Xiphophorus hellerii (green swordtail): 116733680 Help Entry 116733680         CDS       T07363                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism xhe  Xiphophorus hellerii (green swordtail) Pathway xhe04020   Calcium signaling pathway xhe04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:xhe00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116733680 (ryr3)    04020 Calcium signaling pathway     116733680 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:xhe04040]     116733680 (ryr3) Ion channels [BR:xhe04040]  Voltage-gated cation channels   Ryanodine receptor    116733680 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 Motif Other DBs NCBI-GeneID:  116733680 NCBI-ProteinID:  XP_032440369 LinkDB All DBs Position 15:complement(11066049..11202716) Genome browser AA seq 4854 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLEPTSEAKYVPP DMCICNFVLEQSLSVRALQEMLANTGASSEGKADHEKWAGQGGGHRTLLYGHAILLRHSF SDMYLTCLKTSRSLTDKLSFDVGLQEDSVGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSNCNGNIQVDASFMQTLWNVQPTCSSGSMAVGYLIGGHVMRLCHGHDESLT IPGADKSEEEQRIVNYEAGKGASRARSLWRLEPLRISWSGSHIRWGQSFRLRHLSTGHYL ALTEDRGLVLEDREKCHTKATAFCFKASKEKGDSGMKRDIDGMGVPEIKYGDSVCFVMHV ATGLWLSYLAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTFLF KNFIKALDSAAAGETNAVAGYVEEVLQTLNDLIEYFKQPDVDLEHEEKQARLRSLIKQQD LFKEEGMLALLSKCIDRMNLYDSAAHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRTN CTQFSRNLDWLVSKLERMESSSGILEVLHCVLVESPEALNIIQKAHIKSIISLLYKHGRN HKILDVLCSLCVCNGVAVRTNQNLICDNLLPKRDLLLQTRLVNDVQSMRPNIFLGIAEGS AQYKKWYYELVIDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKARFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKDYKRDHDGV RDLLGTTQFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFSKLPETEKNYNVQMSSETLKTLLALGCHVAQVNVHAEEDLKKNKLP KDYMMSNGYKPAPLELSDVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKSR RNPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEVVHAIDNQSIETIRFFR VEQTYAVKTGKWYFEFEVLSGGDMRVGWARPGCRPDVELGTDDQAYVFDGYRGRRMHAGS RYFGHPWKKGDVVGCMINMEDKSMIFTLNGELLITSKGSELGFADFETEDGFIPVCSLGM SQIGRMNLGKDASMFKYYTMCGLQEGFEPFAVNMNREITMWFSKRLPTFFNVPHDHMHIE VTRIDGTVDSPPCLKVTHKTFGTQNSNSDMVYCRLSMPVEFYSADRLLDESLKLSQTPKE DGSIDYGSITTYYHSVRVFAGQDPATVWVGWVTPDYHYYSKNFSLSKTQTVTVTLGDERG RVHESIQRSNCYMVCAADALGPSSSSRSNTDLEIGCLVDLATGLVSFTANGKELPTAYQV EPNTKLFPAVFCCPTSSNLFQFEFVKIKDAMPLSSAMFRSEQRNPVPQCPPRLDVQTIVA VLWSRMPNIFLNVETARVSERHGWVVQCLEPLQMIAVHIPEENRCLDIMELSEHEDLRKF HYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYDVLISIHLET AKEARLMMNNEFIIPVTDETRSIKLFPDESKRHSLPGVGLSTSLKPRVNFSPVGIISTKR HQLLYSPQIPLGVLKEKAISMLMEAVQGGGSHIRDPVGGSLEYQFVPILKLIGTLLIMGV LTSDEVRLILLLIEPNVFGEAKEGEEGSGGEVVVAGEKEEVSKNEEKAVEAGEEETKESK PAARGLLEKSLPESVKHQMCELLHYFCDCELQHRIEAIVSFSDRFVSKLQYNQKFRYNEL MQAFNMSAAVTAKKTKEFRSPPHEQINILLNFSAGEDCPCPEEIQDELTSFHEELRLHCG IPVEEEEEEQDTSIKGRLLALLYKIKGPPQKTEEEPAETEQAAPTNLKELISQTITSWAQ ESHIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLS VRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPK MVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNN GLALALEEPDLEKVVTYLAGCGLQSCAILVAKGYPDLGWNPIEGERYLSFLRFVVFCNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKSPAGATMG SGEEEGEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLV GIISIPLKMPVINKDGSVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFL PDLKASASLDTEALSTTETALAMNRYIGSALLPLLTRCASLFGNTEHYAHLVDSTLETIY RLSKGRSLTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPLLTEYCKMPLRLLTNH YEQNWKYYCLPSGMGGFGMASEEELLLTKKLFWGIFDSLSQKKYDSELFKMAKLCLCAIA GALPPDFVDTSLGATVEKQESVDAQGNFEPKPINTANISLPEKLDYIANKYAEHSHDKWA SEKMSAGWKHGDSLDEQTKTHPLLKPYKSLSEKERETYRWPVKESLKSMLAMNWNIERTK EGEAMFQQRESEKQRKLSESQSNGFSPAPMDLHNVTLSRELQTMVEVVAENYHNIWAKKK KSELLSKGGGLAHPLLVPYDTLTAKEKYRDKEKAQELFKFLQISGYIITRGLKDMEQDSS SMEKRFAYKFLKRLLKNIDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPMIDQT FKNHCLYFLSTPNKNLSSCGYASNKEKEMVTSLFCKMAALVRHRISLFGSDSAIMVSCLH ILSHSLDTRTVMKSGAELVKVGFKAFFESAAEDLEKLVEMLKLGKFMQSRAQMKSVTQSI NYVTVALLPILTALFEHIRTHEFDVDLLMDDVQLSCYRILMCFYLLGTGKNVFVERHLPA IGESLATLVGAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKL LKDVNDVSECGARYSDMPQVIEVVLPMLCNYLSYWWEKGPENSPPDTDCCTMVTSEHLSI ILGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTMEKLKKKTVKVVS EEELLKADGKGDNQEAELLILDEFSVLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSTEL FRMVAEIFILWCKSNNFKREEQNFVIQNEINNLGFLTGEGKSKMSKSGGDQERKHKRRRG EYYSIQTSLIVAALKKLLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEHLRQNLHLQ EKSDDPAVHWQLNLYKDVVVKSEEPSDSEHTVERIQSISAAVFNLEQVEQPLRNKKCIVQ KLLSKQRKRAVVACFRMAPLYNLPRHRAINFFIPAYERLWIEAEEYSFEEKLVQDLAKTP MKIVEEEEEEVAEIKPDPLHQLILHFSHNALTERSYLEVDPLYIAYADMMAKSCAEDEEE EEEEGREKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGIS ILNGGNVQVQQKMLGYLTDKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEG SIHTRRGSKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLL RLQESISDFYWYYSGKDVIDETGKHNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSR LWDAVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQM VDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPECKGVISKKEFQKSMESQKQYN QSEIEFLLSCAEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDARLTTFL DLAESVLSYFEPYLGRIEILGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNE GGESEKMEMFVNFCEDTIFEMQLASQISEPDAVEQPEEEDEEEVHSILEELSGGEDGALE SASAFTTACRSVKKNISEIRQIFTIKTARKQFKKIKKLSIKELITGFFSFSWMIFIGFFK GIFSLVFGFFHVIWSSMFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDVGEGDKVEAME SSGSSDKTMAPAGDATEVDVMLEMLTPKKEGGKHVEPGLGDVSELSGESSTADSKKKAAA KTAAPSESETEKADTETREKEDKPKEEEAKEPAVEEKPKPRSSQPKEASPAFMSTIFTIL DVYLNKILNYLARNFYNLRFLALFVCFAINFILLFYKVTGEAEEEEEDEEHRWDEEDDEN TLFDMDEFVLQESTGYMLPTLRFLAVFHTVISLLCLVGYYCLKVPLVVFKREKEIARKLE FDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDMYGAERIAELLG LDKSALDFDPTVETVEKEASLLSWLSSIDTKYHIWKLGVVLTDNYFLYLIWYTTMSIFGH FNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14565 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaggatgagatccagttcttgagaactgacgatgaggtg gtgctccagagcgtggccaccatccagaaggagcatcgcaaattctgcctggccgcggag ggactcggaaaccgcctgtgttacttggaacccacctctgaagccaagtatgttcctcca gacatgtgcatttgtaactttgtgctggagcagtcgctgtcggtccgcgccctgcaggag atgctggctaacactggagcgagcagcgaagggaaagctgaccatgaaaaatgggcgggt cagggaggcggacaccggaccctgctctacggtcacgccatcctcttacgtcactccttc agtgacatgtacttgacctgtttgaagacatcaaggtctctgacagacaagctgtcattt gatgtcggactgcaagaagattcagtaggagaagcctgctggtggacgattcatccggcg tccaagcagagatcggaaggagagaaagtccgcattggagatgatctgattcttgtcagc gtgtccactgagagatacctgcatctctcgaactgcaacggcaacattcaggtagacgcc tccttcatgcagaccctctggaacgtccagcctacgtgttcgtcaggcagcatggctgta gggtatttgattggcgggcatgtaatgcgtctctgtcatggtcacgacgagagcttgaca atccctggagcagataagagtgaagaggagcaaagaatagtgaactacgaggcggggaag ggagcatcaagagcccgctccctgtggagactggagcctctcaggatcagctggagcggc agccatattcgatggggccagtctttccgtctgcgtcatctctccactggtcactatctg gccttgactgaagaccgtggtttggtcctggaggacagagagaagtgtcacaccaaagcc actgctttttgctttaaggcatccaaggaaaaaggcgattctggcatgaagagggatatt gacgggatgggagtacccgagataaagtatggtgactctgtctgttttgtcatgcacgtg gcaactggactgtggctgtcctacctggcgcctgatgccaaatcgtctcgtcttggtccc ctgaaaagaagggcctgccttcactctgagggccacatggatgatggtctcatcctacag cgctgccagcatgaggaatctcgggctgctcgcatcatccgaaacaccacattcctcttc aaaaacttcataaaggcactggacagcgctgcagctggagagacgaatgcggtggccgga tatgttgaagaggtgctgcagacgttgaacgatctgattgaatatttcaagcagcccgat gtagatctagagcacgaggaaaaacaggcgaggcttcgctcactcatcaaacaacaagac ctcttcaaggaggagggtatgctggcccttctctccaaatgcattgaccggatgaacctg tatgatagcgcggcccacttcggagagatggccggggaggaagctggtgcagcgtggaag gacatcctcaacctcctctatgaactcctggctgcactgattcgtggaaaccggaccaac tgcacccagttctcccgaaacttggactggctggtcagcaaactggaaagaatggagtca tcatcaggaatcttagaagtcctccactgtgtgttggtggaaagcccagaagccctgaac atcattcagaaagctcacattaaatccatcatctctcttctctacaagcacggacgcaac cacaagattctggacgtgctgtgctctctgtgtgtgtgcaatggggtggcagtgagaacc