Xenorhabdus nematophila AN6/1: XNC2_0683
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Entry
XNC2_0683 CDS
T03752
Symbol
thrA
Name
(GenBank) bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
xnm
Xenorhabdus nematophila AN6/1
Pathway
xnm00260
Glycine, serine and threonine metabolism
xnm00261
Monobactam biosynthesis
xnm00270
Cysteine and methionine metabolism
xnm00300
Lysine biosynthesis
xnm01100
Metabolic pathways
xnm01110
Biosynthesis of secondary metabolites
xnm01120
Microbial metabolism in diverse environments
xnm01230
Biosynthesis of amino acids
Module
xnm_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
xnm_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
xnm_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
xnm00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
XNC2_0683 (thrA)
00270 Cysteine and methionine metabolism
XNC2_0683 (thrA)
00300 Lysine biosynthesis
XNC2_0683 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
XNC2_0683 (thrA)
Enzymes [BR:
xnm01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
XNC2_0683 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
XNC2_0683 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
CEK21679
LinkDB
All DBs
Position
I:600571..603045
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AA seq
824 aa
AA seq
DB search
MRVLKFGGTSVANHQRVLSVADIAENELSLGQVALVLSAPAKITNHLVAMIEKTVAGQDI
VSNISDATQIFTDLLSGLKKHQAGFDYVRLKGIVEREFANLKQILHGISLLQQCPDSINA
ALICCGEKLSIAIMEAVLQARGHQVTVIDPVKNLLAHGHYLESTVDIHESSKRIAERNIP
ADHIILMAGFTAGNENGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRAV
ADARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTANPDAPGTLISNGLM
GHGQKDNEMPIKGITNLDHMAMINVSGPGMKGMVGMAARVFSVMSSKGISVVLITQSSSE
YSISFCVPQKELAKAQKALTEEFYLELKDGVLDPIDVINNLAIISVVGDGMRTQRGISAR
FFSALTRANINIIAIAQGSSERSISAVIENSAATTAVRLCHQMLFNTAQIVEVFVVGVGG
VGSALIEQIRRQQAWLKQKHIELRVCGIANSRALLTDMQGICLDNWQQVLSEATEPFSLS
RLIRLEKEYHLLNPVIVDCTSNQAIAEQYASFLSDGFNVVTPNKKANTLSMGYYRQIRQA
AEKSKRKFLYDTNVGAGLPVIENLQNLLNAGDELVQFSGILSGSLSYIFGMLDEGMTLSQ
ATLLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELEDIHVEPVLPASFDANGDV
DNFLQRLPQLDQEFSQRAADAAEQGKVLRYVGLIEQGCCTVRMVAVDGNDPLYKVKNGEN
ALAFYTRYYQPIPLVLRGYGAGNDVTAAGVFADILRTLSWKLGV
NT seq
2475 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtattgaaatttgggggcacctcagttgccaatcaccagcgagtattgagtgtt
gctgacatcgccgagaatgagttatcccttgggcaagttgctttggttctctcggcacca
gcaaagatcaccaaccatcttgtggcaatgattgaaaaaacggttgcaggacaagatatt
gtttccaatataagcgatgctacccaaatctttactgatttactgtcgggcttgaaaaag
catcaggcagggttcgattatgtccgtctaaaaggcattgtagagcgtgaatttgcaaat
ctgaaacagattctgcatggcatttctctgttgcaacaatgtccagatagcatcaatgca
gcattgatctgttgcggtgaaaaactgtctattgccattatggaggcagtcttacaggct
cgcggccaccaagtgactgtcattgatcccgtcaaaaatctattggcacatggacattat
cttgaatccactgtcgatatccatgaatcttctaaacgcattgctgaacgcaatattcct
gctgaccatattatcctgatggcgggttttaccgcgggtaatgaaaatggagaattagtg
gtactgggacgtaacggttctgattattcagccgcagtgctggcggcatgtctgcgagcc
gattgttgtgaaatctggactgatgtggatggtgtttacacttgcgatccgagagcagtt
gctgatgcccgcttgctgaaaagcatgtcatatcaagaagcgatggaattgtcctatttt
ggtgcaaaagtcctccatccccgcaccattgcccctatcgcccaatttcagattccttgt
ctgattaaaaatactgccaatcctgatgcgcccggtactctgatcagtaatgggctgatg
ggtcatggacaaaaagacaatgagatgccaatcaaaggcattaccaatctggatcatatg
gcgatgatcaacgtctccggccccggaatgaaaggtatggtcgggatggctgcacgggta
ttttccgttatgtccagcaaaggtatttcagttgtcttgatcacccaatcttcgtctgag
tacagcatcagtttctgcgtaccacaaaaagagttggcgaaagcgcagaaggcactgaca
gaagagttttatctggaactgaaagatggtgtgcttgatccgattgatgtgataaataac
cttgccattatctctgtcgttggggacggtatgcgtacccagcgtgggatttcggcccgt
ttcttctccgcattgacacgcgccaatatcaatatcattgcgattgcgcagggatcttct
gagcgttccatttccgccgtcattgaaaatagtgcggcaacgacagcggttcggctttgc
caccaaatgctgtttaacaccgcacaaatcgtcgaagtcttcgttgtcggtgtgggaggt
gtcggcagtgcactgatagagcaaatccgtcgccaacaggcgtggctcaaacaaaagcac
attgaattacgtgtctgcggtattgccaactcccgtgccctgttgaccgatatgcagggt
atttgtttggataactggcaacaagtgctttcagaagccactgagccatttagcctgagc
cgcttgatccgccttgaaaaggagtaccaccttctgaatccggtcattgttgactgtact
tccaatcaggcgattgcggaacaatacgccagctttctcagcgatggttttaacgttgtt
acaccgaataaaaaagccaatacattatctatggggtattaccgccaaatccgtcaggcg
gctgagaaatccaaacgcaagttcttgtatgacacaaacgtaggtgcgggattacccgtt
atcgaaaacttgcagaacctgcttaatgcaggggatgaattagtgcaattcagcggcatt
ttgtcgggttctctctcctatatcttcggcatgctcgatgaaggaatgaccctttcacaa
gctaccttgctggcgaaagagaaaggctttactgaacctgatccacgcgatgatctctcc
ggaatggatgttgcccgcaagctactgattctggcacgtgaagcgggttatgaactggag
ttagaagatatccacgtagaacctgtattgcctgcttcgttcgatgccaatggtgatgtc
gataatttcctgcaacgtttgccgcaactggatcaggaattcagccaacgtgcagcagat
gcagcagaacaagggaaagttttgcgttatgttggtctgattgagcaaggttgttgtact
gtgagaatggtcgctgttgacggcaatgatccgctttataaagtcaaaaatggtgaaaac
gcgctggctttctatacccgttattatcaacctatcccgctggtcctgcgtggttatggt
gcggggaatgatgttacagcagccggtgtttttgctgatatattacgcactttgtcatgg
aaattgggggtttaa
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