+C Two-component system KO
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Two-Component System - Anoxybacillus sp. B7M1
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C GFC29_2013 sensory box protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C GFC29_1545 his Kinase A domain protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C GFC29_2014 phoP; alkaline phosphatase synthesis transcriptional regulatory protein phoP K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
C GFC29_1546 HAMP domain protein K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]
C GFC29_3766 hypothetical protein K07775 resD; two-component system, OmpR family, response regulator ResD
C GFC29_1547 hypothetical protein K07775 resD; two-component system, OmpR family, response regulator ResD
B VicK-VicR (cell wall metabolism)
C GFC29_2717 yycG; sensor histidine kinase yycG K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
C GFC29_2718 yycF; transcriptional regulatory protein yycF K07668 vicR; two-component system, OmpR family, response regulator VicR
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
C GFC29_2479 histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein K11629 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3]
C GFC29_2480 hypothetical protein K11630 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
C GFC29_1429 HAMP domain protein K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C GFC29_1430 hypothetical protein K18941 arlR; two-component system, OmpR family, response regulator ArlR
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C GFC29_1544 hypothetical protein K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
C GFC29_3029 histidine kinase family protein K07680 comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3]
C GFC29_3188 bacterial regulatory s, luxR family protein K07691 comA; two-component system, NarL family, competent response regulator ComA
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
C GFC29_2442 degS; sensor protein degS K07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3]
C GFC29_2441 bacterial regulatory s, luxR family protein K07692 degU; two-component system, NarL family, response regulator DegU
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
C GFC29_81 histidine kinase family protein K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C GFC29_80 bacterial regulatory s, luxR family protein K11618 liaR; two-component system, NarL family, response regulator LiaR
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C GFC29_3461 GAF domain protein K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
C GFC29_984 5TMR of 5TMR-LYT family protein K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C GFC29_726 5TMR of 5TMR-LYT family protein K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C GFC29_208 5TMR of 5TMR-LYT family protein K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C GFC29_138 kinE; sporulation kinase E K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3]
C GFC29_2642 spo0F; sporulation initiation phosphotransferase F K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F
C GFC29_1646 spo0A; sporulation transcription factor Spo0A K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
C GFC29_3443 sensory box protein K11691 K11691; two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3]
C GFC29_3442 faeA-like family protein K11692 K11692; two-component system, CitB family, response regulator DctR
B MalK-MalR (malate transport)
B Unclassified
C GFC29_1365 sensory box protein K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
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ALytTR family
B LysS-LysR
C GFC29_710 5TMR of 5TMR-LYT family protein K07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3]
C GFC29_711 response regulator K07705 lytT; two-component system, LytTR family, response regulator LytT
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C GFC29_3245 hypothetical protein K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C GFC29_2632 cckA; two-component sensor histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C GFC29_2631 AAA domain family protein K02481 flgR; two-component system, NtrC family, response regulator
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ACheA family
B CheA-CheYBV (chemotaxis)
C GFC29_413 cheW-like domain protein K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C GFC29_545 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C GFC29_403 hypothetical protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C GFC29_412 cheB methylesterase family protein K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C GFC29_210 response regulator K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
C GFC29_650 histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C GFC29_649 response regulator K07719 glnL; two-component system, response regulator GlnL
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
C GFC29_663 HAMP domain protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C GFC29_680 HAMP domain protein K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C GFC29_567 helix-turn-helix domain protein K07720 yesN; two-component system, response regulator YesN
C GFC29_664 helix-turn-helix domain protein K07720 yesN; two-component system, response regulator YesN
C GFC29_1269 helix-turn-helix domain protein K07720 yesN; two-component system, response regulator YesN
C GFC29_1330 helix-turn-helix domain protein K07720 yesN; two-component system, response regulator YesN
C GFC29_681 helix-turn-helix domain protein K07720 yesN; two-component system, response regulator YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C GFC29_3246 histidine kinase family protein K19694 chiS; two-component system, sensor histidine kinase ChiS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023