+F Repair protein KO
#
DNA Repair and Recombination Proteins - Antechinus flavipes (yellow-footed antechinus)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 127552211 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 127545594 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 127539676 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 127562035 LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 127554181 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 127545593 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 127550380 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 127537907 G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 127542822 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 127539142 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 127563418 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 127552216 methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 127551750 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 127551964 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 127548522 endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 127539862 endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 127543424 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 127549142 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 127542477 DNA-(apurinic or apyrimidinic site) endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 127556834 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 127548837 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 127555083 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 127541297 DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 127545349 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 127549685 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 127550801 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 127548207 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 127548185 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 127541865 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 127556601 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 127548273 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 127556406 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 127558992 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 127549415 tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 127560706 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 127548163 LOW QUALITY PROTEIN: aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 127556599 bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 127557048 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 127554697 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 127551498 DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 127559548 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 127549147 poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 127554154 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 127554770 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 127552426 DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 127542093 homeodomain-only protein isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 127544805 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
F 127554935 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 127542911 centrin-2 isoform X1 K10840 CETN2; centrin-2
F 127541983 centrin-1-like K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 127538369 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 127563077 LOW QUALITY PROTEIN: cullin-4B-like K10609 CUL4; cullin 4
F 127543030 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 127553488 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 127539823 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 127541912 DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 127560880 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 127540426 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 127550751 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 127559362 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 127554284 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 127545098 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 127538269 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 127540298 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 127563453 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 127540451 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 127556052 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 127539613 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 127558642 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 127544331 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 127553521 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 127538369 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 127563077 LOW QUALITY PROTEIN: cullin-4B-like K10609 CUL4; cullin 4
F 127543030 cullin-4B isoform X1 K10609 CUL4; cullin 4
F 127553488 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 127539823 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 127557771 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 127551798 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 127539787 LOW QUALITY PROTEIN: UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 127544777 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 127554295 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 127556321 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 127541268 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 127548563 LOW QUALITY PROTEIN: general transcription factor IIH subunit 1-like K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 127559045 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 127545396 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 127561044 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 127562368 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 127558341 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 127559402 cyclin-H K06634 CCNH; cyclin H
E 127549594 CDK-activating kinase assembly factor MAT1 isoform X1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 127558830 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 127555614 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 127539300 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 127560815 DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 127556320 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 127539061 LOW QUALITY PROTEIN: DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 127553430 DNA excision repair protein ERCC-5 K10846 ERCC5; DNA excision repair protein ERCC-5
E 127556601 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 127551744 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 127553040 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 127554954 cullin-5 K10612 CUL5; cullin 5
E 127543762 elongin-C K03872 ELOC; elongin-C
E 127555703 elongin-A isoform X1 K15076 ELOA; elongin-A
E 127543086 elongin-A-like K15076 ELOA; elongin-A
E 127551994 elongin-A-like K15076 ELOA; elongin-A
E 127552218 elongin-A-like K15076 ELOA; elongin-A
E 127559860 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 127561814 ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 127548059 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 127559152 DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 127548062 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 127554471 PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 127564365 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 127549485 DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 127556834 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 127548837 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 127555083 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 127541297 DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 127558830 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 127555614 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 127539300 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 127540303 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 127558705 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 127552928 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 127545526 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 127554676 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 127548185 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 127559600 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 127557048 high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 127554697 high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 127556601 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 127549314 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 127549849 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 127544265 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 127560081 LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 127553145 BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 127560081 LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 127542604 BRCA1-A complex subunit Abraxas 1-like isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 127541128 BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 127550269 BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 127545074 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 127548707 BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 127542950 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 127559273 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 127560081 LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 127559949 Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 127538868 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 127560081 LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 127543956 DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 127553349 LOW QUALITY PROTEIN: DNA endonuclease RBBP8-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 127549849 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 127544265 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 127560081 LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 127554686 breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 127540097 partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 127549238 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 127549238 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 127549664 DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 127559977 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 127558995 DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 127539150 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 127549875 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 127564617 DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 127560377 RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 127563394 DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 127554252 helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 127544285 DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 127538904 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 127541885 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 127551416 recQ-like DNA helicase BLM K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 127544581 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 127560466 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 127551416 recQ-like DNA helicase BLM K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 127545792 LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 127541096 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 127539211 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 127558830 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 127555614 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 127539300 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 127556105 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 127544016 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 127546568 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 127551282 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 127549404 serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 127548096 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 127549402 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 127540742 AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 127549563 AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 127547415 AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 127563572 AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 127538317 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 127542405 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 127542468 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 127542767 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 127542904 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 127547298 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 127547310 protein LRATD1 isoform X1 K22805 FAM84A; protein FAM84A
E 127555711 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 127544444 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 127564191 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 127551653 non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 127559784 SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 127551481 SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 127560065 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 127549674 exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 127541804 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 127564161 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 127550850 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 127551553 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 127556049 structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 127542234 structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 127547299 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 127549322 spatacsin K19026 SPG11; spatacsin
