Xenopus laevis (African clawed frog): 399433 Help Entry 399433            CDS       T01010                                  Symbol syne1.L Name (RefSeq) nesprin-1 isoform X3   KO K19326   nesprin-1 Organism xla  Xenopus laevis (African clawed frog) Pathway xla04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:xla00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     399433 (syne1.L)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:xla03036]     399433 (syne1.L) Chromosome and associated proteins [BR:xla03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     399433 (syne1.L) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 CH SYNE1 KASH Spectrin_SYNE1_2 SYNE3 Motif Other DBs NCBI-GeneID:  399433 NCBI-ProteinID:  XP_018118520 Xenbase:  XB-GENE-5956730 UniProt:  A0A8J0V7E0 LinkDB All DBs Position 5L:49318504..49603993 Genome browser AA seq 8797 aa AA seqDB search MATSRMASRSTRDIANVMQRLQDEQEAVQKRTFTKWMNSHLAKRQPPMVINELFEDIKDG TKLIALLEVLSGQKLPCEKGKQMKRIHWVANIGAALKFLEGRRIKLVNINSTDIADGRPS IVLGLIWTIILYFQIEELTSNLPQLHALSSSTSSVDSVVSSEAATPPIKRKIVNKIQGSA KKALLRWVQYTAAKRIGIEVKDFGPSWRNGIAFHSVIYAIRPDLVDMDIEKLKRRTNREN LEEAFSIAEIELGIPRLLDPEDVDVDKPDEKSIMTYIAQFLKHYPDPHNTSLEGQEDSRE DRIVFRDMKVWLEQFEKDISRAQMVESSLQDRYQSFKQYRVQYEVKRKQVETLIHPLGKD GKLSLDQTMVKQAWEKVTARIFDWHIQLDKSLPAPLGTIASWLYRAEVALREEIVVQQSH EETANMIHRKLEQHKDVLKSLDGYKKAFQEIHRSRSVNGVPVPIEQLEDMAERFSYVASS SQLHMIKLEFMELKYRLLALLVLAESKLKSWIIKYGRRDSVELLLQNYIAFIDGNRFFEQ YEFTSHSLKQAAEMYVKADGSADEVENVTKFLNETTVQWKNLSVEVRSVRSMLEEVITNW DKYSNTVASLQAWLEDAEKMLNQPEHAKKDFFRHLPHLIQQHTTMNDAGNFLIETCDESV SKDIKQQLLLLNGRWRELFMEVKHYAREDEYERARKEYADGLIALAAFAEGGNERISTPL DVSFLNVKMFVQDLEDIKQKMPIIEAQYKSVTRMAQLLTKESSQAEANEMLSAVSRVKDQ LNKIREHYPPLLYESQQLLTPLGEFEGHLTNFYECLEKIHGIISVADLDMQSASVFKQQQ RELLSCQESCKKTLIIIEKYGQAVHKALTISKSLHHFDRSALQKKLADAQDAYQNAIKKT TEWRKTVDANNMLMKKFEESRTELENVLKTAEMYFKETGNPSDLLKKHTDFFGQLDQKVL NTFLKACDELTDILPEDDQQPLQDTVRKLHKQWKDLQSEAPYHLLHLKIELEKNRILTTV EESKVELARENKMLPIEGSEKIIREHRTFFSEKGFYHLCEKRLRLIEELCLKLRDQDPVK GVLESNKRAVRDMNTQIGSTHLKLMEHQDKWKDFRSRFSELSGWLIEKEKQLKKIRSSAN DSTRYGQFKALVEEIRQDVMKQEDTLKYLKDRITALSDISVEADVTKQNKELARISTDFK EFLEHLAEIEKLLSTVRDCVQCKEQVQTVLSQLITSTRDAQTEAEKILDTESFTEAQELL HHYQQNIKKIRSDKKDVQQQIVQAKQLQGERGVTGPALEDLTRLEVELENVEQTMVKQEE HLQVTMNTWEQIESGKESVKSLLKQISPALGRSLNFNSLESLSSEIQQAKEVCKQSEDTS IQVEDLVKKSSEIQLGAKSKQSLQQQTKSIQEKVKEVKESVLENITKMETVKLKWENFNL DFEVHSAWVSEKEKELTMLESSPFSPELQIKQIQEILKELNTQSNEITNLESKCQSFAQF ITSAEMARIRARMSQMTKNWAGLKDHAHRLEETILGNAVQQQKFNETFEEVQNSLNEIED KLSQPVTNCSSAAETYKILHSHQELCHTVESMKNIILSLTTSARKLITKEKAMQEILKLQ QKHEALSAQAKVRLTLLEQLLAQWQRQERDFSGFMAWLDRSEALAAHQDDRFPADKGKLE AELQAIKDLQYEVQAQNQRYTGLMETSESLYNTCTAENLEEIKERLQKLTERWKALPKTI LQRLQSVESALQEHQKFDSMVLEFSLCIKKFLKELQDTAEITTSDYEAAQNINKNHVTEV KRQEKELQSLKEQLEKICLLTNSEEHLVLQGRAGDCNQLYEEAIQITNRREDCLPKLGEF