+E Polyketide biosynthesis proteins KO
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Polyketide Biosynthesis Proteins - Amycolatopsis sp. YIM 10
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APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
E YIM_33630 ppsA4; Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsA K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]
E YIM_42700 ppsA7; Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsA K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
D Chivosazol hybrid PKS-NRPS
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
D Difficidin PKS
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:ANIA_01034]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:ANIA_01036]
C Bacterial type
D YIM_40785 ppsA6; Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsA K15314 sgcE; enediyne polyketide synthase
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
C C7-C14 cyclized polyketide type
D Octaketide PKS
E YIM_23710 Actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
E YIM_19405 Metallo-beta-lactamase superfamily protein K05555 actIV; cyclase [EC:4.-.-.-]
D Nonaketide PKS
E YIM_23710 Actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
D Decaketide PKS
E YIM_23710 Actinorhodin polyketide synthase acyl carrier protein K05553 actI3; minimal PKS acyl carrier protein
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D YIM_22225 Alpha-pyrone synthesis polyketide synthase-like Pks11 K16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246]
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
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ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:ANIA_02545]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
D YIM_39185 srfAA; Surfactin synthase subunit 1 K12743 PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [EC:6.3.2.26]
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
C Iturin family lipopeptide synthetase
C Fengycin family lipopeptide synthetase
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D YIM_40210 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_18515 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_18520 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_17240 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_22885 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_32320 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_25775 MbtH-like protein K05375 mbtH; MbtH protein
D YIM_25315 MbtH-like protein K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D YIM_26035 dhbB2; Isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D YIM_26035 dhbB2; Isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D YIM_26035 dhbB2; Isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D YIM_26035 dhbB2; Isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D YIM_26035 dhbB2; Isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
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APolyketide tailoring proteins
B Hydrolase
C YIM_40780 1,4-dihydroxy-2-naphthoyl-CoA hydrolase K15315 sgcE10; enediyne core biosynthesis thioesterase
B Ketoreductase
C YIM_22710 lcdH1; L-carnitine dehydrogenase K05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]
B Oxygenase
C YIM_39550 Cytochrome P450-SU1 K16389 amphN; cytochrome P450 monooxygenase
C YIM_39555 penM; Pentalenolactone synthase K16390 amphL; cytochrome P450 monooxygenase
C YIM_37285 Cytochrome P450 107B1 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C YIM_40790 Cytochrome P450 107B1 K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
C YIM_40820 nphA2; 4-nitrophenol 2-monooxygenase, oxygenase component K21184 sgcC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]
C YIM_42885 Fluoroacetate dehalogenase K21159 sgcF; epoxide hydrolase
C YIM_18405 Fluoroacetate dehalogenase K21159 sgcF; epoxide hydrolase
C YIM_04210 dhmA2; Haloalkane dehalogenase K21159 sgcF; epoxide hydrolase
C YIM_33920 Soluble epoxide hydrolase K21159 sgcF; epoxide hydrolase
C YIM_24530 haloalkane dehalogenase K21159 sgcF; epoxide hydrolase
C YIM_25920 hypothetical protein K21159 sgcF; epoxide hydrolase
C YIM_26600 hypothetical protein K21159 sgcF; epoxide hydrolase
C YIM_29860 Soluble epoxide hydrolase K21159 sgcF; epoxide hydrolase
C YIM_22215 caiD5; Carnitinyl-CoA dehydratase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
C YIM_41465 tfdB2; 2,4-dichlorophenol 6-monooxygenase K14672 whiEVIII; putative polyketide hydroxylase
B Methylase
C YIM_09465 dnrK1; Carminomycin 4-O-methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
C YIM_15125 dnrK2; Carminomycin 4-O-methyltransferase K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
B Glycosyltransferase
C YIM_39540 rebG5; 4'-demethylrebeccamycin synthase K16388 amphDI; polyene glycosyltransferase
B Halogenase
C YIM_16050 lodB; Putative FAD-dependent oxidoreductase LodB K16431 cepH; FAD-dependent halogenase [EC:1.14.19.-]
B beta-Branched incorporating proteins
B Others
C YIM_38365 hypothetical protein K14627 actVI3; dehydratase [EC:4.2.1.-]
C YIM_41025 hypothetical protein K21160 sgcE2; enediyne biosynthesis protein E2
C YIM_41020 hypothetical protein K21161 sgcE3; enediyne biosynthesis protein E3
C YIM_41015 ASPIC and UnbV K21162 sgcE4; enediyne biosynthesis protein E4
C YIM_41010 hypothetical protein K21163 sgcE5; enediyne biosynthesis protein E5
C YIM_41005 Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase K21164 sgcE7; enediyne biosynthesis protein E7
C YIM_41000 hypothetical protein K21165 sgcE8; enediyne biosynthesis protein E8
C YIM_40995 choA2; Cholesterol oxidase precursor K21166 sgcE9; enediyne biosynthesis protein E9
C YIM_40975 hypothetical protein K21167 sgcE11; enediyne biosynthesis protein E11
C YIM_40805 lgrB10; Linear gramicidin synthase subunit B K21186 sgcC5; condensation enzyme
C YIM_40775 hsaB2; Flavin-dependent monooxygenase, reductase subunit HsaB K21185 sgcE6; flavin reductase
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ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
B Oxygenase
B Glycosyltransferase
C YIM_26400 novM3; L-noviosyl transferase K16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]
B Aminotransferase
B Others
C YIM_39180 cefE1; Deacetoxycephalosporin C synthase K04126 PCBC; isopenicillin-N synthase [EC:1.21.3.1]
C YIM_39195 cefD; Isopenicillin N epimerase K04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]
C YIM_39200 cefE2; Deacetoxycephalosporin C synthase K12744 cefE; deacetoxycephalosporin-C synthase [EC:1.14.20.1]
C YIM_39165 cefF; Deacetoxycephalosporin C hydroxylase K12745 cefF; deacetoxycephalosporin-C hydroxylase [EC:1.14.11.26]
C YIM_39160 novN2; Decarbamoylnovobiocin carbamoyltransferase K04128 cmcH; hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7]
C YIM_39175 Rhamnosyl O-methyltransferase precursor K18062 cmcI; cephamycin C biosynthesis protein
C YIM_39170 hypothetical protein K18063 cmcJ; cephamycin C biosynthesis protein
C YIM_21185 Lactate 2-monooxygenase K16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]
C YIM_22215 caiD5; Carnitinyl-CoA dehydratase K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
C YIM_22195 caiD4; Carnitinyl-CoA dehydratase K16426 dpgD; dehydration protein DpgD
C YIM_40855 Aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
C YIM_25325 Aspartate racemase K01779 racD; aspartate racemase [EC:5.1.1.13]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: June 19, 2024