+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Calonectris borealis (Cory's shearwater)</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      142084496 MGMT; (RefSeq) methylated-DNA--protein-cysteine methyltransferase isoform X1	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      142090137 ALKBH2; (RefSeq) DNA oxidative demethylase ALKBH2 isoform X1	K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33] 
D      142083143 ALKBH3; (RefSeq) alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54] 
D      142080330 ASCC3; (RefSeq) activating signal cointegrator 1 complex subunit 3 isoform X1	K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] 
D      142085356 deoxyribodipyrimidine photo-lyase-like	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        142090135 UNG; (RefSeq) uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        142075637 CCNO; (RefSeq) cyclin-O	K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-] 
E        142085405 TDG; (RefSeq) G/T mismatch-specific thymine DNA glycosylase isoform X1	K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] 
E        142089440 MPG; (RefSeq) DNA-3-methyladenine glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        142073584 SMUG1; (RefSeq) LOW QUALITY PROTEIN: single-strand selective monofunctional uracil DNA glycosylase	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        142084844 LOW QUALITY PROTEIN: uncharacterized protein LOC142084844	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        142086054 MBD4; (RefSeq) methyl-CpG-binding domain protein 4 isoform X1	K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-] 
E        142086165 OGG1; (RefSeq) N-glycosylase/DNA lyase isoform X1	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
E        142086852 NEIL1; (RefSeq) endonuclease 8-like 1 isoform X1	K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18] 
E        142081290 NEIL2; (RefSeq) endonuclease 8-like 2	K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18] 
E        142081923 NEIL3; (RefSeq) endonuclease 8-like 3	K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18] 
E        142089280 NTHL1; (RefSeq) endonuclease III-like protein 1 isoform X1	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      Long Patch-BER factors
E        DNA polymerase delta complex
F          142093433 POLD2; (RefSeq) DNA polymerase delta subunit 2	K02328 POLD2; DNA polymerase delta subunit 2 
F          142077978 POLD3; (RefSeq) DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
F          142088269 POLD4; (RefSeq) DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
E        DNA polymerase epsilon complex
F          142090372 POLE; (RefSeq) DNA polymerase epsilon catalytic subunit A	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
F          142082570 POLE2; (RefSeq) DNA polymerase epsilon subunit 2	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
F          142091263 POLE3; (RefSeq) DNA polymerase epsilon subunit 3 isoform X1	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
F          142093683 POLE4; (RefSeq) DNA polymerase epsilon subunit 4	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
E        142093583 PCNA; (RefSeq) proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        142088317 FEN1; (RefSeq) flap endonuclease 1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      Short Patch-BER factors
E        142093599 POLB; (RefSeq) DNA polymerase beta	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
E        142077999 XNDC1N; (RefSeq) protein XNDC1N isoform X1	K10803 XRCC1; DNA-repair protein XRCC1 
E        142090637 LIG3; (RefSeq) DNA ligase 3 isoform X1	K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] 
D      Other BER factors
E        142082800 TDP1; (RefSeq) tyrosyl-DNA phosphodiesterase 1 isoform X1	K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] 
E        142075760 APTX; (RefSeq) aprataxin isoform X1	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        142081099 APLF; (RefSeq) aprataxin and PNK-like factor	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        142077749 HMGB1; (RefSeq) high mobility group protein B1 isoform X1	K10802 HMGB1; high mobility group protein B1 
