KEGG   Zalophus californianus (California sea lion): 113932035
Entry
113932035         CDS       T07874                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
zca  Zalophus californianus (California sea lion)
Pathway
zca01521  EGFR tyrosine kinase inhibitor resistance
zca01522  Endocrine resistance
zca01524  Platinum drug resistance
zca04010  MAPK signaling pathway
zca04012  ErbB signaling pathway
zca04014  Ras signaling pathway
zca04015  Rap1 signaling pathway
zca04022  cGMP-PKG signaling pathway
zca04024  cAMP signaling pathway
zca04062  Chemokine signaling pathway
zca04066  HIF-1 signaling pathway
zca04068  FoxO signaling pathway
zca04071  Sphingolipid signaling pathway
zca04072  Phospholipase D signaling pathway
zca04140  Autophagy - animal
zca04150  mTOR signaling pathway
zca04151  PI3K-Akt signaling pathway
zca04152  AMPK signaling pathway
zca04210  Apoptosis
zca04211  Longevity regulating pathway
zca04213  Longevity regulating pathway - multiple species
zca04218  Cellular senescence
zca04261  Adrenergic signaling in cardiomyocytes
zca04370  VEGF signaling pathway
zca04371  Apelin signaling pathway
zca04380  Osteoclast differentiation
zca04510  Focal adhesion
zca04517  IgSF CAM signaling
zca04550  Signaling pathways regulating pluripotency of stem cells
zca04611  Platelet activation
zca04613  Neutrophil extracellular trap formation
zca04620  Toll-like receptor signaling pathway
zca04625  C-type lectin receptor signaling pathway
zca04630  JAK-STAT signaling pathway
zca04660  T cell receptor signaling pathway
zca04662  B cell receptor signaling pathway
zca04664  Fc epsilon RI signaling pathway
zca04666  Fc gamma R-mediated phagocytosis
zca04668  TNF signaling pathway
zca04722  Neurotrophin signaling pathway
zca04725  Cholinergic synapse
zca04728  Dopaminergic synapse
zca04810  Regulation of actin cytoskeleton
zca04910  Insulin signaling pathway
zca04914  Progesterone-mediated oocyte maturation
zca04915  Estrogen signaling pathway
zca04917  Prolactin signaling pathway
zca04919  Thyroid hormone signaling pathway
zca04920  Adipocytokine signaling pathway
zca04922  Glucagon signaling pathway
zca04923  Regulation of lipolysis in adipocytes
zca04926  Relaxin signaling pathway
zca04929  GnRH secretion
zca04931  Insulin resistance
zca04932  Non-alcoholic fatty liver disease
zca04933  AGE-RAGE signaling pathway in diabetic complications
zca04935  Growth hormone synthesis, secretion and action
zca04936  Alcoholic liver disease
zca04973  Carbohydrate digestion and absorption
zca05010  Alzheimer disease
zca05017  Spinocerebellar ataxia
zca05132  Salmonella infection
zca05135  Yersinia infection
zca05142  Chagas disease
zca05145  Toxoplasmosis
zca05152  Tuberculosis
zca05160  Hepatitis C
zca05161  Hepatitis B
zca05162  Measles
zca05163  Human cytomegalovirus infection
zca05164  Influenza A
zca05165  Human papillomavirus infection
zca05166  Human T-cell leukemia virus 1 infection
zca05167  Kaposi sarcoma-associated herpesvirus infection
zca05168  Herpes simplex virus 1 infection
zca05169  Epstein-Barr virus infection
zca05170  Human immunodeficiency virus 1 infection
zca05200  Pathways in cancer
zca05205  Proteoglycans in cancer
zca05207  Chemical carcinogenesis - receptor activation
zca05208  Chemical carcinogenesis - reactive oxygen species
zca05210  Colorectal cancer
zca05211  Renal cell carcinoma
zca05212  Pancreatic cancer
zca05213  Endometrial cancer
zca05214  Glioma
zca05215  Prostate cancer
zca05218  Melanoma
zca05220  Chronic myeloid leukemia
zca05221  Acute myeloid leukemia
zca05222  Small cell lung cancer
zca05223  Non-small cell lung cancer
zca05224  Breast cancer
zca05225  Hepatocellular carcinoma
zca05226  Gastric cancer
zca05230  Central carbon metabolism in cancer
zca05231  Choline metabolism in cancer
zca05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
zca05415  Diabetic cardiomyopathy
zca05417  Lipid and atherosclerosis
zca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:zca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    113932035 (AKT3)
   04012 ErbB signaling pathway
    113932035 (AKT3)
   04014 Ras signaling pathway
    113932035 (AKT3)
   04015 Rap1 signaling pathway
    113932035 (AKT3)
   04370 VEGF signaling pathway
    113932035 (AKT3)
   04371 Apelin signaling pathway
    113932035 (AKT3)
   04630 JAK-STAT signaling pathway
    113932035 (AKT3)
   04668 TNF signaling pathway
    113932035 (AKT3)
   04066 HIF-1 signaling pathway
    113932035 (AKT3)
   04068 FoxO signaling pathway
    113932035 (AKT3)
   04072 Phospholipase D signaling pathway
    113932035 (AKT3)
   04071 Sphingolipid signaling pathway
    113932035 (AKT3)
   04024 cAMP signaling pathway
    113932035 (AKT3)
   04022 cGMP-PKG signaling pathway
    113932035 (AKT3)
   04151 PI3K-Akt signaling pathway
    113932035 (AKT3)
   04152 AMPK signaling pathway
    113932035 (AKT3)
   04150 mTOR signaling pathway
    113932035 (AKT3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    113932035 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    113932035 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    113932035 (AKT3)
   04218 Cellular senescence
    113932035 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    113932035 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    113932035 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    113932035 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    113932035 (AKT3)
   04613 Neutrophil extracellular trap formation
    113932035 (AKT3)
   04620 Toll-like receptor signaling pathway
    113932035 (AKT3)
   04625 C-type lectin receptor signaling pathway
    113932035 (AKT3)
   04660 T cell receptor signaling pathway
    113932035 (AKT3)
   04662 B cell receptor signaling pathway
    113932035 (AKT3)
   04664 Fc epsilon RI signaling pathway
    113932035 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    113932035 (AKT3)
