+E Polyketide biosynthesis proteins KO
#
Polyketide Biosynthesis Proteins - Bacillus sp. SDLI1
%
!
APolyketide synthase (PKS)
B Modular type I PKS
C cis-AT PKS
D Erythronolide PKS
D Oleandomycin synthase
D Pikromycin PKS
D Avermectin PKS
D Tylactone synthase
D Protomycinolide IV synthase
D Niddamycin PKS
D Rapamycin PKS
D Immunomycin PKS
D Ansamitocin PKS
D Rifamycin PKS
D Polyene macrolide PKS
D Pimaricinolide synthase
D Candicidin PKS
D Soraphen PKS
D Stigmatellin PKS
D Mycolactone PKS
D Coelimycin PKS
D Aureothin PKS
D Spectinabilin PKS
D Phthiocerol / Phenolphthiocerol PKS
C trans-AT PKS
D Bacillanene hybrid PKS-NRPS
E AUL54_18785 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_02040 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_03375 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_02045 acyltransferase K15328 pksD; bacillaene synthase trans-acting acyltransferase
E AUL54_02015 non-ribosomal peptide synthetase K13611 pksJ; bacillaene biosynthesis, polyketide synthase / nonribosomal peptide synthetase PksJ/BaeJ
E AUL54_02010 polyketide synthase K13612 pksL; bacillaene polyketide synthase PksL/BaeL
E AUL54_02005 polyketide synthase K13613 pksM; bacillaene polyketide synthase PksM/BaeM
E AUL54_02000 non-ribosomal peptide synthetase K13614 pksN; bacillaene biosynthesis, polyketide synthase / nonribosomal peptide synthetase PksN/BaeN
E AUL54_01995 polyketide synthase K13615 pksR; bacillaene polyketide synthase PksR/BaeR
D Chivosazol hybrid PKS-NRPS
E AUL54_18785 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_02040 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_03375 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E ------ chiPKS; chivosazol hybrid polyketide synthase / nonribosomal peptide synthetase [SCL:sce4137 sce4136 sce4135 sce4134 sce4133]
D Macrolactin PKS
E AUL54_18785 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_02040 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_03375 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_03370 polyketide synthase K25842 mlnB; macrolactin polyketide synthase MlnB
E AUL54_03365 polyketide synthase K25843 mlnC; macrolactin polyketide synthase MlnC
E AUL54_03360 polyketide synthase K25844 mlnD; macrolactin polyketide synthase MlnD
E AUL54_03355 polyketide synthase K25845 mlnE; macrolactin polyketide synthase MlnE
E AUL54_03350 polyketide synthase K25846 mlnF; macrolactin polyketide synthase MlnF
E AUL54_03345 polyketide synthase K25847 mlnG; macrolactin polyketide synthase MlnG
E AUL54_03340 MlnH K25848 mlnH; macrolactin polyketide synthase MlnH
D Difficidin PKS
E AUL54_18785 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_02040 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_03375 malonyl CoA-ACP transacylase K15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains
E AUL54_18810 polyketide synthase K25849 dfnD; difficidin synthase DfnD
E AUL54_18815 polyketide synthase K25850 dfnE; difficidin synthase DfnE
E AUL54_18820 polyketide synthase K25851 dfnF; difficidin synthase DfnF
E AUL54_18825 polyketide synthase K25852 dfnG; difficidin synthase DfnG
E AUL54_18830 polyketide synthase K25853 dfnH; difficidin synthase DfnH
E AUL54_18835 polyketide synthase K25854 dfnI; difficidin synthase DfnI
E AUL54_18840 DfnJ K25855 dfnJ; difficidin synthase DfnJ
D Rhizoxin hybrid PKS-NRPS
D Myxovirescin hybrid PKS-NRPS
E ------ taPKS; myxovirescin biosynthesis, hybrid polyketide synthase / nonribosomal peptide synthetase [MXA:MXAN_3935 MXAN_3933 MXAN_3932]
D Albicidin synthase, hybrid PKS-NRPS
E ------ albXIII; albicidin synthase trans-acting acyltransferase AlbXIII [XAL:XALC_1516]
E ------ albPKS; albicidin synthase, hybrid polyketide synthase / nonribosomal peptide synthetase [XAL:XALC_1529 XALC_1532 XALC_1523]
D Etnangien PKS
E ------ etnPKS; etnangien polyketide synthase [SCL:sce3188 sce3189 sce3190 sce3191 sce3192 sce3193]
B Iterative type I PKS
C Fungal nonreducing PKS (NR-PKS)
C Fungal partially reducing PKS (PR-PKS)
C Fungal highly reducing PKS (HR-PKS)
C Fungal hybrid type
D Zearalenone synthase
D Asperfuranone NR/HR-PKS
E ------ AFOE; asperfuranone biosynthesis, nonreducing iterative type I polyketide synthase AfoE [ANI:AN1034.2]
E ------ AFOG; asperfuranone biosynthesis, highly reducing iterative type I polyketide synthase AfoG [ANI:AN1036.2]
C Bacterial type
B Type II PKS
C C9-C14 cyclized polyketide type
D Spore pigment PKS
C C7-C14 cyclized polyketide type
D Octaketide PKS
D Nonaketide PKS
D Decaketide PKS
B Type III PKS
C Plant type
C Fungal type
C Bacterial type
D AUL54_00290 chalcone synthase K16167 bpsA; alkylresorcinol/alkylpyrone synthase
D ------ arsB; alkylresorcinol synthase [AVN:Avin_29550]
D ------ arsC; alkylpyrone synthase [AVN:Avin_29530]
B PKS-NRPS hybrid
C Bacterial type (modular)
D Myxalamid hybrid PKS-NRPS
D Myxothiazol hybrid PKS-NRPS
E ------ mtaPKS; myxothiazol hybrid polyketide synthase / nonribosomal peptide synthetase [SUR:STAUR_4014 STAUR_4015 STAUR_4016 STAUR_4017 STAUR_4018 STAUR_4019]