LQTHNESTAVLRHLKETVDVTVSLDKAKSESLAKELNDIVAEMDNLTSLSVGLDSSLTKA QYHLRSGATNQRTSCRALTDNLSLELEVVQTYFGTKQSEAEALGALWKSFTECREKLLKC IEDIEEKADKEEMKEPTLQALQQRLKFFNELEEEMNSHKHEKQWLMDKAKQIAQKDLAMA AEADKVLSGFNMTWDDTKRLISDSQEQCSELIDLMSAYEHLNYTIIKLIENAENMITIKS TLKDQEDIRRTIAKHESAKNELGENQKELDEFTNKGKQLLLDLKRVHGCNSRIIKQDMDS TMDKWLDVLERIDDNLERLKVSLALWEDVLLINDEIDGWSSSSISQMSSNLNNSQHMKTC LEDFQSEVANKGQKLEEFHSKVYELKELTKSQEPPTELQFMEADLRQKLEHAKDVSQMAR GTLTEFSSQKMQLETFIDQMTDWLTKVEESVLKYVHSQDPDDLKKLKDIQKELQTQQSSI DTTQENLNSLCRKYRSMELETLGGSVTALIKKYEAVNQLCLRSHASLQDTLEKRFYESMR EFEEWFDHVKEGVREYSDWSGDSRTLEGKIQHLQGILDSVTEGESKLDIALEEGEKLYFC LPKPVMVSIQEQISKAQKDFQSFKKQCLKDKQALEDCISELGSLEEQHKKLSLWIHELEE RLKTETLGESKQHIPEKKNEIQKVEMFLEELLASRESFDRLSQRAQALNEDGLGGGQEVR LASQLHTSYQNLIKIIKEKLRICQVALQDHQIFEEALQTTWSWLKDMQDKLITTESTVGS KNTLEKRLLQVQEMLLVKGEGEVKLNLAIGKGEQAMKSSNKDGQMVIQMQLQTLMDVWGT VNNTATHCLSGLEAILSQWNEYTERKTQLELWLETTDQKLEQPIQPQNGLKEKFTLLDYI QAIVSDIEDHSTTIHHLIEKAKELHQRTEDDAFSDSVQDELKTHFNDILTVAKEKMRKVE DIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDASGDVSAIQKKLTKIKELMDSRQTGAER LSRIETLAPAVKQNTTDSGCEQMDNEIHSLQADWKQWESSVCHSQKALDGLLNQMAISEQ EFSNQVSKLEDALQDFSQFLEKWTQKLMQVEGKDSDKEIVEHWHRQKDVLTALNDAEHVT DELKTQLNDLCRFSKDLSIYSAKVSSSIKEYNSLCLQASKGCQNNEQALQQRFRMAFRDF QQWLVNAKVTTAKCFDIPQSVSEASASLQKIQECLSESENGQHKLQTVMIRGELLYSIMT EEKAKVTRQKMLTAKDNWKGFISSLHQKESALENLKIQMNDFETSADPVQTWLSATEKIV QDSNNRLHDLPSKRKEQQKLQSIQEEISSHEPQITRLKDKAQQLREGQSACKSFAHRGSQ LSAQYLALSSLTKEKMSRMDRIVAEHQQFSQGMIELEDWISEAIQILQSYCHPTADRNVL DSRMSKLEALLLVKQEKEIQMNMLLSRGESVVRNTSPEGAPAIQNQLQDLKNTWASLLSS CIQCKSHLEGALSKWTSYQDDVRQFSNWMERVEERLHDMGKQYAELREKTAAQSKVKLLN EEILSHGSLLEKIEVKGSSMSEHYVTQLELQELQENYSALKEKAKDAIFKVDKLVRAHQD YQQGLKSFEEWLQLETETLDCHMHLDGDTQMHEATLLELQELQVRCAEGQALLNTILHTR EEVIPLGVPQMEERELESLRQDWQVYQQRLAETRSQLNSTLSKLKQMENKFQKTDEWLTS IEGKVNIRTSRQSDRATKETQLHQMKKWHDEVLVYKDEVEEVGTLAQRVLEDGKSNSRVG SLATMLTSRYQAVILHILEQMKFLEEELRYSEESEVSIRSYTEWYAEARRKFLTLTSDIG VVDKATMEKKRKNLEFLLSDMDVGQSLLKSAREKGERVLKYLESTEADQLETEINGHVQR QEELTYSIRREYTALEKTFHLAKEFSDKYRQQAQWLSEFQAILQTSVEPKTELYEKKAQL AKYKSIQQTVLSREPSVKLVIEKGEALIGVTFDNTIGERIQKLQKDFQELCSLVKTTVVD LEESVKEHEEYNSELQDVEKWLLQMSSRLVAPDLMESGNLEIITQQLANHKAMMEEIAGF EQRLNSLKSKGDKLVFYCAEHLQAKFKQSIQAHLQGIRDSYAAICSTVQRVYLSFENELQ KHVSHQDTLLQCQAWFSAVQPEIKSGIKAPLSLAEATKQAKHYRTLQEQANTYLDLLCTA CDLSDVTVKNAAIDIQQTKQTIEQRMKQSQELTSGWEEVMQIKAELQAYFQDAGQQLQNM KRRRAELEIKLAQNMVLQIKDFNQKLQSKQHKITFLTEKVNKLTNGQESPEHVEIGQLSN KWLDFCFQANNLLLQREEDLQRTRDYHERLNIVDVFLEKLATEWDNLARSDTESTAAHLE ALKTLVSILQERRFALEDLKDQKQKLIDHLNVDDRELAKEQTRHFEHRWAQLEDLVKNKI LSCVTTLEELGLVNSRLQELTEWAEDQQPSISEALKQSPPPELAQNLLMDHLTICNEVET KQVLLKTLMKDADRIMANLGLNERQQLQKALVDSQNHIDCLSDLVNQRKKHLNKALSEKT QFLMAAYQTLNQIYQHEKKVTLQEHICLFPDDVNKQIRCCKNAQASLKAPQSDINSLWNQ GRELMKDATEQEKTEVLGKLQEIQNAYESALQKCGQRLIELEKCYVSRKYFKEDLDKACH