+E Ubiquitin system KO
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Ubiquitin System - Auxenochlorella protothecoides
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C F751_2642 Ubiquitin-60S ribosomal protein L40-2 K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C F751_2321 Ubiquitin-40S ribosomal protein S27a-1 K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C F751_6968 40S ribosomal protein S30 K02983 RP-S30e; small subunit ribosomal protein S30e
C F751_5121 Autophagy-related protein 8d K08341 GABARAP; GABA(A) receptor-associated protein
C F751_3322 Ubiquitin-like protein ATG12A K08336 ATG12; ubiquitin-like protein ATG12
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C F751_6092 Ubiquitin-activating enzyme E1 2 K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C F751_3840 SUMO-activating enzyme subunit 1B-1 K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C F751_5004 SUMO-activating enzyme subunit 2 K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C F751_5208 NEDD8-activating enzyme E1 catalytic subunit K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C F751_6244 NEDD8-activating enzyme E1 regulatory subunit K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C F751_6700 Adenylyltransferase and sulfurtransferase MOCS3 K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C F751_1018 Ubiquitin-like modifier-activating enzyme 5 K12164 UBA5; ubiquitin-like modifier-activating enzyme 5
C F751_0604 Ubiquitin-like modifier-activating enzyme ATG7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C F751_6840 Ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C F751_5324 Ubiquitin-conjugating enzyme E2 C K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C F751_1431 Ubiquitin-conjugating enzyme E2 28 K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C F751_0271 Ubiquitin-conjugating enzyme E2 14 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C F751_1254 Ubiquitin-conjugating enzyme E2 5 K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C F751_2334 Ubiquitin-conjugating enzyme E2 32 K10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
C F751_3882 putative ubiquitin-conjugating enzyme E2 33 K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C F751_2372 Ubiquitin-conjugating enzyme E2 36 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C F751_4839 Ubiquitin-conjugating enzyme E2 S K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C F751_3522 putative ubiquitin-conjugating enzyme E2 18 K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
C F751_1709 Protein PEROXIN-4 K10689 PEX4; peroxin-4 [EC:2.3.2.23]
B UBL-conjugating enzymes
C F751_0864 SUMO-conjugating enzyme SCE1 K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C F751_6769 NEDD8-conjugating enzyme Ubc12 K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C F751_6644 Autophagy-related protein 3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
C F751_1437 Ubiquitin-like-conjugating enzyme ATG10 K17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10
C F751_6230 Ubiquitin-fold modifier-conjugating enzyme 1 K12165 UFC1; ufm1-conjugating enzyme 1
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AUbiquitin ligases (E3)
B HECT type E3
C HECT type E3 associated proteins
B U-box type E3
C F751_3174 putative ubiquitin conjugation factor E4 K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C F751_5697 Peptidyl-prolyl cis-trans isomerase-like 2 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C F751_6782 U-box domain-containing protein 72 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D F751_1027 E3 ubiquitin-protein ligase BRE1-like 2 K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
C MDM2/MDM4 proteins
C NFX1 proteins
D F751_3337 NF-X1-type zinc finger protein NFXL2 K15683 NFXL1; NF-X1-type zinc finger protein NFXL1
C Pellino proteins
C Peripheral membrane proteins
D F751_3340 Peroxisome biogenesis factor 10 K13346 PEX10; peroxin-10
D F751_3680 Peroxisome assembly protein 12 K13345 PEX12; peroxin-12
D F751_1791 Peroxisome biogenesis protein 2 K06664 PEX2; peroxin-2
C RBR proteins
D F751_0607 putative E3 ubiquitin-protein ligase K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
C ATL proteins
C Other single Ring-finger type E3
D F751_2271 E3 ubiquitin protein ligase RIN2 K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
D F751_1769 BRCA1-associated protein K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D F751_6538 CCR4-NOT transcription complex subunit 4 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D F751_3281 E3 ubiquitin-protein ligase listerin K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D F751_0291 E3 ubiquitin-protein ligase makorin K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
