+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Amycolatopsis mediterranei S699
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
E AMES_0615 rifA; rifamycin polyketide synthase K15670 rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74]
E AMES_0616 rifB; rifamycin polyketide synthase K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6
E AMES_0617 rifC; rifamycin polyketide synthase K15672 rifC_D; rifamycin polyketide synthase modules 7 and 8
E AMES_0618 rifD; rifamycin polyketide synthase K15672 rifC_D; rifamycin polyketide synthase modules 7 and 8
E AMES_0619 rifE; rifamycin polyketide synthase K15673 rifE; rifamycin polyketide synthase modules 9 and 10
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
E AMES_3329 phenolpthiocerol synthesis type-I polyketide synthase PpsD K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
D AMES_6759 type I polyketide synthase K15314 sgcE; enediyne polyketide synthase
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
E AMES_5367 actV; polyketide cyclase/dehydratase K14670 whiEVI; aromatase
E AMES_5372 polyketide synthesis cyclase K14671 whiEVII; cyclase
C C7-C14 cyclized polyketide type
D Octaketide PKS
E AMES_5370 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E AMES_5369 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E AMES_5368 actI; 3-oxoacyl-ACP synthase acylcarrier protein K05553 actI3; minimal PKS acyl carrier protein
E AMES_1359 beta-lactamase class B K05555 actIV; cyclase [EC:4.-.-.-]
E AMES_0395 beta-lactamase class B K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E AMES_5370 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E AMES_5369 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E AMES_5368 actI; 3-oxoacyl-ACP synthase acylcarrier protein K05553 actI3; minimal PKS acyl carrier protein
D Decaketide PKS
E AMES_5370 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E AMES_5369 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
E AMES_5368 actI; 3-oxoacyl-ACP synthase acylcarrier protein K05553 actI3; minimal PKS acyl carrier protein
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D AMES_3988 mbtH; MbtH protein K05375 mbtH; MbtH protein
D AMES_4971 mbtH; MbtH protein K05375 mbtH; MbtH protein
D AMES_6146 mbtH; MbtH protein K05375 mbtH; MbtH protein
D AMES_4709 mbtH; MbtH protein K05375 mbtH; MbtH protein
D AMES_4734 mbtH; MbtH protein K05375 mbtH; MbtH protein
D AMES_3069 mbtH; MbtH protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
C Bacillibactin synthetase
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
C Myxochelin synthetase
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
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APolyketide tailoring proteins
B Hydrolase
C AMES_6758 hypothetical protein K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
C AMES_6278 hydroxylacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]
B Oxygenase
C AMES_0644 mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase
C AMES_7228 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C AMES_4260 epocide hydrolase domain-containing protein K21159 sgcF; epoxide hydrolase
C AMES_4283 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C AMES_6747 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C AMES_3144 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C AMES_3889 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C AMES_6122 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase
C AMES_5479 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C AMES_5371 cupin 2 domain-containing protein K14673 whiEII; putative monooxygenase
C AMES_5377 FAD-dependent oxidoreductase K14672 whiEVIII; putative polyketide hydroxylase
C AMES_5376 FAD-dependent oxidoreductase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C AMES_0648 methyltransferase type 11 K15467 rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315]
C AMES_3195 O-methyltransferase-related protein K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C AMES_4698 acyl-CoA dehydrogenase K16026 asm15; methoxymalonate biosynthesis protein
C AMES_4697 FkbH-like protein K16027 asm16; methoxymalonate biosynthesis protein
C AMES_0620 rifF; N-acetyltransferase/amide synthase K15466 rifF; amide synthase
C AMES_0645 acyltransferase K16023 rif20; acetyltransferase
C AMES_6565 cyclase-dehydratase K14627 actVI3; dehydratase [EC:4.2.1.-]
C AMES_6768 hypothetical protein K21160 sgcE2; enediyne biosynthesis protein E2
C AMES_6767 enediyne biosynthesis protein K21161 sgcE3; enediyne biosynthesis protein E3
C AMES_6766 ASPIC/UnbV domain-containing protein K21162 sgcE4; enediyne biosynthesis protein E4
C AMES_6765 hypothetical protein K21163 sgcE5; enediyne biosynthesis protein E5
C AMES_6764 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7
C AMES_6763 hypothetical protein K21165 sgcE8; enediyne biosynthesis protein E8
C AMES_6762 oxidoreductase K21166 sgcE9; enediyne biosynthesis protein E9
C AMES_6760 wyosine base formation K21167 sgcE11; enediyne biosynthesis protein E11
C AMES_6757 oxidoreductase K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
C AMES_3910 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
C AMES_5434 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
B Others
C AMES_0890 (S)-2-hydroxy-acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C AMES_4740 aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024