WVKQADVLTYPEINLMNDDTELLALLSRYQHILEQAPEYENLLLSLQRTGQEILPSLDDL DHSYLQEKLNSLPKQFNCVIGLAKEKLTKVHEAIYTRKEYASLIDLTGKALKELEDNFIL MDKVPSRISAEEVASLQQDCASLLNEVLSLGTAINELNQKKEIFRSNGQPWLPEDMLQLT SQYYKLKRLIQQKVSHLEDMTDAYWKHEDLCSKLNMKFETLSKELEQVNNETLPAEEKLK SYRSLAANLKDAGVLHRNVIEHLEELSPILERAVYEKEDLQIKQWQEKLKSWHLVMKERM GECENRLVQSIDFQIEISRTLEWLSHMKVELHEPVILDGKLESIQEEIRKLQLQQEETVS RLRIINALSIREKKKYLNAKECVPVDLETSVISLSKLEEEVQDAINLKQSALDKMYITSH RYHKVLQCSLDWVKDAQELLQQTSSGVDVETAEECLKNAMEFISTENKFNGHVDELHLLV SELEDFVQKSARDQLKQSVATQKAKGKDTNEQIKAELDLLKRFTAQWHSYQEERQDVIMS LNEAEIKLSRFSVMKDASGLKAEEKHLNHKSLVSLVNSFHEKITALEEKASVIEKLGSDA SKASICKSMTTVWQRWTRLRSTAREQEKILEEAVQEWKELSEKIQQSTLMIDKLQEKLPE NSTEKAFKAELVELLENHEAFSRELEQEQTAVTMLRQHALNGVLRDAETESTSLEDTPVM QEIKAMQDRCANMQQKVKKSKKLVEQELKEREDVEKDLNVVKTWIKETKDSLLNPSSEGD EYLQELKILQEELNCHRHKVEKLSEEQQSKYLEMYTILPSELSLLLAEVALALGTINEEI QARQREALHNQALHHGFSQQINDIEDELKTILEKLKEKTNNLPRAKNDHKKLCETLDTCN IKLVELDAAVQDFAEQSPSQAKQLIDKVGKLTEIHQQASQEAEQKAGKLKQAAVQLEEYN EMLEFILKWIEKAKILVHGHIIWTSASQLRDQSLTNQALLEESRDIHSDLEAMNEKTEYL ASVYCTEGMARHVSDLGHQTEDLQQILRHRLQSLQDAAKDMKDFESEVRALQTALEQAQT TLTSPELGRLSLKEQLSHRQHLLSKMESLKPKVQAVQTCQSALRIPEEVVTNLPICRTAL RLQEETSRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEEAHHELQDAKVTTSNIQE LQFQIKRHEELAKKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLTEGMEELDA ELLPAHSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVN QDIAYYQALSAEQLQTDAAKIQPNMSTPQEIFEPGLESAANAKLDDLQRSWETLKNVISE KQRTLYEALERQQRYQDSLQSISTKMEAIEVKLNESLEPSKTPESQMAEHQALMDEIVML QEEISKLQASFADELVSESLDSDAADQLALQSTLTVLAERMATIRMKASGKRQLLEEKLN EQLEEQRHEQALQRYRGEADELDRWLLSTRATLDDILLAFEEPMAMDAQLIDCQNMLLEI EHKVVALSELSVHSENLLMEGKAHTKEESEQLAIKLRTLKASLLELQRVLQDKQISIQAK LAWGEVKAHKQAEHENVHEKEESESELSSSQSPSVQEWIVQSRTTRSLQKQNSLQRQKEL EQELAEQKKLLQSVASRGGEIINQQTVTERSELRENTDSLSCELGLEGFRSPSEDQMRMK WESLHQELSAKEKLVQNALEQEQEQPIFSKTNRLVHGVPFYKGDRKAQDKPSVTKLLDSL NQSLEDVSSQGGGVETKSLPYERKLYDAVSATSSWLDDVEDQIFVATALQPEETEACLYH QETLAKYIKEMSEEMDKNKNLFFRTFSRSGDNQEIIEDTLYCLLGRLNILESVVNHRCCQ MKQRLQDLLAFQNDLKILFTSLADNKYIILQKLAEAAERPAKEQIQAILQAEDSLKELDT EINELKKRGDKLQADQSSMQDLSKLQDTYDELMMIIGSRRSGLNQNLALRSQYERALQDL ADLIETGTEKMSGGQKFIVSSRDEVETLLDKHKEYFQGLESHVILTETLFRKISSYALPS ESQNNSVLIAGASALLKQAHKRGVELEYILETWMLLDGKYQELMKQLEVIESSIPTVGLV EETEERLLERIELFECFKSSLTECQPKLYQILEDSKRLLMSVNCPELEGFINNLGEYWGN NRNRISKELQRLENILKLWTRYKNESAELGNWLRSAIDRLEFWTQQSVTVPQELETVRDH LNAFLEFSKEVDAKSSLKSSVMSTGNQLLRLKKVDTASLRSDLTKIDTQWTELLIHIPVV QEKLHQLQMDKLPSRHAITEVMTWISLMEDIIKEDEENIRNVVGCEVIQEYLLRYKGFKI DVNCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEKLGAMNRRWQILQGLITEKIQMLE RLLESWTEYGNSVQTLKSWFERQEKKLQRQQSIGDQASVQNSLKECQELEDLIRVKEKEV EKVEQSGLSLIRDKKENVTAAVLQTLRELNHSWANLDHMVGQLKILLQSVLDQWSIYKQL HEELNSYLMEAKYSLSRFRLMTGSMEAVKVQVENLKKLQEELEKKEDRLDKFGSVTNQLL NTCKSSVTDGLKTTLKEVNTRWNDLMEEISEQLHSSKTLLQLWQKYKDYSVQCNATVQQQ EDRANQLLKTAANKDIGDEEITIWIHDCSVLLKGLNTTKTSLVSLSETGEQLKQQVDTSA TTAILSDHLSLNQRLSVLEQALLRQQSILQAGVLDYETFIKSLEGLEAWIIEAGEVLNGQ DPNRSSDLSTIQERMEELKRQMLRFSSMAPDLDRLNELGYRLPLNDKEIKRIQSLNRQWT VTSSQTTERFSKLQSFLLQHQTFLEKCETWMEFLIETEQKLAVEISGNYQSLLEQQRAHE LFQAEMFSRQQILHSIIGDGQRLLEQGQVDDSDEFNLKLTLLSNQWQGVIRRAQQRKGII DSQIRQWQRYREMAEKLRKWLVEMSYQPVSGLGGNPIPLQQARNLLDEIQLKDKVLHRQQ GSYILTVEAGKQLLLCADSGAEAALQTELMDIQERWKATSVRLEEQKKQLAFLLKDWEKC EKGTAASLEKLRNFRKNLSQPLPDHHDELHTEQIRCKELENAVEGWVEDLMFLTNLKENF TQHITADDIAILNERIELLQRQWEELCHQVSLRRQQVSERLNEWAIFNEKNKELCEWLTQ MESKVSQNGDISIEEMIEKLKKDYQEEIAVARENKMQLQQMGERLAKASHESKASEIEYK LSKVNDRWQHLLDLIGARVKKLKETLVAVQQLDKNMSSLRSWLGHIESELSKPIVYETSD SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDTECDSIQQATRSLDR RWRNICAMSMERRLKIEETWRLWQKFLDDFSRFEDWLTISERTAAFPSSSGVLYTVAKEE LKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACKLKQMVHEGNQRWDNLQRRVTS ILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKLKQLKAFQQEISL NNGKIDQIIAHGEQLIEKSEPLDAAVIEEELDELRRYCLEVFGRVERYHKKLIRLPLTDD EHDFSDREVDLDEIADLTDIPWHTKTSAGTLSPLPSSNHSLSLVVPMRSERSGRDTPASM DSIPLEWDHDYDLSRDLETAVSQALCSDEEEQQDKNYFPQGAAGITGELGLETQIRHLDK ALDTSRFHLQQTENVIRSRTPTGPELDSSYMGYMKLLGECRESIDTVRKVSEKLKEEEEK LSGFINLNSPETQSSGVIERWELIHAQAHNKELRMKQKLQQWQQFISDLNNVWDWLADTE EEVEQLNQLDVSTDIQAIEQRIKKLKELQKAVDSRKAIVLSINLCSSEFTQANTPESKEL QERLKQMNVRWERLGSALEEWRYKLQDALMQCQDFHEMSHGLLLWLENIDRRRTEILPIN PNLDADTLQDHLKLLSQMKRELLESQLKVASLQDMSCQLLVNAEGKDCLEAKEKVHVIGN RLKVLLKEVTRHIKDIEKILDISSNQLELTSWSSADELDTSGSLSPVSGRSTPSRQRTPR GKYSVSQPGPSANNPPSRSKEDGSGSYRSEANEAQQHQSFFQRVLRAALPFQLFLLLLIG LACLVPMTEEDYSCTLSNNFARSFHPMLRYTNGPPPI NT seq 26394 nt NT seq  +upstreamnt  +downstreamnt atggccacatctcggatggcaagcagatccacaagggacattgctaatgtgatgcaaaga ctgcaggatgagcaagaggcagtccagaagagaacatttacaaaatggatgaattctcat ttagctaagagacagcccccgatggtaatcaatgagctgtttgaagatataaaagatgga acaaagctgattgcactattagaagtcctgtctggccaaaaattaccttgtgaaaaagga aaacaaatgaagcgtattcattgggtggctaacattggagcagcccttaagtttttagaa ggaagacggattaaactggtgaatataaactcaacagatattgctgatgggagaccctct attgttcttggcttgatatggaccataatcctgtatttccagatagaagaattaacaagc aatcttccccagctgcatgcattgtccagcagcacatcttcagtggatagtgttgtgagt tcggaagccgcaactcctcctattaaacgcaaaatagtaaacaagatccaaggaagcgcc aagaaagcactgctgagatgggtgcaatacacagcggccaagcggattggtatcgaagta aaggattttggtcccagctggagaaatggaattgcctttcactcggtaatatatgcaatc cgtccagatttggtagacatggatatagaaaagctgaagaggagaaccaatcgggaaaac ctcgaggaggctttttctatagctgaaattgagttgggaatcccaaggctgctggatcca gaagatgtggatgttgataaacctgatgagaagtctattatgacctacatagctcagttt ctcaaacattatcctgacccccacaacacctcattagaaggacaggaggatagtagagaa gacaggattgttttcagagatatgaaagtttggcttgaacaatttgaaaaagatatcagt cgggctcaaatggtagaaagcagcttacaggacagatatcagtcatttaaacaatacaga gtgcaatacgaagtcaagagaaaacaggtggaaactttaatccatcccttgggaaaagat ggcaaactttcacttgatcagactatggttaaacaagcatgggaaaaagtcacagcacgg