Zootoca vivipara (common lizard): 118081853 Help Entry 118081853         CDS       T07275                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism zvi  Zootoca vivipara (common lizard) Pathway zvi04020   Calcium signaling pathway zvi04260   Cardiac muscle contraction zvi04261   Adrenergic signaling in cardiomyocytes zvi04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:zvi00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118081853 (RYR2)    04020 Calcium signaling pathway     118081853 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     118081853 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     118081853 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:zvi04040]     118081853 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:zvi04990]     118081853 (RYR2) Ion channels [BR:zvi04040]  Voltage-gated cation channels   Ryanodine receptor    118081853 (RYR2) Domain-containing proteins not elsewhere classified [BR:zvi04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    118081853 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  118081853 NCBI-ProteinID:  XP_034964272 LinkDB All DBs Position LG3:complement(42591563..42846588) Genome browser AA seq 4951 aa AA seqDB search MAEAGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRTSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSISSERYLHLSYGNGSLRVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLMDDKSLLLTDKEKADVKSTAFCFRSSKEKLDVGIRKDVEGMGAPEIKYGDSV CFIQHVDTGLWLTYQSVDAKPVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDDLSKKAKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGETWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHVGPFTTAEATHLRVGWASTEGYSPYPVGGEEWGGNGVGD DLYSYSFDGLHLWSGCVARSVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNTDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAILPKEKLKVEHSREY KQDRNSTRDLLGPNISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFAKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKQLKLPKNYLLSSGYKPAPMDLSCIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLIGYGYNLEAPDQDHAARPDVFCG MMERFRIFRTEKTYAVKTGKWYFEFEVVTAGDMRVGWAKPGCQPDQELGSDEQAFVFDGF KAQRWHQGNEHFGRSWLTGDIVGCMVDLNERTVMFTLNGEILLDDSGSELAFKDFEVGDG FIPACSLGLSQVGRMNFGKEVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPPNHEHIEVTRIDGTADSSPCLKVTQKSFGSQNSKTEIMFYRLSMPIECAEVFSKMPGG GVPSSGSRLGPKNDLDDYDADSDFEVLMKTAHGHLVPDRIEKEAVKSEFNNHKDYTQEKP SRLKQRFMLRRTKPDYSSSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANV WVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRN NNGLEIGCSVDAATGVLSFTANGKEISTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIK NVMPLSAGLFKSEHKNPVPQCPPRLHVQFLTHVLWSRVPNHFLKVDISRISERQGWSVQC LEPLQFMSLHIPEENRSIDILELSEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVD ESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPD ENKKHGLPGIGLSTSLRPRMQFSSPSFVRINNECYQYSPEFPLEILKTKTIEMLTEAVQE GSLHVRDPVGGTTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPSVFKEDAVHEDET RVIAKKELIADGLNLETGGEKVPEEGLLQMKLPEPVKLQMCHLLQYLCDCQIRHRIEAIV AFSDDFVLKLQENQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLNFKDDKNDC PCPEEIRDHLLDFHEDLMAHCGIQLDEDGILDGNSDLTLKGRLLYLVERVTHLKKKQAEK PIDDDANKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGVGGLVRALPKTY TINGVSVEDTISLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCSLLISKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAA MEEAINISEDPTRDGPSPSSGSNKTLSEVEEEDDTIHMGNAIMTFYAALIDLLGRCAPEM HLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSEGFCPDHKA AMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLP LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQ HLLRRLVFDIPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFW GIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVGVMEKQASMDSDGNFNPQPV DTSNITIPEKLDYFINKYAEHSHDKWCMEKFANGWIYGETYSESSKVQPLMKQYKLLAEK EKEIYRWPIKESLKTMLAWGWRVERTREGDTMALYNRPRRISQTSQVSVDTVHGYSPRAI DMSNVTLSRELHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKD REKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG GGRGKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVT SLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRTFLDNAA EDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTMALLPVLSSLFEHIGQHQFGEDLILED VQVSCYRILVSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLNHHNTHSIYN TKTTRDRTGLGLPNSVEELSPNIPSLEKLMEDIVELAESGIRYTQMPHVMEVVLPMLCSY MSHWWEHGPENNPHNSEMCCTALTSEHMNTLLGNILKIIHNNLGIDEGAWMKKLAVFSQP IISKVKPQLLKTHFLPLMEKLKKKAAMVISDEEHLRAEGRGDMSEAELLILDEFTILARD LYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVADVFIYWSKSHNFKREEQNFVVQNEI NNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPVGLNICAPGD QELIALAKNRLSMKDTEDEVRDIIRNNLHLQGKLEDPAIRWQVALYKDLPNRTEVTSDPE KTVERVLDIASVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAV NLFLQGYDKSWVETEDHYFEDTLIEDLAKPGEEPPEEDECIKRVDPLHQLILLFSRTALT EKCKLEEDYLYMAYADIMAKSCHEEDDDNEEEVKSFEEKEMEKQKLLYQQARLHDRGAAE MVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQ SCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYL RTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFN TLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDM VVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTFSDAFKEYDPD GKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNV AVLLTNLSEHMPHDTRLQTFLELADSVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRT QWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANK EENENEKPEEQDPRMGFFSLVTVKSALVALRYNIMTLMKVLSMKSIKKQMKKMKKMTMKD MAMAFFSSYWSILMGLMHFISSVFRGFFQIMYSLLLGGSLVEGAKKIKVAELLANMPDPT QDEVRGEGEEAERKPTEAPLPAEDLTDLKALSEDSDLLSDIFGLDLKREGGQYKLIPHNP NAGLSDLLSSPSLLPLPDVQEKIQDQKVNEDEKDEKEETKFVPEKAEGEDGEKEEKAIED KAKQKQRQHHKHRHGEPETQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSAVAGEKEVPVVNIAENSKLSSLESPSHRIITVHYVLEESSGYMEPTLRILA ILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVIN TQSFPNNYWDKFVKRKVMDKYGEFYGKDRISELLGMDKAALDFSDAREKKKPKKDSSLSA VLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTI LSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFH MYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ QEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQ ESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14856 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcgggcgaaggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgctactgttcacaaagaacaacagaaattgtgccttgccgcagaa ggatttggcaacaggctctgcttcttggaatccacttcaaattcaaagaatgttcctccg gatctctccatctgtacttttgtgctggaacagtccttgtctgtgcgcgccctccaggaa atgctggccaacactgaggagaaagcagaagggctagttgatgtggaaaaatggaaattt atgatgaagactgctcaaggtggtggccatcgaacgctcctctatggacatgcaatattg ctgcgccattcatacagtggtatgtacctgtgttgtctctccacctcaagaacatcaatg gacaaactggcatttgatgtaggcttgcaagaagataccacaggtgaggcctgctggtgg acaatacatcctgcttccaaacagcgttctgaaggagaaaaagtacgtgttggggatgat ctcatcctagttagtatctcatcagaaaggtacttgcatttgtcttatggtaatggcagc ttgcgagttgatgcagccttccagcaaacactgtggagtgtagcccccatcagttcagga agtgaagcagctcaaggttacctgataggaggtgatgtcctgcggttgttacatggtcac atggatgaatgtttgactgtcccttcaggagagcatggagaagagcaaagaagaacagtc cattatgagggtggagccgtgtcgattcatgctcgttctctttggcgattggagactttg agggttgcgtggagtggaagtcacattagatggggccagccattccgattaaggcatata acaacagggaagtatttgagcctgatggatgacaagagcctccttctaacagacaaagag aaagctgatgtgaaatctacagccttttgttttcggtcttccaaggaaaaattggatgtg ggtataagaaaagatgtggaaggaatgggagcacctgaaataaagtacggagactcagtc tgcttcatacagcatgttgacactggattgtggctcacgtaccagtcagtggatgcgaag cctgtaaggatgggatctgtgcaacgcaaggctatcatgcaccacgaaggccatatggat gatggcctaacattgtccagatctcagcatgaagagtcacgtactgcaagagtaattcgt agtaccgtcttccttttcaacaggttcataaggggccttgatgatctcagcaagaaagca aagtcttccacagttgacttacccattgagtcagtcagccttagcctccaggacttgatt ggatacttccatccacctgatgagcatctagaacatgaggacaagcagaaccgcttaaga gcactgaagaatcggcagaatctcttccaggaagagggtatgatcaacttggtgcttgaa tgcattgatcgcttacatgtatacagcagtgcagctcattttgctgatgtagctgggaag gaggcgggagagacttggaaatctatcctaaactcattgtatgaattactagctgcttta attagagggaatcgtaaaaattgtgcccagttttctggctctcttgattggctcattagt agattggagagactggaagcatcttctggcattcttgaggttttgcactgtgtgttggtg gaaagtccagaagctttaaatattattaaagaaggacatattaaatcaattatatgcctt ttggacaaacatggaagaaaccataaggtgttagatgttttatgctctctctgtgtgtgc catggagtagctgtgcggtctaatcagcatttgatctgtgacaatcttctgccaggacga gatctccttctccagacacgtcttgtcaaccatgtgagcagtatgagacccaatattttc cttggaatcagtgagggctctgctcagtatagaaaatggtattatgagctaatggttgac catgttggaccgtttacgacagccgaagctactcaccttcgtgtgggctgggcttcaaca gaaggctattcaccctaccctgtgggtggagaagaatggggaggaaatggtgttggtgat gacctatattcctatagttttgatggacttcatctgtggtcaggttgtgtagcaagatct gtgaattctcccaaccagcatctgttaaggactgatgatgtaatcagctgctgccttgat ctgagtgctccaagcatttcattccggataaatggacagccagtccaggggatgtttgag aatttcaatacagatggccttttctttccagttgtcagcttctctgcagggataaaggta cgttttttgcttggaggccgccatggggaatttaaattccttccacctccaggatatgct ccttgttttgaagctattctgccaaaagagaaattgaaagtggaacacagcagagaatac aaacaggatcggaattccacaagagaccttctgggcccaaatatatctctatcccaagca gctttcactccagtacctgtagatactagtcagattgtattacctccacatttggaaaga attagagaaaaactagctgagaatatccacgaactttgggttatgaataagattgaactt ggatggcagtatggtcctgttagagatgacaacaagcgacagcatccgtgtttggtggag tttgcaaaattgccagaacaagagcgaaattataatctccaaatgtcactagaaacactg aaaacactgctggcgctaggttgtcatgttgggattgctgatgagcatgctgaggaaaaa gtgaagcaactaaaacttccaaagaattatctattgtctagtggatacaagcctgctcct