E        142084332 POLL; (RefSeq) DNA polymerase lambda isoform X1	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        142080953 PARP1; (RefSeq) poly [ADP-ribose] polymerase 1	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
E        142077808 PARP4; (RefSeq) protein mono-ADP-ribosyltransferase PARP4 isoform X1	K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-] 
E        142085988 PARP3; (RefSeq) protein mono-ADP-ribosyltransferase PARP3	K10798 PARP3_4; protein mono-ADP-ribosyltransferase 3/4 [EC:2.4.2.-] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
F          142086185 XPC; (RefSeq) DNA repair protein complementing XP-C cells isoform X1	K10838 XPC; xeroderma pigmentosum group C-complementing protein 
F          142073886 RAD23A; (RefSeq) UV excision repair protein RAD23 homolog A	K10839 RAD23; UV excision repair protein RAD23 
F          142074783 UV excision repair protein RAD23 homolog B-like	K10839 RAD23; UV excision repair protein RAD23 
F          142075480 RAD23B; (RefSeq) UV excision repair protein RAD23 homolog B isoform X1	K10839 RAD23; UV excision repair protein RAD23 
F          142087845 centrin-2	K10840 CETN2; centrin-2 
F          142087903 uncharacterized protein LOC142087903	K10840 CETN2; centrin-2 
E        Cul4-DDB2 complex
F          142084123 RBX1; (RefSeq) E3 ubiquitin-protein ligase RBX1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          142075475 CUL4A; (RefSeq) cullin-4A isoform X1	K10609 CUL4; cullin 4 
F          142087765 CUL4B; (RefSeq) cullin-4B isoform X1	K10609 CUL4; cullin 4 
F          142088296 DDB1; (RefSeq) DNA damage-binding protein 1 isoform X1	K10610 DDB1; DNA damage-binding protein 1 
F          142083105 DDB2; (RefSeq) DNA damage-binding protein 2 isoform X1	K10140 DDB2; DNA damage-binding protein 2 
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
F          142074440 POLR2A; (RefSeq) LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1	K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] 
F          142082024 POLR2B; (RefSeq) DNA-directed RNA polymerase II subunit RPB2 isoform X1	K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] 
F          142087064 POLR2C; (RefSeq) DNA-directed RNA polymerase II subunit RPB3 isoform X1	K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 
F          142085759 POLR2D; (RefSeq) DNA-directed RNA polymerase II subunit RPB4	K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 
F          142093858 POLR2E; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC1	K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 
F          142084653 POLR2F; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1	K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 
F          142085399 POLR2H; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1	K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 
F          142074094 POLR2I; (RefSeq) DNA-directed RNA polymerase II subunit RPB9	K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 
F          142088053 POLR2L; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC5	K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5 
F          142090664 POLR2J; (RefSeq) DNA-directed RNA polymerase II subunit RPB11-a	K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 
F          142078601 POLR2K; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC4	K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 
E        Cul4-CSA complex
F          142084123 RBX1; (RefSeq) E3 ubiquitin-protein ligase RBX1	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          142075475 CUL4A; (RefSeq) cullin-4A isoform X1	K10609 CUL4; cullin 4 
F          142087765 CUL4B; (RefSeq) cullin-4B isoform X1	K10609 CUL4; cullin 4 
F          142088296 DDB1; (RefSeq) DNA damage-binding protein 1 isoform X1	K10610 DDB1; DNA damage-binding protein 1 
F          142075668 ERCC8; (RefSeq) DNA excision repair protein ERCC-8 isoform X1	K10570 ERCC8; DNA excision repair protein ERCC-8 
E        Other TCR factor
F          142084241 ERCC6; (RefSeq) DNA excision repair protein ERCC-6 isoform X1	K10841 ERCC6; DNA excision repair protein ERCC-6 
