+E Replication protein KO
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DNA Replication Proteins - Aphis gossypii (cotton aphid)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 114126294 origin recognition complex subunit 1-like isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 114129873 LOW QUALITY PROTEIN: origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 114125758 origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 114130454 origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 114130262 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 114125770 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 114122889 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 114123176 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 114131314 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 114121365 cell division control protein 6 homolog isoform X1 K02213 CDC6; cell division control protein 6
D 114129087 DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 114131847 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 114128543 DNA replication licensing factor Mcm5-like K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 114131822 DNA replication licensing factor Mcm5-like K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 114122116 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 114130334 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 114122409 cyclin-A2 K06627 CCNA; cyclin-A
D 114125620 G1/S-specific cyclin-E K06626 CCNE; G1/S-specific cyclin-E1
D 114127444 cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 114125435 cell division cycle 7-related protein kinase-like K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 114127569 DNA replication complex GINS protein PSF1-like isoform X1 K10732 GINS1; GINS complex subunit 1
D 114121327 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 114123839 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 114128227 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 114130739 DNA topoisomerase 2-binding protein 1-B isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 114128597 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 114124244 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 114125952 cell division control protein 45 homolog isoform X1 K06628 CDC45; cell division control protein 45
D 114122928 DNA helicase MCM8 isoform X2 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 114120214 DNA helicase MCM9-like K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 114128470 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 114131595 mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 114130174 cyclin-dependent kinase 2-interacting protein-like K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 114125223 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 114128395 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 114120439 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 114124466 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
D 114130576 uncharacterized protein LOC114130576 isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 114120742 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 114120926 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 114119350 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 114128351 uncharacterized protein LOC114128351 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 114122085 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 114130924 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 114129179 origin recognition complex subunit 1-like K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 114129158 LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 114121190 DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 114120034 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 114120296 LOW QUALITY PROTEIN: replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 114120492 replication protein A 32 kDa subunit-B K10739 RFA2; replication factor A2
D 114130481 uncharacterized protein LOC114130481 K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 114120789 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 114122298 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 114128924 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 114119922 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 114128560 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 114125523 uncharacterized protein LOC114125523 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 114130928 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 114122888 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 114131864 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 114126040 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 114129144 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 114120840 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 114122910 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 114131797 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
B DNA Replication Termination Factors
C DNA methylation enzymes
D 114123209 DNA (cytosine-5)-methyltransferase 1-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 114123222 DNA (cytosine-5)-methyltransferase PliMCI-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 114130880 geminin-like K10749 GMNN; geminin
D 114132017 geminin-like K10749 GMNN; geminin
D 114127364 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 114121266 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 114124311 cyclin-dependent kinase 1-like isoform X2 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 114128655 cyclin-dependent kinase 1-A-like isoform X2 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 114132543 cyclin-dependent kinase 1-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 114128021 uncharacterized protein LOC114128021 isoform X2 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 114121699 telomerase-binding protein EST1A-like K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 114121100 nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 114125867 telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 114123173 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 114127328 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 114129502 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 114126639 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 114125867 telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 114125158 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 114125902 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 114120291 small nuclear ribonucleoprotein Sm D2-like K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 114131319 small nuclear ribonucleoprotein Sm D2-like K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 114120438 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 114123617 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 114127201 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 114127726 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 126549348 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 126551563 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 114120937 enhanced level of genomic instability 1 K11134 ELG1; telomere length regulation protein
D 114122298 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 114128924 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 114119922 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 114128560 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 114120189 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 114127380 nibrin K10867 NBN; nibrin
C Other termination factors
D 114119972 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 114129382 LOW QUALITY PROTEIN: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 114124653 recQ-like DNA helicase Blm isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 114126638 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 114129523 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 114119077 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 114124357 poly [ADP-ribose] polymerase tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 114123677 PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 114133023 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 114119135 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 114123189 transcriptional activator protein Pur-beta-B isoform X3 K21772 PURA; transcriptional activator protein Pur-alpha
D 114130812 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 114128212 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 114132020 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 114120833 DNA topoisomerase I, mitochondrial K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 114131395 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 114123064 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 114125806 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 114124644 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 114125523 uncharacterized protein LOC114125523 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 114130928 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 114125523 uncharacterized protein LOC114125523 isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 114130928 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 114120840 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 114122910 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025