+C Peptidases and inhibitors KO
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Peptidases and Inhibitors - Bacillus megaterium WSH-002
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AAspartic peptidases
B Family A1: pepsin family
B Family A2: retropepsin family
B Family A5: thermopsin family
B Family A8: signal peptidase II family
C BMWSH_0968 lspA; Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36]
B Family A22: presenilin family
B Family A24: type IV prepilin peptidase family
B Family A25: gpr protease family
C BMWSH_0669 gpr; Spore protease (Germination protease) K06012 gpr; spore protease [EC:3.4.24.78]
B Family A26: omptin family
B Family A28
B Family A31: HybD endopeptidase family
B Family A36
C BMWSH_0956 spoIIGA; Sporulation specific protein K06383 spoIIGA; stage II sporulation protein GA (sporulation sigma-E factor processing peptidase) [EC:3.4.23.-]
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ACysteine peptidases
B Family C1: papain family
B Family C2: calpain family
B Family C3: picornain family
B Family C4: NIa protease family
B Family C5
B Family C9
B Family C10: streptopain family
B Family C11: clostripain family
B Family C12: ubiquitin C-terminal hydrolase family
B Family C13: legumain family
B Family C14: caspase family
B Family C15: pyroglutamyl peptidase I family
C BMWSH_4136 Pyrrolidone-carboxylate peptidase K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3]
B Family C16
B Family C19: ubiquitin-specific protease family
B Family C25: gingipain family
B Family C26: gamma-glutamyl hydrolase family
C BMWSH_4977 guaA; GMP synthase PP-ATPase domain/subunit-like protein K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C BMWSH_3414 Glutamine amidotransferase class-I domain protein K07010 K07010; putative glutamine amidotransferase
B Family C27
B Family C30
B Family C37
B Family C39
B Family C40
C BMWSH_0145 yojL; putative endopeptidase lytE K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
C BMWSH_2217 Soluble lytic murein transglycosylase regulatory protein K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
C BMWSH_3573 Cell wall lytic activity K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
C BMWSH_1617 Endopeptidase lytE K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
C BMWSH_4180 lytE; Cell wall-associated hydrolase (Invasion-associated proteins)-like protein K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
C BMWSH_2170 Cell wall lytic activity K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
C BMWSH_2729 cwlO; hypothetical protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C BMWSH_3746 ykfC; Endopeptidase ykfC K20742 ykfC; gamma-D-glutamyl-L-lysine dipeptidyl-peptidase [EC:3.4.14.13]
C BMWSH_4775 Polysugar degrading enzyme K20742 ykfC; gamma-D-glutamyl-L-lysine dipeptidyl-peptidase [EC:3.4.14.13]
B Family C44
C BMWSH_4951 purF; Amidophosphoribosyltransferase (PRPP amidotransferase) K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C BMWSH_3162 gltA; glutamate synthase (large subunit) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C BMWSH_5036 glmS; Glucosamine/fructose-6-phosphate aminotransferase, isomerizing K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C BMWSH_4157 asnB; Asparagine synthase K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
C BMWSH_4604 asnO1; Asparagine synthetase [glutamine-hydrolyzing] 3 K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
B Family C45
B Family C46: hedgehog family
B Family C47: staphopain family
B Family C48: Ulp1 endopeptidase family
B Family C50: separase family
B Family C54: Aut2 peptidase family
B Family C55: YopJ protease family
B Family C56: PfpI endopeptidase family
C BMWSH_2569 Peptidase C56 family protein K05520 yhbO; deglycase [EC:3.5.1.124]
C BMWSH_4900 yraA; Intracellular protease 1 (Intracellular protease I) K05520 yhbO; deglycase [EC:3.5.1.124]
B Family C57: vaccinia virus I7 peptidase family
B Family C58
B Family C59
B Family C60
C BMWSH_2025 Sortase family protein K07284 srtA; sortase A [EC:3.4.22.70]
C BMWSH_2258 Peptidase C60 sortase A and B K07284 srtA; sortase A [EC:3.4.22.70]
C BMWSH_1217 Sortase (Surface protein transpeptidase) K07284 srtA; sortase A [EC:3.4.22.70]
B Family C63
B Family C64
B Family C65
B Family C67