   04062 Chemokine signaling pathway
    113932035 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    113932035 (AKT3)
   04922 Glucagon signaling pathway
    113932035 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    113932035 (AKT3)
   04920 Adipocytokine signaling pathway
    113932035 (AKT3)
   04929 GnRH secretion
    113932035 (AKT3)
   04915 Estrogen signaling pathway
    113932035 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    113932035 (AKT3)
   04917 Prolactin signaling pathway
    113932035 (AKT3)
   04926 Relaxin signaling pathway
    113932035 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    113932035 (AKT3)
   04919 Thyroid hormone signaling pathway
    113932035 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    113932035 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    113932035 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    113932035 (AKT3)
   04728 Dopaminergic synapse
    113932035 (AKT3)
   04722 Neurotrophin signaling pathway
    113932035 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    113932035 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    113932035 (AKT3)
   04213 Longevity regulating pathway - multiple species
    113932035 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113932035 (AKT3)
   05205 Proteoglycans in cancer
    113932035 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    113932035 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    113932035 (AKT3)
   05230 Central carbon metabolism in cancer
    113932035 (AKT3)
   05231 Choline metabolism in cancer
    113932035 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113932035 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    113932035 (AKT3)
   05212 Pancreatic cancer
    113932035 (AKT3)
   05225 Hepatocellular carcinoma
    113932035 (AKT3)
   05226 Gastric cancer
    113932035 (AKT3)
   05214 Glioma
    113932035 (AKT3)
   05221 Acute myeloid leukemia
    113932035 (AKT3)
   05220 Chronic myeloid leukemia
    113932035 (AKT3)
   05218 Melanoma
    113932035 (AKT3)
   05211 Renal cell carcinoma
    113932035 (AKT3)
   05215 Prostate cancer
    113932035 (AKT3)
   05213 Endometrial cancer
    113932035 (AKT3)
   05224 Breast cancer
    113932035 (AKT3)
   05222 Small cell lung cancer
    113932035 (AKT3)
   05223 Non-small cell lung cancer
    113932035 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113932035 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    113932035 (AKT3)
   05161 Hepatitis B
    113932035 (AKT3)
   05160 Hepatitis C
    113932035 (AKT3)
   05164 Influenza A
    113932035 (AKT3)
   05162 Measles
    113932035 (AKT3)
   05168 Herpes simplex virus 1 infection
    113932035 (AKT3)
   05163 Human cytomegalovirus infection
    113932035 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113932035 (AKT3)
   05169 Epstein-Barr virus infection
    113932035 (AKT3)
   05165 Human papillomavirus infection
    113932035 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113932035 (AKT3)
   05135 Yersinia infection
    113932035 (AKT3)
   05152 Tuberculosis
    113932035 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    113932035 (AKT3)
   05142 Chagas disease
    113932035 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    113932035 (AKT3)
   05017 Spinocerebellar ataxia
    113932035 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    113932035 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    113932035 (AKT3)
   05415 Diabetic cardiomyopathy
    113932035 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    113932035 (AKT3)
   04932 Non-alcoholic fatty liver disease
    113932035 (AKT3)
   04931 Insulin resistance
    113932035 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    113932035 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113932035 (AKT3)
   01524 Platinum drug resistance
    113932035 (AKT3)
   01522 Endocrine resistance
    113932035 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:zca01001]
    113932035 (AKT3)
Enzymes [BR:zca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     113932035 (AKT3)
Protein kinases [BR:zca01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   113932035 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1
Other DBs
NCBI-GeneID: 113932035
NCBI-ProteinID: XP_027466209
UniProt: A0A6J2EBI5
LinkDB
Position
10:complement(62933696..63250613)
AA seq 479 aa
MSDVTVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCVDNERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccgtggtgaaagaaggctgggttcagaagaggggagaatatataaaa
aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggacc
actgttatagagagaacatttcatgtagatactccagaggaaagggaagagtggacagaa
gctattcaggctgtagcagacagacttcagagacaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggggaggaggagatggatgcttccacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtgggaaatactatgctatgaagattctgaag
aaagaagtaattattgcaaaggatgaagtggcgcatactctgactgagagcagagtatta
aagaacaccagacacccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgtaaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgctctggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatttaatgctggat
aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgca
gccaccatgaagacattctgtggcacaccagaatatctggcaccagaggtgttagaagac
aacgactatggccgagccgtggattggtggggcctgggggtcgtcatgtatgagatgatg
tgtgggaggctacctttctacaaccaggatcatgagaaactttttgaactaatactaatg
gaagacattaaatttcctcgaacactttcttcagatgcaaaatcactgctttcagggctc
ttgataaaggatccaaataaacgccttggcgggggcccagatgatgcaaaagaaattatg
aggcacagtttcttctctggagtcaactggcaagatgtttatgataaaaagcttgtacct
ccttttaagcctcaagtaacatctgagacagataccagatattttgatgaagaatttaca
gctcagactattacaataaccccacctgaaaaatatgacgaggacggcatggactgcgtg
gacaacgagcggcggccgcacttccctcagttctcctactccgccagcggccgcgagtaa

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