KEGG   Zalophus californianus (California sea lion): 113911010
Entry
113911010         CDS       T07874                                 
Symbol
EGFR
Name
(RefSeq) epidermal growth factor receptor isoform X1
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca01521  EGFR tyrosine kinase inhibitor resistance
zca01522  Endocrine resistance
zca03272  Virion - Hepatitis viruses
zca04010  MAPK signaling pathway
zca04012  ErbB signaling pathway
zca04014  Ras signaling pathway
zca04015  Rap1 signaling pathway
zca04020  Calcium signaling pathway
zca04066  HIF-1 signaling pathway
zca04068  FoxO signaling pathway
zca04072  Phospholipase D signaling pathway
zca04144  Endocytosis
zca04151  PI3K-Akt signaling pathway
zca04510  Focal adhesion
zca04520  Adherens junction
zca04540  Gap junction
zca04630  JAK-STAT signaling pathway
zca04810  Regulation of actin cytoskeleton
zca04912  GnRH signaling pathway
zca04915  Estrogen signaling pathway
zca04921  Oxytocin signaling pathway
zca04926  Relaxin signaling pathway
zca04928  Parathyroid hormone synthesis, secretion and action
zca04934  Cushing syndrome
zca05160  Hepatitis C
zca05163  Human cytomegalovirus infection
zca05165  Human papillomavirus infection
zca05171  Coronavirus disease - COVID-19
zca05200  Pathways in cancer
zca05205  Proteoglycans in cancer
zca05206  MicroRNAs in cancer
zca05207  Chemical carcinogenesis - receptor activation
zca05208  Chemical carcinogenesis - reactive oxygen species
zca05210  Colorectal cancer
zca05212  Pancreatic cancer
zca05213  Endometrial cancer
zca05214  Glioma
zca05215  Prostate cancer
zca05218  Melanoma
zca05219  Bladder cancer
zca05223  Non-small cell lung cancer
zca05224  Breast cancer
zca05225  Hepatocellular carcinoma
zca05226  Gastric cancer
zca05230  Central carbon metabolism in cancer
zca05231  Choline metabolism in cancer
zca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:zca00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    113911010 (EGFR)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113911010 (EGFR)
   04012 ErbB signaling pathway
    113911010 (EGFR)
   04014 Ras signaling pathway
    113911010 (EGFR)
   04015 Rap1 signaling pathway
    113911010 (EGFR)
   04630 JAK-STAT signaling pathway
    113911010 (EGFR)
   04066 HIF-1 signaling pathway
    113911010 (EGFR)
   04068 FoxO signaling pathway
    113911010 (EGFR)
   04020 Calcium signaling pathway
    113911010 (EGFR)
   04072 Phospholipase D signaling pathway
    113911010 (EGFR)
   04151 PI3K-Akt signaling pathway
    113911010 (EGFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    113911010 (EGFR)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113911010 (EGFR)
   04520 Adherens junction
    113911010 (EGFR)
   04540 Gap junction
    113911010 (EGFR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113911010 (EGFR)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    113911010 (EGFR)
   04915 Estrogen signaling pathway
    113911010 (EGFR)
   04921 Oxytocin signaling pathway
    113911010 (EGFR)
   04926 Relaxin signaling pathway
    113911010 (EGFR)
   04928 Parathyroid hormone synthesis, secretion and action
    113911010 (EGFR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113911010 (EGFR)
   05206 MicroRNAs in cancer
    113911010 (EGFR)
   05205 Proteoglycans in cancer
    113911010 (EGFR)