D Coronatine hybrid PKS-NRPS
D Microcystin synthetase
D Epothilone synthetase
D Bleomycin synthetase
D Colibactin synthetase
C Fungal type (trans-ER, iterative)
D Aspyridone synthetase
C Fungal type (iterative)
#
ANonribosomal peptide synthetase (NRPS)
B Linear NRPS
C ------ EASA; emericellamide biosynthesis, nonribosomal peptide synthetase EasA [ANI:AN2545.2]
C ------ lgrABCD; linear pentadecapeptide gramicidin synthetase [BBE:BBR47_28920 BBR47_28930 BBR47_28940 BBR47_29500]
C ------ mcnABCE; cyanopeptolin synthetase [MAR:MAE_60030 MAE_60020 MAE_60010 MAE_60000]
C ACV synthetase
C Bacitracin synthetase
C Viomycin synthetase
C Pristinamycin I synthetase
C Tyrocidine synthetase
C Surfactin family lipopeptide synthetase
D AUL54_09000 non-ribosomal peptide synthetase K15654 srfAA; surfactin/lichenysin synthetase A
D AUL54_08995 non-ribosomal peptide synthetase K15655 srfAB; surfactin/lichenysin synthetase B
D AUL54_08990 non-ribosomal peptide synthetase K15656 srfAC; surfactin/lichenysin synthetase C
C Iturin family lipopeptide synthetase
D AUL54_01495 non-ribosomal peptide synthetase K15661 ituA; iturin family lipopeptide synthetase A
D AUL54_01500 non-ribosomal peptide synthetase K15662 ituB; iturin family lipopeptide synthetase B
D AUL54_01505 non-ribosomal peptide synthetase K15663 ituC; iturin family lipopeptide synthetase C
C Fengycin family lipopeptide synthetase
D AUL54_01355 non-ribosomal peptide synthetase K15664 ppsA; plipastatin/fengycin lipopeptide synthetase A
D AUL54_01360 non-ribosomal peptide synthetase K15665 ppsB; plipastatin/fengycin lipopeptide synthetase B
D AUL54_01365 non-ribosomal peptide synthetase K15666 ppsC; plipastatin/fengycin lipopeptide synthetase C
D AUL54_01370 non-ribosomal peptide synthetase K15667 ppsD; plipastatin/fengycin lipopeptide synthetase D
D AUL54_01375 non-ribosomal peptide synthetase K15668 ppsE; plipastatin/fengycin lipopeptide synthetase E
C Arthrofactin type cyclic lipopeptide synthetase
C Vancomycin synthetase
C Nocardicin synthetase
D AUL54_15205 protein mbtH K05375 mbtH; MbtH protein
C Bialaphos synthetase
C L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
B Iterative NRPS
C Enterobactin synthetase
D AUL54_15195 isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D AUL54_15190 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Bacillibactin synthetase
D AUL54_15195 isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D AUL54_15190 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D AUL54_15200 non-ribosomal peptide synthetase K04780 dhbF; glyine---[glycyl-carrier protein] ligase [EC:6.2.1.66]
C Gramicidin synthetase
B Nonlinear NRPS
C Yersiniabactin synthetase
C Pyochelin synthetase
C Mycobactin synthetase
C Vibriobactin synthetase
D AUL54_15195 isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D AUL54_15190 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
C Myxochelin synthetase
D AUL54_15190 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
D AUL54_15195 isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
C Petrobacin synthetase
C Syringomycin synthetase
C Vanchrobactin synthetase
D AUL54_15195 isochorismatase K01252 entB; bifunctional isochorismate lyase / aryl carrier protein [EC:3.3.2.1 6.3.2.14]
D AUL54_15190 entE; 2,3-dihydroxybenzoate-AMP ligase K02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]
#
APolyketide tailoring proteins
B Hydrolase
B Ketoreductase
B Oxygenase
C AUL54_01990 cytochrome K15468 pksS; cytochrome P450 family 107 subfamily K polypeptide 1
B Methylase
C AUL54_00295 hypothetical protein K16168 bpsB; methyltransferase
B Glycosyltransferase
B Halogenase
B beta-Branched incorporating proteins
C AUL54_02050 poly(3-hydroxyalkanoate) synthetase K15327 pksC; polyketide biosynthesis malonyl-CoA-[acyl-carrier-protein] transacylase
C AUL54_02035 poly(3-hydroxyalkanoate) depolymerase K15337 acpK; polyketide biosynthesis acyl carrier protein
C AUL54_18850 3-hydroxy-3-methylglutaryl-ACP synthase K15311 pksG; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22]
C AUL54_02030 3-hydroxy-3-methylglutaryl-ACP synthase K15311 pksG; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22]
C AUL54_02025 enoyl-CoA hydratase K15312 pksH; 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase [EC:4.2.1.181]
C AUL54_18855 enoyl-CoA hydratase K15313 pksI; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]
C AUL54_02020 enoyl-CoA hydratase K15313 pksI; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]
B Others
#
ANonribosomal peptide tailoring proteins
B Reductase
B Thioesterase
C AUL54_08985 thioesterase K15657 srfATE; external thioesterase TEII
B Oxygenase
B Glycosyltransferase
B Aminotransferase
B Others
C AUL54_07445 hypothetical protein K01779 racD; aspartate racemase [EC:5.1.1.13]
!
#
#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: February 19, 2024