+F Repair protein KO
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DNA Repair and Recombination Proteins - Anolis carolinensis (green anole)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100553369 mgmt; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 100557858 alkbh3; alkB homolog 3, alpha-ketoglutaratedependent dioxygenase K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 100551655 ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 100567162 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 100562732 ccno; cyclin O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100567264 tdg; thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 100557008 mpg; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100551589 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100552457 mutyh; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100560136 mbd4; methyl-CpG binding domain 4, DNA glycosylase K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 100554936 ogg1; 8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 103282810 neil1; nei like DNA glycosylase 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 100553937 neil2; nei like DNA glycosylase 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 100566810 neil3; nei like DNA glycosylase 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 103281794 nthl1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 100554177 apex1; apurinic/apyrimidinic endodeoxyribonuclease 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 100567501 apex2; apurinic/apyrimidinic endodeoxyribonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100564729 pold1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 100553924 pold2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
F 100559358 pold3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
F 100558195 pold4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 100553994 pole; DNA polymerase epsilon, catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 100553208 pole2; DNA polymerase epsilon 2, accessory subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
E 100560949 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100555152 fen1; flap structure-specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 103281575 probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100565521 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 100552750 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100561839 xrcc1; X-ray repair cross complementing 1 K10803 XRCC1; DNA-repair protein XRCC1
D Other BER factors
E 100563188 tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 100558032 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 103279496 aplf; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100558808 pnkp; polynucleotide kinase 3'-phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 100560708 hmgb1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 100558291 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100567376 parp1; poly(ADP-ribose) polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 100566501 parp2; poly(ADP-ribose) polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100552908 parp3; poly(ADP-ribose) polymerase family member 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100563335 parp4; poly(ADP-ribose) polymerase family member 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 100561749 xpc; XPC complex subunit, DNA damage recognition and repair factor K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 100559933 rad23b; RAD23 homolog B, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 100567571 rad23a; RAD23 homolog A, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 100567273 cetn2; centrin 2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 100566553 rbx1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100564485 cul4b; cullin 4B K10609 CUL4; cullin 4
F 100559251 cul4a; cullin 4A K10609 CUL4; cullin 4
F 100567601 ddb1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100554400 ddb2; damage specific DNA binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 100561860 polr2a; RNA polymerase II subunit A K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100560133 polr2b; RNA polymerase II subunit B K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 100561197 polr2c; RNA polymerase II subunit C K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 100567905 polr2d; RNA polymerase II subunit D K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 100556802 polr2f; RNA polymerase II subunit F K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 100561991 polr2g; RNA polymerase II subunit G K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 100555951 polr2h; RNA polymerase II subunit H K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 100553019 polr2j; RNA polymerase II subunit J K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 100559488 polr2k; RNA polymerase II subunit K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 100566553 rbx1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100564485 cul4b; cullin 4B K10609 CUL4; cullin 4
F 100559251 cul4a; cullin 4A K10609 CUL4; cullin 4
F 100567601 ddb1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100554473 ercc8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 100565525 ercc6; ERCC excision repair 6, chromatin remodeling factor K10841 ERCC6; DNA excision repair protein ERCC-6
F 100557054 uvssa; UV stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 100551987 elof1; elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100556993 ercc3; ERCC excision repair 3, TFIIH core complex helicase subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 103283011 ercc2; ERCC excision repair 2, TFIIH core complex helicase subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 100563258 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 100558064 gtf2h2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100558483 gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 100556108 gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 100557344 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 100557869 cdk7; cyclin dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 100561616 ccnh; cyclin H K06634 CCNH; cyclin H
E 100556266 mnat1; MNAT1, CDK activating kinase assembly factor K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 100556142 rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 100554910 rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 100553184 rpa3; replication protein A3 K10740 RPA3; replication factor A3
D Other NER factors
