+F Repair protein KO
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DNA Repair and Recombination Proteins - Anoplophora glabripennis (Asian longhorned beetle)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 108904249 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 108904050 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 108906831 uncharacterized protein LOC108906831 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 108909358 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108909376 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108909380 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108910754 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 108903328 uncharacterized protein LOC108903328 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 108904108 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 108903958 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 108915753 uncharacterized protein LOC108915753 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 108911888 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 108906173 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 108913256 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 108910785 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 108917528 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 108913762 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 108909569 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 108913667 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 108904359 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 108912983 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 108907016 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 108917369 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 108910497 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 108912578 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 108903797 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 108906101 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 108908673 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 108917046 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 108909032 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 111691508 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 108917525 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 108903301 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 108917391 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 108907443 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 108909244 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 108904676 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 108916542 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 108908389 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 108905783 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 108905867 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 108917577 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 108913466 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 108909181 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 108913190 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 108911704 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 108917670 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 108913541 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 108917391 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 108907443 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 108909244 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 108915733 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 108905749 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 108909612 DNA excision repair protein haywire K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 108907403 TFIIH basal transcription factor complex helicase XPD subunit isoform X2 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 108917344 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 108906724 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 108910499 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 108907817 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 108906910 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 108908215 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 108908818 cyclin-H K06634 CCNH; cyclin H
E 108909760 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 108913276 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 108907102 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 108904564 uncharacterized protein LOC108904564 K10740 RPA3; replication factor A3
D Other NER factors
E 108916898 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 108906359 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 108915963 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 108908366 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 108912983 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 108914647 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 108916126 cullin-3 K03869 CUL3; cullin 3
E 108917351 cullin-5 K10612 CUL5; cullin 5
E 108905049 elongin-C K03872 ELOC; elongin-C
E 108910008 elongin-B K03873 ELOB; elongin-B
E 108910604 transcription elongation factor B polypeptide 3 isoform X1 K15076 ELOA; elongin-A
E 108904739 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 108914081 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 108906283 probable DNA mismatch repair protein Msh6 isoform X2 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 108906584 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 108916388 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 108910739 LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh3-like K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 108911888 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 108906173 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 108913256 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 108913276 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 108907102 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 108904564 uncharacterized protein LOC108904564 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 108907882 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 108911006 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 108911855 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 108903479 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 108905057 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 108913667 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 108909103 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 108917046 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 108912983 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 108916627 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 108904716 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 108917919 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 108913978 uncharacterized protein LOC108913978 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108903912 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 108913978 uncharacterized protein LOC108913978 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108906337 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 108917860 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 108916722 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 108913978 uncharacterized protein LOC108913978 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108917901 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 108913978 uncharacterized protein LOC108913978 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108916627 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 108904716 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 108917919 nibrin K10867 NBN; nibrin
D BRCA complex
E 108913978 uncharacterized protein LOC108913978 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 108915759 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 108915759 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 108907847 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 108904570 DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 108911090 DNA repair protein XRCC2 homolog K10879 XRCC2; DNA-repair protein XRCC2
E 108903581 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 108911824 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 108905974 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 108916467 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 108913407 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 108904670 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 108915247 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 108909992 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 108904670 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 108914644 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 108906466 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 108907432 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 108913276 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 108907102 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 108904564 uncharacterized protein LOC108904564 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 108909648 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 108910829 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 108911945 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 108913897 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 108908264 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 108907257 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 108908144 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 108918025 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 108904201 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 108906468 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 108905667 non-structural maintenance of chromosomes element 4 homolog A isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 108907176 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 108914949 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 108907670 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 108906596 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 108905988 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 108916006 spatacsin K19026 SPG11; spatacsin
E 108917315 zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 108905509 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 108910348 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 108911272 uncharacterized protein LOC108911272 K23112 BRAT1; BRCA1-associated ATM activator 1
E 108912954 protein tilB homolog isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 108906780 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 108904520 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 108916788 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 108907361 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 108915783 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 108909761 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 108912326 ATP-dependent DNA helicase 2 subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 108915248 uncharacterized protein LOC108915248 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 108915253 uncharacterized protein LOC108915253 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 108908199 uncharacterized protein LOC108908199 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 108909059 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 108916627 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 108904716 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 108915356 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 108905733 uncharacterized protein LOC108905733 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 108907016 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 108903797 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 108906101 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 108904290 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 108904602 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 108904713 Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 108904909 enhancer of split mbeta protein-like K06054 HES1; hairy and enhancer of split 1
E 108914040 centromere protein S-like K11511 APITD1; centromere protein S
E 108909765 centromere protein X-like K15360 STRA13; centromere protein X
E 108910753 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 108904670 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 108914644 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 108906466 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 108907432 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 108906846 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 108913978 uncharacterized protein LOC108913978 isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
D Other FA pathway factors
E 108914781 fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 108915759 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 108907847 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 108917204 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 108908621 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 108915186 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 108908284 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 108906583 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 108908345 E3 ubiquitin-protein ligase CHFR-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 108917745 E3 ubiquitin-protein ligase RNF169-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 108904344 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 108909658 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 108908433 zinc finger CW-type PWWP domain protein 1-like K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 108916786 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 108916449 N-acetyltransferase eso1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 108915921 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 108908027 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 108916130 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 108916262 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 108915685 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 108903617 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 108916289 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 108913667 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 108908991 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 108910905 MATH and LRR domain-containing protein PFE0570w-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 108903857 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 108914346 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 108915523 cell cycle checkpoint protein RAD1-like isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 108911006 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 108911855 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108903479 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 108905057 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 108915523 cell cycle checkpoint protein RAD1-like isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 108904053 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 108913174 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 108912682 claspin-like K25773 CLSPN; claspin
C Triple T complex
D 108909537 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 108917945 large proline-rich protein bag6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 108905284 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 108910069 Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 108913050 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 108912590 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 108914996 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 108914024 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 108903434 ovarian-specific serine/threonine-protein kinase Lok-like isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 108903438 serine/threonine-protein kinase Chk2-like isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 108916442 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 108907439 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 108904087 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 108914038 neuron navigator 3 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 108907008 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 108917073 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 108916382 uncharacterized protein LOC108916382 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 108907496 plastin-2 K17336 PLS3; plastin-3
D 108917376 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 108909192 KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 108905621 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 108910337 vacuolar protein sorting-associated protein 4-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 108912622 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 108907991 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 108909190 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 108904610 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 108913597 uncharacterized protein LOC108913597 isoform X1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 108916684 homeobox protein Wariai-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 108911204 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 108915805 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 108909195 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 108906177 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 108914215 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 108910660 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 111692396 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 108913022 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 108914093 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 108909134 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E 108910754 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 108909358 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108909376 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108909380 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 108903958 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 108911556 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 108911556 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 111692396 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 108913022 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024