+E Replication protein KO
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DNA Replication Proteins - Bos taurus (cow)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 513523 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 511281 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 523714 ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 529245 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 519409 ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 515476 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 519016 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 515301 CDC6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 510120 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 281302 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 504367 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 506970 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 517812 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 539924 MCM7; DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 281667 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 521939 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 533526 CCNE1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 538436 CCNE2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 519217 CDK2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 516094 CDC7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 510916 DBF4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 615016 DBF4B; protein DBF4 homolog B isoform X1 K06629 DBF4; protein DBF4
C GINS complex
D 523427 GINS1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 100299171 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 538943 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 616799 GINS4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 540574 TOPBP1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 515472 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 507122 CDC45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 507507 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 100139498 MCM9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 527595 MCM10; protein MCM10 homolog isoform X2 K10736 MCM10; minichromosome maintenance protein 10
D 514863 MCMBP; mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 614572 HELB; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 613767 CINP; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 617904 MTBP; mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 529868 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 534848 POLA1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 514793 POLA2; DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 506240 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 514682 PRIM2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 785457 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 518653 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 510678 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 613730 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 281990 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 281991 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 537616 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D 617899 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 533090 POLG; DNA polymerase subunit gamma-1 isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 505152 POLG2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 504844 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 507912 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 512754 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D 104971312 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
C RFC (replication factor C)
D 514842 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 504637 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 508652 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 508389 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 515602 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 613354 RNASEH1; ribonuclease H1 isoform 2 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 512830 RNASEH2A; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 509258 RNASEH2B; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 505618 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 515499 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 540969 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 616242 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 506390 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 529922 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100124507 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 513059 ATAD5; ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 281119 DNMT1; DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 359716 DNMT3A; DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 353354 DNMT3B; DNA (cytosine-5)-methyltransferase 3B K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 526377 GMNN; geminin K10749 GMNN; geminin
D 100301340 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 132345077 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 327679 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 281668 CCNB2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100301478 CCNB3; G2/mitotic-specific cyclin-B3 isoform X2 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 281061 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 511292 POT1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 519474 TERF1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 506501 TERF2; telomeric repeat-binding factor 2 isoform 1 K11111 TERF2; telomeric repeat-binding factor 2
E 540420 TINF2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 509625 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 510353 ACD; adrenocortical dysplasia protein homolog isoform X5 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 100295202 TERB1; telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 768019 TERB2; telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 788447 MAJIN; membrane-anchored junction protein K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 513500 CTC1; CST complex subunit CTC1 isoform X1 K23311 CTC1; CST complex subunit CTC1
E 514213 STN1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 510634 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 516411 SMG6; telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 513598 SMG5; nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 518884 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 505802 TEP1; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 515057 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 520891 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 616675 NOP10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 525619 DKC1; H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 518884 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 613304 SNRPB; small nuclear ribonucleoprotein-associated protein B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 104971292 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 104974918 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 107131841 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 508788 SNRPD1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 514932 SNRPD2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 617823 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 107132043 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 107132237 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 112442575 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 112442676 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 531493 SNRPE; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 107131530 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 615240 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 107131494 small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 107132386 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 107132556 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 522621 SNRPG; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 504637 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 508652 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 508389 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 515602 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 525093 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 788127 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 522943 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 526824 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 505061 WRN; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 534148 BLM; recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 512740 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 516371 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 286764 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 505828 PARP2; poly [ADP-ribose] polymerase 2 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
D 533901 TNKS2; poly [ADP-ribose] polymerase tankyrase-2 isoform X2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 535030 TNKS; poly [ADP-ribose] polymerase tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 525027 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 505721 RTEL1; regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 526097 TELO2; telomere length regulation protein TEL2 homolog isoform X2 K11137 TELO2; telomere length regulation protein
D 504587 TRIR; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 541247 RIF1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 534330 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 782746 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 512941 PURG; purine-rich element-binding protein gamma isoform X1 K21800 PURG; purine-rich element-binding protein gamma
D 509631 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 534664 SDE2; splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 513536 RTF2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 534799 TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 282097 TOP2B; DNA topoisomerase 2-beta isoform X3 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 787696 TOP2A; DNA topoisomerase 2-alpha isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 527411 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 537418 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 515765 SSBP1; single-stranded DNA-binding protein, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 613354 RNASEH1; ribonuclease H1 isoform 2 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 613354 RNASEH1; ribonuclease H1 isoform 2 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 540969 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 616242 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100124507 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025