F          142081662 UVSSA; (RefSeq) UV-stimulated scaffold protein A isoform X1	K23720 UVSSA; UV-stimulated scaffold protein A 
F          142073883 ELOF1; (RefSeq) transcription elongation factor 1 homolog	K25829 ELOF1; transcription elongation factor 1 
D      TFIIH complex
E        142083478 ERCC3; (RefSeq) general transcription and DNA repair factor IIH helicase/translocase subunit XPB isoform X1	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        142074047 ERCC2; (RefSeq) general transcription and DNA repair factor IIH helicase subunit XPD isoform X1	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        142088098 GTF2H1; (RefSeq) general transcription factor IIH subunit 1 isoform X1	K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 
E        142090243 GTF2H3; (RefSeq) general transcription factor IIH subunit 3 isoform X1	K03143 TFIIH3; transcription initiation factor TFIIH subunit 3 
E        142080523 GTF2H5; (RefSeq) general transcription factor IIH subunit 5	K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit 
E        142075586 CDK7; (RefSeq) cyclin-dependent kinase 7 isoform X1	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        142075471 CCNH; (RefSeq) cyclin-H isoform X1	K06634 CCNH; cyclin H 
E        142082642 MNAT1; (RefSeq) CDK-activating kinase assembly factor MAT1 isoform X1	K10842 MNAT1; CDK-activating kinase assembly factor MAT1 
D      RPA (replication factor A)
E        142090590 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit isoform X1	K07466 RFA1; replication factor A1 
E        142092970 RPA2; (RefSeq) replication protein A 32 kDa subunit isoform X1	K10739 RFA2; replication factor A2 
E        142079460 RPA3; (RefSeq) replication protein A 14 kDa subunit isoform X1	K10740 RPA3; replication factor A3 
D      Other NER factors
E        142075293 XPA; (RefSeq) DNA repair protein complementing XP-A cells	K10847 XPA; DNA-repair protein complementing XP-A cells 
E        142073988 ERCC1; (RefSeq) DNA excision repair protein ERCC-1	K10849 ERCC1; DNA excision repair protein ERCC-1 
E        142089453 ERCC4; (RefSeq) DNA repair endonuclease XPF	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
E        142075745 ERCC5; (RefSeq) DNA excision repair protein ERCC-5 isoform X1	K10846 ERCC5; DNA excision repair protein ERCC-5 
E        142084311 MMS19; (RefSeq) MMS19 nucleotide excision repair protein homolog isoform X1	K15075 MET18; DNA repair/transcription protein MET18/MMS19 
E        142090096 CCDC117; (RefSeq) coiled-coil domain-containing protein 117 isoform X1	K27967 CCDC117; coiled-coil domain-containing protein 117 
E        142093496 CIAO1; (RefSeq) putative cytosolic iron-sulfur protein assembly protein CIAO1 isoform X1	K24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1 
E        142086550 CIAO2A; (RefSeq) cytosolic iron-sulfur assembly component 2A	K26403 CIAO2; cytosolic iron-sulfur assembly component 2 
E        142087305 CIAO2B; (RefSeq) cytosolic iron-sulfur assembly component 2B isoform X1	K26403 CIAO2; cytosolic iron-sulfur assembly component 2 
E        142085821 CUL3; (RefSeq) cullin-3 isoform X1	K03869 CUL3; cullin 3 
E        142077828 CUL5; (RefSeq) cullin-5 isoform X1	K10612 CUL5; cullin 5 
E        142078701 ELOC; (RefSeq) elongin-C	K03872 ELOC; elongin-C 
E        142077548 elongin-B-like	K03873 ELOB; elongin-B 
E        142080200 elongin-A-like isoform X1	K15076 ELOA; elongin-A 
E        142092834 ELOA; (RefSeq) elongin-A isoform X1	K15076 ELOA; elongin-A 
E        142073536 UBAP2L; (RefSeq) ubiquitin-associated protein 2-like isoform X1	K26545 UBAP2; ubiquitin-associated protein 2 
E        142074711 ubiquitin-associated protein 2-like isoform X1	K26545 UBAP2; ubiquitin-associated protein 2 
E        142075699 ubiquitin-associated protein 2-like isoform X1	K26545 UBAP2; ubiquitin-associated protein 2 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        142080970 MSH2; (RefSeq) DNA mismatch repair protein Msh2 isoform X1	K08735 MSH2; DNA mismatch repair protein MSH2 
E        142075600 MSH3; (RefSeq) DNA mismatch repair protein Msh3 isoform X1	K08736 MSH3; DNA mismatch repair protein MSH3 