atggatctgagttgtatcaaactgaccccttctcaggaagctatggttgataaacttgca gagaatgctcacaatgtatgggcaagagatcgtatcaggcagggttggacatatggaatc cagcaggatgtgaagaaccgtcgaaacccccgacttgtgccctatgcccttcttgatgat cgcaccaagaaatcaaacaaagacagtctccgggaagcagttcgtaccctcattggctat ggttataaccttgaggctcctgatcaagaccatgctgcaagaccagatgtattctgtggt atgatggaaaggtttaggatcttccgcacagagaagacatatgcagtgaaaacaggaaag tggtattttgagtttgaagtagtgaccgcaggagacatgagggttggttgggccaagcca ggttgtcaaccggatcaagagcttggatcagatgaacaagcatttgtttttgatggattc aaggctcaacggtggcaccagggaaatgagcattttggacgttcttggctgacaggggat attgtaggctgtatggttgacttgaatgagcgcaccgtgatgttcactctgaatggagaa atccttcttgatgactcaggttccgagcttgcattcaaggactttgaggttggtgatggc tttatacctgcatgtagcctgggattatcacaagtgggcagaatgaactttggcaaagaa gtgagcaccttgaaatatttcactatttgtggtttacaagaaggctacgaaccatttgcg gtgaatacaaacagggacatcaccatatggctgagcaagagactacctcagtttctccca gtaccaccaaatcatgaacatattgaggttacaagaatagatggtactgcggacagctcc ccatgcttgaaggtcacacagaagtcctttgggtctcagaatagtaaaacagaaatcatg ttctatcggctcagcatgcctattgagtgtgcagaagtattctctaaaatgcctggagga ggagtgcccagttccgggagccgccttggaccaaagaatgacttggatgattatgatgcg gattctgactttgaagttcttatgaagactgctcatggtcaccttgtacctgatcgtata gaaaaagaagctgtaaaatcagagttcaataaccataaagactacactcaagagaaacct tcacgcctcaagcaaagatttatgctgagaaggacgaagccagactacagctcaagccac tctgcgaggctcactgaagatgtcctagcagatgaaagagatgattatgattacttaatg caaacatctacatattattattctgtgcgtatctttcctggacaagaacctgctaatgtc tgggtgggctggattacatctgacttccatcagtatgacacaagctttgatttggataga gtccgtactgttaccgtaaccctaggagatgaaaaagggaaagttcatgagagcatcaaa cgcagcaactgctatatggtatgcgctggggagagcatgagtcccgggcaaggacgcaat aacaatgggctcgagattggctgttcagttgatgctgcaactggtgtcctgtccttcaca gctaatggcaaagagataagcacctattatcaggttgaaccaagcactaaattatttcct gcagtatttgcacaagccacaagccccaatgttttccaatttgaattgggaagaattaag aatgtaatgccattgtcagctggcctgttcaaaagtgagcacaaaaacccagtcccccag tgccctccccgtctgcatgttcagtttctgacacatgtgctttggagtagagtaccaaac cactttctgaaagttgacatatcacggatcagtgaacgtcaaggctggtcagtacagtgc ctggagcctttgcagttcatgtcacttcacatcccagaggaaaacaggtctatagacatt ttagaattgtcagaacaagaagaattgttgaaattccactaccatactctcagactgtac tcagctgtttgtgctcttgggaataatcgagtagcgcatgccatgtgcagccatgtggat gagtctcagcttctttatgcaattgagaacaagtatatgccgggcttgttacgtgctggc tattatgaccttctaattgacattcaccttaatacttacgctactgcaaggctgatgatg aacaatgaatttattgttcccatgacagatgagactaagagcattactctgttccctgat gaaaacaaaaagcatggcctacctggcataggactcagcacttccctacggcccagaatg cagttttcctctcccagttttgtaagaatcaacaatgagtgttatcagtacagtcctgaa tttcctctggaaatattgaagactaaaaccatagagatgctgacggaggcagttcaagag ggcagcctccatgtcagagatccagtaggtgggactacagagtttctctttgttcctttg atcaagcttttttacactcttctcataatggggatcttccataatggagacctgaagcat atcttgcagctgattgaacctagtgtttttaaggaagacgcagtccatgaggatgagact cgagtaatagcaaaaaaagaattaattgccgatggcctaaatttggagacaggaggagag aaggtcccagaagaaggactccttcaaatgaaacttcctgagccagtgaaattgcagatg tgtcatttacttcagtacctttgtgactgtcagatacgccatcggatagaagccattgta gcattttcagatgattttgtattaaaacttcaagagaatcagcgtttccgatacaatgag gttatgcaggcgttaaatatgtctgcagcactgacagccaagaaaacaaaggagtttcgc tctccaccacaggaacagattaatatgctgctgaattttaaggatgataaaaatgattgc