+E Polyketide biosynthesis proteins KO #

  Polyketide Biosynthesis Proteins - Amycolatopsis mediterranei S699

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APolyketide synthase (PKS) B Modular type I PKS C cis-AT PKS D Erythronolide PKS D Oleandomycin synthase D Pikromycin PKS D Avermectin PKS D Tylactone synthase D Protomycinolide IV synthase D Niddamycin PKS D Rapamycin PKS D Immunomycin PKS D Ansamitocin PKS D Rifamycin PKS E RAM_03155 rifamycin polyketide synthase K15670 rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74] E RAM_03160 rifamycin polyketide synthase K15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6 E RAM_03165 rifamycin polyketide synthase K15672 rifC_D; rifamycin polyketide synthase modules 7 and 8 E RAM_03170 rifamycin polyketide synthase K15672 rifC_D; rifamycin polyketide synthase modules 7 and 8 E RAM_03175 rifamycin polyketide synthase K15673 rifE; rifamycin polyketide synthase modules 9 and 10 D Polyene macrolide PKS D Pimaricinolide synthase D Candicidin PKS D Soraphen PKS D Stigmatellin PKS D Mycolactone PKS D Coelimycin PKS D Aureothin PKS D Spectinabilin PKS D Phthiocerol / Phenolphthiocerol PKS E RAM_17125 phenolpthiocerol synthesis type-I polyketide synthase PpsD K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292] C trans-AT PKS D Bacillanene hybrid PKS-NRPS D Chivosazol hybrid PKS-NRPS E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133] D Macrolactin PKS D Difficidin PKS D Rhizoxin hybrid PKS-NRPS D Myxovirescin hybrid PKS-NRPS E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932] D Albicidin synthase, hybrid PKS-NRPS E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516] E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523] D Etnangien PKS E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193] B Iterative type I PKS C Fungal nonreducing PKS (NR-PKS) C Fungal partially reducing PKS (PR-PKS) C Fungal highly reducing PKS (HR-PKS) C Fungal hybrid type D Zearalenone synthase D Asperfuranone NR/HR-PKS E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034] E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036] C Bacterial type D RAM_35220 type I polyketide synthase K15314 sgcE; enediyne polyketide synthase B Type II PKS C C9-C14 cyclized polyketide type D Spore pigment PKS E RAM_27690 polyketide cyclase/dehydratase K14670 whiEVI; aromatase E RAM_27715 polyketide synthesis cyclase K14671 whiEVII; cyclase C C7-C14 cyclized polyketide type D Octaketide PKS E RAM_27705 3-oxoacyl-[acyl-carrier-protein] synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E RAM_27700 3-oxoacyl-[acyl-carrier-protein] synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E RAM_27695 3-oxoacyl-ACP synthase acylcarrier protein K05553 actI3; minimal PKS acyl carrier protein E RAM_02025 beta-lactamase class B K05555 actIV; cyclase [EC:4.-.-.-] E RAM_06935 beta-lactamase class B K05555 actIV; cyclase [EC:4.-.-.-] D Nonaketide PKS E RAM_27705 3-oxoacyl-[acyl-carrier-protein] synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E RAM_27700 3-oxoacyl-[acyl-carrier-protein] synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E RAM_27695 3-oxoacyl-ACP synthase acylcarrier protein K05553 actI3; minimal PKS acyl carrier protein D Decaketide PKS E RAM_27705 3-oxoacyl-[acyl-carrier-protein] synthase II K05551 actI1; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E RAM_27700 3-oxoacyl-[acyl-carrier-protein] synthase II K05552 actI2; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235] E RAM_27695 3-oxoacyl-ACP synthase acylcarrier protein K05553 actI3; minimal PKS acyl carrier protein B Type III PKS C Plant type C Fungal type C Bacterial type D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550] D ------ arsC; alkylpyrone synthase [AVN:Avin_29530] B PKS-NRPS hybrid C Bacterial type (modular) D Myxalamid hybrid PKS-NRPS D Myxothiazol hybrid PKS-NRPS E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019] D Coronatine hybrid PKS-NRPS D Microcystin synthetase D Epothilone synthetase D Bleomycin synthetase D Colibactin synthetase C Fungal type (trans-ER, iterative) D Aspyridone synthetase C Fungal type (iterative) # ANonribosomal peptide synthetase (NRPS) B Linear NRPS