E 100566327 xpa; XPA, DNA damage recognition and repair factor K10847 XPA; DNA-repair protein complementing XP-A cells
E 100565865 ercc1; ERCC excision repair 1, endonuclease non-catalytic subunit K10849 ERCC1; DNA excision repair protein ERCC-1
E 100567423 ercc4; ERCC excision repair 4, endonuclease catalytic subunit K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 107982244 DNA repair protein complementing XP-G cells-like K10846 ERCC5; DNA excision repair protein ERCC-5
E 100565521 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100559300 mms19; MMS19 homolog, cytosolic iron-sulfur assembly component K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 100559387 cul3; cullin 3 K03869 CUL3; cullin 3
E 100560291 cul5; cullin 5 K10612 CUL5; cullin 5
E 100561237 eloc; elongin C K03872 ELOC; elongin-C
E 100562302 elob; elongin B K03873 ELOB; elongin-B
E 100562650 eloa; elongin A K15076 ELOA; elongin-A
E 100564540 ubap2; ubiquitin associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 100562005 msh2; mutS homolog 2 K08735 MSH2; DNA mismatch repair protein MSH2
E 100554606 msh3; mutS homolog 3 K08736 MSH3; DNA mismatch repair protein MSH3
E 100562407 msh6; mutS homolog 6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100559382 pms1; PMS1 homolog 1, mismatch repair system component K10864 PMS1; DNA mismatch repair protein PMS1
E 100555611 mlh1; mutL homolog 1 K08734 MLH1; DNA mismatch repair protein MLH1
E 100564282 pms2; PMS1 homolog 2, mismatch repair system component K10858 PMS2; DNA mismatch repair protein PMS2
E 100552500 mlh3; mutL homolog 3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 100564729 pold1; DNA polymerase delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 100553924 pold2; DNA polymerase delta 2, accessory subunit K02328 POLD2; DNA polymerase delta subunit 2
E 100559358 pold3; DNA polymerase delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
E 100558195 pold4; DNA polymerase delta 4, accessory subunit K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 100556142 rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 100554910 rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 100553184 rpa3; replication protein A3 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 100555731 rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 100561657 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 100562656 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 100562628 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 100558796 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 100560949 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100564366 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 100560708 hmgb1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 100565521 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100561391 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
E 100567947 wdr76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 100557944 mre11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 100566478 rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100557161 nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 100553919 brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100563125 bard1; BRCA1 associated RING domain 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 100553919 brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100565768 fam175a; family with sequence similarity 175 member A K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 100553959 uimc1; ubiquitin interaction motif containing 1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 100563067 bre; brain and reproductive organ-expressed (TNFRSF1A modulator) K12173 BRE; BRCA1-A complex subunit BRE
E 100562849 brcc3; BRCA1/BRCA2-containing complex subunit 3 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 100553919 brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 103281603 brip1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100552672 topbp1; topoisomerase (DNA) II binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 100567826 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 100553919 brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100562615 rbbp8; RB binding protein 8, endonuclease K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 100557944 mre11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 100566478 rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100557161 nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 100553919 brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100554942 brca2; BRCA2, DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 103281553 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 100553658 rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 100553658 rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 100558163 rad51b; RAD51 paralog B K10869 RAD51L1; RAD51-like protein 1
E 100553814 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 100553974 xrcc2; X-ray repair cross complementing 2 K10879 XRCC2; DNA-repair protein XRCC2
E 100557067 xrcc3; X-ray repair cross complementing 3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 100552854 rad52; RAD52 homolog, DNA repair protein K10873 RAD52; DNA repair and recombination protein RAD52
E 100566882 rdm1; RAD52 motif containing 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 100555206 rad54l; RAD54-like (S. cerevisiae) K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 100566154 rad54l2; RAD54-like 2 (S. cerevisiae) K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 100560445 rad54b; RAD54 homolog B (S. cerevisiae) K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 100559305 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 100561844 wrn; Werner syndrome RecQ like helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 100559578 blm; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100552491 recql4; RecQ like helicase 4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 100559578 blm; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100555549 top3b; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100551633 top3a; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100558457 rmi1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 100562209 rmi2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 100556142 rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 100554910 rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 100553184 rpa3; replication protein A3 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 100557380 ppp4c; protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 100556649 serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100557583 ppp4r1; protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100563915 ppp4r2; protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100551585 ppp4r3a; protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100563911 ppp4r3b; protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100562723 ppp4r4; protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 103282150 ap5b1; adaptor related protein complex 5 beta 1 subunit K19022 AP5B1; AP-5 complex subunit beta-1