E        142080972 MSH6; (RefSeq) DNA mismatch repair protein Msh6 isoform X1	K08737 MSH6; DNA mismatch repair protein MSH6 
D      MutL homologs
E        142083751 PMS1; (RefSeq) PMS1 protein homolog 1 isoform X1	K10864 PMS1; DNA mismatch repair protein PMS1 
E        142079244 MLH1; (RefSeq) DNA mismatch repair protein Mlh1 isoform X1	K08734 MLH1; DNA mismatch repair protein MLH1 
E        142089132 PMS2; (RefSeq) mismatch repair endonuclease PMS2	K10858 PMS2; DNA mismatch repair protein PMS2 
E        142082863 MLH3; (RefSeq) DNA mismatch repair protein Mlh3 isoform X1	K08739 MLH3; DNA mismatch repair protein MLH3 
D      DNA polymerase delta complex
E        142093433 POLD2; (RefSeq) DNA polymerase delta subunit 2	K02328 POLD2; DNA polymerase delta subunit 2 
E        142077978 POLD3; (RefSeq) DNA polymerase delta subunit 3 isoform X1	K03504 POLD3; DNA polymerase delta subunit 3 
E        142088269 POLD4; (RefSeq) DNA polymerase delta subunit 4	K03505 POLD4; DNA polymerase delta subunit 4 
D      RPA (replication factor A)
E        142090590 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit isoform X1	K07466 RFA1; replication factor A1 
E        142092970 RPA2; (RefSeq) replication protein A 32 kDa subunit isoform X1	K10739 RFA2; replication factor A2 
E        142079460 RPA3; (RefSeq) replication protein A 14 kDa subunit isoform X1	K10740 RPA3; replication factor A3 
D      RFC (replication factor C)
E        142081792 RFC1; (RefSeq) replication factor C subunit 1 isoform X1	K10754 RFC1; replication factor C subunit 1 
E        142085408 RFC4; (RefSeq) replication factor C subunit 4 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
E        142090693 RFC2; (RefSeq) replication factor C subunit 2 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
E        142077737 RFC3; (RefSeq) replication factor C subunit 3 isoform X1	K10756 RFC3_5; replication factor C subunit 3/5 
E        142090016 RFC5; (RefSeq) replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
D      Other MMR factors
E        142093583 PCNA; (RefSeq) proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
E        142081417 EXO1; (RefSeq) exonuclease 1	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
E        142077749 HMGB1; (RefSeq) high mobility group protein B1 isoform X1	K10802 HMGB1; high mobility group protein B1 
E        142086541 WDR76; (RefSeq) WD repeat-containing protein 76	K24755 WDR76; WD repeat-containing protein 76 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
E        142077876 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        142088800 RAD50; (RefSeq) DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        142078653 NBN; (RefSeq) nibrin isoform X1	K10867 NBN; nibrin 
D      BRCA1-core complex
E        142092041 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        142083790 BARD1; (RefSeq) BRCA1-associated RING domain protein 1	K10683 BARD1; BRCA1-associated RING domain protein 1 
D      BRCA1-A complex
E        142092041 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        142077579 BRCA1-A complex subunit Abraxas 1 isoform X1	K20774 FAM175A; BRCA1-A complex subunit Abraxas 
E        142082152 ABRAXAS1; (RefSeq) BRCA1-A complex subunit Abraxas 1	K20774 FAM175A; BRCA1-A complex subunit Abraxas 
E        142088715 UIMC1; (RefSeq) BRCA1-A complex subunit RAP80 isoform X1	K20775 UIMC1; BRCA1-A complex subunit RAP80 
E        142093951 BABAM1; (RefSeq) BRISC and BRCA1-A complex member 1	K20776 BABAM; BRISC and BRCA1-A complex member 1 
E        142080803 BABAM2; (RefSeq) BRISC and BRCA1-A complex member 2	K12173 BRE; BRCA1-A complex subunit BRE 
E        142087684 BRCC3; (RefSeq) lys-63-specific deubiquitinase BRCC36	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
D      BRCA1-B complex
E        142092041 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        142090480 BRIP1; (RefSeq) Fanconi anemia group J protein isoform X1	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        142079295 TOPBP1; (RefSeq) DNA topoisomerase 2-binding protein 1 isoform X1	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      BRCA1-C complex