atttttgattggcacatacagcttgataagtctctgcctgctcctttgggaacaatagcc tcctggttgtacagagcagaggttgcactgcgagaggaaattgttgttcagcaatctcac gaggaaactgcaaatatgatacacagaaagttagagcaacataaggacgtccttaagagc ctggatggttacaaaaaagcctttcaagagatccaccgctctcgatctgtcaacggagtt cccgtccccatagagcagcttgaagatatggcagaaagattcagttatgtagcttcatct tcccaacttcatatgatcaagttagaattcatggaattaaaatacagattgttagcattg ttagtcttggctgaatcaaaattaaaatcatggatcataaagtatggcagaagagactct gttgaactcctcttgcagaattacattgcatttatagatggcaatagattctttgaacaa tatgaatttacgagccattcccttaagcaggctgctgagatgtatgtgaaagcagatggc tcagcagatgaagttgaaaatgtaaccaaattcctgaatgaaaccacagtgcaatggaag aacctttcagtggaggtgagaagtgtccggagcatgttagaggaagtcatcaccaactgg gataaatacagtaacacagtggccagtctgcaagcctggctagaggacgccgaaaagatg ctcaaccaacctgaacatgcaaaaaaagacttctttcgccatttgccgcacttgatccag cagcatacaacaatgaacgatgctggcaacttcctcattgaaacatgtgatgaaagtgtc tcaaaagacatcaaacagcagctgctgctactcaatgggagatggcgagaactcttcatg gaagtcaaacactacgctcgagaagatgagtatgagagggcaagaaaagagtatgcagat ggcttgatcgcattagcagcatttgcagaaggaggcaatgaacggatttccacccctttg gatgtgtcttttctaaatgtcaagatgtttgtgcaagatttagaggatattaaacagaaa atgccaataatcgaagctcagtacaaatcggtcacaagaatggcgcagctgctaacaaag gaatcatctcaggcagaagctaatgaaatgctatcagcagtatcaagagtcaaggaccag ttaaacaaaataagggaacactacccaccattactttatgaatcccaacagcttcttaca ccacttggagaatttgagggccacctgacaaatttctatgaatgcctagagaaaatccat gggattatttccgtagcagaccttgacatgcagtcagcttcagtatttaaacagcagcaa cgggagctgctttcttgccaagagagctgcaagaaaactttgattattattgagaaatat ggtcaggctgtccacaaggcattaacaatcagtaaatccctgcatcactttgatcgctcc gcactacaaaagaagctggcagatgctcaagatgcgtatcagaatgcgataaagaagaca acagaatggaggaaaactgtagacgccaataatatgttgatgaagaaatttgaagagtct cgaacagaacttgagaatgttttaaaaacagctgaaatgtacttcaaagagacaggaaac ccctctgatctccttaagaaacatactgatttttttggacagttggatcagaaggtactt aacacttttctgaaagcttgtgatgagctaacagatatacttccagaggacgaccagcag ccactgcaagacactgttaggaaactccacaaacaatggaaggacctgcagagtgaagca ccttatcatttgctgcatttgaaaattgaattggaaaagaacaggattttaacaacggtg gaagaaagcaaagtggagcttgctcgagagaacaagatgttgccaatagaaggcagcgag aagataattagagaacataggactttttttagtgagaagggattttaccatctgtgtgaa aaaagattgcgtttaattgaagagctgtgtttaaaacttcgtgaccaagacccagtgaaa ggcgtacttgaatcgaacaaaagagcagtgcgggacatgaacacacagattggcagcact catctcaagcttatggagcaccaagataaatggaaggattttaggagcagattcagtgaa ttgtcaggctggctgatagaaaaagaaaaacaactgaaaaagatcaggagcagcgcaaat gattccacacgatatgggcaattcaaggctttggttgaggaaattagacaagatgtgatg aagcaagaagataccctgaaatatctgaaagacaggatcactgcactttctgacatatca gtggaggcagacgtaactaagcagaacaaagaactagccaggatctcaaccgatttcaaa gaattcttagaacacctagctgagattgaaaaacttttgagcactgtcagagattgcgtg caatgcaaagaacaagtgcaaactgttctcagccagttaattacaagcaccagagatgcc cagactgaagcagaaaagatactggacacagaaagctttactgaagctcaggagttgctt catcattaccagcaaaatataaaaaaaatccgatcagacaagaaggatgtccaacagcag