ccttgtcctgaagaaataagggaccacctcttggattttcatgaagatttgatggcacac tgtggaattcagttagatgaagatggaattctggatggaaatagtgatttaactcttaaa ggtcgcctgctgtatcttgtggaaagagtcacacacttgaaaaagaaacaagctgagaag cccattgatgatgatgctaataagccatcaactctccaacagctgatctcagagaccatg gtacgatgggcacaagaatcagtgatagaagacccagagttggtgagggccatgttcgtt ttgctacatcgccaatatgatggagttggtggcctggttcgagccttgccaaagacatac actataaatggtgtatctgtagaagatacaatcagcttacttgcttctcttggtcagatc cgttctctcctcagtgtcagaatgggcaaggaagaagagaagcttatgattcgtggatta ggagatataatgaacaataaagttttttaccaacatcctaatcttatgagagcattgggt atgcatgagactgtgatggaggtaatggtgaatgtacttggaggaggagagtcaaaggaa atcacctttcctaagatggtggcaaattgctgtcgttttctatgttatttttgccgcatc agcaggcagaatcaaaaggctatgtttgatcatcttagctatcttctggaaaatagcagt gttgggcttgcatccccttctatgcgtggatcaactcctttggatgtagcggcagcatct gtaatggataataatgagcttgcactagctttgcgggaacctgatctagaaaaggtagtt cgctacttggctggatgtggtttgcaaagctgctcattgctgatttctaaaggttaccca gatattggatggaacccagtggaaggagaacgatacttggattttcttcgttttgctgtt ttttgcaatggagaaagtgttgaagagaatgccaatgtggtggtaagactgctcattcga cgtcctgaatgttttggaccagcactgagaggagaaggtggaaatggcctgcttgctgcc atggaggaagccataaacatatcagaagaccctacaagagatggaccttcaccaagtagc ggatccaataaaacactaagtgaggtggaagaagaagatgataccattcacatgggaaat gccatcatgaccttttatgctgctttgattgatctcctaggacgctgtgctccagaaatg catctaatccatgctggcaaaggagaagcaattagaataagatccattctgcggtctttg attcctttggaagatttggtgggcgtgattagtattcctttccacatgccaacaatagca aaagatggtactgtggtggaacctgatatgtcagaggggttttgcccagaccacaaggca gccatggtcttgttccttgacagggtctatgggattgaagaccaggattttcttctacac cttcttgaagttggctttctgccagatcttcgtgctgctgcttcattagatacggttgct ctgagtgctacagatatggccctggctctcaatcggtacctctgcactgctgttttgcct ttattaactagatgtgctcctctttttgctggcacagaacaccatgcttcccttatagat tccttgctacacactgtgtaccgactttccaagggctgctctcttaccaaagctcaacgg gactctattgaagagtgcctactctccatatgtggtcagctgaggccttcaatgatgcaa catttgttgagaagattagtgtttgatattccgctgctaaatgagcatgcaaagatgcct cttaagttgctgacaaatcattatgaaagatgttggaagtattactgtttaccaggagga tggggcaactttggtgctgcttcagaagaagaacttcatttgtccaggaagttgttctgg ggtatttttgatgccttatctcaaaagaaatacgaacaggaactattcaaactggccttg ccatgcctgagtgcagtggctggggctttacctcctgattacatggaatcaaactatgtg ggtgtgatggaaaagcaagcttccatggattcagatgggaactttaatccacaacctgtt gatacttcaaacattacaattcctgaaaagctagactactttattaacaaatatgcagaa cattcccatgataaatggtgcatggaaaagtttgcaaatgggtggatatatggtgaaaca tactcagaatcttccaaagtgcagccattaatgaaacaatataaacttttagcagaaaag gagaaagaaatttacagatggccaatcaaggagtccttgaaaaccatgcttgcttgggga tggcgggttgaaagaacaagggaaggagatactatggctctttataacaggccacgccga atatcacagacaagtcaggtttctgtagatactgtccatggttatagccctcgtgcaatt gacatgagtaatgttaccctctccagagaactgcatgctatggctgaaatgatggctgaa aactatcacaatatatgggcaaagaaaaagaaaatggagcttgaagcaaaagtgggagga ggaaaccatcccttacttgttccatacgatacactgacagccaaagaaaaggccaaggat agagagaaagcacaagatatcctgaagttcctacagatcaatggatatgtggtctcgaga ggtctaaaggatctagaattagatacaccttctatcgagaaacgatttgcttacagtttt cttcaacagctgataagatatgtggatgaagcccatcagtatattctggagtttgatggt ggtggcagaggcaaaggagaacaatttccttatgaacaagaaatcaagttctttgctaaa gttgtacttcctttaatcgaccagtattttaagaaccatcgcctgtatttcctatctgct