D F751_5421 RING finger and CHY zinc finger domain-containing protein 1 K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
D F751_2057 E3 ubiquitin-protein ligase COP1 K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
D F751_1888 E3 ubiquitin-protein ligase K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
D F751_4719 E3 ubiquitin-protein ligase RNF25 K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
D F751_1561 RING finger protein 121 K15698 RNF121_175; RING finger protein 121/175
D F751_2981 E3 ubiquitin-protein ligase RNF13 K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27]
D F751_5541 U4/U6.U5 tri-snRNP-associated protein 1 K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D F751_2948 E3 ubiquitin-protein ligase SHPRH K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D F751_5130 E3 ubiquitin-protein ligase SHPRH K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D F751_3543 E3 ubiquitin-protein ligase synoviolin K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D F751_1634 E3 ubiquitin-protein ligase ORTHRUS 2 K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
D F751_6561 LIM domain and RING finger protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D F751_0527 E3 ubiquitin-protein ligase AIP2 K16274 AIP2; E3 ubiquitin-protein ligase AIP2 [EC:2.3.2.27]
D F751_3317 putative E3 ubiquitin-protein ligase BAH1-like protein K16275 BAH; E3 ubiquitin-protein ligase BAH [EC:2.3.2.27]
D F751_2254 putative RING finger protein K16276 K16276; zinc finger protein-like protein
D F751_6910 E3 ubiquitin-protein ligase MGRN1 K27504 LOG2; E3 ubiquitin-protein ligase LOG2 [EC:2.3.2.27]
B Atypical E3
B UBL E3 ligases
C F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C F751_4468 E3 UFM1-protein ligase 1-like protein K22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]
C F751_3838 DCN1-like protein 2 K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E F751_6385 Cullin-1 K03347 CUL1; cullin 1
D Adaptor protein
D Target recognizing subunit (F-box)
E F751_1758 F-box/LRR-repeat protein 20 K10273 FBXL7; F-box and leucine-rich repeat protein 7
E F751_3003 F-box protein SKIP16 K10290 FBXO3; F-box protein 3
C Cul2 complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E F751_1753 Transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E F751_1050 Transcription elongation factor B polypeptide 2 K03873 ELOB; elongin-B
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E F751_5453 Cullin-3B K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
E F751_0924 BTB/POZ and MATH domain-containing protein 1 K10523 SPOP; speckle-type POZ protein
C Cul4 complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E F751_2615 Cullin-4 K10609 CUL4; cullin 4
D Adoptor protein
E F751_3719 DNA damage-binding protein 1a K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E F751_3019 Protein DAMAGED DNA-BINDING 2 K10140 DDB2; DNA damage-binding protein 2
E F751_5996 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E F751_2057 E3 ubiquitin-protein ligase COP1 K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
E F751_0491 Denticleless protein-like protein K11790 DTL; denticleless
E F751_2065 WD repeat-containing protein LWD1 K11805 DCAF7; DDB1- and CUL4-associated factor 7
E F751_5971 DDB1- and CUL4-associated factor 8 K11804 DCAF8; DDB1- and CUL4-associated factor 8
E F751_5620 Ras-related protein YPTC6 K11801 DCAF11; DDB1- and CUL4-associated factor 11
E F751_2465 DDB1- and CUL4-associated factor 12 K11803 DCAF12; DDB1- and CUL4-associated factor 12
E F751_6211 DDB1- and CUL4-associated factor 13 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E F751_0621 WD repeat-containing protein 26 K22382 WDR26; WD repeat-containing protein 26
E F751_2609 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E F751_1753 Transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E F751_1050 Transcription elongation factor B polypeptide 2 K03873 ELOB; elongin-B
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E F751_6626 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E F751_2520 Anaphase-promoting complex subunit 11 K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E F751_6310 Anaphase-promoting complex subunit 2 K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E F751_5700 Cell division cycle protein 20-like protein K03363 CDC20; cell division cycle 20, cofactor of APC complex
E F751_3581 Protein FIZZY-RELATED 2 K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E F751_2579 Anaphase-promoting complex subunit 1 K03348 APC1; anaphase-promoting complex subunit 1
E F751_3839 Cell division cycle protein 27-like protein K03350 APC3; anaphase-promoting complex subunit 3
E F751_3344 Anaphase-promoting complex subunit 4 K03351 APC4; anaphase-promoting complex subunit 4
