+E Replication protein KO
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DNA Replication Proteins - Amphimedon queenslandica (sponge)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 100641869 origin recognition complex subunit 1-like K02603 ORC1; origin recognition complex subunit 1
D 100640872 origin recognition complex subunit 1-like K02603 ORC1; origin recognition complex subunit 1
D 100638208 origin recognition complex subunit 2-like K02604 ORC2; origin recognition complex subunit 2
D 105313946 origin recognition complex subunit 3-like isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 100631447 origin recognition complex subunit 4-like K02606 ORC4; origin recognition complex subunit 4
D 100639573 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 105312107 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 100637002 uncharacterized protein LOC100637002 K02608 ORC6; origin recognition complex subunit 6
D 105312014 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 100633262 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 100639844 DNA replication licensing factor mcm2-like isoform X1 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 100632081 zygotic DNA replication licensing factor mcm3-like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 100631974 DNA replication licensing factor mcm4-A-like K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 100639067 DNA replication licensing factor mcm5-A-like K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 100638779 zygotic DNA replication licensing factor mcm6-B-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 100634112 DNA replication licensing factor mcm7-like K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 105312400 G2/mitotic-specific cyclin-A-like K06627 CCNA; cyclin-A
D 100634156 G1/S-specific cyclin-E1-like K06626 CCNE; G1/S-specific cyclin-E1
D 100641341 cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 100633672 cell division cycle 7-related protein kinase-like isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 105316547 protein DBF4 homolog A-like K06629 DBF4; protein DBF4
C GINS complex
D 100641507 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 100640954 DNA replication complex GINS protein PSF2-like K10733 GINS2; GINS complex subunit 2
D 100632021 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 105316424 DNA replication complex GINS protein SLD5-like K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 105311927 DNA topoisomerase 2-binding protein 1-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 100633800 ATP-dependent DNA helicase Q4-like isoform X2 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 105316746 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 100641622 DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 105313992 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 109580597 cyclin-dependent kinase 2-interacting protein-like K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 105316532 uncharacterized protein LOC105316532 K26116 MTBP; Mdm2-binding protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 100635297 DNA polymerase alpha catalytic subunit-like K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 105311914 DNA polymerase alpha subunit B-like K02321 POLA2; DNA polymerase alpha subunit B
D 100639739 DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 100640139 LOW QUALITY PROTEIN: DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 100641853 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 100640956 DNA polymerase epsilon catalytic subunit A-like isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 100631990 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 100632348 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 100636363 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 100632272 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 100636502 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 100641131 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 100632432 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D 105316540 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D 100635013 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 100640381 DNA polymerase subunit gamma-1-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 109581855 DNA polymerase subunit gamma-2, mitochondrial-like K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 105313379 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 100634744 replication protein A 32 kDa subunit-B-like isoform X1 K10739 RFA2; replication factor A2
D 105314528 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 100634225 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
D 100633792 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 100635345 replication factor C subunit 2-like isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
D 100638914 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 100634941 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 100639076 replication factor C subunit 3-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100638786 LOW QUALITY PROTEIN: replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 100633086 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100637803 ribonuclease H2 subunit A-like K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 105316552 ribonuclease H2 subunit B-like K10744 RNASEH2B; ribonuclease H2 subunit B
D 109589872 ribonuclease H2 subunit C-like K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 100635638 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 100635767 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 100633028 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 100634853 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 100641788 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 105313246 uncharacterized protein LOC105313246 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 100636382 LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 1-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100636742 DNA (cytosine-5)-methyltransferase 1-like isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100642138 DNA (cytosine-5)-methyltransferase 3A-like isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 109582481 uncharacterized protein LOC109582481 K10749 GMNN; geminin
D 105313864 G2/mitotic-specific cyclin-B-like K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 105312818 G2/mitotic-specific cyclin-B1-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100641209 G2/mitotic-specific cyclin-B3-like K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 100636755 cyclin-dependent kinase 1-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 109581522 protection of telomeres protein 1-like K11109 POT1; protection of telomeres protein 1
D TERB1-TERB2-MAJIN complex
E 109580948 uncharacterized protein LOC109580948 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 109584766 uncharacterized protein LOC109584766 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 109581157 uncharacterized protein LOC109581157 isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 105316844 CST complex subunit STN1-like isoform X2 K23312 STN1; CST complex subunit STN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 109580413 telomerase-binding protein EST1A-like K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 105313034 protein SMG5-like K11125 SMG5; protein SMG5
D 105312267 telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 100639414 telomerase protein component 1-like K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 100634429 probable H/ACA ribonucleoprotein complex subunit 1 isoform X1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 100632775 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100641334 centromere/microtubule-binding protein CBF5-like isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 105312267 telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 100637222 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 109585317 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100636938 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 100638061 small nuclear ribonucleoprotein Sm D3-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 100636082 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 100640351 small nuclear ribonucleoprotein F-like K11098 SNRPF; small nuclear ribonucleoprotein F
E 100639896 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 100633792 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 100635345 replication factor C subunit 2-like isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
D 100638914 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 100634941 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 100639076 replication factor C subunit 3-like isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100638786 LOW QUALITY PROTEIN: replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 100639228 double-strand break repair protein MRE11A-like K10865 MRE11; double-strand break repair protein MRE11
D 100639685 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D 100641266 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100632682 LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 100633457 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100636193 DNA repair endonuclease XPF-like K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 100633207 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 100635781 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100634632 poly [ADP-ribose] polymerase 3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100633591 uncharacterized protein LOC100633591 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100637824 tankyrase-2-like K10799 TNKS; tankyrase [EC:2.4.2.30]
D 105316648 PIN2/TERF1-interacting telomerase inhibitor 1-like K11135 PINX1; Pin2-interacting protein X1
D 100637753 regulator of telomere elongation helicase 1-like K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 100640976 regulator of telomere elongation helicase 1-like K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 105313112 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 109582869 uncharacterized protein C19orf43 homolog K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 100633307 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100635374 uncharacterized protein LOC100635374 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 105312372 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100634875 uncharacterized protein LOC100634875 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100632310 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 105314408 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 109588017 uncharacterized protein LOC109588017 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100638306 uncharacterized protein LOC100638306 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 105314614 uncharacterized protein LOC105314614 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100634117 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 105316684 ATP-dependent DNA helicase PIF6-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100638680 transcriptional activator protein Pur-alpha-like K21772 PURA; transcriptional activator protein Pur-alpha
D 105316516 telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
D 100637133 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 100638710 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 100640882 DNA topoisomerase I, mitochondrial-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100632881 DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100637912 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 100636662 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 105312723 single-stranded DNA-binding protein 1-A, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 100633086 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 100633086 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 100635767 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 100633028 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100641788 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022