+F Repair protein KO
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DNA Repair and Recombination Proteins - Biomphalaria glabrata (bloodfluke planorb)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106068743 methylated-DNA--protein-cysteine methyltransferase-like isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 106068156 alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 106056468 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3-like isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 106057501 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 106056406 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106072128 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 106070853 G/T mismatch-specific thymine DNA glycosylase-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 106079626 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106059354 LOW QUALITY PROTEIN: A/G-specific adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 106063237 methyl-CpG-binding domain protein 4-like K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 106051318 N-glycosylase/DNA lyase-like isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 106062843 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 106061433 DNA-(apurinic or apyrimidinic site) lyase-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 106076557 recombination repair protein 1-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 106053396 DNA-(apurinic or apyrimidinic site) lyase 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 106073353 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 106058143 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
F 106066693 DNA polymerase delta subunit 3-like isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 106067124 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 106050560 LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 106056840 DNA polymerase epsilon subunit 2-like isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 106062989 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 106067113 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 106057737 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 106079169 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 106055642 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 106068386 uncharacterized protein LOC106068386 K10803 XRCC1; DNA-repair protein XRCC1
E 106065399 DNA repair protein XRCC1-like isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 106051680 LOW QUALITY PROTEIN: DNA ligase 3-like K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 106051988 tyrosyl-DNA phosphodiesterase 1-like K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 106056408 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106055392 ABC transporter F family member 4-like K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 106061013 LOW QUALITY PROTEIN: bifunctional polynucleotide phosphatase/kinase-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 106061415 LOW QUALITY PROTEIN: uncharacterized protein F21D5.5-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 106074940 LOW QUALITY PROTEIN: high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 106077133 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 106073313 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 106056544 poly [ADP-ribose] polymerase 3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 106060547 poly [ADP-ribose] polymerase 4-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 106059884 DNA repair protein complementing XP-C cells-like K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 106063577 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 106069540 cullin-4A-like K10609 CUL4; cullin 4
F 106052815 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 106057429 DNA damage-binding protein 2-like K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 106061006 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 106066121 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 106070115 DNA-directed RNA polymerase II subunit RPB3-like K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 106073308 DNA-directed RNA polymerase II subunit RPB4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 106061391 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 106059912 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 106059198 DNA-directed RNA polymerase II subunit RPB7 isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 106055222 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 106055354 DNA-directed RNA polymerase II subunit RPB9-like K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 106056871 DNA-directed RNA polymerase II subunit RPB11-like K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 106076424 DNA-directed RNA polymerase II subunit RPB11-like K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 106069540 cullin-4A-like K10609 CUL4; cullin 4
F 106052815 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 106064979 DNA excision repair protein ERCC-8-like K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 106061886 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 106051872 UV-stimulated scaffold protein A-like K23720 UVSSA; UV-stimulated scaffold protein A
F 106064436 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 106078442 TFIIH basal transcription factor complex helicase XPB subunit-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 106061803 TFIIH basal transcription factor complex helicase XPD subunit-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 106067415 general transcription factor IIH subunit 1-like K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 106071410 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 106052932 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 106056176 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 106072025 general transcription factor IIH subunit 4-like isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 106074176 cyclin-dependent kinase 7-like K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 106054066 cyclin-H-like isoform X1 K06634 CCNH; cyclin H
E 106073770 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 106077619 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 106067122 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 106072880 uncharacterized protein LOC106072880 K10740 RPA3; replication factor A3
D Other NER factors
E 106061173 DNA repair protein complementing XP-A cells-like K10847 XPA; DNA-repair protein complementing XP-A cells
E 106079618 DNA excision repair protein ERCC-1-like K10849 ERCC1; DNA excision repair protein ERCC-1
E 106061251 DNA repair endonuclease XPF-like isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 106055751 LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells-like K10846 ERCC5; DNA excision repair protein ERCC-5
E 106070450 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 106056385 LOW QUALITY PROTEIN: cullin-3-B-like K03869 CUL3; cullin 3
E 106059911 cullin-5-like K10612 CUL5; cullin 5
E 106062246 transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E 106074753 transcription elongation factor B polypeptide 2-like K03873 ELOB; elongin-B
E 106079908 protein lingerer-like K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 106078541 DNA mismatch repair protein Msh2-like K08735 MSH2; DNA mismatch repair protein MSH2
E 106070971 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 106071126 DNA mismatch repair protein Msh6-like K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 106067580 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 106052286 LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh1-like K08734 MLH1; DNA mismatch repair protein MLH1
E 106073528 mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 106073353 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 106058143 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E 106066693 DNA polymerase delta subunit 3-like isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 106067124 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 106077619 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 106067122 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 106072880 uncharacterized protein LOC106072880 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 106071476 replication factor C subunit 1-like isoform X1 K10754 RFC1; replication factor C subunit 1
E 106073049 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 106064892 replication factor C subunit 4-like isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 106057338 LOW QUALITY PROTEIN: replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
E 106057943 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
E 106077799 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 106057737 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 106074940 LOW QUALITY PROTEIN: high mobility group protein B1-like K10802 HMGB1; high mobility group protein B1
