KEGG   Zalophus californianus (California sea lion): 113922602
Entry
113922602         CDS       T07874                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca01522  Endocrine resistance
zca04010  MAPK signaling pathway
zca04012  ErbB signaling pathway
zca04014  Ras signaling pathway
zca04024  cAMP signaling pathway
zca04068  FoxO signaling pathway
zca04071  Sphingolipid signaling pathway
zca04137  Mitophagy - animal
zca04140  Autophagy - animal
zca04141  Protein processing in endoplasmic reticulum
zca04210  Apoptosis
zca04215  Apoptosis - multiple species
zca04217  Necroptosis
zca04310  Wnt signaling pathway
zca04380  Osteoclast differentiation
zca04510  Focal adhesion
zca04517  IgSF CAM signaling
zca04530  Tight junction
zca04620  Toll-like receptor signaling pathway
zca04621  NOD-like receptor signaling pathway
zca04622  RIG-I-like receptor signaling pathway
zca04625  C-type lectin receptor signaling pathway
zca04657  IL-17 signaling pathway
zca04658  Th1 and Th2 cell differentiation
zca04659  Th17 cell differentiation
zca04660  T cell receptor signaling pathway
zca04664  Fc epsilon RI signaling pathway
zca04668  TNF signaling pathway
zca04722  Neurotrophin signaling pathway
zca04723  Retrograde endocannabinoid signaling
zca04728  Dopaminergic synapse
zca04750  Inflammatory mediator regulation of TRP channels
zca04910  Insulin signaling pathway
zca04912  GnRH signaling pathway
zca04914  Progesterone-mediated oocyte maturation
zca04917  Prolactin signaling pathway
zca04920  Adipocytokine signaling pathway
zca04926  Relaxin signaling pathway
zca04930  Type II diabetes mellitus
zca04931  Insulin resistance
zca04932  Non-alcoholic fatty liver disease
zca04933  AGE-RAGE signaling pathway in diabetic complications
zca04935  Growth hormone synthesis, secretion and action
zca04936  Alcoholic liver disease
zca05010  Alzheimer disease
zca05012  Parkinson disease
zca05016  Huntington disease
zca05017  Spinocerebellar ataxia
zca05020  Prion disease
zca05022  Pathways of neurodegeneration - multiple diseases
zca05132  Salmonella infection
zca05133  Pertussis
zca05135  Yersinia infection
zca05142  Chagas disease
zca05145  Toxoplasmosis
zca05152  Tuberculosis
zca05161  Hepatitis B
zca05162  Measles
zca05166  Human T-cell leukemia virus 1 infection
zca05167  Kaposi sarcoma-associated herpesvirus infection
zca05169  Epstein-Barr virus infection
zca05170  Human immunodeficiency virus 1 infection
zca05171  Coronavirus disease - COVID-19
zca05200  Pathways in cancer
zca05208  Chemical carcinogenesis - reactive oxygen species
zca05210  Colorectal cancer
zca05212  Pancreatic cancer
zca05231  Choline metabolism in cancer
zca05415  Diabetic cardiomyopathy
zca05417  Lipid and atherosclerosis
zca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:zca00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    113922602 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113922602 (MAPK8)
   04012 ErbB signaling pathway
    113922602 (MAPK8)
   04014 Ras signaling pathway
    113922602 (MAPK8)
   04310 Wnt signaling pathway
    113922602 (MAPK8)
   04668 TNF signaling pathway
    113922602 (MAPK8)
   04068 FoxO signaling pathway
    113922602 (MAPK8)
   04071 Sphingolipid signaling pathway
    113922602 (MAPK8)
   04024 cAMP signaling pathway
    113922602 (MAPK8)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    113922602 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    113922602 (MAPK8)
   04137 Mitophagy - animal
    113922602 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    113922602 (MAPK8)
   04215 Apoptosis - multiple species
    113922602 (MAPK8)
   04217 Necroptosis
    113922602 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113922602 (MAPK8)
   04530 Tight junction
    113922602 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    113922602 (MAPK8)
   04621 NOD-like receptor signaling pathway
    113922602 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    113922602 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    113922602 (MAPK8)
   04660 T cell receptor signaling pathway
    113922602 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    113922602 (MAPK8)
   04659 Th17 cell differentiation
    113922602 (MAPK8)
   04657 IL-17 signaling pathway
    113922602 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    113922602 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113922602 (MAPK8)
   04920 Adipocytokine signaling pathway
    113922602 (MAPK8)
   04912 GnRH signaling pathway
    113922602 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    113922602 (MAPK8)
   04917 Prolactin signaling pathway
    113922602 (MAPK8)
   04926 Relaxin signaling pathway
    113922602 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    113922602 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    113922602 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    113922602 (MAPK8)
   04722 Neurotrophin signaling pathway
    113922602 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    113922602 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    113922602 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113922602 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    113922602 (MAPK8)
   05231 Choline metabolism in cancer
    113922602 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113922602 (MAPK8)
   05212 Pancreatic cancer
    113922602 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113922602 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    113922602 (MAPK8)
   05161 Hepatitis B
    113922602 (MAPK8)
   05171 Coronavirus disease - COVID-19
    113922602 (MAPK8)
   05162 Measles
    113922602 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113922602 (MAPK8)
   05169 Epstein-Barr virus infection
    113922602 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113922602 (MAPK8)
   05135 Yersinia infection
    113922602 (MAPK8)
   05133 Pertussis
    113922602 (MAPK8)
   05152 Tuberculosis
    113922602 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    113922602 (MAPK8)
   05142 Chagas disease
    113922602 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113922602 (MAPK8)
   05012 Parkinson disease
    113922602 (MAPK8)
   05016 Huntington disease
    113922602 (MAPK8)
   05017 Spinocerebellar ataxia
    113922602 (MAPK8)
   05020 Prion disease
    113922602 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    113922602 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113922602 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    113922602 (MAPK8)
   05415 Diabetic cardiomyopathy
    113922602 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    113922602 (MAPK8)
   04936 Alcoholic liver disease
    113922602 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    113922602 (MAPK8)
   04931 Insulin resistance
    113922602 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    113922602 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    113922602 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:zca01001]
    113922602 (MAPK8)
Enzymes [BR:zca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     113922602 (MAPK8)
Protein kinases [BR:zca01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   113922602 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 113922602
NCBI-ProteinID: XP_027450513
UniProt: A0A6J2D847
LinkDB
Position
15:46765155..46879577
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagactctacgttt
acagtcttgaaacggtatcagaatttgaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccggcca
tttcagaatcagactcatgctaaacgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcgaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacctaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacagccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaattgatgcatctaaaaggatctctgtagatgaagctctccagcacccgtat
atcaatgtttggtatgatccttctgaggcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacatacaatagaagaatggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttataagggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcgtcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagacacagacagcagtctagaagcatcagcc
ggacctctgggctgctgtagatga

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