attgtccaagctaagcaactgcaaggagaaagaggagtcactggcccagctctggaagac ttgacaagactggaagtcgaactggaaaatgtagaacagacaatggtaaagcaggaagag catttacaggtcacaatgaacacgtgggagcaaatagaatcaggcaaagaatcagtaaaa tcactattgaagcagataagtcccgctcttggccgatctttaaattttaactctttagag agtttgtcatcagaaattcagcaggcaaaggaggtttgtaagcaaagcgaagatacctca atccaagtagaagatttagtgaagaaatcatctgagatacagcttggagccaagagcaaa cagtctcttcagcagcaaacaaaatctattcaagagaaagtcaaggaagtgaaagagtcg gttttagaaaatatcactaaaatggaaacagtgaagctaaaatgggagaattttaatctg gattttgaagtgcattcagcctgggtttccgaaaaagaaaaagaactgaccatgctggaa tcttcacccttttctccagaactgcagattaagcaaattcaggaaattcttaaagagcta aacacccaaagtaatgaaataacaaaccttgaaagcaagtgccagtcctttgctcagttt 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tgggaaagtttacaccaggagcttagcgcaaaagaaaaactggtgcagaatgccttggaa caggagcaagagcagccaatattcagcaaaacaaacagactagtccatggggtgccattt tacaaaggagatagaaaggcccaagataaaccatcagttacaaagcttctagatagcctg aaccaatctcttgaagatgtatcatctcagggcggtggtgtagaaacgaagagcctccca tatgaaagaaaattgtatgatgcagtctctgccacatcttcatggcttgatgatgtggaa gatcagatttttgtggcaacagctcttcaaccagaggaaacagaggcatgcctataccat caagagacactagcaaaatatataaaagagatgtctgaagaaatggataagaacaagaat ctgttcttccgcacattctcccgcagtggggataaccaagagatcattgaagatactttg tactgtctgctgggcagactgaatatattggagtcggtagtgaatcatcgttgttgccag atgaagcagagactgcaagatcttttggcctttcagaatgatttaaagattctctttaca tcactggctgataacaagtacataatactgcagaaattggcagaagcagctgagagacct gcaaaagaacaaatacaggctattttgcaagcagaagacagccttaaagaactggacaca gaaataaatgaactgaagaaacgaggggacaaattacaagcagatcagtcatcaatgcaa gatctttcaaagttgcaggatacatacgacgagttgatgatgataattggctcaaggaga agtggtctgaatcagaatcttgcactgagaagtcagtatgaacgtgctctccaagacctg gctgatttaattgaaacaggaactgagaagatgtcagggggacagaaattcattgtttcc tccagagatgaagttgaaactttgttagacaagcacaaggagtatttccagggtttggaa tcacatgtgatcctcactgaaacccttttcaggaaaatcagcagctatgctctgccaagt gaatcacaaaataactcagtactaattgccggagcttcagcacttcttaaacaggctcac aaaagaggcgtggaattggaatacatacttgaaacctggatgcttttagatggaaagtat caagagctaatgaaacagctggaagtgattgaaagcagcatacctactgttggactggtg gaagaaactgaagaaagactactggagaggattgagctgtttgagtgctttaagtcaagt ttaacagagtgccaaccaaaactgtaccaaattttagaagacagcaagagacttttgatg tctgtgaattgtccagagctggaaggcttcataaataatttgggagaatactgggggaat aacagaaatcgtatctccaaagaattacagagactggaaaatatcctgaaactgtggacc agatataagaacgaatctgccgagcttggtaattggctgcggtctgcaattgatcgactt gaattctggactcaacagtctgtaacggtccctcaagagctggaaactgtccgagaccat ctaaatgctttcttggagttttccaaagaagttgatgccaaatcatctctgaaatcttca gtcatgagtactgggaatcagctgcttcgcctaaaaaaagtagatacagcgtcactgcgt tctgatctgacgaaaatagatacccagtggactgagctgctcattcatatcccagtagtg caagagaaattgcatcagttgcaaatggacaagttgccttcccgccatgccataactgaa gtaatgacttggatctcattgatggaagatattattaaggaggatgaagagaatatacgg aatgtagtaggatgtgaggttatccaggaataccttctaagatacaaggggtttaagatt gatgtcaactgcaagcaacttactgtggacttcgttaatcagtcggtgctgcagattagt