aaccagaatctgatctgtgacaacctgctgccaaaaagggacctgctgctccagacccga ctggtcaacgatgtccaaagtatgaggcccaacatcttcctgggcatcgctgaaggttcg gctcagtataagaagtggtactacgagttggtcatcgaccaggtggaccactttgtgacc ggagagccgacccacctgagagtgggctgggccaacaccaaaggctacgctccgtatccc ggcggaggagagggatggggtggaaacggcgttggggatgacctttactcctacagcttt gatggacttcatctgtggtcaggtcggatccccagagccgtggcctccattaaccagcac ctgctgaactcggacgatgtggtcagttgctgcttggatttgggcgctcccagcatgtcc ttcaggatcaacgggcagccggtgcagggcatgttcgaggactttaacaccgacggattc ttcttccctgtcgtcagtttctctgctggagtgaaagcccgtttcctgcttggtgggcgt cacggagactttaagtttttgccgccagccggttactctccgtgctacgaagcgctcctg cccaaggagaagatgcacgtggagcctgtgaaggattacaagcgggaccatgacggggtc cgtgacctgctgggaaccacccagttcctgtctcaggcctcctttattcccactccggtt gacaccagccagattgttctgccccctcatctggagaacatccgtgacaagttggcagaa aacatccacgaactttggggaatgaataagattgaactgggctggacgtatggcaaggtt cgtgatgacaacaagaggcagcacccttgtcttgtggatttcagcaagctgcctgaaact gaaaagaactacaacgtgcagatgtcaagcgaaacactcaagacgctgttggcactcggc tgccatgttgcccaggttaatgttcacgctgaagaggacctgaagaaaaacaaattacca aaagactacatgatgtctaatggatacaagcctgcgccactggaactctctgacgtgaaa ctgactccaggtcaagaggttctggttgataaactggccgaaaacgcacacaatgtttgg gccaaagacagaatcaaacaaggatggacctatggcatccagcaggatgtgaagagcaga cgtaatcctcgcttggtgccatatgctttattggatgaacgcacaaagaaatctaacaga gacagtctgagagaggccattcggacgatggttggatacggatatgacatcgaccctcca gaccaggaggttgtgcatgcaatagataatcagagcatcgagacaatccgctttttccgc gtggagcaaacgtacgccgtgaagaccgggaagtggtactttgagtttgaggtcctgagt ggaggcgacatgagggtcggctgggccaggccgggctgcaggcccgacgtggagctggga acggatgaccaggcctacgtctttgatggatacaggggtcgacggatgcatgccggtagc cgttactttggacatccttggaagaagggcgacgtggttggttgcatgatcaacatggag gacaaatccatgattttcactctgaatggagagctcctgatcaccagcaagggctctgaa ctcggcttcgctgactttgaaacagaggatggttttattccggtgtgcagtctcgggatg tctcagatcggccgcatgaacctcggcaaggatgccagcatgtttaaatactacaccatg tgtggtctccaggagggctttgagccttttgctgtcaacatgaacagggagataaccatg tggttcagcaagcgcttgcccacctttttcaacgttccacacgaccacatgcacatcgag gttaccaggattgacgggacagtggacagccccccgtgtcttaaggtcacacataagacg tttggcacccagaacagcaacagcgacatggtttactgcagactgagcatgccggtggag ttctactctgcagacaggctgctggacgagtcactgaaactcagccaaactcccaaagaa gatggaagtattgactatggaagcatcacaacttattaccactctgtgagagtgtttgcc ggacaggatcccgccaccgtgtgggtgggctgggtcacaccagactatcactactacagc aagaacttcagtctcagcaagacgcaaaccgtcaccgtcactctgggagacgagcggggc cgggtccacgagagtattcagaggagcaactgctacatggtgtgtgcagcagatgcactc ggcccgtcttcctccagccgctcaaacaccgacctggaaatcggctgtctggtcgacttg gccaccggcctcgtctccttcactgccaacggcaaagaactgcctacagcgtatcaggtg gagccaaacaccaagctgttcccggctgtgttttgctgccccaccagttccaaccttttc cagtttgaatttgtcaaaataaaggatgccatgccgctgtcgtcagccatgttcagaagc