E 106079525 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 106078482 double-strand break repair protein MRE11A-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 106076215 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 106069099 BRCA1-associated RING domain protein 1-like isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 106059346 BRCA1-A complex subunit Abraxas-like K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 106058720 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 106057227 BRCA1-A complex subunit BRE-like K12173 BRE; BRCA1-A complex subunit BRE
E 106055644 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 106067990 uncharacterized protein LOC106067990 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 106064934 DNA topoisomerase 2-binding protein 1-B-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 106078482 double-strand break repair protein MRE11A-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 106076215 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 106054222 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 106054222 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106068141 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 106069704 DNA repair protein RAD51 homolog 4-like isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 106061688 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 106073320 DNA repair protein XRCC3-like isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 106056554 DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 106069053 RAD52 motif-containing protein 1-like isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 106066848 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 106067058 uncharacterized protein LOC106067058 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 106074090 DNA repair and recombination protein RAD54B-like K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 106072856 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 106064417 Werner syndrome ATP-dependent helicase homolog isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 106051076 LOW QUALITY PROTEIN: Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106053605 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 106051076 LOW QUALITY PROTEIN: Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106071754 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106054096 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106066330 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 106065056 uncharacterized protein LOC106065056 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 106077619 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 106067122 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 106072880 uncharacterized protein LOC106072880 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 106068099 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 106069029 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 106056515 serine/threonine-protein phosphatase 4 regulatory subunit 2-like K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 106056827 serine/threonine-protein phosphatase 4 regulatory subunit 3A-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 106056868 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 106056632 AP-5 complex subunit beta-1-like K19022 AP5B1; AP-5 complex subunit beta-1
E 106053125 AP-5 complex subunit mu-1-like K19023 AP5M1; AP-5 complex subunit mu-1
E 106078409 uncharacterized protein LOC106078409 K19024 AP5S1; AP-5 complex subunit sigma-1
E 106055623 AP-5 complex subunit zeta-1-like K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 106078680 LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 5-like K22803 SMC5; structural maintenance of chromosomes protein 5
E 106068913 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 106061827 non-structural maintenance of chromosomes element 1 homolog isoform X1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 106058519 LOW QUALITY PROTEIN: uncharacterized protein LOC106058519 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 106052218 uncharacterized protein LOC106052218 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 106074819 crossover junction endonuclease EME1-like K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 106071181 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 106069688 uncharacterized protein LOC106069688 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 106065244 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 106078655 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 106071395 structure-specific endonuclease subunit slx1-like K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 106079906 flap endonuclease GEN homolog 1-like K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 106061175 spatacsin-like K19026 SPG11; spatacsin
E 106055371 zinc finger FYVE domain-containing protein 26-like K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 106063703 RAD51-associated protein 1-like K20778 RAD51AP1; RAD51-associated protein 1
E 106057985 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 106068174 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106058744 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106059885 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106060135 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106060136 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106060137 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106078441 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106072909 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 106069605 DNA repair-scaffolding protein-like K22806 SPIDR; DNA repair-scaffolding protein
E 106074790 uncharacterized protein LOC106074790 K22810 FAM84B; protein FAM84B
E 106070662 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 106059155 uncharacterized protein LOC106059155 K25771 SWSAP1; ATPase SWSAP1
E 106058502 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 106066875 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 106066633 uncharacterized protein LOC106066633 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 106076144 LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 5-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 106065855 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 106074827 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 106078482 double-strand break repair protein MRE11A-like isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 106076215 DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 106063468 DNA ligase 4-like K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 106051599 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 106079299 non-homologous end-joining factor 1-like K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 106077133 DNA polymerase lambda-like K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 106060785 DNA-directed DNA/RNA polymerase mu-like isoform X1 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 106055642 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 106056408 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106055392 ABC transporter F family member 4-like K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 106056546 protein artemis-like isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 106079775 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 106071858 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 106071859 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 106073145 LOW QUALITY PROTEIN: structural maintenance of chromosomes flexible hinge domain-containing protein 1-like K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 106068815 jmjC domain-containing protein 8-like isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E 106062077 Fanconi anemia group A protein homolog K10888 FANCA; fanconi anemia group A protein
E 106052814 uncharacterized protein LOC106052814 isoform X1 K10892 FANCE; fanconi anemia group E protein
E 106059897 E3 ubiquitin-protein ligase FANCL-like K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 106073783 uncharacterized protein LOC106073783 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 106072279 transcription factor HES-4-A-like K06054 HES1; hairy and enhancer of split 1
E 106061486 uncharacterized protein PB18E9.04c-like K06054 HES1; hairy and enhancer of split 1
E 106078717 transcription factor HES-1-B-like K06054 HES1; hairy and enhancer of split 1
E 106053534 centromere protein S-like K11511 APITD1; centromere protein S
E 106055733 centromere protein X-like isoform X1 K15360 STRA13; centromere protein X
E 106073455 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 106051076 LOW QUALITY PROTEIN: Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106071754 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106054096 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106066330 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