E 127549663 zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 127564144 RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 127557726 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 127564360 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 127552037 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 127550790 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 127550384 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 127553478 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 127543892 DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 127544449 protein LRATD2 K22810 FAM84B; protein FAM84B
E 127563733 BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 127562456 cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 127544931 hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 127558777 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 127544768 ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 127555052 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 127553795 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 127562021 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 127544591 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 127541276 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 127537814 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 127538430 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 127553134 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 127543891 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 127549849 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 127553453 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 127559297 DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 127553087 non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 127551498 DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 127547613 DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 127547151 DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 127548273 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 127560706 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 127548163 LOW QUALITY PROTEIN: aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 127564118 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 127544104 tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 127543982 structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 127545115 PWWP domain-containing DNA repair factor 3A isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 127549116 protein PAXX K25772 PAXX; protein PAXX
E 127564181 cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 127543112 jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 127548514 shieldin complex subunit 1 K26128 SHLD1; shieldin complex subunit 1
E 127551784 shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 127558141 shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 127546407 Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 127553626 Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein
E 127561706 Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 127561177 Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 127540449 Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 127540612 Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 127548104 E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 127549550 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 127550641 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 127560649 Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 127556038 transcription factor HES-4 K06054 HES1; hairy and enhancer of split 1
E 127558308 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 127555891 centromere protein S isoform X1 K11511 APITD1; centromere protein S
E 127560618 centromere protein X K15360 STRA13; centromere protein X
E 127562718 ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
E 127562786 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 127551416 recQ-like DNA helicase BLM K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 127545792 LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 127541096 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 127539211 recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 127551874 Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 127551386 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 127560081 LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 127554686 breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 127559949 Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 127540097 partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 127551320 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 127549238 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 127559977 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 127543374 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 127563220 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 127550407 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 127550581 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 127556705 serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 127538829 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 127541841 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 127539115 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 127554440 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 127539093 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 127561624 E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 127554195 E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 127555081 E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 127553716 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 127560869 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 127549076 taperin K24164 TPRN; taperin
E 127560986 zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 127556702 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 127538764 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
E 127549314 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 127561788 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 127543485 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 127558797 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 127553746 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 127562099 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 127541500 DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 127543042 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 127549821 ubiquitin-conjugating enzyme E2 B isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 127551587 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 127552963 helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 127548906 ubiquitin-conjugating enzyme E2 variant 1 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 127543888 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 127539451 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 127547978 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 127548185 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 127537814 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 127559663 DNA-dependent metalloprotease SPRTN isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 127542688 germ cell nuclear acidic protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 127541292 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 127548486 cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 127553609 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 127556462 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 127559062 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 127558705 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 127552928 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 127545526 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 127554676 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 127556462 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 127564518 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 127551244 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 127555406 claspin K25773 CLSPN; claspin
C Triple T complex
D 127543374 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 127550420 LOW QUALITY PROTEIN: TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 127548211 TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 127561062 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 127562552 ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 127542466 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 127564182 Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 127552991 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 127554958 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 127560870 cellular tumor antigen p53 isoform X1 K04451 TP53; tumor protein p53
D 127554847 serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 127545635 serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 127547413 M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 127549958 M-phase inducer phosphatase 3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 127548860 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 127544337 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 127548618 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 127558652 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 127545717 14-3-3 protein eta isoform X1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 127558846 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 127540764 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 127564221 wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 127539628 LOW QUALITY PROTEIN: wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 127560849 period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 127563159 period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 127555914 period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 127561032 mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 127543228 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 127551378 apoptosis-enhancing nuclease isoform X1 K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 127563414 serine/threonine-protein kinase PLK3 isoform X1 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 127545128 inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 127541207 serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 127557386 serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 127553863 serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 127554607 LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek4-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 127564037 serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 127538900 serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 127553856 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 127563222 LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 127544758 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 127538545 KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 127545296 KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 127558999 schlafen family member 11 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 127543719 charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 127543681 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 127547740 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 127549239 abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 127559540 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 127554121 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 127558280 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 127541217 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 127542323 three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 127551596 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 127559296 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 127558809 LOW QUALITY PROTEIN: exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 127560667 endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 127557241 DNA annealing helicase and endonuclease ZRANB3-like K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 127545075 ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 127541127 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 127561682 DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 127540851 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 127537805 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 127561807 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 127559286 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 127558055 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
D 127540283 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
D 127554892 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 127555187 nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 127563931 oxidized purine nucleoside triphosphate hydrolase isoform X1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 127548314 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 127551128 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 127555272 ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 127544345 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 127548691 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 127552211 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 127554181 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 127545593 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 127539142 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 127542822 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 127563418 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 127543424 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 127564572 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 127564572 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 127555187 nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 127551128 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024