+C Two-component system KO
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Two-Component System - Achromobacter xylosoxidans A8
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C AXYL_00495 phoR; phosphate regulon sensor kinase PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C AXYL_00496 phoB; phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C AXYL_02218 response regulator 4 K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C AXYL_00985 HAMP domain protein 3 K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C AXYL_01481 RisS protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C AXYL_01482 ompR2; transcriptional regulatory protein OmpR 2 K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
C AXYL_00984 ompR1; transcriptional regulatory protein OmpR 1 K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
C AXYL_03931 transcriptional regulatory protein CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C AXYL_04681 heavy metal sensor kinase family protein 2 K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C AXYL_01120 sensor kinase CusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C AXYL_06102 heavy metal sensor kinase family protein 4 K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C AXYL_00493 heavy metal sensor kinase family protein 1 K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C AXYL_05743 heavy metal sensor kinase family protein 3 K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C AXYL_04680 irlR4; transcriptional activator protein IrlR 4 K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C AXYL_06101 irlR6; transcriptional activator protein IrlR 6 K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C AXYL_05742 irlR5; transcriptional activator protein IrlR 5 K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C AXYL_01121 irlR2; transcriptional activator protein IrlR 2 K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C AXYL_04252 irlR3; transcriptional activator protein IrlR 3 K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C AXYL_00494 irlR1; transcriptional activator protein IrlR 1 K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C AXYL_03153 HAMP domain protein 10 K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C AXYL_03152 qseB2; transcriptional regulatory protein QseB 2 K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C AXYL_01191 kdpD; sensor protein KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C AXYL_01190 KDP operon transcriptional regulatory protein KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C AXYL_00617 HAMP domain protein 2 K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C AXYL_01378 HAMP domain protein 5 K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C AXYL_00751 His Kinase A phosphoacceptor domain protein 2 K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C AXYL_06506 His Kinase A phosphoacceptor domain protein 14 K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C AXYL_00618 response regulator 1 K07774 tctD; two-component system, OmpR family, response regulator TctD
C AXYL_00750 tctD1; transcriptional regulatory protein TctD 1 K07774 tctD; two-component system, OmpR family, response regulator TctD
C AXYL_01379 tctD2; transcriptional regulatory protein TctD 2 K07774 tctD; two-component system, OmpR family, response regulator TctD
C AXYL_06507 tctD4; transcriptional regulatory protein TctD 4 K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
C AXYL_03323 HAMP domain protein 12 K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
C AXYL_03210 HAMP domain protein 11 K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
C AXYL_03324 response regulator 10 K18073 parR; two-component system, OmpR family, response regulator ParR
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C AXYL_01781 HAMP domain protein 6 K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AXYL_03631 His Kinase A phosphoacceptor domain protein 9 K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AXYL_03932 HAMP domain protein 14 K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C AXYL_01782 qseB1; transcriptional regulatory protein QseB 1 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_01867 tctD3; transcriptional regulatory protein TctD 3 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_03632 qseB3; transcriptional regulatory protein QseB 3 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_05204 response regulator 14 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_03278 response regulator 9 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_05656 response regulator 16 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_06463 response regulator 22 K02483 K02483; two-component system, OmpR family, response regulator
C AXYL_01964 response regulator 3 K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C AXYL_02966 HAMP domain protein 9 K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C AXYL_02967 transcriptional regulatory protein DegU K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C AXYL_06020 periplasmic sensor signal transduction histidine kinase 3 K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C AXYL_01043 His Kinase A phosphoacceptor domain protein 3 K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C AXYL_01045 His Kinase A phosphoacceptor domain protein 4 K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C AXYL_06040 sensory box protein 11 K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C AXYL_05372 rcsB; capsular synthesis regulator component B K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C AXYL_06039 response regulator 19 K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C AXYL_02261 response regulator 5 K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C AXYL_06025 His Kinase A phosphoacceptor domain protein 11 K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C AXYL_06026 His Kinase A phosphoacceptor domain protein 12 K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C AXYL_06024 bacterial regulatory protein, LuxR family protein 12 K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C AXYL_02897 periplasmic sensor signal transduction histidine kinase 1 K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C AXYL_05787 response regulator 17 K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C AXYL_03346 His Kinase A phosphoacceptor domain protein 8 K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C AXYL_03345 ntrC; nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
C AXYL_06083 HAMP domain protein 17 K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
C AXYL_06082 response regulator 20 K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
C AXYL_01756 atoC; acetoacetate metabolism regulatory protein AtoC K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C AXYL_02102 dctB; C4-dicarboxylate transport sensor protein DctB K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C AXYL_02101 dctD; C4-dicarboxylate transport transcriptional regulatory protein DctD K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C AXYL_02736 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C AXYL_02735 response regulator 6 K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C AXYL_02741 cheY; chemotaxis regulatory protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C AXYL_02740 cheB1; chemotaxis-specific methylesterase 1 K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C AXYL_03674 cheA2; CheA signal transduction histidine kinase 2 K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C AXYL_03672 response regulator receiver modulated diguanylate cyclase K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C AXYL_03673 cheB2; chemotaxis-specific methylesterase 2 K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C AXYL_03032 fixJ2; transcriptional regulatory protein FixJ 2 K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C AXYL_05285 His Kinase A phosphoacceptor domain protein 10 K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C AXYL_05286 response regulator 15 K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C AXYL_00429 His Kinase A phosphoacceptor domain protein 1 K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
B PdtaS-PdtaR
B NasS-NasT
C AXYL_05136 response regulator 13 K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023