KEGG   Zalophus californianus (California sea lion): 113912439
Entry
113912439         CDS       T07874                                 
Symbol
ROCK1
Name
(RefSeq) rho-associated protein kinase 1 isoform X1
  KO
K04514  Rho-associated protein kinase 1 [EC:2.7.11.39]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca04022  cGMP-PKG signaling pathway
zca04024  cAMP signaling pathway
zca04062  Chemokine signaling pathway
zca04071  Sphingolipid signaling pathway
zca04270  Vascular smooth muscle contraction
zca04350  TGF-beta signaling pathway
zca04360  Axon guidance
zca04510  Focal adhesion
zca04520  Adherens junction
zca04530  Tight junction
zca04611  Platelet activation
zca04670  Leukocyte transendothelial migration
zca04810  Regulation of actin cytoskeleton
zca04921  Oxytocin signaling pathway
zca05135  Yersinia infection
zca05163  Human cytomegalovirus infection
zca05200  Pathways in cancer
zca05205  Proteoglycans in cancer
zca05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:zca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    113912439 (ROCK1)
   04071 Sphingolipid signaling pathway
    113912439 (ROCK1)
   04024 cAMP signaling pathway
    113912439 (ROCK1)
   04022 cGMP-PKG signaling pathway
    113912439 (ROCK1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113912439 (ROCK1)
   04520 Adherens junction
    113912439 (ROCK1)
   04530 Tight junction
    113912439 (ROCK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113912439 (ROCK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113912439 (ROCK1)
   04670 Leukocyte transendothelial migration
    113912439 (ROCK1)
   04062 Chemokine signaling pathway
    113912439 (ROCK1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    113912439 (ROCK1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    113912439 (ROCK1)
  09158 Development and regeneration
   04360 Axon guidance
    113912439 (ROCK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113912439 (ROCK1)
   05206 MicroRNAs in cancer
    113912439 (ROCK1)
   05205 Proteoglycans in cancer
    113912439 (ROCK1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    113912439 (ROCK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    113912439 (ROCK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:zca01001]
    113912439 (ROCK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:zca03036]
    113912439 (ROCK1)
Enzymes [BR:zca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.39  ROCK-subfamily protein kinase
     113912439 (ROCK1)
Protein kinases [BR:zca01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   113912439 (ROCK1)
Chromosome and associated proteins [BR:zca03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    113912439 (ROCK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Pkinase_C APH
Other DBs
NCBI-GeneID: 113912439
NCBI-ProteinID: XP_027431278
UniProt: A0A6J2BN87
LinkDB
Position
14:complement(43883585..44036605)
AA seq 1355 aa
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRSSPNV
DKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
AQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSVSQLESLNRELQERNRILENSKTQTD
KDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLSLQLEQES
NKRLLLQNELKTQAFEADNLKGLEKHMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNREYLKKIQELQSEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETNSMLTKDIELLRKENE
ELTDKTRRAEEEYKLKKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALE
CRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKRWVTHLVKKIPKNP
PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTSS
NT seq 4068 nt   +upstreamnt  +downstreamnt
atgtcgactggggacagttttgagactcggtttgaaaaaatcgacaacctgctgcgggat
ccgaaatcggaagtgaattcagattgtttgctggatggattggatgctttggtatatgat
ttggattttcctgccttaagaaaaaacaaaaatattgacaactttttaagcagatataaa
gacacaataaataaaattagagatttacgaatgaaagctgaagattatgaagtagtgaag
gtgattggtagaggtgcatttggagaagttcaattggtaaggcataaatccactaggaag