E 100563625 ap5m1; adaptor related protein complex 5 mu 1 subunit K19023 AP5M1; AP-5 complex subunit mu-1
E 100560797 ap5s1; adaptor related protein complex 5 sigma 1 subunit K19024 AP5S1; AP-5 complex subunit sigma-1
E 100556349 ap5z1; adaptor related protein complex 5 zeta 1 subunit K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 100563197 smc5; structural maintenance of chromosomes 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100565483 smc6; structural maintenance of chromosomes 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100561937 fam84a; family with sequence similarity 84 member A K22805 FAM84A; protein FAM84A
E 100560743 nsmce1; NSE1 homolog, SMC5-SMC6 complex component K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 100557160 nsmce2; NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100567306 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 100565039 nsmce4a; NSE4 homolog A, SMC5-SMC6 complex component K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 100564368 slf1; SMC5-SMC6 complex localization factor 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 103278239 slf2; SMC5-SMC6 complex localization factor 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 100560632 eme1; essential meiotic structure-specific endonuclease 1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 100553135 exd2; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 100556222 swi5; SWI5 homologous recombination repair protein K10991 SWI5; DNA repair protein Swi5/Sae3
E 100560242 sfr1; SWI5 dependent homologous recombination repair protein 1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 100567090 slx1a; SLX1 homolog A, structure-specific endonuclease subunit K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 103280801 slx4; SLX4 structure-specific endonuclease subunit K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 100561546 gen1; GEN1, Holliday junction 5' flap endonuclease K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 100559164 spg11; spastic paraplegia 11 (autosomal recessive) K19026 SPG11; spatacsin
E 100557770 zfyve26; zinc finger FYVE-type containing 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100558575 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 100560254 samhd1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100564003 fignl1; fidgetin like 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100562887 spidr; scaffolding protein involved in DNA repair K22806 SPIDR; DNA repair-scaffolding protein
E 100558733 fam84b; family with sequence similarity 84 member B K22810 FAM84B; protein FAM84B
E 100565597 brat1; BRCA1 associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 100556700 c3h21orf2; chromosome 3 C21orf2 homolog K23456 CFAP410; cilla- and flagella-associated protein
E 100564950 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 103277734 swsap1; SWIM-type zinc finger 7 associated protein 1 K25771 SWSAP1; ATPase SWSAP1
E 100556862 emsy; EMSY, BRCA2 interacting transcriptional repressor K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 100566160 hsf2bp; heat shock transcription factor 2 binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 100553040 mms22l; MMS22 like, DNA repair protein K26125 MMS22L; protein MMS22-like
E 100565210 tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 100567093 bod1l1; biorientation of chromosomes in cell division 1 like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 100562155 parpbp; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
E 103279228 c6h17orf53; chromosome 6 open reading frame, human C17orf53 K27803 HROB; homologous recombination OB-fold protein
E 100554532 mcm8; minichromosome maintenance 8 homologous recombination repair factor K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
E 100553098 mcm9; minichromosome maintenance 9 homologous recombination repair factor K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 100552071 xrcc6; X-ray repair cross complementing 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 100558367 xrcc5; X-ray repair cross complementing 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 100562493 prkdc; protein kinase, DNA-activated, catalytic polypeptide K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 100557944 mre11; MRE11 homolog, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 100566478 rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 100561936 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100561020 xrcc4; X-ray repair cross complementing 4 K10886 XRCC4; DNA-repair protein XRCC4
E 100565479 nhej1; non-homologous end joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 100558291 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 107982265 DNA-directed DNA/RNA polymerase mu-like K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 103280921 DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 100561065 dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 100552750 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 100558032 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 103279496 aplf; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100553017 dclre1c; DNA cross-link repair 1C K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 100567257 tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 100565669 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 103281558 chromosome unknown open reading frame, human C9orf142 K25772 PAXX; protein PAXX
E 100553510 c5h7orf49; chromosome 5 open reading frame, human C7orf49 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 100564954 jmjd8; jumonji domain containing 8 K25792 JMJD8; jumonji domain-containing protein 8
E 103279528 c1h20orf196; uncharacterized protein C20orf196 homolog K26128 SHLD1; shieldin complex subunit 1
E 103279430 fam35a; family with sequence similarity 35 member A K26129 SHLD2; shieldin complex subunit 2
E 107982361 uncharacterized LOC107982361 K26130 SHLD3; shieldin complex subunit 3
E 100563732 bend4; BEN domain containing 4 K27845 BEND4; BEN domain-containing protein 4
C FA (Fanconi anemia) pathway
D FA core complex
E 100561925 Fanconi anemia group A protein-like K10888 FANCA; fanconi anemia group A protein