E        142092041 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        142078829 RBBP8; (RefSeq) DNA endonuclease RBBP8	K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-] 
E        142077876 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        142088800 RAD50; (RefSeq) DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        142078653 NBN; (RefSeq) nibrin isoform X1	K10867 NBN; nibrin 
D      BRCA complex
E        142092041 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        142077741 BRCA2; (RefSeq) breast cancer type 2 susceptibility protein	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        142089301 PALB2; (RefSeq) LOW QUALITY PROTEIN: partner and localizer of BRCA2	K10897 PALB2; partner and localizer of BRCA2 
E        142088372 RAD51; (RefSeq) DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
D      RecA family proteins
E        142088372 RAD51; (RefSeq) DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        142082981 RAD51B; (RefSeq) DNA repair protein RAD51 homolog 2 isoform X1	K10869 RAD51L1; RAD51-like protein 1 
E        142090499 RAD51C; (RefSeq) DNA repair protein RAD51 homolog 3 isoform X1	K10870 RAD51L2; RAD51-like protein 2 
E        142090640 RAD51D; (RefSeq) DNA repair protein RAD51 homolog 4	K10871 RAD51L3; RAD51-like protein 3 
E        142079635 XRCC2; (RefSeq) DNA repair protein XRCC2 isoform X1	K10879 XRCC2; DNA-repair protein XRCC2 
E        142082693 XRCC3; (RefSeq) DNA repair protein XRCC3 isoform X1	K10880 XRCC3; DNA-repair protein XRCC3 
D      Rad52 family proteins
E        142086315 RAD52; (RefSeq) DNA repair protein RAD52 homolog isoform X1	K10873 RAD52; DNA repair and recombination protein RAD52 
E        142091837 RDM1; (RefSeq) RAD52 motif-containing protein 1 isoform X1	K10874 RDM1; RAD52 motif-containing protein 1 
D      Rad54 family proteins
E        142084823 RAD54L; (RefSeq) LOW QUALITY PROTEIN: DNA repair and recombination protein RAD54-like	K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] 
E        142086330 RAD54L2; (RefSeq) helicase ARIP4 isoform X1	K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] 
E        142078638 RAD54B; (RefSeq) DNA repair and recombination protein RAD54B isoform X1	K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-] 
D      RecQ family DNA helicases
E        142086803 RECQL; (RefSeq) ATP-dependent DNA helicase Q1 isoform X1	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        142082281 WRN; (RefSeq) bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1	K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4] 
E        142086543 BLM; (RefSeq) recQ-like DNA helicase BLM	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        142078467 RECQL4; (RefSeq) ATP-dependent DNA helicase Q4	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
E        142091113 RECQL5; (RefSeq) ATP-dependent DNA helicase Q5 isoform X1	K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] 
D      Bloom's syndrome complex (BTR)
E        142086543 BLM; (RefSeq) recQ-like DNA helicase BLM	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        142089240 TOP3A; (RefSeq) DNA topoisomerase 3-alpha	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        142090308 TOP3B; (RefSeq) DNA topoisomerase 3-beta-1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        142075780 RMI1; (RefSeq) recQ-mediated genome instability protein 1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        142089053 RMI2; (RefSeq) recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      RPA (replication factor A)
E        142090590 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit isoform X1	K07466 RFA1; replication factor A1 
E        142092970 RPA2; (RefSeq) replication protein A 32 kDa subunit isoform X1	K10739 RFA2; replication factor A2 
E        142079460 RPA3; (RefSeq) replication protein A 14 kDa subunit isoform X1	K10740 RPA3; replication factor A3 
D      Protein phosphatase 4
E        142078867 PPP4R1; (RefSeq) serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        142089740 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        142086091 PPP4R2; (RefSeq) serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X1	K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 