B Family C69
B Family C70
B Family C75
B Family C76
B Family C78
B Family C79
B Family C82
B Family C83
B Family C85
B Family C86
B Family C88
B Family C89
B Family C97
B Family C98
B Family C110
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AGlutamic peptidases
B Family G1
B Family G4
B Family G5: prenyl protease 2 family
C BMWSH_1368 CAAX amino terminal protease family protein K07052 K07052; CAAX protease family protein
C BMWSH_1496 yyaK; YyaK K07052 K07052; CAAX protease family protein
C BMWSH_1346 Abortive infection protein K07052 K07052; CAAX protease family protein
C BMWSH_0872 ypbD; putative metal-dependent membrane protease, CAAX family K07052 K07052; CAAX protease family protein
C BMWSH_1666 Putative membrane-bound metalloprotease K07052 K07052; CAAX protease family protein
C BMWSH_1770 Abortive infection protein K07052 K07052; CAAX protease family protein
C BMWSH_2067 CAAX amino terminal protease family protein K07052 K07052; CAAX protease family protein
C BMWSH_4983 CAAX amino terminal protease family protein K07052 K07052; CAAX protease family protein
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AMetallo peptidases
B Family M1
B Family M2
B Family M3
C BMWSH_4533 pepF; Oligoendopeptidase F K08602 pepF; oligoendopeptidase F [EC:3.4.24.-]
B Family M4: thermolysin family
C BMWSH_2914 Bacillolysin (Thermolysin-like metalloprotease, peptidase M4) K01400 nprE; bacillolysin [EC:3.4.24.28]
B Family M5: mycolysin family
B Family M6: immune inhibitor A family
C BMWSH_2922 InhA K09607 ina; immune inhibitor A [EC:3.4.24.-]
B Family M7: snapalysin family
B Family M8: leishmanolysin family
B Family M9
B Family M10
B Family M12: astacin/adamalysin family
B Family M13: neprilysin family
B Family M14: carboxypeptidase A family
B Family M15: zinc D-Ala-D-Ala carboxypeptidase family
C BMWSH_4766 yodJ; Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
C BMWSH_2285 Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
C BMWSH_1700 Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
C BMWSH_3308 Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin K17733 cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]
C BMWSH_4921 ycdD; Peptidoglycan L-alanyl-D-glutamate endopeptidase cwlK K17733 cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]
B Family M16: pitrilysin family
B Family M17: leucyl aminopeptidase family
C BMWSH_0315 pepA; putative cytosol aminopeptidase (Leucine aminopeptidase)(LAP) (Leucyl aminopeptidase) K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
B Family M18
B Family M19: membrane dipeptidase family
C BMWSH_1111 Renal dipeptidase family protein K01273 DPEP; membrane dipeptidase [EC:3.4.13.19]
B Family M20
C BMWSH_4902 putative peptidase M20 family protein K01295 cpg; glutamate carboxypeptidase [EC:3.4.17.11]
C BMWSH_0406 Dipeptidase; probable Xaa-His dipeptidase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C BMWSH_0809 yqjE; Peptidase T-like protein K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4]
C BMWSH_2897 pepD; Peptidase family M20/M25/M40 superfamily K01270 pepD; dipeptidase D [EC:3.4.13.-]
C BMWSH_4643 yhaA; N-acyl-L-amino acid amidohydrolase (L-aminoacylase) K01436 yhaA; amidohydrolase [EC:3.5.1.-]
C BMWSH_4040 yxeP; Uncharacterized hydrolase yxeP K21613 scmP; N-acetylcysteine deacetylase [EC:3.5.1.-]
C BMWSH_2585 abgB; Peptidase M20D, amidohydrolase K12941 abgB; aminobenzoyl-glutamate utilization protein B
C BMWSH_3898 Peptidase, M20/M25/M40 family K05823 dapL; N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]
C BMWSH_2173 yurH; Amidase, hydantoinase/carbamoylase K02083 allC; allantoate deiminase [EC:3.5.3.9]
B Family M23
C BMWSH_0289 Peptidase M23 K21472 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-]
B Family M24
C BMWSH_3621 maP3; Methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C BMWSH_4927 Methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C BMWSH_5077 map; Methionine aminopeptidase 1 K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
B Family M26
B Family M27
B Family M28: aminopeptidase Y family
C BMWSH_3244 ywaD; Aminopeptidase K19701 ywaD; aminopeptidase YwaD [EC:3.4.11.6 3.4.11.10]
B Family M29: aminopeptidase T family
C BMWSH_2319 Aminopeptidase 2 K19689 ampS; aminopeptidase [EC:3.4.11.-]