E 100564315 fancb; Fanconi anemia complementation group B K10889 FANCB; fanconi anemia group B protein
E 100555906 fancc; Fanconi anemia complementation group C K10890 FANCC; fanconi anemia group C protein
E 100552131 fance; Fanconi anemia complementation group E K10892 FANCE; fanconi anemia group E protein
E 103278196 fancf; Fanconi anemia complementation group F K10893 FANCF; fanconi anemia group F protein
E 100555106 fancg; Fanconi anemia complementation group G K10894 FANCG; fanconi anemia group G protein
E 100566011 fancl; Fanconi anemia complementation group L K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 103279881 fancm; Fanconi anemia complementation group M K10896 FANCM; fanconi anemia group M protein
E 100558497 faap24; Fanconi anemia core complex associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 100563979 faap100; Fanconi anemia core complex associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 100558625 hes4; hes family bHLH transcription factor 4 K06054 HES1; hairy and enhancer of split 1
E 100558110 hes1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 100561983 cenps; centromere protein S K11511 APITD1; centromere protein S
E 100564242 cenpx; centromere protein X K15360 STRA13; centromere protein X
E 100567260 ube2t; ubiquitin conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 100559578 blm; Bloom syndrome RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100555549 top3b; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100551633 top3a; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100558457 rmi1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 100562209 rmi2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 100560437 fancd2; Fanconi anemia complementation group D2 K10891 FANCD2; fanconi anemia group D2 protein
E 100552745 fanci; Fanconi anemia complementation group I K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 100553919 brca1; BRCA1, DNA repair associated K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100554942 brca2; BRCA2, DNA repair associated K08775 BRCA2; breast cancer 2 susceptibility protein
E 103281603 brip1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 103281553 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 100560146 fan1; FANCD2 and FANCI associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 100553658 rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 100553814 rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 100566450 telo2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
E 100560711 usp1; ubiquitin specific peptidase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 100568246 wdr48; WD repeat domain 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 100560299 ppp6c; protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 100565063 ppp6r1; protein phosphatase 6 regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 103281746 ppp6r2; protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 100566466 ppp6r3; protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 100555016 ankrd28; ankyrin repeat domain 28 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 100561779 ankrd44; ankyrin repeat domain 44 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 100555909 ankrd52; ankyrin repeat domain 52 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 100553293 rnf8; ring finger protein 8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100561030 rnf168; ring finger protein 168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 100558966 rnf169; ring finger protein 169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 100566865 herc2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 100557461 wrap53; WD repeat containing antisense to TP53 K23314 WRAP53; telomerase Cajal body protein 1
E 103281774 tprn; taperin K24164 TPRN; taperin
E 103281568 zcwpw1; zinc finger CW-type and PWWP domain containing 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 100563229 wdr70; WD repeat domain 70 K24752 WDR70; WD repeat-containing protein 70
E 100561391 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
E 100567947 wdr76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 100558919 polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 100556595 poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 100555251 polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 100553599 rev1; REV1, DNA directed polymerase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100565094 rev3l; REV3 like, DNA directed polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 100564033 ube2a; ubiquitin conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 100551860 ube2b; ubiquitin conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 103279877 rad18; RAD18, E3 ubiquitin protein ligase K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 100557402 E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 100555259 hltf; helicase like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 103278778 ube2v1; ubiquitin conjugating enzyme E2 V1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100560470 ube2v2; ubiquitin conjugating enzyme E2 V2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100560649 ube2n; ubiquitin conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 100560949 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100562155 parpbp; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
D 100559634 sprtn; SprT-like N-terminal domain K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 103281513 acrc; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100556948 rad9a; RAD9 checkpoint clamp component A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100565399 rad9b; RAD9 checkpoint clamp component B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 100566308 hus1; HUS1 checkpoint clamp component K10903 HUS1; HUS1 checkpoint protein
D 100565978 rad1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 100558454 rad17; RAD17 checkpoint clamp loader component K06662 HRAD17; cell cycle checkpoint protein
D 100561657 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100562656 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100562628 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 100558796 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 100565978 rad1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 100555324 timeless; timeless circadian clock K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 100556155 tipin; TIMELESS interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 100567034 clspn; claspin K25773 CLSPN; claspin
C Triple T complex
D 100566450 telo2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