gagcagcggaacccggttccacagtgtccgccgcgtctagatgtgcaaaccatcgtggcc gttctttggagccggatgccaaacatcttcctgaacgtggagacggctcgggtcagcgag cggcacggctgggtggtgcagtgtctggaacctctgcagatgattgccgtgcacatacct gaagagaacaggtgtttggacatcatggagttgtcggagcatgaagacctgaggaagttt cactaccacactctgaagttgtactgcgccctctgtgctctgggaaacacgcgtgtggct cacgccctctgcagccacttagaccaatcacagcttctctacaccatcgacaaccagtac ctatcgggcatgctcagagaaggcttctacgacgtcctcatcagcattcatcttgagacg gcgaaagaggcacggctaatgatgaacaacgaattcattatccctgtgacggacgagacc cggtccatcaagctgttcccggatgaatccaaaaggcattctcttcccggagtcggcctg agcacgtccctcaaacctcgggtcaacttctccccagtcggcatcatcagcaccaaacgc caccagctcctttacagtccccagatccccctgggcgtcctgaaggagaaagccatcagc atgctgatggaggctgtgcagggaggaggctcccacatccgagacccggtaggtgggagc ctagagtaccagttcgttcccatcctgaagctcatcggaacgctgctcatcatgggagtc ctgaccagcgacgaggtgaggctgattctcctcctcatcgagcccaacgtgtttggggag gccaaggagggagaagaagggagtgggggcgaggtggtggtggcgggagagaaagaggag gtgagcaagaacgaggagaaggctgtggaggcgggagaggaggagaccaaggagagcaaa ccagccgccagaggtctgctggagaagtccctgccggagtctgtcaaacaccagatgtgc gagctgctgcactacttctgcgactgcgagctgcagcaccgcatcgaggccatcgtctcc ttctccgaccgcttcgtttccaaactgcagtacaaccagaagtttcgctacaacgagctg atgcaggctttcaacatgtccgccgccgtcacggccaagaagaccaaggagtttcgctcg ccgccacatgaacagatcaatattctgctgaacttcagtgcgggggaggactgcccttgt cccgaggagatccaggatgaactcacgtctttccatgaagaattacggctgcactgtgga attcccgtggaggaggaggaggaagagcaggacacatcgattaaaggtcggctcctggct ctgctctacaagatcaagggcccccctcagaagacagaagaggagcccgcagagacagag caggccgccccgaccaacctgaaggagctgatttctcagactatcaccagctgggcccag gagtcccacatccaggacccggagctggtcagagtcatgttcagcctgctgaggaggcag tacgacggcatcggcgaactgctgcgagccatgaagaagtcgtacaccatcagcgccgcc tcggtgcaggatgccatcaacctgctggcgtctctgggtcaaatcaggtcgctgctttct gtgcgcatgggcaaggaggaggaaaagctcatgatcgatgggctcggggacatcatgaac aacaaggttttctatcagcatcccaatctgatgagagttttgggaatgcatgagacggtc atggaggtcatggtaaacgtcctgggtggagacaagtcccaggagattgcctttcccaag atggtggccagctgctgtcgatttctgtgctatttctgccgcatcagccgccagaaccag aaggccatgtttgaccacctgagctacctgctggagaacagcagcgttggattggcgtct gaagcgatgcgaggctccactcctctggatgttgcagcatcttcagtgatggacaacaac ggtctggctttggctctggaggaacctgacctggaaaaggtggtgacgtacctggcagga tgtggcctgcagagctgtgccatactggttgccaagggttacccggacctgggctggaac cccatagagggagagcgctacctctcatttctgagatttgtcgtcttctgcaatggtgag agcgtggaggaaaatgctaacgtggtggtgaagctgctgatccgacgtcccgagtgcttc ggccccgccctgagaggcgaggggggacagggtctactggctgcgatgaaggaggccatc aagatctctgaggatcccgctctggacctgcccaagagcccggctggagccaccatgggg tctggtgaagaggaaggagaagttatccacatgggcaacgccatcatgtccttctactcc gccctcatcgacctgctgggacgctgcgctccagagatgcatcttatcaatgcagggaaa