+F Repair protein KO
#
DNA Repair and Recombination Proteins - Adelges cooleyi (spruce gall adelgid)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 126840248 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 126839146 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 126843819 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 126841229 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126841569 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126843272 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126836444 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126845305 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126837431 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126834660 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 126839888 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 126838258 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 126846432 exodeoxyribonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 126847249 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 126841453 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F 126842715 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 126844927 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 126847081 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 126841150 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 126840422 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 126841343 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 126838566 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 126842825 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 126834363 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 126844319 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 126847475 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 126838214 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 126834318 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 126847214 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 126846863 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 126846562 DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 126841042 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 126840653 RING-box protein 1A-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126836636 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126844195 cullin-4B K10609 CUL4; cullin 4
F 126848020 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 126844172 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 126837465 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 126839042 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 126834655 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 126836749 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 126838516 DNA-directed RNA polymerase II subunit Rpb4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 126843412 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 126844910 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 126847951 DNA-directed RNA polymerase II subunit RPB7-like isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 126842963 DNA-directed RNA polymerase II subunit RPB7-like isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 126838176 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 126840311 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 126840888 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 126836601 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 126838124 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 126840653 RING-box protein 1A-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126836636 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 126844195 cullin-4B K10609 CUL4; cullin 4
F 126848020 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 126832878 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 126842697 UV-stimulated scaffold protein A-like isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 126838475 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 126847745 general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 126842815 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 126846465 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 126837925 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 126834376 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 126836744 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 126837332 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 126843381 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 126835159 cyclin-H K06634 CCNH; cyclin H
E 126832763 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 126840958 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 126833195 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 126843041 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 126839039 uncharacterized protein LOC126839039 K10740 RPA3; replication factor A3
E 126839230 uncharacterized protein LOC126839230 isoform X1 K10740 RPA3; replication factor A3
D Other NER factors
E 126840497 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 126836194 DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 126836101 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 126838566 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 126833425 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 126839845 LOW QUALITY PROTEIN: cullin-3-B-like K03869 CUL3; cullin 3
E 126833840 cullin-3-B-like K03869 CUL3; cullin 3
E 126842183 cullin-3-B-like K03869 CUL3; cullin 3
E 126834593 cullin-3-B-like K03869 CUL3; cullin 3
E 126845385 cullin-3-like K03869 CUL3; cullin 3
E 126836571 cullin-3-like K03869 CUL3; cullin 3
E 126836839 cullin-3-B-like K03869 CUL3; cullin 3
E 126842742 cullin-5 K10612 CUL5; cullin 5
E 126844899 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 126842739 elongin-C K03872 ELOC; elongin-C
E 126844430 elongin-C-like K03872 ELOC; elongin-C
E 126844641 elongin-B-like K03873 ELOB; elongin-B
E 126838540 elongin-B K03873 ELOB; elongin-B
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 126847084 DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 126844871 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 126833344 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 126833945 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 126836233 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 126847249 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 126841453 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E 126840958 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 126833195 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 126843041 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 126839039 uncharacterized protein LOC126839039 K10740 RPA3; replication factor A3
E 126839230 uncharacterized protein LOC126839230 isoform X1 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 126842777 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 126842388 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 126838480 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 126843265 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 126838399 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 126840422 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 126839394 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 126847214 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 126838566 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 126842371 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 126833412 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 126840213 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
E 126836630 BRCA1-A complex subunit Abraxas 1-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 126837230 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 126841775 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D BRCA1-C complex
E 126833412 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 126840213 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 126844415 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 126844415 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 126846191 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 126838211 DNA repair protein RAD51 homolog 4-like K10871 RAD51L3; RAD51-like protein 3
E 126847182 DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 126835042 DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 126833909 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 126840464 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 126838344 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 126842001 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126844992 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126834609 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 126842778 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 126842001 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126844992 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126841764 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126834139 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126845896 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 126840958 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 126833195 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 126843041 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
E 126839039 uncharacterized protein LOC126839039 K10740 RPA3; replication factor A3
E 126839230 uncharacterized protein LOC126839230 isoform X1 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 126838062 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 126835342 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 126841746 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 126845634 serine/threonine-protein phosphatase 4 regulatory subunit 4-like K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 126847386 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 126839118 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 126838610 uncharacterized protein LOC126838610 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 126841327 uncharacterized protein LOC126841327 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
D Other HR factors
E 126833937 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 126843366 exonuclease 3'-5' domain-containing protein 2-like isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 126846426 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 126841115 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 126836635 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 126833676 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 126845946 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 126840074 uncharacterized protein LOC126840074 K11339 MORF4L1; mortality factor 4-like protein 1