C BMWSH_0424 Peptidase M29 aminopeptidase II K19689 ampS; aminopeptidase [EC:3.4.11.-]
B Family M32: carboxypeptidase Taq family
C BMWSH_1383 ypwA; Thermostable carboxypeptidase 1 K01299 E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]
C BMWSH_3781 Thermostable carboxypeptidase 1 K01299 E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]
B Family M34: anthrax lethal factor family
B Family M35: deuterolysin family
B Family M36: fungalysin family
B Family M38: beta-aspartyl dipeptidase family
C BMWSH_3607 iadA; Isoaspartyl dipeptidase K01305 iadA; beta-aspartyl-dipeptidase (metallo-type) [EC:3.4.19.-]
B Family M41: FtsH endopeptidase family
C BMWSH_5140 ftsH; Cell division protease ftsH-like protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
B Family M42: glutamyl aminopeptidase family
C BMWSH_2595 yhfE; Deblocking aminopeptidase, M42 family K01269 yhfE; aminopeptidase [EC:3.4.11.-]
B Family M43: cytophagalysin family
B Family M44
B Family M48: Ste24 endopeptidase family
C BMWSH_2403 ykrL; Zn-dependent protease with chaperone function-like protein K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
B Family M49: dipeptidyl-peptidase III family
B Family M50: S2P protease family
C BMWSH_0588 spoIVFB; Peptidase M50 K06402 spoIVFB; stage IV sporulation protein FB [EC:3.4.24.-]
C BMWSH_1069 yluC; Zinc metalloprotease rasP K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
B Family M54
B Family M55: DppA aminopeptidase family
C BMWSH_3752 dppA; Dipeptide ABC transporter ATP-binding protein K16203 dppA1; D-amino peptidase [EC:3.4.11.-]
B Family M56
B Family M67
B Family M72
B Family M73
B Family M74
B Family M80
B Family M82
C BMWSH_0881 ypdC; Membrane proteinase PrsW, regulator of anti-sigma factor RsiW K24131 prsW; protease PrsW [EC:3.4.-.-]
C BMWSH_1987 Membrane protein-like protein K24131 prsW; protease PrsW [EC:3.4.-.-]
B Family M85
B Family M88
B Family M90
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AAsparagine peptide lyases
B Family N1
B Family N8
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AMixed peptidases
B Family P1: DmpA aminopeptidase family
B Family P2
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ASerine peptidases
B Family S1: chymotrypsin family
C BMWSH_1316 hhoA; Trypsin-like protein serine protease, contains C-terminal PDZ domain, Do-like protein K04771 degP; serine protease Do [EC:3.4.21.107]
B Family S3: togavirin family
B Family S6
B Family S7: flavivirin family
B Family S8: subtilisin family
C BMWSH_p211 alp; Alkaline serine protease, subtilase family protein K01342 aprE; subtilisin [EC:3.4.21.62]
C BMWSH_4073 Cell wall-associated protease K13274 wprA; cell wall-associated protease [EC:3.4.21.-]
C BMWSH_p10062 Peptidase S8 and S53 subtilisin kexin sedolisin K08651 E3.4.21.66; thermitase [EC:3.4.21.66]
C BMWSH_3711 ispA; Major intracellular serine protease (ISP-1) K13275 isp; major intracellular serine protease [EC:3.4.21.-]
C BMWSH_4424 isp; Peptidase S8 and S53 subtilisin kexin sedolisin K13275 isp; major intracellular serine protease [EC:3.4.21.-]
C BMWSH_1729 lanP; Nisin leader peptide-processing serine protease NisP K20486 nisP; lantibiotic leader peptide-processing serine protease [EC:3.4.21.-]
C BMWSH_0121 Minor extracellular serine protease K14647 vpr; minor extracellular serine protease Vpr [EC:3.4.21.-]
C BMWSH_3033 vpr; Protease K14647 vpr; minor extracellular serine protease Vpr [EC:3.4.21.-]
B Family S9: prolyl oligopeptidase family
B Family S10
B Family S11: D-Ala-D-Ala carboxypeptidase A family
C BMWSH_0838 dacF; D-alanyl-D-alanine carboxypeptidase (Penicilin binding protein) K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C BMWSH_4973 dacA; D-alanyl-D-alanine carboxypeptidase dacA K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C BMWSH_0857 dacB; D-alanyl-D-alanine carboxypeptidase (Penicillin-binding protein) K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
B Family S12: D-Ala-D-Ala carboxypeptidase B family
B Family S13: D-Ala-D-Ala peptidase C family
B Family S14: ClpP endopeptidase family
C BMWSH_0219 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C BMWSH_1417 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C BMWSH_2105 clpP; ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
B Family S15
