+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Amycolatopsis sp. AA4
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
D CU254_17290 beta-ketoacyl synthase K15314 sgcE; enediyne polyketide synthase
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
C C7-C14 cyclized polyketide type
D Octaketide PKS
E CU254_30580 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
E CU254_00730 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
E CU254_34460 MBL fold metallo-hydrolase K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
D Decaketide PKS
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D CU254_20490 MbtH family protein K05375 mbtH; MbtH protein
D CU254_12970 MbtH family protein K05375 mbtH; MbtH protein
D CU254_16025 MbtH family protein K05375 mbtH; MbtH protein
D CU254_16105 MbtH family protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D CU254_12985 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D CU254_12985 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
D CU254_12950 non-ribosomal peptide synthetase K04788 mbtB; mycobactin phenyloxazoline synthetase
C Vibriobactin synthetase
D CU254_12985 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D CU254_12985 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D CU254_12985 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
C CU254_17295 acyl-CoA thioesterase K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
C CU254_34485 hydroxylacyl-CoA dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]
B Oxygenase
C CU254_13715 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CU254_41355 cytochrome P450 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C CU254_27965 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_40120 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_40495 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_14905 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_17025 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_05320 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_31470 epoxide hydrolase K21159 sgcF; epoxide hydrolase
C CU254_27895 FAD-dependent oxidoreductase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C CU254_34420 methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
B Others
C CU254_26650 cyclase K14627 actVI3; dehydratase [EC:4.2.1.-]
C CU254_17280 DUF1702 domain-containing protein K21161 sgcE3; enediyne biosynthesis protein E3
C CU254_17285 hypothetical protein K21162 sgcE4; enediyne biosynthesis protein E4
C CU254_17405 homocysteine S-methyltransferase family protein K21169 calE2; enediyne biosynthesis protein CalE2
C CU254_17325 hypothetical protein K21170 calE3; enediyne biosynthesis protein CalE3
C CU254_17390 cysteine desulfurase K21171 calE4; enediyne biosynthesis protein CalE4
C CU254_17395 class I SAM-dependent methyltransferase K21172 calE5; enediyne biosynthesis protein CalE5
C CU254_17400 PLP-dependent transferase K21173 calE6; methionine gamma-lyase
C CU254_17365 aminotransferase class V-fold PLP-dependent enzyme K21174 calE9; enediyne biosynthesis protein CalE9
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
B Aminotransferase
B Others
C CU254_03020 alpha-hydroxy-acid oxidizing protein K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C CU254_14925 aspartate/glutamate racemase family protein K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024