+C Two-component system KO
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Two-Component System - Brevibacillus choshinensis
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C JNE38_07420 HAMP domain-containing protein K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C JNE38_21860 two-component sensor histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C JNE38_07415 response regulator transcription factor K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
C JNE38_03525 HAMP domain-containing histidine kinase K07650 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3]
C JNE38_00175 response regulator transcription factor K07770 cssR; two-component system, OmpR family, response regulator CssR
C JNE38_03530 response regulator transcription factor K07770 cssR; two-component system, OmpR family, response regulator CssR
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C JNE38_02205 universal stress protein K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
C JNE38_12510 HAMP domain-containing protein K07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]
C JNE38_12505 response regulator transcription factor K07775 resD; two-component system, OmpR family, response regulator ResD
B VicK-VicR (cell wall metabolism)
C JNE38_30310 response regulator transcription factor K07668 vicR; two-component system, OmpR family, response regulator VicR
C JNE38_02360 response regulator transcription factor K07668 vicR; two-component system, OmpR family, response regulator VicR
C JNE38_06730 response regulator transcription factor K07668 vicR; two-component system, OmpR family, response regulator VicR
C JNE38_08100 response regulator transcription factor K07668 vicR; two-component system, OmpR family, response regulator VicR
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
C JNE38_03180 sensor histidine kinase K11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]
C JNE38_03175 response regulator transcription factor K11634 yxdJ; two-component system, OmpR family, response regulator YxdJ
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
C JNE38_02035 HAMP domain-containing histidine kinase K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
C JNE38_02030 response regulator transcription factor K14983 ciaR; two-component system, OmpR family, response regulator CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
C JNE38_06860 HAMP domain-containing histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C JNE38_18345 HAMP domain-containing histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C JNE38_18380 HAMP domain-containing protein K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C JNE38_06855 response regulator transcription factor K18941 arlR; two-component system, OmpR family, response regulator ArlR
C JNE38_18385 response regulator transcription factor K18941 arlR; two-component system, OmpR family, response regulator ArlR
C JNE38_18350 response regulator transcription factor K18941 arlR; two-component system, OmpR family, response regulator ArlR
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
C JNE38_08655 response regulator transcription factor K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
B Unclassified
C JNE38_01990 HAMP domain-containing protein K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C JNE38_01995 response regulator transcription factor K02483 K02483; two-component system, OmpR family, response regulator
C JNE38_07235 response regulator K02483 K02483; two-component system, OmpR family, response regulator
C JNE38_14810 response regulator transcription factor K02483 K02483; two-component system, OmpR family, response regulator
C JNE38_15175 response regulator transcription factor K02483 K02483; two-component system, OmpR family, response regulator
C JNE38_21865 response regulator transcription factor K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C JNE38_11240 response regulator transcription factor K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
C JNE38_28450 histidine kinase K07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3]
C JNE38_28445 response regulator transcription factor K07692 degU; two-component system, NarL family, response regulator DegU
B DesK-DesR (membrane lipid fluidity regulation)
C JNE38_03865 sensor histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
C JNE38_03870 response regulator transcription factor K07693 desR; two-component system, NarL family, response regulator DesR
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
C JNE38_02520 sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C JNE38_04770 sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
C JNE38_04775 response regulator transcription factor K11618 liaR; two-component system, NarL family, response regulator LiaR
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
C JNE38_02265 PAS domain S-box protein K07683 nreB; two-component system, NarL family, sensor histidine kinase NreB [EC:2.7.13.3]
C JNE38_02270 response regulator transcription factor K07696 nreC; two-component system, NarL family, response regulator NreC
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
C JNE38_27925 PAS domain S-box protein K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C JNE38_06830 PAS domain S-box protein K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C JNE38_07185 PAS domain S-box protein K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C JNE38_11965 PAS domain S-box protein K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C JNE38_16820 PAS domain S-box protein K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]
C JNE38_27675 GHKL domain-containing protein K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C JNE38_29740 HAMP domain-containing histidine kinase K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C JNE38_14650 HAMP domain-containing histidine kinase K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C JNE38_19055 HAMP domain-containing histidine kinase K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C JNE38_22885 two-component sensor histidine kinase K07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]
C JNE38_00535 PAS domain-containing protein K13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3]
C JNE38_28960 response regulator K02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F
C JNE38_12180 spo0A; sporulation transcription factor Spo0A K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
C JNE38_06745 sensor histidine kinase K11691 K11691; two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3]
C JNE38_06750 response regulator K11692 K11692; two-component system, CitB family, response regulator DctR
B MalK-MalR (malate transport)
B Unclassified
C JNE38_06420 sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
C JNE38_16885 sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
C JNE38_22385 sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
C JNE38_16880 response regulator K02475 K02475; two-component system, CitB family, response regulator
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ALytTR family
B LysS-LysR
C JNE38_11475 histidine kinase K07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3]
C JNE38_11480 response regulator transcription factor K07705 lytT; two-component system, LytTR family, response regulator LytT
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C JNE38_22755 sensor histidine kinase K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C JNE38_02310 histidine kinase K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C JNE38_22750 response regulator transcription factor K02477 K02477; two-component system, LytTR family, response regulator
C JNE38_30130 response regulator K02477 K02477; two-component system, LytTR family, response regulator
C JNE38_02085 LytTR family transcriptional regulator DNA-binding domain-containing protein K02477 K02477; two-component system, LytTR family, response regulator
C JNE38_02305 response regulator transcription factor K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
C JNE38_04215 atoS; two-component system sensor histidine kinase AtoS K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]
C JNE38_04220 sigma-54-dependent Fis family transcriptional regulator K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C JNE38_25020 histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C JNE38_25025 sigma-54-dependent Fis family transcriptional regulator K02481 flgR; two-component system, NtrC family, response regulator
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ACheA family
B CheA-CheYBV (chemotaxis)
C JNE38_17820 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C JNE38_29915 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C JNE38_17870 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C JNE38_22665 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C JNE38_26820 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C JNE38_17825 chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
C JNE38_27425 response regulator K02658 pilH; twitching motility two-component system response regulator PilH
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
C JNE38_02125 sensor histidine kinase K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C JNE38_04425 sensor histidine kinase K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C JNE38_24305 sensor histidine kinase K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C JNE38_02130 response regulator K07719 glnL; two-component system, response regulator GlnL
C JNE38_04430 response regulator K07719 glnL; two-component system, response regulator GlnL
C JNE38_24300 response regulator K07719 glnL; two-component system, response regulator GlnL
B HspS-HspR (hexose phosphates uptake)
C JNE38_08890 response regulator K25213 hptR; two-component system, response regulator HptR
C JNE38_24185 response regulator K25213 hptR; two-component system, response regulator HptR
B YesM-YesN
C JNE38_03560 sensor histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C JNE38_24190 sensor histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C JNE38_03555 response regulator K07720 yesN; two-component system, response regulator YesN
C JNE38_22075 helix-turn-helix domain-containing protein K07720 yesN; two-component system, response regulator YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
C JNE38_29430 histidine kinase N-terminal domain-containing protein K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]
C JNE38_29425 response regulator K22010 pdtaR; two-component system, response regulator PdtaR
C JNE38_13605 response regulator K22010 pdtaR; two-component system, response regulator PdtaR
B NasS-NasT
B Unclassified
C JNE38_06680 response regulator K19694 chiS; two-component system, sensor histidine kinase ChiS
C JNE38_22480 response regulator K19694 chiS; two-component system, sensor histidine kinase ChiS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023