gtatatgctatgaagcttctcagtaaatttgaaatgattaagagatccgattctgctttt
ttctgggaagaaagggacatcatggcttttgctaacagcccttgggtcgtccagcttttt
tatgcattccaagatgatcgttatctctacatggtgatggagtacatgcctggtggagat
cttgtaaacttaatgagcaactatgatgtgcctgaaaaatgggcacgattctataccgca
gaagtagttcttgcattggatgcaatccattccatgggtttcattcatagagatgtgaaa
cctgataacatgctgctggataaatctggacatttgaagttagcagattttggtacttgt
atgaagatgaataaggaaggtatggtacgatgtgatacagcagttggaacacctgattac
atttcccctgaagtattaaaatctcaaggtggtgatggctattatggacgcgaatgtgac
tggtggtcagttggggtatttttatatgaaatgcttgtaggtgatacacctttttatgca
gattctctggttggaacttacagtaagattatgaaccataaaaattcacttacttttcct
gatgataatgatatatcaaaagaagcaaaaaatcttatttgtgccttccttactgacaga
gaggtgagattagggcgaaatggtgtagaagaaatcaaacgacatctcttcttcaaaaat
gatcagtgggcttgggaaacactcagagacactgtagcacctgttgtacctgatttaagc
agtgacatcgatacaagtaattttgatgacttggaggaagataaaggagatgaagaaaca
ttccccatacctaaagcttttgttggcaatcagttaccttttgtaggatttacatattat
agcaatcgtagatacttatcttcggcaaatcctaatgataaccgaagtagccccaatgtg
gataagagcttgcaggaaaatttgcaaaaaacaatttataagctggaagaacagctgcat
aatgaaatgcaattaaaagatgaaatggagcagaagtgcagaacttcaaacataaaacta
gacaagataatgaaagaattggatgaagaggggaatcaaagaagaaacctagaatctaca
gtgtctcagattgagaaggaaaaaatgttgctccagcatagaattaatgagtaccagaga
aaagcagaacaggaaaatgagaagaggaggaatgtagaaaatgaagtttctacattaaag
gatcagttggaagacttaaagaaagtaagtcaaaattcacagcttgctaatgagaagctg
gcacaattacaaaagcagctagaagaagccaatgacttacttaggacagaatcagacaca
gccgtaagattaaggaagagtcacacagagatgagtaagtcagttagtcagctagagtcc
ctaaacagagaattgcaggagagaaatagaattttagagaattccaagacacagacggac
aaggactattaccagctgcaagctgtgttagaagctgaacgaagagacagaggtcatgat
tctgagatgattggagaccttcaagctcgaattacatctttacaagaggaggtgaagcat
ctcaaacataatcttgaaagagtggaaggagaaagaaaagaagctcaagacatgcttaat
cactcagaaaaggaaaaaaataatttagagatagatttaaactataagcttaaatcatta
caacaacgtttagaacaagaggtaaatgaacataaagtaaccaaagctcgtttaactgac
aaacatcaatctattgaagaggcaaagtctgttgcaatgtgtgaaatggaaaaaaagctg
aaggaagagagagaagctagagagaaggctgaaaatagagttgttcagattgagaaacag
tgttcaatgctagatgttgatctgaaacaatctcagcagaagctcgagcatttgactgaa
aataaagaaaggatggaggatgaagttaagaatctatcccttcaactggagcaggaatca
aacaagcgactgttgttacagaatgaattgaagactcaagcatttgaagcagacaattta
aaaggtctagaaaagcacatgaaacaggaaataaatactttattggaagcaaagagatta
ttagaatttgaattagctcagcttacaaaacagtatagaggaaatgaaggacagatgcgg
gagctccaagatcagcttgaagctgagcagtatttctcgacactttataaaacccaggta
aaggaacttaaggaagaaattgaagaaaaaaacagagaatacttaaagaaaatacaagag
ctacaaagtgagaaggaaactcttgctactcagttggatctagcagaaacaaaagctgag
tctgagcagttggctcgagggctgctggaagaacagtattttgaattaacccaagaaagc
aagaaagctgcttccagaaatagacaagagattacagataaagatcatactgttagtcgg
cttgaagaaacaaacagcatgttaaccaaagatattgaattattaagaaaagaaaatgaa
gagctaactgataaaacgaggagggcagaggaagaatataaattgaagaaggaggaggag
atcagtaatcttaaggctgcctttgaaaagaatatcaatacagaaagaacccttaaaacg
caggctgttaacaagttggcagaaataatgaatcggaaagattttaaaattgatagaaag
aaagctaatacacaggatttgagaaagaaagaaaaggaaaatcgaaagctgcaactggaa
ctcaaccaagaaagagagaaattcaatcagatggtagtgaaacatcagaaggaactgaat
gacatgcaagcgcaattggtagaagaatgtacacataggaatgaacttcagatgcaattg
gctagcaaagagagtgatattgagcaattgcgtgctaaacttttggacctttcggattct
acaagtgttgctagttttcctagtgctgatgaaactgatggtaaccttccagagtcaaga
attgaaggttggctttcaataccaaatagaggaaatatcaaacgatatggctggaagaaa
cagtatgttgtggtaagcagcaaaaaaattttgttctataatgatgaacaagataaggaa
caatccaatccatccatggtattggacatagataaattgtttcacgttcgacctgtaacc
caaggagatgtttacagagctgaaactgaagaaattcctaaaatattccagatactatat
gcaaatgaaggtgaatgtagaaaagatgtagagatggaaccagtacaacaagcggaaaag
actaattttcaaaaccacaaaggccatgagttcattcctacactctaccactttcctgcc
aactgtgaggcatgtgccaaacctctctggcatgtttttaagccacctcctgccctggaa
tgtcgaagatgccacgtgaagtgccacagagatcacctggataagaaagaggacttaatt
tctccatgtaaagtaagttatgatgtaacatcagcaagagatatgctgctgttagcgtgt
tctcaggatgaacaaaaaagatgggtaacacatttggtaaagaagatccctaagaatcca
ccatctggttttgttcgtgcatcccctcgaacgctttctacaagatctactgcaaatcag
tctttccgaaaagtggtcaaaaatacatctggaaaaactagcagttaa

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