ggtgaagcattgcgtatcagagccatcctgcgctctctggttcccacgtcagacctggtg ggcatcatcagcatccccctcaagatgcctgtgattaataaagacggatccgtgacagaa cctgacatgtcggcctgcttctgcccggaccacaaggcccccatggtgcttttcctggac agagtttacggcattgaggaccagagtttcctgctgcagatgctggaagtcgggttcctg ccggacctcaaagcctcggcgtctctggacacggaagcactgagcaccacggagacggcg ctggccatgaatcgctacatcggttcggctctgcttcctctgctaacccgctgcgcctct ctgttcggcaacacggagcactacgcgcatttggtcgactccacgctggagaccatctat cggctgtccaaaggtcgctcgctcacgaaagcccagcgggacgccatcgaggagtgtctg ctggccatctgcaagcatcttcgtccatccatgatgcagcagctgctcaggcgcctcgtc ttcgacgttcctctgctcactgaatactgcaagatgcctctccggctgctgaccaaccat tatgagcagaactggaagtattactgcctgccgtctgggatgggcggcttcggcatggcc tctgaggaagaactgcttctcacaaagaaactcttctggggaatttttgactctctttct cagaagaaatatgattctgaactgtttaaaatggccaagttgtgcctgtgtgccatcgct ggagctttgcctccagactttgtggataccagcttaggggcgacggtggagaaacaggag tcagtggatgcacagggaaactttgagccaaaacccatcaacactgccaacatctccctt cctgaaaaacttgactacattgctaataagtatgcagagcattcccacgacaagtgggct tcagagaagatgtcggctggctggaaacacggagacagtttggacgagcagaccaaaacc catccactgctgaagccttataaatctttaagtgagaaggagagggagacttaccgctgg cctgtgaaagagtccctgaagagcatgctggcgatgaactggaacattgagaggaccaag gagggagaagccatgttccagcagcgagagagtgaaaaacagagaaagctttcagaatct cagtctaacggattcagtcctgctccgatggacctgcacaatgtcactctgtcccgagag ttacagactatggtggaagtggttgcagaaaattaccacaacatctgggctaagaagaag aagtcagaacttctgagtaaaggaggagggttggctcacccgctgcttgttccctatgat accttgactgctaaagagaagtacagagacaaagaaaaggcccaagagctcttcaagttc ctgcagattagtggctatattatcacaagaggtctgaaggacatggagcaggactcgtca tccatggaaaaacgttttgcctacaagttcctaaagaggctgttgaagaatatcgactct gctcaggagtttatcgcccatcttgaggccatggctaccagtgggaaaactgacaagtcc ccccatgaccaggagatcaagttctttgcaaaggttttacttccaatgattgatcagaca tttaagaaccactgcctttacttcctgtccacacctaacaagaacctgagcagctgtggc tacgcctccaacaaggagaaggagatggtcaccagcctgttctgtaagatggccgctctt gttagacacaggatttctctcttcggaagtgactctgcgatcatggtgagctgtcttcac atcctgtcccactcactcgacacaagaacagtgatgaaatccggcgcagagctggtcaaa gtcgggttcaaggccttctttgagagcgcggcggaggacttggagaagctggtggagatg ctgaagctggggaagttcatgcagtcacgcgcgcagatgaagagcgtcactcagagcatc aactatgtgactgtggccctgctgcccatcctcactgccctgtttgaacacatcaggacg cacgagtttgacgtggacctgctcatggatgatgtgcagctgtcctgctaccgaatcctg atgtgtttctacctcctgggaaccggaaagaatgtctttgtggagagacatcttccagcg attggggagagtctggcgaccttggtgggagcgatgccggtggcgttcctggagcctcat ctcaacgctcacaacccactttcagttttcaacaccaagacgccccgagagcgagccatc ctgagcatgcccgacacggtggaggagatgtgtccagaaatgcctcgcctcgacaagctg ctcaaggacgtcaacgacgtgtcggagtgcggcgctcgctacagtgacatgccacaggtc attgaggtcgtcctccccatgctgtgcaactacttgtcctactggtgggagaaaggcccg gagaactcgccgccggacaccgactgctgcaccatggtgacgtctgaacacctgagcatc