+F Repair protein KO
#
DNA Repair and Recombination Proteins - Amycolatopsis methanolica
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D AMETH_1090 ogt; methylated-DNA-protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D AMETH_5842 ogt; O-6-methylguanine DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D AMETH_6206 phrB; deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E AMETH_1547 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E AMETH_2685 alkA; DNA-3-methyladenine glycosylase II K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E AMETH_6540 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E AMETH_6635 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E AMETH_6412 DNA/RNA helicase, superfamily II K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D AMETH_3465 DNA hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_5829 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_4601 putative DNA hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_2799 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_0984 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_4939 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_5368 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_4782 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D AMETH_1090 ogt; methylated-DNA-protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D AMETH_5842 ogt; O-6-methylguanine DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D AMETH_6206 phrB; deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E AMETH_1547 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E AMETH_6936 mug; TDG/mug DNA glycosylase family protein K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E AMETH_4920 dpo; uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E AMETH_5934 udgB; uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E AMETH_5841 alkA; DNA repair protein and transcriptional regulator, AraC family K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E AMETH_5558 alkA; DNA-3-methyladenine glycosylase II K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E AMETH_2685 alkA; DNA-3-methyladenine glycosylase II K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E AMETH_6540 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E AMETH_0948 tag; DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E AMETH_0154 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E AMETH_1566 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E AMETH_1700 nei; formamidopyrimidine-DNA glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E AMETH_2505 nei; endonuclease VIII K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E AMETH_6635 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E AMETH_2301 xthA; exodeoxyribonuclease III Xth K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E AMETH_0798 xthA; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E AMETH_4125 xthA; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E AMETH_7010 nfo; endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
D DNA ligase
E AMETH_1485 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E AMETH_2958 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E AMETH_2652 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E AMETH_2615 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
E AMETH_4124 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E AMETH_1125 uvrD2; ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AMETH_0762 uvrD; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AMETH_1026 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AMETH_2958 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E AMETH_1485 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F AMETH_0641 rpoB; DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F AMETH_0642 rpoC; DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F AMETH_0683 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F AMETH_4139 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F AMETH_5951 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
E AMETH_5849 xseA; exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E AMETH_5851 xseB; exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E AMETH_5161 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E AMETH_0005 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E AMETH_1556 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E AMETH_1791 holA; DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E AMETH_6590 holB; DNA polymerase III K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E AMETH_3911 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E AMETH_5120 dnaQ; DNA-directed DNA polymerase K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E AMETH_6687 dnaX; DNA polymerase III, subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E AMETH_1485 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E AMETH_1125 uvrD2; ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AMETH_0762 uvrD; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AMETH_1026 ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AMETH_1682 ssb; single-strand binding protein K03111 ssb; single-strand DNA-binding protein
E AMETH_7015 ssb; single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E AMETH_5022 recA; recA protein K03553 recA; recombination protein RecA
E AMETH_2873 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E AMETH_2874 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E AMETH_2872 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E AMETH_4136 priA; primosomal protein N K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E AMETH_5843 sbcC; DNA repair ATPase K03546 sbcC; DNA repair protein SbcC/Rad50
E AMETH_5844 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E AMETH_5022 recA; recA protein K03553 recA; recombination protein RecA
E AMETH_6510 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E AMETH_0007 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E AMETH_1456 putative transcriptional regulator K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E AMETH_1550 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E AMETH_0192 putative transcriptional regulator K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E AMETH_1934 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
E AMETH_6684 recR; Recombination protein recR K06187 recR; recombination protein RecR
E AMETH_2692 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E AMETH_2873 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E AMETH_2874 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E AMETH_2872 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E AMETH_5843 sbcC; DNA repair ATPase K03546 sbcC; DNA repair protein SbcC/Rad50
E AMETH_5844 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E AMETH_0281 Ku protein K10979 ku; DNA end-binding protein Ku
E AMETH_5205 DNA end-binding protein Ku K10979 ku; DNA end-binding protein Ku
E AMETH_4914 lig; DNA ligase D/DNA polymerase LigD K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E AMETH_5252 DNA polymerase LigD, ligase domain protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E AMETH_1315 lig; ATP-dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
E AMETH_3587 lig; ATP-dependent DNA ligase K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F AMETH_0010 gyrA; DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F AMETH_1271 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F AMETH_0009 gyrB; DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F AMETH_1270 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F AMETH_6594 topA; DNA topoisomerase IA K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F AMETH_4908 topA; DNA topoisomerase IB K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F AMETH_1528 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F AMETH_1934 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
F AMETH_6684 recR; Recombination protein recR K06187 recR; recombination protein RecR
F AMETH_1485 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F AMETH_2707 recQ; Helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F AMETH_1782 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F AMETH_5640 recQ; ATP-dependent DNA helicase, RecQ family K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F AMETH_2652 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F AMETH_2615 uvrB; UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D AMETH_2735 dinP; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D AMETH_4347 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D AMETH_2508 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D AMETH_5022 recA; recA protein K03553 recA; recombination protein RecA
D AMETH_1962 lexA; LexA family transcriptional regulator K01356 lexA; repressor LexA [EC:3.4.21.88]
D AMETH_4984 lexA; LexA family transcriptional regulator K01356 lexA; repressor LexA [EC:3.4.21.88]
D AMETH_2692 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D AMETH_0775 DNA polymerase K14161 imuB; protein ImuB
D AMETH_0777 dnaE; Error-prone DNA polymerase K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D AMETH_1682 ssb; single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D AMETH_7015 ssb; single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D AMETH_6258 hypothetical protein K14623 dinD; DNA-damage-inducible protein D
D AMETH_6317 hypothetical protein K14623 dinD; DNA-damage-inducible protein D
D AMETH_5021 recX; regulatory protein recX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D AMETH_1404 dinG; ATP-dependent DNA helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D AMETH_3913 DEAD/DEAH box helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D AMETH_5026 lhr; DEAD/H associated domain protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D AMETH_3465 DNA hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_5829 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_4601 putative DNA hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_2799 hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_0984 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_4939 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_5368 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AMETH_1529 NUDIX hydrolase K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]
D AMETH_2700 nudF; NTP pyrophosphohydrolase K01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D AMETH_4782 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D AMETH_4981 nrdA; ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D AMETH_4044 nrdA; ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D AMETH_1834 nrdB; ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D AMETH_6378 nrdB; ribonucleotide reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D AMETH_4045 nrdB; ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D AMETH_6092 nrdB; ribonucleotide-diphosphate reductase subunit beta K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024