D 100552688 tti1; TELO2 interacting protein 1 K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 100555197 bag6; BCL2 associated athanogene 6 K23390 BAG6; large proline-rich protein BAG6
D 100563261 ubl4a; ubiquitin like 4A K23388 UBL4; ubiquitin-like protein 4
D 100554680 ubl4b; ubiquitin like 4B K23388 UBL4; ubiquitin-like protein 4
D 100558172 get4; golgi to ER traffic protein 4 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100561948 atr; ATR serine/threonine kinase K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 100561356 atrip; ATR interacting protein K10905 ATRIP; ATR interacting protein
D 100556408 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100560063 atm; ATM serine/threonine kinase K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 103282543 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 100564808 chek1; checkpoint kinase 1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 103280245 M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100558641 cdc25a; cell division cycle 25A K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100568149 cdc25b; cell division cycle 25B K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 100565034 cdc25c; cell division cycle 25C K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 100553372 ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100556120 ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100559510 ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100566139 ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100563850 14-3-3 protein gamma-A-like K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100563970 nav2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 100557537 wee1; WEE1 G2 checkpoint kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100560382 wee2; WEE1 homolog 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100556661 per1; period circadian clock 1 K21944 PER1; period circadian protein 1
D 100556699 per2; period circadian clock 2 K02633 PER2; period circadian protein 2
D 103280590 mdc1; mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 100564741 pls3; plastin 3 K17336 PLS3; plastin-3
D 100567427 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 100559459 plk3; polo like kinase 3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 100560174 nek4; NIMA related kinase 4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100552798 nek1; NIMA related kinase 1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100558250 nek5; NIMA related kinase 5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100553690 nek10; NIMA related kinase 10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 100562432 nek11; NIMA related kinase 11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 100565040 donson; downstream neighbor of SON K22422 DONSON; protein downstream neighbor of Son
D 100553956 kank2; KN motif and ankyrin repeat domains 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100560908 kank4; KN motif and ankyrin repeat domains 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100565358 kank1; KN motif and ankyrin repeat domains 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100553838 chmp4c; charged multivesicular body protein 4C K24782 CHMP4C; charged multivesicular body protein 4C
D 100559678 vps4b; vacuolar protein sorting 4 homolog B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100559561 vps4a; vacuolar protein sorting 4 homolog A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100556656 zfyve19; zinc finger FYVE-type containing 19 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 100554996 sde2; SDE2 telomere maintenance homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 100566188 polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 100553351 mybbp1a; MYB binding protein 1a K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 100559397 primpol; primase and DNA directed polymerase K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100561159 trex1; three prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 100565360 trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 100563616 dclre1a; DNA cross-link repair 1A K15340 DCLRE1A; DNA cross-link repair 1A protein
D 100551606 dclre1b; DNA cross-link repair 1B K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 100560828 endov; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 100552441 zranb3; zinc finger RANBP2-type containing 3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 103282639 ankle1; ankyrin repeat and LEM domain containing 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 100565575 helq; helicase, POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 100555712 ercc6l2; ERCC excision repair 6 like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 100567086 prpf19; pre-mRNA processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 100563906 cdc5l; cell division cycle 5 like K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 100562552 bcas2; BCAS2, pre-mRNA processing factor K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 100552926 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
D 107982940 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 103279748 nudt15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100564610 nudt1; nudix hydrolase 1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100558579 nudt18; nudix hydrolase 18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 100557203 dut; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100562780 rrm1; ribonucleotide reductase catalytic subunit M1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 100566226 rrm2b; ribonucleotide reductase regulatory TP53 inducible subunit M2B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 100568029 rrm2; ribonucleotide reductase regulatory subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100553369 mgmt; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 100567162 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 100551589 smug1; single-strand-selective monofunctional uracil-DNA glycosylase 1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100557008 mpg; N-methylpurine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100552457 mutyh; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 103281794 nthl1; nth like DNA glycosylase 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100557227 ssbp1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100557227 ssbp1; single stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 103279748 nudt15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100557203 dut; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024