E        142081163 PPP4R3B; (RefSeq) serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        142082789 PPP4R3A; (RefSeq) serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        142082760 PPP4R4; (RefSeq) serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1	K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 
D      AP-5 complex
E        142082620 AP5M1; (RefSeq) AP-5 complex subunit mu-1	K19023 AP5M1; AP-5 complex subunit mu-1 
E        142081592 AP5S1; (RefSeq) AP-5 complex subunit sigma-1	K19024 AP5S1; AP-5 complex subunit sigma-1 
E        142089188 AP5Z1; (RefSeq) AP-5 complex subunit zeta-1	K19025 AP5Z1; AP-5 complex subunit zeta-1 
D      SMC5-SMC6 complex
E        142075649 SMC5; (RefSeq) structural maintenance of chromosomes protein 5 isoform X1	K22803 SMC5; structural maintenance of chromosomes protein 5 
E        142080121 SMC6; (RefSeq) structural maintenance of chromosomes protein 6 isoform X1	K22804 SMC6; structural maintenance of chromosomes protein 6 
E        142080127 LRATD1; (RefSeq) protein LRATD1	K22805 FAM84A; protein FAM84A 
E        142089313 NSMCE1; (RefSeq) non-structural maintenance of chromosomes element 1 homolog isoform X1	K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] 
E        142078526 NSMCE2; (RefSeq) E3 SUMO-protein ligase NSE2 isoform X1	K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-] 
E        142074266 non-structural maintenance of chromosomes element 3 homolog isoform X1	K22823 NSMCE3; non-structural maintenance of chromosomes element 3 
E        142084457 NSMCE4A; (RefSeq) non-structural maintenance of chromosomes element 4 homolog A	K22825 NSMCE4; non-structural maintenance of chromosomes element 4 
E        142075343 SLF1; (RefSeq) SMC5-SMC6 complex localization factor protein 1 isoform X1	K26126 SLF1; SMC5-SMC6 complex localization factor protein 1 
E        142084341 SLF2; (RefSeq) SMC5-SMC6 complex localization factor protein 2 isoform X1	K26127 SLF2; SMC5-SMC6 complex localization factor protein 2 
E        142088704 SIMC1; (RefSeq) SUMO-interacting motif-containing protein 1 isoform X1	K28408 SIMC1; SUMO-interacting motif-containing protein 1 
D      Other HR factors
E        142091194 EME1; (RefSeq) structure-specific endonuclease subunit EME1	K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-] 
E        142089398 EME2; (RefSeq) structure-specific endonuclease subunit EME2	K10883 EME2; crossover junction endonuclease EME2 
E        142082990 EXD2; (RefSeq) exonuclease 3'-5' domain-containing protein 2 isoform X1	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        142091566 SWI5; (RefSeq) DNA repair protein SWI5 homolog	K10991 SWI5; DNA repair protein Swi5/Sae3 
E        142084373 SFR1; (RefSeq) swi5-dependent recombination DNA repair protein 1 homolog isoform X1	K10992 SFR1; Swi5-dependent recombination DNA repair protein 1 
E        142089417 SLX4; (RefSeq) structure-specific endonuclease subunit SLX4 isoform X1	K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) 
E        142080122 GEN1; (RefSeq) flap endonuclease GEN homolog 1 isoform X1	K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-] 
E        142086551 SPG11; (RefSeq) spatacsin	K19026 SPG11; spatacsin 
E        142082969 ZFYVE26; (RefSeq) zinc finger FYVE domain-containing protein 26 isoform X1	K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 
E        142088058 RAD51AP1; (RefSeq) RAD51-associated protein 1 isoform X1	K20778 RAD51AP1; RAD51-associated protein 1 
E        142086548 MORF4L1; (RefSeq) mortality factor 4-like protein 1 isoform X1	K11339 MORF4L1; mortality factor 4-like protein 1 
E        142089575 SAMHD1; (RefSeq) deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1	K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] 
E        142078988 FIGNL1; (RefSeq) fidgetin-like protein 1	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        142078789 SPIDR; (RefSeq) DNA repair-scaffolding protein	K22806 SPIDR; DNA repair-scaffolding protein 
E        142079811 LRATD2; (RefSeq) protein LRATD2	K22810 FAM84B; protein FAM84B 