gcaagtaggcctcttagcagtggggggcatgcctcaaataaggagaaagaaatggtgaca agcctattctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaatgat gcgacttcaatagtcaattgtctgcatatcttgggacagaccttggatgcaaggacagtg atgaagacaggactggagtctgttaagatggctttgaggacatttttggataatgctgca gaggacctggagaagacaatggagaatcttaagcaagggcagtttacgcacactaggagt cagccaaaaggagtgacacaaataattaactataccactatggcccttctgccagtgcta tcttcattatttgaacacattggacagcatcaatttggagaagatttaatattggaagat gttcaagtctcatgttacagaatattggtcagcttgtatgctctggggacaagcaaaagt atctatgtggagcggcagcgctcagctttaggtgaatgcctagctgcttttgctggtgcc tttcctgtggcattcttagaaactcatctgaaccatcacaacacacattctatttacaac accaagactacaagagatagaacaggtcttggcttaccaaacagtgtagaagaactttct ccaaacattccttctctggagaagctaatggaagatattgtggaattagctgaatctggc attcgctacacacaaatgcctcatgtaatggaagttgtgctgccgatgctctgtagctac atgtcacactggtgggagcatggaccagaaaacaatcctcacaatagtgaaatgtgctgc acagctttgacttcagagcatatgaatacccttctaggaaacatactgaaaatcatacat aataatttgggcatagatgagggagcctggatgaagaaattagcagtgttttctcagcct atcataagcaaagtgaagcctcagctcctgaaaacgcattttctgccactgatggagaaa ctgaagaaaaaagctgcaatggttatatctgatgaagaacatttaagagcagaaggccga ggagatatgtctgaggcagaactcctcatcctagatgagttcacaatattggcacgggac ctttacgccttctacccattgttgattagatttgtggactacaacagagcaaagtggcta aaagaacctaatccagaggcagaggacctgtttcgtatggttgctgatgtattcatttac tggtcgaaatcccataattttaaaagggaagaacaaaattttgttgtgcagaatgaaatc aacaacatgtctttccttattactgatacaaagtccaagatgtccaaggcagctgtttct gatcaggaaaggaaaaaaatgaagcggaaaggtgatcgttattcaacacagacttccctt attgtggcagctttaaaaagacttctgcctgttgggctcaatatttgtgcccctggtgac caagaactaattgcactggcaaaaaacagattaagtatgaaagacaccgaagatgaagtt cgagatattatacgtaataaccttcacttacagggcaagcttgaagatcctgccattagg tggcaggttgctctttacaaagatcttccaaacaggactgaagttacttcagatccagag aagacggtggaaagggtcctggatatagctagtgtactttttcatctggaacaggttgaa catcctcagagatcaaaaaaagcagtatggcataaacttctatctaaacagagaaaaaga gcggtggtagcttgcttcagaatggcaccactatataatcttccacggcaccgagctgtc aatctttttcttcaaggatatgacaagtcgtgggtggaaacagaagaccactactttgaa gacacactgatagaagatttagcaaaacctggagaagaaccaccagaagaagatgaatgt attaagagagttgatcctttgcaccagcttattttgctattcagtcgaacagcattaact gaaaaatgtaagctggaagaagattatctttatatggcatatgctgatataatggcaaag agctgccatgaagaagatgatgataatgaagaggaagtcaagagttttgaagaaaaagaa atggaaaagcaaaagctcctgtaccagcaagcaagactccatgatcgaggagctgctgaa atggtccttcagacaattagtgccagtaaaggtgagatgggtccaatggttgcagccacc ctaaaacttgggattgccatcttgaatggaggaaattctactgttcagcagaaaatgctt gactacctcaaggacaaaaaggatgtaggcttctttcagagccttgctggtcttatgcag tcttgtagtgttcttgacctaaatgcttttgaacgccagaacaaagcagagggccttggc atggtaacagaagaaggatcaggagaaaaggtgatgcaagatgatgaatttacttgtgac ctcttccggttcctccagttgctttgcgaggggcacaactcagattttcaaaattacttg aggactcagactggcaacaatacaactgtcaatattataatatctactgtggattattta ctgagagttcaggaatcaattagtgatttctattggtattactctggaaaggatgttatt gatgaacaaggacaacgtaatttctctaaagcaattcaagttgctaagcaggttttcaat actcttacagaatatattcagggaccatgtacgggtaaccagcagagtctggcgcatagc agactgtgggatgctgttgttggttttcttcatgtatttgcccatatgcagatgaagctt tctcaggattctagccaaattgaattactgaaagaattaatggatcttcagaaggatatg