KEGG   Zalophus californianus (California sea lion): 113916244
Entry
113916244         CDS       T07874                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca01521  EGFR tyrosine kinase inhibitor resistance
zca01522  Endocrine resistance
zca04010  MAPK signaling pathway
zca04012  ErbB signaling pathway
zca04014  Ras signaling pathway
zca04015  Rap1 signaling pathway
zca04022  cGMP-PKG signaling pathway
zca04024  cAMP signaling pathway
zca04062  Chemokine signaling pathway
zca04068  FoxO signaling pathway
zca04071  Sphingolipid signaling pathway
zca04072  Phospholipase D signaling pathway
zca04140  Autophagy - animal
zca04150  mTOR signaling pathway
zca04151  PI3K-Akt signaling pathway
zca04210  Apoptosis
zca04218  Cellular senescence
zca04270  Vascular smooth muscle contraction
zca04360  Axon guidance
zca04370  VEGF signaling pathway
zca04371  Apelin signaling pathway
zca04510  Focal adhesion
zca04540  Gap junction
zca04550  Signaling pathways regulating pluripotency of stem cells
zca04613  Neutrophil extracellular trap formation
zca04625  C-type lectin receptor signaling pathway
zca04630  JAK-STAT signaling pathway
zca04650  Natural killer cell mediated cytotoxicity
zca04660  T cell receptor signaling pathway
zca04662  B cell receptor signaling pathway
zca04664  Fc epsilon RI signaling pathway
zca04666  Fc gamma R-mediated phagocytosis
zca04720  Long-term potentiation
zca04722  Neurotrophin signaling pathway
zca04726  Serotonergic synapse
zca04730  Long-term depression
zca04810  Regulation of actin cytoskeleton
zca04910  Insulin signaling pathway
zca04912  GnRH signaling pathway
zca04914  Progesterone-mediated oocyte maturation
zca04915  Estrogen signaling pathway
zca04916  Melanogenesis
zca04917  Prolactin signaling pathway
zca04919  Thyroid hormone signaling pathway
zca04921  Oxytocin signaling pathway
zca04926  Relaxin signaling pathway
zca04928  Parathyroid hormone synthesis, secretion and action
zca04929  GnRH secretion
zca04935  Growth hormone synthesis, secretion and action
zca05010  Alzheimer disease
zca05022  Pathways of neurodegeneration - multiple diseases
zca05034  Alcoholism
zca05132  Salmonella infection
zca05152  Tuberculosis
zca05160  Hepatitis C
zca05161  Hepatitis B
zca05163  Human cytomegalovirus infection
zca05164  Influenza A
zca05165  Human papillomavirus infection
zca05167  Kaposi sarcoma-associated herpesvirus infection
zca05170  Human immunodeficiency virus 1 infection
zca05200  Pathways in cancer
zca05205  Proteoglycans in cancer
zca05206  MicroRNAs in cancer
zca05207  Chemical carcinogenesis - receptor activation
zca05208  Chemical carcinogenesis - reactive oxygen species
zca05210  Colorectal cancer
zca05211  Renal cell carcinoma
zca05212  Pancreatic cancer
zca05213  Endometrial cancer
zca05214  Glioma
zca05215  Prostate cancer
zca05218  Melanoma
zca05219  Bladder cancer
zca05220  Chronic myeloid leukemia
zca05221  Acute myeloid leukemia
zca05223  Non-small cell lung cancer
zca05224  Breast cancer
zca05225  Hepatocellular carcinoma
zca05226  Gastric cancer
zca05230  Central carbon metabolism in cancer
zca05231  Choline metabolism in cancer
zca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:zca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113916244 (RAF1)
   04012 ErbB signaling pathway
    113916244 (RAF1)
   04014 Ras signaling pathway
    113916244 (RAF1)
   04015 Rap1 signaling pathway
    113916244 (RAF1)
   04370 VEGF signaling pathway
    113916244 (RAF1)
   04371 Apelin signaling pathway
    113916244 (RAF1)
   04630 JAK-STAT signaling pathway
    113916244 (RAF1)
   04068 FoxO signaling pathway
    113916244 (RAF1)
   04072 Phospholipase D signaling pathway
    113916244 (RAF1)
   04071 Sphingolipid signaling pathway
    113916244 (RAF1)
   04024 cAMP signaling pathway
    113916244 (RAF1)
   04022 cGMP-PKG signaling pathway
    113916244 (RAF1)
   04151 PI3K-Akt signaling pathway
    113916244 (RAF1)
   04150 mTOR signaling pathway
    113916244 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    113916244 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    113916244 (RAF1)
   04218 Cellular senescence
    113916244 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113916244 (RAF1)
   04540 Gap junction
    113916244 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    113916244 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113916244 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    113916244 (RAF1)
   04625 C-type lectin receptor signaling pathway
    113916244 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    113916244 (RAF1)
   04660 T cell receptor signaling pathway
    113916244 (RAF1)
   04662 B cell receptor signaling pathway
    113916244 (RAF1)
   04664 Fc epsilon RI signaling pathway
    113916244 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    113916244 (RAF1)
   04062 Chemokine signaling pathway
    113916244 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113916244 (RAF1)
   04929 GnRH secretion
    113916244 (RAF1)
   04912 GnRH signaling pathway
    113916244 (RAF1)