E        142089172 BRAT1; (RefSeq) integrator complex assembly factor BRAT1 isoform X1	K23112 BRAT1; BRCA1-associated ATM activator 1 
E        142085682 CFAP410; (RefSeq) cilia- and flagella-associated protein 410	K23456 CFAP410; cilla- and flagella-associated protein 
E        142093763 HDGFL2; (RefSeq) hepatoma-derived growth factor-related protein 2 isoform X1	K25065 HDGFL2; hepatoma-derived growth factor-related protein 2 
E        142090539 ZSWIM7; (RefSeq) zinc finger SWIM domain-containing protein 7 isoform X1	K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7 
E        142073912 SWSAP1; (RefSeq) ATPase SWSAP1	K25771 SWSAP1; ATPase SWSAP1 
E        142077941 EMSY; (RefSeq) BRCA2-interacting transcriptional repressor EMSY isoform X1	K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY 
E        142094328 HSF2BP; (RefSeq) heat shock factor 2-binding protein	K25791 HSF2BP; heat shock factor 2-binding protein 
E        142080320 MMS22L; (RefSeq) protein MMS22-like	K26125 MMS22L; protein MMS22-like 
E        142078460 TONSL; (RefSeq) tonsoku-like protein	K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 
E        142081737 BOD1L1; (RefSeq) biorientation of chromosomes in cell division protein 1-like 1 isoform X1	K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 
E        142085453 PARPBP; (RefSeq) PCNA-interacting partner isoform X1	K27412 PARPBP; PCNA-interacting partner 
E        142091870 ASB16; (RefSeq) ankyrin repeat and SOCS box protein 16 isoform X1	K27803 HROB; homologous recombination OB-fold protein 
E        142081060 MCM8; (RefSeq) DNA helicase MCM8	K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4] 
E        142080412 MCM9; (RefSeq) DNA helicase MCM9	K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4] 
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
E        142083865 XRCC6; (RefSeq) X-ray repair cross-complementing protein 6 isoform X1	K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 
E        142083481 XRCC5; (RefSeq) X-ray repair cross-complementing protein 5 isoform X1	K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 
E        142078786 PRKDC; (RefSeq) LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit	K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1] 
D      MRX complex
E        142077876 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X1	K10865 MRE11; double-strand break repair protein MRE11 
E        142088800 RAD50; (RefSeq) DNA repair protein RAD50	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      DNA Ligase 4 complex
E        142075704 LIG4; (RefSeq) DNA ligase 4	K10777 LIG4; DNA ligase 4 [EC:6.5.1.1] 
E        142075807 XRCC4; (RefSeq) DNA repair protein XRCC4 isoform X1	K10886 XRCC4; DNA-repair protein XRCC4 
E        142083899 NHEJ1; (RefSeq) non-homologous end-joining factor 1	K10980 NHEJ1; non-homologous end-joining factor 1 
D      X-family DNA polymerases
E        142084332 POLL; (RefSeq) DNA polymerase lambda isoform X1	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        142084286 DNTT; (RefSeq) DNA nucleotidylexotransferase isoform X1	K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31] 
E        142093599 POLB; (RefSeq) DNA polymerase beta	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
D      Other NHEJ factors
E        142075760 APTX; (RefSeq) aprataxin isoform X1	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        142081099 APLF; (RefSeq) aprataxin and PNK-like factor	K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-] 
E        142079596 DCLRE1C; (RefSeq) protein artemis isoform X1	K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-] 
E        142078921 TDP2; (RefSeq) tyrosyl-DNA phosphodiesterase 2	K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] 
E        142078845 SMCHD1; (RefSeq) structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1	K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 
E        142093898 PWWP3A; (RefSeq) PWWP domain-containing DNA repair factor 3A	K23386 PWWP3; PWWP domain-containing DNA repair factor 3 
E        142091238 PAXX; (RefSeq) protein PAXX isoform X1	K25772 PAXX; protein PAXX 