   05207 Chemical carcinogenesis - receptor activation
    113911010 (EGFR)
   05208 Chemical carcinogenesis - reactive oxygen species
    113911010 (EGFR)
   05230 Central carbon metabolism in cancer
    113911010 (EGFR)
   05231 Choline metabolism in cancer
    113911010 (EGFR)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113911010 (EGFR)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113911010 (EGFR)
   05212 Pancreatic cancer
    113911010 (EGFR)
   05225 Hepatocellular carcinoma
    113911010 (EGFR)
   05226 Gastric cancer
    113911010 (EGFR)
   05214 Glioma
    113911010 (EGFR)
   05218 Melanoma
    113911010 (EGFR)
   05219 Bladder cancer
    113911010 (EGFR)
   05215 Prostate cancer
    113911010 (EGFR)
   05213 Endometrial cancer
    113911010 (EGFR)
   05224 Breast cancer
    113911010 (EGFR)
   05223 Non-small cell lung cancer
    113911010 (EGFR)
  09172 Infectious disease: viral
   05160 Hepatitis C
    113911010 (EGFR)
   05171 Coronavirus disease - COVID-19
    113911010 (EGFR)
   05163 Human cytomegalovirus infection
    113911010 (EGFR)
   05165 Human papillomavirus infection
    113911010 (EGFR)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    113911010 (EGFR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113911010 (EGFR)
   01522 Endocrine resistance
    113911010 (EGFR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:zca01001]
    113911010 (EGFR)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:zca04147]
    113911010 (EGFR)
Enzymes [BR:zca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     113911010 (EGFR)
Protein kinases [BR:zca01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   113911010 (EGFR)
Exosome [BR:zca04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   113911010 (EGFR)
  Exosomal proteins of pancreatic cancer cells
   113911010 (EGFR)
  Exosomal proteins of bladder cancer cells
   113911010 (EGFR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 Borrelia_P83
Other DBs
NCBI-GeneID: 113911010
NCBI-ProteinID: XP_027428940
UniProt: A0A6J2BAA0
LinkDB
Position
12:9080852..9278289
AA seq 1207 aa
MRPSGTVGAALLVLLAAHFQASPALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNTVQRIPLENLQIIRGNVLYENTHALS
VLSNYGTNKTGLQELPLRNLHEILQGAVRFSNNPVLCNVETIQWRDIVDSDFVSNMSMDF
QNQAGSCQKCDPDCPDGSCWGPGKENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACSSDNYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTRTLPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNQKLCYANTINWKKL
FGTSSQKTKIINNKDEKGCKAIGHVCHPLCSSEGCWGPEPKDCVSCRNVSRGRECVEKCN
VLEGEPREFVDNSECIQCHPECLPQAMNITCTGRGPDSCVKCAHYIDGPHCVKTCPAGVM
GENNTLVWKFADANRVCHLCHSNCTYGCAGPGLEGCATNGPKIPSIATGIVGGLLLVVVV
ALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ
QGFFHSPSTSRTPLLSSLSATSNNSTVACIDRNGSCPLKEDSFLQRYSSDPTGTLTEDNI
DDTFLPAPEYINQSVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAVDNPEYLNTH
PPCVNSVLDGPSLWAQKGNHQISLDNPDYQQDFFPNEAKSNGIFKGPAAENADYLRVAPP
SSEFIGA
NT seq 3624 nt   +upstreamnt  +downstreamnt
atgcgaccctccggaacggtgggagccgcgctcctggtactgctggctgcgcacttccag
gcgagtccggcgctggaggaaaagaaagtttgccaaggcacaagtaaccgactcacccag
ttgggcacttttgaagaccactttctcagccttcagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctacatgcaaaggaattatgacctttccttcttaaag
accatccaggaagttgctggctacgtactcattgccctcaacacggtacagaggatccct
ttggaaaacctgcagatcatccgaggaaatgtgctctatgaaaacacccatgccttatcc