attctgggaaacatcctgaagatcctcaacaacaatctgggcattgacgacgctccctgg atgaagaggattgcagtttactcgcagccaatcatctgcaaagctggagctgatttgttg agaacccacttcctgcccacaatggaaaaactaaagaaaaagacggtgaaggttgtgtct gaggaggagctgctgaaagccgacggtaaaggagacaaccaggaagcagagctgctcatc ctggatgagttctctgtgctctgcagggacctctacgctttctaccccatgctcatccgc tacgtggacaacaacaggtccaggtggctgaaggagccagatgcagactccactgagctc ttcaggatggtggctgagattttcatcctctggtgcaaatccaacaacttcaagcgtgag gagcaaaactttgtgattcagaacgagatcaacaatctgggcttcctaaccggggagggc aaatccaagatgtccaagtctggtggggaccaggagcggaaacataaacgccgccgcggt gaatattactccattcagacgtctctgatcgtagctgcgctcaagaagctgctgcctatc ggcttgaacatgtgcacaccgggagaccaggagctcatctctttggcaaagatacgctac agcctgaaagacacggacgatgaggtgaaggagcatttgcgtcagaacctccacctgcag gaaaagtctgatgatccagcagttcactggcagctgaacctttataaagacgtagtggtg aaatcggaggagccgtcggattcggagcacacggtggagagaatccagagcatctctgca gcagtcttcaatttggagcaggtggaacagcctctgaggaacaagaagtgcatcgtccag aagctgctgtccaagcagcgtaagcgggccgtcgtcgcttgtttccgcatggctccactc tacaatttacccaggcatcgtgctatcaacttcttcatcccagcctatgagagactttgg atagaggcagaggagtactcctttgaggaaaagctagttcaggacctggcaaaaaccccg atgaagatcgtggaggaagaggaagaagaggtggctgagatcaagccggacccgctccac cagctcatcctccacttcagccacaacgctctgacggagagaagctacctggaagtagat cctttatatatcgcgtatgcagacatgatggcaaagagctgtgcagaggatgaggaggaa gaggaagaagaagggcgggaaaagacattcgaggaaaaggagatggaaaagcagaagatc ctgtaccagcaggcgaggctgcacgctcgtggggctgcagaaatggtgctgcagatgatc agcgccagcaaaggtcgtctgggccccatggtgacctgcaccctcaaactgggcatctcc atcctaaatggaggcaacgtgcaagttcaacagaaaatgctcggttacttgacggacaaa agagacgcaggctttttcaagagtctgtcaggactgatgcagtcttgcagtgtcttggac ctgaatgcatttgagaggcaaaacaaggcagaaggacttggcatggtgacggaagaaggt tcaatccacactcggcggggctccaaggtgcttcagaacgacgaattcaccaaagatctg ttccgctttttgcaacttctctgcgagggccacaacggagatttccaaaacttcctgaga acccaaactggaaacacgaccacagtgaacatcatcatcagcactgtggactacttgctc cgcctccaggaatcaatcagtgatttttattggtattattctgggaaagatgtaattgat gaaactgggaagcacaacttctccaaagctttatctgtagccaagcagatatttaactcg ctcactgagtacattcaggggccttgcattggaaaccagcagagtttagctcacagcaga ctgtgggatgcagtcgtcggcttcctgcatgtgtttgccaacatgcaaatgaagctttca caggatgccagtcagattgagttgttgaaggaactgatggatttacagaaggacatggtt gtcatgttgctgtctctccttgagggaaacgtggtgaacgggacaatcgggaagcagatg gtcgacaccctggtggagtcttccagtaacgtggagatgatcctaaaattcttcgacatg ttcctcaaactgaaagatctcacgacgtccgacaactttaaggagtacgacccggaatgc aaaggagtcatttccaaaaaggagttccagaagtcgatggagagccagaagcagtacaac cagtcagaaatcgaattcctgctgtcgtgcgcggaggccgatgagaacgacatgttcaac tataaggagtttgtggagcgattccacgagcccgccaaggacatcgggttcaacgtggcc gtgctgctgaccaacctgtccgaacacatgccccacgacgcccggctcaccaccttcctg