgggacagacttgtg atcaacacacaatccttccccaacaactactgggataagtttgtcaagaggaaggtgatg gataagtacggggagttttatggccatgaccgcatcagtgagctgctggggttggacaag gctgctctggatttcagtgatgctcacaagaaaagaaaacccaggaaagacagttcactg gccgctgtgctcaactccatcgatgtgaagtatcagatctggaagcttggggttgttttt actgataattccttcctgtatctggcctggtacatgaccatgtccatcctgggtcactat aacaacttcttctttgctgcccatctgctggacattgctatgggcttcaagaccctgcgg accatcctctcttcagtcacacataatggtaaacagcttgtgctcactgtcggtctgtta gctgtggtggtttacctttacacagtggttgccttcaacttctttagaaagttttacaac aaaagtgaagatggagaacttccagacatgaagtgtgatgacatgttgacatgttacatg tttcacatgtatgtgggcgttcgagcaggcggagggattggcgaccaaattgaggatcct gcgggcgatgagtacgagatctaccggatcatctttgacatcacattcttcttctttgtc attgtaatcctgctggccatcatacagggcttgatcattgatgcttttggtgaactgaga gaccagcaggaacaagtcaaagaagacatggagaccaaatgtttcatctgtggaatagga aatgagtattttgacacagtaccacatgggtttgaaactcacacactacaagagcacaac ttagccaactacttattctttttgatgtatctgataaacaaagatgaaactgagcacaca ggccaggagtcttatgtatggaagatgtaccaggagcgctgctgggagttttttcctgct ggtgactgtttccggaaacagtatgaggatcaactcaactga

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