Zalophus californianus (California sea lion): 113908705
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Entry
113908705 CDS
T07874
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
zca
Zalophus californianus (California sea lion)
Pathway
zca00230
Purine metabolism
zca01100
Metabolic pathways
zca04927
Cortisol synthesis and secretion
zca04934
Cushing syndrome
zca05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
zca00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
113908705 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
113908705 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
113908705 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
113908705 (PDE8A)
Enzymes [BR:
zca01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
113908705 (PDE8A)
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GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS
PAS_9
PDE8
PAS_4
PAS_3
DUF5894
PAS_8
Response_reg
SPO22
Sina_ZnF
Motif
Other DBs
NCBI-GeneID:
113908705
NCBI-ProteinID:
XP_027424813
UniProt:
A0A6J2B4M0
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Position
6:142128228..142285458
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AA seq
896 aa
AA seq
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MGCAPSIHISEGRAVYHGGKEAEDAPGAAAPPPPAGPRLPPGQKTTASPGARGAGLAESE
PRDGSGRKVAAADVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQ
AVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIIGVVRRTDREESSVMP
LIAAGFTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSIFTALERSQEAIEITSED
HIIQYANPAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYHTKK
KNGDNVQQNVKIIPVIGQGGKIRHYVSIIRVCNGSNKAEKITECVQSDTHTDNQSGKHKD
RRKSSLDVRTLASRTSEVGSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEA
LDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNLQQVPSS
INTPISLHDVPPRIARAMENEEYWDFNIFELEAATHKRPLIYLGLKMFARFGICEFLNCS
EPTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLCKERIKVCPAPLTQCRGHWPYW
WPVPPGSESPWALTGSLRSSFEAAGKRRRGYGTGSFTEERFQSRKQTLDPVDEVAALIAA
TVHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMERND
YRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAALEVNGEVNRDEEAINTMLRTPEN
RTLIKRMLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRKDLPVVMPVFDRNTCS
IPKSQISFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2691 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacatttccgagggccgggcggtgtaccacggcggcaag
gaggccgaggacgcgccgggcgccgccgcgccgccgccgcccgccgggccgcgcctccca
cccggccagaagaccaccgcctcgcccggggcccgcggcgccggcctcgcggagtccgag
cctcgcgacggcagcggcaggaaggtagcagcagctgatgtgcagtttggccccatgaga
tttcatccagatcaactccaggtacttttagtgtttaccaaagaagataaccagtgtaat
ggattctgcagggcctgtgaaaaagcagggtttaagtgcacagttaccaaggaggctcag
gctgttcttgcctgtttcctggacaaacatcatgacatcatcatcatagaccacagaaac
ccccggcagctggacgcagaggcactgtgcaggtctattagatcatcaaaactctctgaa
aacacagttattattggtgtagtacgcaggacggatagagaagagtcatctgtgatgccc
ctcattgctgctggctttacaaggaggtatgtggaaaaccccagcctcatggcctgttac
aatgaactgctccagctggagttcggagaggtgcggtcccagctaaaactcagggcttgt
aactcaatattcactgcattagagagaagtcaagaagcaattgaaattacaagtgaagac
cacattatacagtatgcaaatcctgcatttgaaacaaccatgggctatcagtcaggtgaa
ttaataggaaaggagttagcagaagtgcctataaatgaaaaaaaagctgatttgctcgat
actataaattcatgcatcaggataggcaaggagtggcaaggaatctaccacaccaaaaag
aaaaatggagataatgtgcaacaaaatgtgaagataatacctgtcattggacagggagga
aaaattagacactatgtgtccattatcagagtgtgcaatggcagcaataaggctgagaaa
ataactgaatgtgttcagtctgacactcatacagataatcagtcaggcaaacataaagac
agaaggaaaagctcgctagatgtcagaactcttgcttctcgaacaagcgaagttggcagc
cagagacgacactcctccatggcccggatacattccatgacgatcgaggcgcccatcacc
aaggttatcaacattatcaatgctgcccaggaaagcagccccatgcctgtgacagaagcc
ttagaccgtgtgctagaaattctaagaaccactgaattatattcaccacagtttggtgct
aaggatgatgatcctcatgccaatgacctcgttgggggcttaatgtctgatggtttgcga
agactatccgggaatgagtatgttctttcaacaaaaaatcttcagcaggtgcccagcagt
ataaacacccccatctcccttcacgacgtccccccacggatagctcgggccatggagaac
gaggagtactgggactttaatatatttgaactggaggctgccacacataaaaggcctttg
atttatcttggtctcaaaatgtttgctcgcttcggaatctgtgaattcttgaactgctcc
gagccaacgctgagatcgtggttacagatcattgaagccaattaccactcttctaacccc
taccacaactcgacacactctgccgacgtgcttcacgccactgcctactttctttgcaaa
gagaggataaaggtctgtcctgctccgctgactcagtgcaggggccactggccctactgg
tggccagtcccacctggctcagagtccccctgggcgctgactggcagcttgaggtccagc
tttgaggcagcaggaaagaggagaagaggttatggtacggggagcttcacagaagagagg
ttccagtcgaggaagcaaaccttagatccggttgatgaggtcgctgcgcttattgcagcc
accgtccacgacgtggaccaccctgggcgaaccaactcgttcctgtgcaatgctggaagt
gagctggccatcttgtataatgacactgctgtgctggagagccaccacgcggccttggcc
ttccagctgaccacccgagatgacaaatgcaatatcttcaagaacatggagaggaatgac
tatcggacactgcgccaggctatcatcgacatggtcttagccacagaaatgacaaagcac
tttgagcatgtcaacaaatttgtcaacagcatcaacaagcccctggcagcactcgaagta
aatggggaagtgaatagagatgaagaagccataaacactatgctcaggactccagagaac
cggactctgattaaacgaatgctgattaaatgcgcagatgtgtccaatccctgccgaccc
ctggagcagtgcattgagtgggctgcacgcatctcagaagaatatttttctcagactgat
gaggagaagcggaaggacttacctgtggtgatgccagtttttgacagaaacacctgcagc
atccccaaatcccagatctccttcattgactactttatcacagacatgttcgatgcttgg
gatgcctttgtagacctgcccgagttaatgcagcatcttgacaacaattttaaatactgg
aaaggactggatgaaatgaagctgcggagcctccgaccgcccccggaatag
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