E 126841599 uncharacterized protein LOC126841599 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 126841601 uncharacterized protein LOC126841601 K11339 MORF4L1; mortality factor 4-like protein 1
E 126842233 uncharacterized protein LOC126842233 K11339 MORF4L1; mortality factor 4-like protein 1
E 126843057 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 126836808 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 126847782 uncharacterized protein LOC126847782 K11339 MORF4L1; mortality factor 4-like protein 1
E 126841808 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 126843750 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 126843042 uncharacterized protein LOC126843042 K25791 HSF2BP; heat shock factor 2-binding protein
E 126845407 uncharacterized protein LOC126845407 K25791 HSF2BP; heat shock factor 2-binding protein
E 126836262 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 126838096 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 126833762 X-ray repair cross-complementing protein 5-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 126844061 X-ray repair cross-complementing protein 5-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 126845710 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 126846482 DNA-dependent protein kinase catalytic subunit-like isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 126833412 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 126840213 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 126845570 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
E 126842825 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 126838214 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 126847497 protein artemis-like isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 126845361 E3 ubiquitin-protein ligase FANCL-like K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 126832745 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 126835558 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 126842001 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126844992 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 126841764 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126834139 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126845896 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 126838521 Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 126844245 Fanconi anemia group I protein-like K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 126841775 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 126844415 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 126846191 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 126841147 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 126839368 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 126838046 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 126832739 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 126838005 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 126847340 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 126839076 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
E 126842371 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 126832935 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 126836137 DNA repair protein Rev1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D 126843031 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 126845357 ubiquitin-conjugating enzyme E2-17 kDa-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 126838712 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 126845969 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 126840422 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 126835920 DNA-dependent metalloprotease dvc-1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 126838593 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 126846742 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 126839384 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 126842872 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 126842388 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 126838480 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 126843265 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 126838399 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 126839384 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 126840645 LOW QUALITY PROTEIN: protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
C Triple T complex
D 126843468 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 126842803 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 126836273 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 126839917 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 126834288 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 126837047 myosin light chain kinase A-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 126838210 probable myosin light chain kinase DDB_G0292624 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 126833510 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 126836071 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126844790 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126846490 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 126833462 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 126842868 wee1-like protein kinase 1-B isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 126836522 plastin-3 K17336 PLS3; plastin-3
D 126840557 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 126844617 vacuolar protein sorting-associated protein 4-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 126837364 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 126839148 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 126846755 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
C Nucleases
D 126847730 uncharacterized protein LOC126847730 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 126839201 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 126840843 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 126838387 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 126840097 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 126845789 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 126837955 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 126839140 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839683 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839850 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839959 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839961 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839976 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833075 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833092 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833093 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833117 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833118 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833604 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842163 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842174 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842294 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842297 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842333 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842460 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126835122 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126843907 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126836214 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126845349 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126845368 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126836782 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126837800 LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126847684 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126847757 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833305 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 126833958 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 126841308 ribonucleoside-diphosphate reductase subunit M2 B-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 126844849 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 126837155 ribonucleoside-diphosphate reductase subunit M2 B-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 126843819 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 126841229 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126841569 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126843272 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126836444 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126845305 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126837431 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 126839888 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 126834660 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 126842004 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 126842004 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 126839140 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839683 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839850 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839959 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839961 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126839976 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833075 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833092 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833093 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833117 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833118 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126833604 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842163 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842174 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842294 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842297 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842333 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126842460 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126835122 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126843907 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126836214 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126845349 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126845368 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126836782 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126837800 LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126847684 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 126847757 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024