   04915 Estrogen signaling pathway
    113916244 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    113916244 (RAF1)
   04917 Prolactin signaling pathway
    113916244 (RAF1)
   04921 Oxytocin signaling pathway
    113916244 (RAF1)
   04926 Relaxin signaling pathway
    113916244 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    113916244 (RAF1)
   04919 Thyroid hormone signaling pathway
    113916244 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    113916244 (RAF1)
   04916 Melanogenesis
    113916244 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    113916244 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    113916244 (RAF1)
   04720 Long-term potentiation
    113916244 (RAF1)
   04730 Long-term depression
    113916244 (RAF1)
   04722 Neurotrophin signaling pathway
    113916244 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    113916244 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113916244 (RAF1)
   05206 MicroRNAs in cancer
    113916244 (RAF1)
   05205 Proteoglycans in cancer
    113916244 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    113916244 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    113916244 (RAF1)
   05230 Central carbon metabolism in cancer
    113916244 (RAF1)
   05231 Choline metabolism in cancer
    113916244 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113916244 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113916244 (RAF1)
   05212 Pancreatic cancer
    113916244 (RAF1)
   05225 Hepatocellular carcinoma
    113916244 (RAF1)
   05226 Gastric cancer
    113916244 (RAF1)
   05214 Glioma
    113916244 (RAF1)
   05221 Acute myeloid leukemia
    113916244 (RAF1)
   05220 Chronic myeloid leukemia
    113916244 (RAF1)
   05218 Melanoma
    113916244 (RAF1)
   05211 Renal cell carcinoma
    113916244 (RAF1)
   05219 Bladder cancer
    113916244 (RAF1)
   05215 Prostate cancer
    113916244 (RAF1)
   05213 Endometrial cancer
    113916244 (RAF1)
   05224 Breast cancer
    113916244 (RAF1)
   05223 Non-small cell lung cancer
    113916244 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    113916244 (RAF1)
   05161 Hepatitis B
    113916244 (RAF1)
   05160 Hepatitis C
    113916244 (RAF1)
   05164 Influenza A
    113916244 (RAF1)
   05163 Human cytomegalovirus infection
    113916244 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113916244 (RAF1)
   05165 Human papillomavirus infection
    113916244 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113916244 (RAF1)
   05152 Tuberculosis
    113916244 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113916244 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    113916244 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    113916244 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113916244 (RAF1)
   01522 Endocrine resistance
    113916244 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:zca01001]
    113916244 (RAF1)
Enzymes [BR:zca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     113916244 (RAF1)
Protein kinases [BR:zca01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   113916244 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 113916244
NCBI-ProteinID: XP_027438044
UniProt: A0A6J2C1I2
LinkDB
Position
1:complement(53898218..53976225)
AA seq 648 aa
MEHIQGAWKTISNGFGFKDTVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaacggttttggattcaaagacaca
gtgtttgacggccccagctgcatctcccctacaatagttcagccatttggctttcagcgt
cgggcatcagatgatggcaaacttacggactcgtctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcacgat
tgccttatgaaagcactcaaggtgaggggcctacagccggagtgctgtgccgtgttcaga
cttctccatgaacataaaggtaaaaaagcacgtttagattggaatactgatgccgcctcg
ctgattggagaagaacttcaagtagatttcctggatcacgttcccctcacaacacacaac
tttgcacgaaagaccttcctgaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgttgtcagacttgtggctacaaatttcacgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttattgtttccaaattctact
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacattc
aactcctccagcccttcctctgaaggttccctgtcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcagaatgattgaggatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccagcacagagagagcgggcacca
ggatctgggacccaggagaaaaataaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctgtccactcggattgggtcaggctccttt
ggcacggtgtataagggcaagtggcacggagatgttgcagtaaaaatcctaaaggttgtc
gaccccacaccagagcagttccaggccttcaggaacgaggtggctgtcctccgcaaaaca
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggataacctggcgattgtg
acccagtggtgcgaaggcagcagcctctacaaacacctgcatgtccaggagactaaattc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtgaagtcgcgctggagtggttctcag
caggttgaacaacccactggctctgtcttgtggatggcccctgaggtgatccgaatgcag
gataacaacccgttcagcttccagtctgatgtctactcgtacggcattgtgctctatgag
cttatgacaggggagcttccttactcccacatcaataaccgcgatcagatcatctttatg
gtgggccgagggtatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagagactcgtggccgactgcgtcaagaaggtcaaggaggagaggcctctcttcccc
cagatcctgtcttccatcgagctgctccaacactctctgccgaagatcaaccggagcgct
tcggagccatccctgcaccgggcggcccacactgaggacataaacgcctgcacactgacc
acgtcccctcgactgcctgtcttctag

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