+C Two-component system KO
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Two-Component System - Amycolatopsis mediterranei U32
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
B SenX3-RegX3 (phosphate starvation response)
C AMED_0459 senX; two-component system histidine kinase K07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]
C AMED_0460 regX; two-component system response regulator K07776 regX3; two-component system, OmpR family, response regulator RegX3
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C AMED_1896 kdpD; two-component system sensor kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C AMED_1897 kdpE; two-component system response regulator K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
C AMED_5602 mprB; two-component system histidine kinase K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]
C AMED_3690 mprB; two-component system histidine kinase K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]
C AMED_8332 mprB; two-component system histidine kinase K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]
C AMED_5666 mprB; two-component system histidine kinase K07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]
C AMED_3691 mprA; two-component system response regulator K07669 mprA; two-component system, OmpR family, response regulator MprA
C AMED_8333 mprA; two-component system response regulator K07669 mprA; two-component system, OmpR family, response regulator MprA
C AMED_5601 mprA; two-component system response regulator K07669 mprA; two-component system, OmpR family, response regulator MprA
C AMED_5667 mprA; two-component system response regulator K07669 mprA; two-component system, OmpR family, response regulator MprA
B MtrB-MtrA (osmotic stress response)
C AMED_7992 mtrB; two-component system histidine kinase K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]
C AMED_6914 mtrB; two-component system histidine kinase K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]
C AMED_3013 mtrB; two-component system histidine kinase K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]
C AMED_3767 mtrB; two-component system histidine kinase K07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]
C AMED_7993 mtrA; two-component system response regulator K07670 mtrA; two-component system, OmpR family, response regulator MtrA
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
C AMED_8287 two-component system histidine kinase K18351 vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
C AMED_8142 two-component system histidine kinase K18351 vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
C AMED_8286 two-component system response regulator K18352 vanRAc; two-component system, OmpR family, response regulator VanR
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C AMED_8929 two-component system sensor kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AMED_6746 two-component system histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AMED_3158 two-component system histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AMED_1739 two-component system histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AMED_1738 two-component system response regulator K02483 K02483; two-component system, OmpR family, response regulator
C AMED_3159 two-component system response regulator K02483 K02483; two-component system, OmpR family, response regulator
C AMED_8930 two-component system response regulator K02483 K02483; two-component system, OmpR family, response regulator
C AMED_5078 two-component system response regulator K02483 K02483; two-component system, OmpR family, response regulator
C AMED_0896 two-component system response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
C AMED_4549 desK; two-component system histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C AMED_6601 desK; two-component system histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C AMED_6887 desK; two-component system histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C AMED_4548 desR; two-component system response regulator K07693 desR; two-component system, NarL family, response regulator DesR
C AMED_6600 desR; two-component system response regulator K07693 desR; two-component system, NarL family, response regulator DesR
C AMED_6883 desR; two-component system response regulator K07693 desR; two-component system, NarL family, response regulator DesR
C AMED_6886 desR; two-component system response regulator K07693 desR; two-component system, NarL family, response regulator DesR
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
C AMED_4378 two-component system sensor kinase K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]
C AMED_5571 devS; two-component system sensor kinase K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]
C AMED_5471 devS; two-component system sensor kinase K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]
C AMED_0166 two-component system sensor kinase K07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]
C AMED_4379 devR; two-component system response regulator K07695 devR; two-component system, NarL family, response regulator DevR
C AMED_5573 devR; two-component system response regulator K07695 devR; two-component system, NarL family, response regulator DevR
C AMED_5473 two-component system response regulator K07695 devR; two-component system, NarL family, response regulator DevR
C AMED_0167 devR; two-component system response regulator K07695 devR; two-component system, NarL family, response regulator DevR
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
C AMED_0256 two-component system histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C AMED_0131 two-component system histidine kinase K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C AMED_1589 two-component system histidine kinase K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
C AMED_3937 formyl transferase-like protein K19640 hypX; putative two-component system protein, hydrogenase maturation factor HypX/HoxX
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C AMED_4130 cheB; chemotaxis-specific methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C AMED_4131 cheB; chemotaxis-specific methylesterase CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C AMED_4133 cheR; chemotaxis protein methyltransferase CheR K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
C AMED_3591 cheR; chemotaxis protein methyltransferase CheR K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
C AMED_7972 two-component system sensor kinase K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]
C AMED_6148 nasT; two-component system response regulator K22010 pdtaR; two-component system, response regulator PdtaR
B NasS-NasT
B Unclassified
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023