E F751_2681 Anaphase-promoting complex subunit 6 K03353 APC6; anaphase-promoting complex subunit 6
E F751_0047 Anaphase-promoting complex subunit 8 K03355 APC8; anaphase-promoting complex subunit 8
E F751_0841 hypothetical protein K12456 APC13; anaphase-promoting complex subunit 13
C BRCC complex
D F751_3459 DNA repair protein RAD51-like protein K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D F751_3525 LisH domain-containing protein C29A3.03c K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D F751_1579 Ran-binding protein 10 K23334 RANBP9_10; Ran-binding protein 9/10
D F751_2723 Armadillo repeat-containing protein 8 K23336 ARMC8; armadillo repeat-containing protein 8
D F751_6586 Macrophage erythroblast attacher K18624 MAEA; macrophage erythroblast attacher
D F751_4772 Glucose-induced degradation protein 4-like protein K23335 GID4; glucose-induced degradation protein 4
D F751_7000 Glucose-induced degradation protein 8-like protein K23338 GID8; glucose-induced degradation protein 8
D F751_0621 WD repeat-containing protein 26 K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
D F751_2271 E3 ubiquitin protein ligase RIN2 K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
C LMBR1L-GP78-UBAC2 complex
D F751_2271 E3 ubiquitin protein ligase RIN2 K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D F751_6154 Cullin-associated NEDD8-dissociated protein 1 K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
D F751_3615 DDRGK domain-containing protein 1 K23344 DDRGK1; DDRGK domain-containing protein 1
D F751_4809 UBX domain-containing protein 7 K24350 UBXN7; UBX domain-containing protein 7
D F751_1801 Parkin coregulatedproteinprotein-like protein K26163 PACRG; parkin coregulated gene protein
D F751_1132 Protein SUPPRESSOR OF PHYA-105 1 K16240 SPA1_2; protein suppressor of PHYA-105 1 and protein SPA1-related 2
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D F751_1936 Ubiquitin carboxyl-terminal hydrolase isozyme L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D F751_2591 Ubiquitin carboxyl-terminal hydrolase isozyme L5 K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D F751_4387 Ubiquitin carboxyl-terminal hydrolase 5 K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D F751_5126 Ubiquitin carboxyl-terminal hydrolase 12 K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D F751_2660 Ubiquitin carboxyl-terminal hydrolase 24 K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D F751_1552 Ubiquitin carboxyl-terminal hydrolase 3 K11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12/46 [EC:3.4.19.12]
D F751_6677 Ubiquitin carboxyl-terminal hydrolase 7 K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D F751_5863 Ubiquitin carboxyl-terminal hydrolase 22 K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D F751_3960 Ubiquitin carboxyl-terminal hydrolase 30 K11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]
C OTU
D F751_3335 Ubiquitin thioesterase otubain-like protein K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D F751_0393 OTU domain-containing protein 3 K13717 OTUD3; OTU domain-containing protein 3 [EC:3.4.19.12]
D F751_5650 OTU domain-containing protein 6B K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
C MINDY
D F751_1668 Protein FAM63A K01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1/2 [EC:3.4.19.12]
C JAMM
D F751_2407 26S proteasome non-ATPase regulatory subunit 14-like protein K03030 PSMD14; 26S proteasome regulatory subunit N11
D F751_1062 AMSH-like ubiquitin thioesterase 1 K11866 STAMBP; STAM-binding protein [EC:3.4.19.12]
C PPPDE
D F751_5818 DeSI-like protein K22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]
C ZUFSP
C BRISC complex
B UBL-specific proteases (ULPs)
C F751_5286 Ubiquitin-like-specific protease ESD4 K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C F751_4697 putative ubiquitin-like-specific protease 2A K08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]
C F751_1936 Ubiquitin carboxyl-terminal hydrolase isozyme L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C F751_6513 Desumoylating isopeptidase 1 K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C COP9 signalosome (CSN) complex
D F751_5088 COP9 signalosome complex subunit 1 K12175 GPS1; COP9 signalosome complex subunit 1
D F751_1109 COP9 signalosome complex subunit 2 K12176 COPS2; COP9 signalosome complex subunit 2
D F751_5513 COP9 signalosome complex subunit 4 K12178 COPS4; COP9 signalosome complex subunit 4
D F751_5907 COP9 signalosome complex subunit 5b K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D F751_2195 COP9 signalosome complex subunit 7 K12180 COPS7; COP9 signalosome complex subunit 7
D F751_0224 COP9 signalosome complex subunit 8 K12181 COPS8; COP9 signalosome complex subunit 8
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 3, 2024