E 106065056 uncharacterized protein LOC106065056 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 106071975 Fanconi anemia group D2 protein-like K10891 FANCD2; fanconi anemia group D2 protein
E 106053826 LOW QUALITY PROTEIN: Fanconi anemia group I protein homolog K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 106067990 uncharacterized protein LOC106067990 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 106076812 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 106054222 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106068141 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 106071168 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 106062937 uncharacterized protein LOC106062937 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 106056294 LOW QUALITY PROTEIN: WD repeat-containing protein 48-like K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 106069105 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 106078225 serine/threonine-protein phosphatase 6 regulatory subunit 3-like isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 106079508 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 106072581 E3 ubiquitin-protein ligase RNF8-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 106063195 E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 106066440 E3 ubiquitin-protein ligase HERC2-like K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 106070101 telomerase Cajal body protein 1-like isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 106067594 uncharacterized protein PFB0765w-like isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 106060488 WD repeat-containing protein 70-like isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 106079525 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 106057958 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 106068539 DNA polymerase iota-like K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 106072262 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 106071496 DNA repair protein REV1-like isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 106057776 uncharacterized protein LOC106057776 isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 106074529 DNA polymerase I-like K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 106076447 ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106069768 helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 106060761 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 106059534 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 106057737 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 106066633 uncharacterized protein LOC106066633 K27412 PARPBP; PCNA-interacting partner
D 106054227 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 106058820 acidic repeat-containing protein-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 106055983 uncharacterized protein LOC106055983 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 106073368 checkpoint protein HUS1-like isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 106066821 checkpoint protein HUS1-like K10903 HUS1; HUS1 checkpoint protein
D 106056177 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 106057664 cell cycle checkpoint protein RAD17-like isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 106073049 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 106064892 replication factor C subunit 4-like isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 106057338 LOW QUALITY PROTEIN: replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 106057943 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 106077799 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 106056177 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 106052221 TIMELESS-interacting protein-like K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 106080242 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 106071168 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 106073371 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 106058845 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 106060495 large proline-rich protein bag6-B-like K23390 BAG6; large proline-rich protein BAG6
D 106060499 large proline-rich protein BAG6-like K23390 BAG6; large proline-rich protein BAG6
D 106054039 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 106054910 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 106079489 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 106069747 uncharacterized protein LOC106069747 K10905 ATRIP; ATR interacting protein
D 106066125 serine/threonine-protein kinase Chk1-like K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 106067930 serine/threonine-protein kinase Chk2-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 106057814 M-phase inducer phosphatase-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 106071592 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 106062020 14-3-3-like protein K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 106067725 14-3-3 protein epsilon-like K06630 YWHAE; 14-3-3 protein epsilon
D 106051222 uncharacterized protein LOC106051222 K02633 PER2; period circadian protein 2
D 106063022 mediator of DNA damage checkpoint protein 1-like K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 106079496 plastin-1-like K17336 PLS3; plastin-3
D 106072972 RNA exonuclease 4-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 106056555 LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek4-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 106066437 serine/threonine-protein kinase Nek1-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 106052288 serine/threonine-protein kinase Nek10-like K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 106052867 serine/threonine-protein kinase Nek11-like K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 106052660 protein downstream neighbor of Son-like K22422 DONSON; protein downstream neighbor of Son
D 106064223 KN motif and ankyrin repeat domain-containing protein 1-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 106054409 schlafen family member 13-like K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 106063428 vacuolar protein sorting-associated protein 4A-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106052905 spastin-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106056346 abscission/NoCut checkpoint regulator-like K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 106060196 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 106057537 LOW QUALITY PROTEIN: DNA polymerase theta-like K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
C Nucleases
D 106053328 three-prime repair exonuclease 1-like K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 106062643 DNA cross-link repair 1A protein-like K15340 DCLRE1A; DNA cross-link repair 1A protein
D 106069567 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 106057730 uncharacterized protein LOC106057730 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 106056854 DNA annealing helicase and endonuclease ZRANB3-like isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
C Helicases
D 106062703 uncharacterized protein LOC106062703 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 106070288 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 106051276 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 106056800 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 106050625 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 106066705 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 106058807 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 106058826 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 106067401 ribonucleoside-diphosphate reductase subunit M2-like K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106068743 methylated-DNA--protein-cysteine methyltransferase-like isoform X1 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 106056406 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106072128 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 106079626 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106059354 LOW QUALITY PROTEIN: A/G-specific adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F 106077418 DNA-directed RNA polymerase subunit alpha-like K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 106072939 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E 106063766 protein RecA-like K03553 recA; recombination protein RecA
D RecFOR pathway proteins
E 106063766 protein RecA-like K03553 recA; recombination protein RecA
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 106063766 protein RecA-like K03553 recA; recombination protein RecA
D 106072939 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 106066705 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024