gtcttatccaattacggcacaaataagaccggattgcaggagcttcccctgagaaatcta
cacgaaatcctacaaggagctgtgcggttcagcaacaaccctgtcctctgcaacgtggaa
accatccagtggcgggatatcgttgacagcgattttgtaagcaatatgtcgatggacttc
cagaaccaagcgggcagttgccaaaagtgtgatccagactgtcccgatggaagttgttgg
ggtccgggaaaggagaattgccagaaattgaccaaaatcatctgtgcccagcagtgttca
gggcgctgccgtggcaggtcccccagtgactgctgtcacaaccagtgtgccgccggctgc
acggggccccgcgagagcgactgcctggtctgccgcaagttccgggatgaagccacatgc
aaggacacctgcccgccactcatgctctacaaccccaccacctaccagatggatgtcaac
ccagaaggaaagtacagctttggtgccacttgcgtgaagaaatgcccccgtaactacgtg
gtgacagaccacggttcgtgcgtccgtgcctgcagttccgacaactacgaggtagaggaa
gacggtgtccgcaaatgtaaaaagtgtgaggggccttgccgaaaagtgtgtaacggaata
ggaattggtgaatttaaagacacactttccataaatgctacaaacattaaacacttcaaa
aattgcacctcaatcagtggagatcttcatatcctgcccgtagcatttagaggtgactcc
ttcacgcgtactctacctctcgatccaaaggaactggatattctaaaaactgtaaaggaa
ataacagggtttctgctgattcaggcctggcccgaaaaccggaccgacctccatgctttt
gagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttctcttgcggtc
gtcggcctggacataacgtccttgggattacgctccctcaaggagataagtgacggagat
gtgatcatctcaggaaaccaaaaactgtgctatgcaaatacaataaactggaaaaaacta
tttgggacttcaagtcagaagaccaaaattataaacaacaaagatgaaaaaggctgcaag
gccatcggccacgtctgccatcccttatgctcatcagagggctgctggggcccagagccc
aaagactgtgtgtcctgccgaaacgtcagccggggcagggaatgtgtggagaagtgcaat
gttctggagggggagccaagggagtttgtggacaattccgagtgcatacagtgccatcca
gaatgcctgccccaggccatgaatataacctgcacaggacggggcccagacagctgtgtc
aagtgtgcccactacatcgacggccctcactgcgtcaagacgtgcccagctggtgtcatg
ggagagaacaataccctggtctggaagtttgccgatgccaaccgtgtgtgccacctgtgc
cattccaactgtacctacggttgtgctgggccaggtcttgaaggctgtgcgacaaacggg
cccaagatcccatccattgccaccggcattgtgggtggcctcctcttggtggtggtggtg
gcccttggggtgggcctctttttgcgccggcgccacatcgtccggaagcgcacgcttcgt
agactgctgcaagaaagagagcttgttgagcctcttacacccagcggagaagctcccaac
caagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtgctgggctct
ggagcgttcggcacggtgtacaagggactctggatcccggaaggtgagaaggttaaaatt
cccgtggccatcaaggaattaagagaagccacatctccaaaagccaacaaggaaattctt
gatgaagcctacgtgatggccagcgtagacaatcctcatgtgtgccgcctcctgggcatc
tgcctgacctccacggtccagcttatcacacagctcatgcccttcggctgcctcctggac
tatgtgcgcgagcacaaggacaacattggctcccagtacctgctcaactggtgtgtgcag
attgcaaagggcatgaactacctggaagaccggcgcttggtgcaccgcgacctggcagcc
agaaatgtcctggtgaagacaccacagcatgtcaagatcacagattttgggctggccaaa
ctgcttggagccgaggagaaagagtaccacgcagaaggaggcaaagtgcctatcaagtgg
atggctttggaatcaattttacaccgaatttatacccaccaaagtgatgtgtggagctat
ggagtcaccgtttgggagttgatgacctttgggtccaagccttatgacggtatccccgca
agtgagatctcaaccatcctggagaaaggagagcgcctcccacagccgcccatatgcacc
atcgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgccccaaa
ttccgtgaattgatcatcgaattctccaaaatggcccgagacccccagcgctacctcgtc
atccagggagacgagaggatgcatttgccaagccctacagactccaacttttaccgtgcc
ctgatggacgaagaggacatggaagacgttgtcgatgccgatgagtacctcatcccccag
cagggcttcttccatagcccctccacatcccggacgcccctcctgagttctctgagtgcc
accagcaacaattccaccgtggcttgcattgacagaaatgggagctgccccctcaaagaa
gacagcttccttcaacggtacagctcagaccccactggcaccttgaccgaggacaacata
gatgacactttcctcccagcacctgaatacataaaccaatccgttcccaaaagacctgcg
ggttctgtccagaaccccgtctatcacaatcagcctctaaatccagctcctggcagagac
cctcactaccaaaatccccacagcaacgcagtggacaaccctgagtatctcaacacccat
cctccctgcgtcaacagtgtgctcgacggccccagcctctgggcccagaaaggcaaccac
caaatcagcctggacaaccctgactaccagcaggacttctttcccaacgaagccaagtca
aatggcatttttaagggccctgcagctgaaaatgcagactacctgagggtagcaccacca
agcagtgagtttatcggagcatga

DBGET integrated database retrieval system