agtcaagatgtggaaagtaagagaagtgacaagacagattttgcagagaaactcggagct atgaatagacgctggcaaatccttcaaggattaattacagagaagatccagatgctggaa cgtttgttggaatcatggacagagtatggaaacagtgttcaaaccctgaaatcctggttt gagaggcaagaaaagaagttgcagaggcaacaaagtattggtgatcaggcatctgttcag aacagcttaaaagaatgtcaggaacttgaagacttaataagggttaaggaaaaggaggtg gagaaggttgaacagagtggactttccttaatccgtgataaaaaagaaaatgtcacagca gcagttctacagaccttgagagaacttaaccattcatgggccaacctggaccatatggtg ggtcagctaaagatattgttacaatcagtacttgatcagtggagcatttacaagcaatta catgaagagctgaacagctaccttatggaagccaagtattccctttcccgcttccgcctt atgacaggctcaatggaggcagttaaagtccaagtggaaaaccttaagaaactacaggaa gaactcgaaaagaaagaagacagacttgataaatttggttctgtaacaaatcaactttta aatacatgcaaatcatctgtaacagatggcctcaaaactaccttaaaggaggtcaacaca agatggaatgatttaatggaggaaatatcggaacagctacattcgagcaagaccttgctc cagctgtggcaaaaatacaaagactatagcgttcagtgcaatgccactgttcaacagcaa gaagatcgggctaatcagttattaaaaaccgctgccaacaaggacataggcgacgaggag atcacaatttggatacatgactgcagtgtattacttaaaggcttgaatactacaaaaaca tcattggtgtctttaagtgagacaggagaacagctgaaacaacaagtcgacacatctgcc actacagcaattttgtctgaccacctttccctaaaccaacgtctgtctgtattggagcag gctcttctcaggcaacagtcaattcttcaggctggtgttttagattatgaaacatttata aaaagcctggaaggccttgaggcctggataatcgaagctggagaggtattaaacggtcag gatccaaatcgttcatcagacctctctacaattcaggagagaatggaagaactcaaaagg cagatgttaaggttcagtagtatggctccagacttagatcgcctcaatgaactaggctat agattgcccctgaatgacaaggaaatcaaaaggattcagagccttaatagacaatggact gttacctcgtcgcagaccacagaacgattcagcaagttgcagtctttcttgctacaacat caaacctttctggaaaaatgtgagacttggatggagtttttgattgagaccgagcaaaag ctggctgtagagatttcaggaaactatcaaagtcttctggaacaacaaagagcacatgag ttatttcaagcagaaatgttcagccggcagcagattttgcattccataattggcgatgga cagcgcctgctggaacaaggacaggtggatgacagtgatgagttcaacttgaaactgaca ttactcagcaaccagtggcaaggagtgatccgccgagctcagcagagaaaagggattatt gatagccagatacgacagtggcagcgctaccgggaaatggctgaaaagctgcgaaagtgg ttggtggagatgtcctaccaacctgtcagtggtctgggaggtaatccaataccacttcaa caagccaggaacttacttgatgaaatccagctgaaagataaagtgctccacagacagcaa gggagctatattctaactgtagaagcagggaagcagctccttctttgtgctgatagtgga gcagaggctgccttgcagacggagctcatggatatccaggagagatggaaggccacatca gtcagactggaggagcagaagaaacagcttgcatttctactgaaggactgggaaaaatgt gaaaagggaactgcagcatctctggaaaaactaagaaactttagaaaaaatttgtctcag cctcttccagatcatcacgatgagctgcatacggaacagattcgctgcaaggaacttgaa aatgcagtggaaggatgggtggaggacctcatgtttttaaccaacctcaaggaaaatttc actcagcacatcactgcagatgacattgcaatacttaatgagcgcattgagctcctgcag cgacagtgggaggagctttgccatcaggtatccttgcgacggcagcaagtcagcgagagg ctcaatgagtgggccatatttaatgagaagaacaaggagctctgtgagtggctgacgcag atggaaagcaaggtctcccaaaatggtgacattagcattgaggaaatgattgagaaactt aaaaaggattatcaggaggaaattgctgtagctcgtgaaaataaaatgcagctacagcaa atgggagaacggcttgccaaggccagccatgaaagcaaagcttcagagattgagtacaag ctaagcaaggtgaatgacagatggcagcatctattagatctcattggagcaagagtgaag aaactaaaggagaccttggttgctgtgcaacagctagataagaacatgagcagcctgaga