+C Two-component system KO
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Two-Component System - Aneurinibacillus soli
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C CB4_03716 phoR_3; Alkaline phosphatase synthesis sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C CB4_03717 phoP; Alkaline phosphatase synthesis transcriptional regulatory protein PhoP K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
C CB4_02023 cssS; Sensor histidine kinase CssS K07650 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3]
C CB4_02022 cssR; Transcriptional regulatory protein CssR K07770 cssR; two-component system, OmpR family, response regulator CssR
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C CB4_00972 kdpD; Sensor protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
C CB4_03228 srrB; Sensor protein SrrB K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]
C CB4_03229 srrA_3; Transcriptional regulatory protein SrrA K07775 resD; two-component system, OmpR family, response regulator ResD
B VicK-VicR (cell wall metabolism)
C CB4_00413 yycG_1; Sensor histidine kinase YycG K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
C CB4_00412 yycF_1; Transcriptional regulatory protein YycF K07668 vicR; two-component system, OmpR family, response regulator VicR
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
C CB4_02928 graS; Sensor histidine kinase GraS K19081 braS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3]
C CB4_02930 graR; Response regulator protein GraR K19082 braR; two-component system, OmpR family, response regulator protein BraR/BceR
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
C CB4_02783 yycG_5; Sensor histidine kinase YycG K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
C CB4_00032 arlS_1; Signal transduction histidine-protein kinase ArlS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C CB4_02734 arlS_3; Signal transduction histidine-protein kinase ArlS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C CB4_01248 arlS_2; Signal transduction histidine-protein kinase ArlS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C CB4_00033 arlR_1; Response regulator ArlR K18941 arlR; two-component system, OmpR family, response regulator ArlR
C CB4_02735 arlR_4; Response regulator ArlR K18941 arlR; two-component system, OmpR family, response regulator ArlR
C CB4_01247 arlR_2; Response regulator ArlR K18941 arlR; two-component system, OmpR family, response regulator ArlR
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C CB4_02536 hssR; Heme response regulator HssR K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
C CB4_00672 degS; Signal transduction histidine-protein kinase/phosphatase DegS K07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3]
C CB4_00673 degU_2; Transcriptional regulatory protein DegU K07692 degU; two-component system, NarL family, response regulator DegU
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
C CB4_02233 liaS_2; Sensor histidine kinase LiaS K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C CB4_02234 liaR; Transcriptional regulatory protein LiaR K11618 liaR; two-component system, NarL family, response regulator LiaR
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
C CB4_03330 nreB_1; Oxygen sensor histidine kinase NreB K07683 nreB; two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3]
C CB4_03497 nreC_2; Oxygen regulatory protein NreC K07696 nreC; two-component system, NarL family, response regulator NreC
C CB4_03331 nreC_1; Oxygen regulatory protein NreC K07696 nreC; two-component system, NarL family, response regulator NreC
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
C CB4_00079 kinE_1; Sporulation kinase E K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C CB4_03187 kinE_6; Sporulation kinase E K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C CB4_02235 kinE_4; Sporulation kinase E K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3]
C CB4_00335 kinE_2; Sporulation kinase E K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3]
C CB4_00562 spo0F; Sporulation initiation phosphotransferase F K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F
C CB4_01614 spo0A_1; Stage 0 sporulation protein A K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
C CB4_01349 citA; Sensor histidine kinase CitA K11691 K11691; two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3]
C CB4_01350 citT; Transcriptional regulatory protein CitT K11692 K11692; two-component system, CitB family, response regulator DctR
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C CB4_04039 ypdA_2; Sensor histidine kinase YpdA K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C CB4_04038 ypdB_2; Transcriptional regulatory protein YpdB K02477 K02477; two-component system, LytTR family, response regulator
C CB4_02806 yehT_2; Transcriptional regulatory protein YehT K02477 K02477; two-component system, LytTR family, response regulator
C CB4_00425 yehT_1; Transcriptional regulatory protein YehT K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C CB4_02143 kinE_3; Sporulation kinase E K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C CB4_01865 cheA_1; Chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C CB4_04193 cheA_2; Chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C CB4_01854 cheY_2; Chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CB4_02988 cheY_3; Chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CB4_03937 cheY_4; Chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CB4_01863 cheB; Chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C CB4_01864 cheB2; Chemotaxis response regulator protein-glutamate methylesterase of group 2 operon K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C CB4_02857 cheV; Chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
C CB4_03374 divK; Polar-differentiation response regulator DivK K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
C CB4_01415 glnK_1; Sensor histidine kinase GlnK K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C CB4_02215 glnK_2; Sensor histidine kinase GlnK K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C CB4_01416 cheY_1; Chemotaxis protein CheY K07719 glnL; two-component system, response regulator GlnL
C CB4_02216 spo0A_2; Stage 0 sporulation protein A K07719 glnL; two-component system, response regulator GlnL
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
C CB4_00059 yesS; HTH-type transcriptional regulator YesS K07720 yesN; two-component system, response regulator YesN
C CB4_00103 araC; Arabinose operon regulatory protein K07720 yesN; two-component system, response regulator YesN
B CikA
B RegB-RegA (redox response)
C CB4_03377 zraR_4; Transcriptional regulatory protein ZraR K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C CB4_02807 rpfC_2; Sensory/regulatory protein RpfC K19694 chiS; two-component system, sensor histidine kinase ChiS
C CB4_02000 arcB_2; Aerobic respiration control sensor protein ArcB K19694 chiS; two-component system, sensor histidine kinase ChiS
C CB4_02001 rpfC_1; Sensory/regulatory protein RpfC K19694 chiS; two-component system, sensor histidine kinase ChiS
C CB4_00426 arcB_1; Aerobic respiration control sensor protein ArcB K19694 chiS; two-component system, sensor histidine kinase ChiS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023