C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545] C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500] C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000] C ACV synthetase C Bacitracin synthetase C Viomycin synthetase C Pristinamycin I synthetase C Tyrocidine synthetase C Surfactin family lipopeptide synthetase C Iturin family lipopeptide synthetase C Fengycin family lipopeptide synthetase C Arthrofactin type cyclic lipopeptide synthetase C Vancomycin synthetase C Nocardicin synthetase D RAM_15780 MbtH protein K05375 mbtH; MbtH protein D RAM_20570 MbtH protein K05375 mbtH; MbtH protein D RAM_24270 MbtH protein K05375 mbtH; MbtH protein D RAM_24400 MbtH protein K05375 mbtH; MbtH protein D RAM_25615 MbtH protein K05375 mbtH; MbtH protein D RAM_31990 MbtH protein K05375 mbtH; MbtH protein C Bialaphos synthetase C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase B Iterative NRPS C Enterobactin synthetase C Bacillibactin synthetase C Gramicidin synthetase B Nonlinear NRPS C Yersiniabactin synthetase C Pyochelin synthetase C Mycobactin synthetase C Vibriobactin synthetase C Myxochelin synthetase C Petrobacin synthetase C Syringomycin synthetase C Vanchrobactin synthetase C Isonitrile lipopeptide synthase # APolyketide tailoring proteins B Hydrolase C RAM_35215 hypothetical protein K15315 sgcE10; enediyne core biosynthesis thioesterase B Ketoreductase C RAM_32655 hydroxylacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-] B Oxygenase C RAM_03300 mhpA; 3-(3-hydroxyphenyl)propionate hydroxylase K16022 rif19; flavoprotein hydroxylase C RAM_37725 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31] C RAM_16160 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C RAM_20055 epoxide hydrolase K21159 sgcF; epoxide hydrolase C RAM_21955 epocide hydrolase domain-containing protein K21159 sgcF; epoxide hydrolase C RAM_22080 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C RAM_28275 epoxide hydrolase K21159 sgcF; epoxide hydrolase C RAM_31870 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C RAM_35150 microsomal epoxide hydrolase K21159 sgcF; epoxide hydrolase C RAM_27710 cupin 2 domain-containing protein K14673 whiEII; putative monooxygenase C RAM_27735 FAD-dependent oxidoreductase K14672 whiEVIII; putative polyketide hydroxylase C RAM_27740 FAD-dependent oxidoreductase K14672 whiEVIII; putative polyketide hydroxylase B Methylase C RAM_03320 methyltransferase type 11 K15467 rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315] C RAM_16420 O-methyltransferase-related protein K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303] B Glycosyltransferase B Halogenase B beta-Branched incorporating proteins B Others C RAM_24215 acyl-CoA dehydrogenase K16026 asm15; methoxymalonate biosynthesis protein C RAM_24210 FkbH-like protein K16027 asm16; methoxymalonate biosynthesis protein C RAM_03180 N-acetyltransferase/amide synthase K15466 rifF; amide synthase C RAM_03305 acyltransferase PapA5 K16023 rif20; acetyltransferase C RAM_34190 cyclase-dehydratase K14627 actVI3; dehydratase [EC:4.2.1.-] C RAM_35265 hypothetical protein K21160 sgcE2; enediyne biosynthesis protein E2 C RAM_35260 enediyne biosynthesis protein K21161 sgcE3; enediyne biosynthesis protein E3 C RAM_35255 ASPIC/UnbV domain-containing protein K21162 sgcE4; enediyne biosynthesis protein E4 C RAM_35250 hypothetical protein K21163 sgcE5; enediyne biosynthesis protein E5 C RAM_35245 cytochrome P450 K21164 sgcE7; enediyne biosynthesis protein E7 C RAM_35240 hypothetical protein K21165 sgcE8; enediyne biosynthesis protein E8 C RAM_35235 oxidoreductase K21166 sgcE9; enediyne biosynthesis protein E9 C RAM_35225 wyosine base formation K21167 sgcE11; enediyne biosynthesis protein E11 C RAM_35210 oxidoreductase K21185 sgcE6; flavin reductase # ANonribosomal peptide tailoring proteins B Reductase B Thioesterase B Oxygenase B Glycosyltransferase C RAM_20165 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] C RAM_28035 glycosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310] B Aminotransferase B Others C RAM_04555 (S)-2-hydroxy-acid oxidase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46] C RAM_24430 aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13] ! #
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2025