B Family S16: lon protease family
C BMWSH_0562 lonA; ATP-dependent protease La K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
C BMWSH_0561 lonB; ATP-dependent protease La-like protein K04076 lonB; ATP-dependent Lon protease [EC:3.4.21.53]
C BMWSH_0932 ylbL; ATP-dependent protease La K07177 K07177; Lon-like protease
B Family S21: assemblin family
B Family S24: LexA family
C BMWSH_1140 lexA; SOS-response transcriptional repressor, LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
B Family S26: signal peptidase I family
C BMWSH_1018 Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C BMWSH_1975 sipS; Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C BMWSH_2157 Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C BMWSH_4045 sipT; Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
B Family S28
B Family S31
B Family S32
B Family S33
C BMWSH_1728 putative abhydrolase domain containing 7 K22369 EPHX4; epoxide hydrolase 4 [EC:3.3.-.-]
C BMWSH_2256 putative abhydrolase domain containing 7 K22369 EPHX4; epoxide hydrolase 4 [EC:3.3.-.-]
B Family S41: C-terminal processing peptidase family
C BMWSH_0191 Peptidase S41A, C-terminal protease K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
B Family S45
B Family S49: protease IV family
C BMWSH_0450 sppA; Signal peptide peptidase SppA, 36K type K04773 sppA; protease IV [EC:3.4.21.-]
B Family S50
B Family S51
C BMWSH_2482 ygaJ; Peptidase S51 dipeptidase E K05995 pepE; dipeptidase E [EC:3.4.13.21]
C BMWSH_3604 Cyanophycinase exopeptidase-like protein K13282 cphB; cyanophycinase [EC:3.4.15.6]
B Family S53
B Family S54: Rhomboid family
C BMWSH_0732 yqgP; Serine protease of Rhomboid family, contains TPR repeats K19225 gluP; rhomboid protease GluP [EC:3.4.21.105]
B Family S55: SpoIVB peptidase family
C BMWSH_0784 spoIVB; SpoIVB peptidase 42 kDa isoform K06399 spoIVB; stage IV sporulation protein B [EC:3.4.21.116]
B Family S62
B Family S66
C BMWSH_3747 ykfA; U61 family carboxypeptidase K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
B Family S77: phage prohead processing peptidase family
B Family S78
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AThreonine peptidases
B Family T1: proteasome family
C BMWSH_1027 hslV; ATP-dependent protease peptidase subunit K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
B Family T2
B Family T3: gamma-glutamyltransferase family
C BMWSH_1323 Gamma-glutamyltranspeptidase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C BMWSH_2175 Gamma-glutamyltransferase 2 Threonine peptidase MEROPS family T03 K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C BMWSH_1869 Gamma-glutamyltransferase 2 Threonine peptidase MEROPS family T03 K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C BMWSH_3675 ggt; Gamma-glutamyltranspeptidase small chain K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C BMWSH_4140 Depolymerization of the capsular polymer (Gamma-glutamyltransferase family) K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C BMWSH_4238 Capsule biosynthesis protein capD K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C BMWSH_4240 capD; Capsule anchoring protein CapD K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
#
APeptidases of unknown catalytic type
B Family U32
C BMWSH_0641 yrrN; Uncharacterized protease yrrN K08303 prtC; U32 family peptidase [EC:3.4.-.-]
C BMWSH_0642 yrrO; Collagenase family protease K08303 prtC; U32 family peptidase [EC:3.4.-.-]
B Family U62
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APeptidase inhibitors
B Family I1: Kazal family
B Family I2: Kunitz - BPTI family
B Family I4: serpin family
B Family I11: ecotin family
B Family I17: WAP-type family
B Family I25: cystatin family
B Family I27: calpastatin family
B Family I32: IAP family
B Family I34: IA3 family
B Family I35: timp family
B Family I39: alpha2M family
B Family I47: latexin family
B Family I49: proSAAS family
B Family I51: IC family
B Family I57: staphostatin B family
B Family I63
B Family I80
C BMWSH_2558 YoeB K23598 iseA; iseA protein
C BMWSH_4716 yoeB; YoeB K23598 iseA; iseA protein
B Family I87
B Family I93
!
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 29, 2024
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Classification taken and modified from MEROPS