gtggtcatgttgttatctatgttagaaggtaatgttgtgaatggcacaatcggcaagcag atggttgacatgctagtggaatcctccaacaatgtagaaatgattttaaagttttttgat atgttcctaaaactgaaggatttaactttctctgatgcattcaaagaatatgatcccgac ggaaagggtatcatttcaaaaagagatttccacaaagccatggagagccacaaacactac actcaatcggaaaccgagtttttgctctcatgtgccgaaacagatgagaatgagactttg gactatgaagaatttgtgaaacggtttcatgagccagccaaagacattggcttcaatgtt gctgtcctcctgacaaacttgtcagagcacatgcctcatgacactcggttgcagactttt cttgaactggcggatagtgttttgaactatttccagcccttcttagggcgtatagagata atgggtagcgcaaagcgcattgaacgagtttactttgagataagtgaatcaagtcggaca cagtgggaaaaacctcaagttaaagaatcaaagagacagtttatatttgatgtagtaaat gaaggaggggaaaaggaaaaaatggagctctttgttaatttttgtgaggacaccatattt gaaatgcaattggcagctcagatctctgaatcagatttgaatgagaggtctgcaaataaa gaagaaaatgagaacgagaaacccgaggaacaggatcccagaatgggcttcttctctcta gtaactgttaaatcagctttagtagctctcaggtataacataatgacactcatgaaagtg ctaagcatgaaaagtatcaagaagcagatgaagaagatgaaaaagatgaccatgaaagac atggcaatggcttttttctcctcctattggagcattttaatgggcttaatgcatttcata tcaagtgtcttccgaggcttctttcaaatcatgtacagtttgctgcttggaggaagccta gtggaaggggctaagaaaatcaaagtggctgaactcttagccaacatgcctgaccctact caagatgaggtgcgtggtgaaggggaagaagcggaaagaaagccaacagaagctcccctg cctgcagaagacctgaccgatctcaaagctttgtcagaagatagtgacctcctctctgac atatttggcttggatttaaaaagagagggaggacaatataaactaatcccacataatccc aatgcaggcttaagtgatttgctgagcagtccttctttactccccttacccgatgtgcaa gaaaaaatacaggaccagaaggtgaacgaagatgaaaaggatgagaaagaagaaactaaa tttgtacctgagaaagcagagggagaagatggagaaaaggaagagaaagcaatagaagat aaagcaaagcagaaacagaggcagcatcacaaacacaggcatggtgagccagaaacacaa gaatcagccttctggaagaaaattattgcataccagcagaaacttcttaactattttgct cggaatttctacaatatgaggatgttggctttgtttgttgcatttgccattaatttcatt ctgctcttctataaggtctccacatctgcagtggctggagaaaaggaggtccctgtggtt aatattgctgaaaactccaagctaagcagcttagaaagtccgtcccatagaatcatcaca gtgcactatgtccttgaagaaagtagtggctacatggaacccacactccgcattttagcc attctgcacacagtcatttcctttttctgcatcattggatattactgtctgaaagttcca ctggttatatttaaacgagaaaaggaagtcgcacggaaattagaatttgatgggctgtat attacagaacaaccttcagaagatgatattaaagggcagtgggatagacttgtcatcaac acacaatcgtttcctaacaactattgggacaagtttgtaaaaagaaaggttatggataaa tatggagagttctatggaaaggacagaatcagtgaattgctgggaatggacaaagctgct ctagatttcagtgatgctagagaaaaaaagaaacccaaaaaagatagttctttatcagct gtactgaattctattgatgtaaagtatcagatgtggaaattaggagttgttttcactgat aattcttttctgtaccttgcttggtatatgaccatgtcagtccttggtcattacaacaac tttttctttgctgctcatcttcttgacatagcaatgggattcaaaacgttgcgaactatt ctgtcatcagtaactcacaatggcaaacagcttgtgctcacagtaggattactggcagtg gtagtttacctgtacacagtagtcgcatttaattttttccgcaaattctacaataagagt gaagatggagatatgccagacatgaagtgtgatgatatgctaacgtgctatatgtttcac atgtatgtgggagtgcgtgctggtggtggaattggtgatgaaattgaagacccagcaggc gatgaatatgaaatctatcgaatcatctttgatattacatttttcttttttgtaatagtt attctcctcgctatcatccaaggtttaattattgatgcatttggagaattaagagatcag caggaacaagttaaagaagacatggagaccaaatgctttatttgtgggataggtaatgac tactttgacacagtgccccatggttttgaaacacatactctacaggagcacaacttggct aattatctatttttcctgatgtatctcataaataaagatgaaaccgaacatactggacag gaatcctacgtatggaaaatgtatcaagagcgatgctgggaattttttcctgccggcgac tgctttcgaaagcagtatgaagaccagcttaactaa

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