tcatggctggggcatattgagtctgagttatccaaacccatcgtctatgaaaccagtgat tctgaagaaatacaaaggaaacttaatgagcagcaggagctgcagagagacatagaaaag catagcactggagttgcatctgtcctcaacctgtgtgaagttctcctacatgactgtgat gcgtgtgccacagacactgaatgtgactcgatccagcaggctacacggagtctggaccgc cggtggcggaatatttgtgcaatgtccatggaaaggagattaaaaattgaagaaacatgg aggctctggcagaagtttctggacgacttctcacggtttgaagactggcttacaatttct gaaaggacagctgccttccccagttcttctggtgtgctctacactgtggcaaaagaggag ttaaaaaaatttgaggcctttcaaagacaagtgcatgagagcctgactcagctggagctt attaataaacagtaccgccgtcttgcacgggagaatcgcactgactctgcctgtaagctg aagcagatggtccatgaaggaaaccagcgctgggacaacttacaaagaagagtcacatct atccttagaaggctcaagcattttattggccagcgtgaagaatttgagactgctcgagat agtatcctggtatggctcacagagatggatcttcaattaacaaacattgaacatttttct gaatgtgatgtgcaagcaaaattaaaacagctgaaggcatttcagcaggagatctcctta aacaatggcaagattgatcaaatcatagcccatggtgagcagcttattgagaagagtgag ccactggatgcagcagtcattgaagaagaactggatgagctccgcagatattgtttggag gtctttggtcgtgtggaacgttatcacaaaaagctaatccgcctcccgcttactgatgat gagcatgacttttctgatcgagaggtggatttggatgaaatagctgacctgactgatatc ccctggcacacaaagacctcagctggcacactttccccactgccctcctctaaccattca ttgtcactggttgtgcccatgagaagtgaaagatcaggccgtgatacacctgcaagtatg gactcaatcccactggaatgggatcatgactatgatctaagtcgtgacctggagaccgct gtttctcaggcgctttgctcagatgaggaggaacaacaagataaaaattacttcccccaa ggagcagctggtatcacaggggagttaggattagaaacacagattcgccatctagacaaa gctttggacaccagccgcttccatttgcaacaaacagagaatgttattcgcagcaggact cccactggccctgagctagactcaagctatatgggttatatgaaacttcttggagaatgt cgggaaagtatagacactgtgaggaaggtaagcgagaagctgaaagaagaagaggagaag ctttctggatttattaacttgaacagtccagagacacaatcatcaggtgttattgaacgc tgggagttaattcatgcccaagctcataataaagagctcagaatgaaacagaagcttcag cagtggcaacagttcatctctgacctcaataatgtatgggattggctggcagatactgaa gaggaagtggaacagcttaatcagttagatgtcagcactgatatccaggccatagaacag agaatcaaaaagctcaaggaacttcaaaaggctgttgatagtcgcaaagcaattgttctt tccatcaatttgtgcagttctgaatttactcaggccaatactccagaaagcaaagagctt caagagcggctaaagcaaatgaacgtgagatgggaacgcttgggcagtgcattggaggaa tggcgctataaactgcaagatgcattaatgcagtgtcaggactttcatgaaatgagccat ggattgcttctttggttagaaaacattgatagaagaagaactgagatccttcccattaat cccaaccttgacgcagacactctgcaagatcatctcaagcttttatcgcaaatgaagcgt gagttgctagagtctcagctgaaggtggcatcactgcaagacatgtcctgccagcttctg gtgaatgcggagggcaaggattgccttgaagccaaagaaaaggtgcacgtcattggtaac cgcctcaaggtcctcttaaaagaagtgactcgtcacatcaaagatatagagaaaatatta gacatctcaagcaatcaattggaattgacctcatggtcttcagcagatgaattggacact tctggatctcttagtccagtctctggaagaagcactcctagcagacagcgaacgccacgg ggcaaatatagtgtctcacagcctggaccctctgccaacaacccacctagcaggtccaaa gaagatggctcaggttcctaccgttctgaggccaacgaggctcaacaacaccagtccttt ttccaacgggtgttacgagctgctctgccctttcagcttttcctactgttgttaattggg cttgcctgcctagtgccaatgacagaagaagattacagctgcaccctttctaataatttt gcacgttcttttcatccaatgctccgttatactaatgggccacctcctatatga

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