gacctggccgaaagcgtcctcagctacttcgagccttacctgggtcgcatcgagatctta ggcagcgcaaagcgaatcgaacgcgtttacttcgagatcagcgagtcgagccgcgagcag tgggaaaagccgcaggtgaaggagtcgaagcgtcagttcatcttcgacgtggtgaacgag ggaggagagagcgagaagatggagatgtttgtgaacttctgcgaggacaccatctttgag atgcagctggcctcgcagatctctgagccggacgccgtggagcagccggaggaggaggac gaggaagaggtgcacagcatccttgaggagctctccgggggagaagatggcgccctggag tctgcctcggcgttcaccaccgcgtgtcgttcggtcaagaagaacatttcagaaatccgg cagattttcaccattaaaaccgcgcgcaagcagttcaagaaaatcaagaagctgagcatc aaggaactgatcaccggcttcttctccttctcctggatgatctttattggcttcttcaag gggattttcagcctcgtttttggtttctttcacgtcatctggtcgtccatgtttggcgga gggcttgttgaaggagccaagaacataaaggtgacggatatcctgggcaacatgccggac ccgacgcagttcggcatccatggggacgtgggagaaggagacaaagtggaagccatggag tcgtcgggcagctcggacaaaaccatggctcctgcaggagacgccacagaggtggacgtg atgctggagatgctgacgcctaaaaaggaaggaggaaaacacgtggagcccggcctgggg gacgtatcggagctgagcggggagtcctccactgcagacagtaaaaagaaagccgctgcc aagacagccgcgccctctgagagcgagacagaaaaggcagacacagagacccgggagaag gaggacaaaccaaaggaggaggaggcaaaggaaccagccgtggaggagaaacccaaaccc agatccagtcagcccaaagaggcgtctccggccttcatgtcaaccatcttcaccattctt gacgtctatctgaataagatactgaactacctggctcgtaacttctacaacctccgtttc ctggctctgttcgtttgcttcgccatcaacttcatcctgctcttttacaaggtcactggt gaagctgaggaagaagaggaagacgaggagcaccgttgggatgaggaagacgacgagaac acgctgttcgacatggacgagtttgtgctgcaggagagcaccgggtacatgctgccgacg ctgcgcttcctggccgtgttccacaccgtcatctcgctgctctgcctggtcggctactac tgcctgaaggttcctctggtggtgttcaagagggagaaggagatcgccaggaagctggag ttcgacggtttgtacatcactgagcaaccgtccgacgatgacatcaagggccagtgggat cgactcgtcatcaacacgccatctttccccaacaactactgggacaagtttattaaacgc aaggtgatcaacaaatatggcgacatgtacggggccgagcgcatcgctgagcttttgggc ctggataagagcgctctggactttgaccccaccgtggagactgtggagaaggaagcgtcc ctgctgtcctggttgagctctattgacacaaagtaccacatctggaaactgggggtggtt ttgactgacaattacttcctgtatctgatctggtataccaccatgtccatctttggacac ttcaacaacttcttcttcgctgcacatctgttggacatcgccatgggcttcaagacgctt cgcaccatcctgtcctccgtcactcacaatggcaagcagcttgtgctgaccgtcggtctg ctggccgtggtcgtctacctctacactgtggtggccttcaacttcttcagaaagttctac aataagagcgaggacgaagacgagcccgacatgaagtgtgacgacatgatgacgtgctac ttgttccacatgtatgtgggcgtgagagccggcggaggcatcggagacgagttggaggac ccggccggagatccctacgaactctaccgcatcctgtttgacatcaccttcttcttcttc gtcatcgtcatcctgctagccatcattcagggtttgatcatcgacgcctttggggagctg agagaccagcaggagcaggttaaggaggacatggagaccaaatgcttcatctgcggcatt gggaacgactactttgatcgaacgcctcacgggtttgaaactcacaccctacaagagcac aacctggccaactacctgttcttcctgatgtacctaatcaacaaggatgagactgaacac acgggtcaggagtcgtacgtgtggaagatgtaccaggagagatgctgggacttcttccct gccggagactgcttccgtaagcaatacgaggaccagctgggttag

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