E        142083146 CYREN; (RefSeq) cell cycle regulator of non-homologous end joining isoform X1	K26155 CYREN; cell cycle regulator of non-homologous end joining 
E        142089379 JMJD8; (RefSeq) jmjC domain-containing protein 8 isoform X1	K25792 JMJD8; jumonji domain-containing protein 8 
E        142081055 SHLD1; (RefSeq) shieldin complex subunit 1 isoform X1	K26128 SHLD1; shieldin complex subunit 1 
E        142084138 SHLD2; (RefSeq) shieldin complex subunit 2 isoform X1	K26129 SHLD2; shieldin complex subunit 2 
E        142076018 SHLD3; (RefSeq) shieldin complex subunit 3	K26130 SHLD3; shieldin complex subunit 3 
E        142081813 BEND4; (RefSeq) BEN domain-containing protein 4	K27845 BEND4; BEN domain-containing protein 4 
C    FA (Fanconi anemia) pathway
D      FA core complex
E        142087436 FANCA; (RefSeq) Fanconi anemia group A protein	K10888 FANCA; fanconi anemia group A protein 
E        142094018 FANCB; (RefSeq) Fanconi anemia group B protein isoform X1	K10889 FANCB; fanconi anemia group B protein 
E        142075316 FANCC; (RefSeq) Fanconi anemia group C protein	K10890 FANCC; fanconi anemia group C protein 
E        142093205 FANCE; (RefSeq) Fanconi anemia group E protein	K10892 FANCE; fanconi anemia group E protein 
E        142087988 FANCF; (RefSeq) Fanconi anemia group F protein	K10893 FANCF; fanconi anemia group F protein 
E        142075905 Fanconi anemia group G protein homolog isoform X1	K10894 FANCG; fanconi anemia group G protein 
E        142081160 FANCL; (RefSeq) E3 ubiquitin-protein ligase FANCL	K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
E        142082561 FANCM; (RefSeq) Fanconi anemia group M protein	K10896 FANCM; fanconi anemia group M protein 
E        142087276 FAAP24; (RefSeq) Fanconi anemia core complex-associated protein 24	K10898 FAAP24; fanconi anemia-associated protein 
E        142090890 FAAP100; (RefSeq) Fanconi anemia core complex-associated protein 100	K10993 FAAP100; fanconi anemia core complex 100 kDa subunit 
D      FA core complex binding factors
E        142085581 HES1; (RefSeq) transcription factor HES-1	K06054 HES1; hairy and enhancer of split 1 
E        142092403 HES4; (RefSeq) transcription factor HES-4 isoform X1	K06054 HES1; hairy and enhancer of split 1 
E        142092431 CENPS; (RefSeq) centromere protein S isoform X1	K11511 APITD1; centromere protein S 
E        142090831 CENPX; (RefSeq) centromere protein X	K15360 STRA13; centromere protein X 
E        142093225 UBE2T; (RefSeq) ubiquitin-conjugating enzyme E2 T	K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] 
D      Bloom's syndrome complex (BTR)
E        142086543 BLM; (RefSeq) recQ-like DNA helicase BLM	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        142089240 TOP3A; (RefSeq) DNA topoisomerase 3-alpha	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        142090308 TOP3B; (RefSeq) DNA topoisomerase 3-beta-1	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        142075780 RMI1; (RefSeq) recQ-mediated genome instability protein 1	K10990 RMI1; RecQ-mediated genome instability protein 1 
E        142089053 RMI2; (RefSeq) recQ-mediated genome instability protein 2	K15365 RMI2; RecQ-mediated genome instability protein 2 
D      FANCD2-I complex
E        142086277 FANCD2; (RefSeq) Fanconi anemia group D2 protein isoform X1	K10891 FANCD2; fanconi anemia group D2 protein 
E        142086500 FANCI; (RefSeq) Fanconi anemia group I protein	K10895 FANCI; fanconi anemia group I protein 
D      Downstream FA components
E        142092041 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein	K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27] 
E        142077741 BRCA2; (RefSeq) breast cancer type 2 susceptibility protein	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        142090480 BRIP1; (RefSeq) Fanconi anemia group J protein isoform X1	K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3] 
E        142089301 PALB2; (RefSeq) LOW QUALITY PROTEIN: partner and localizer of BRCA2	K10897 PALB2; partner and localizer of BRCA2 
D      Other FA pathway factors
E        142086784 FAN1; (RefSeq) fanconi-associated nuclease 1 isoform X1	K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] 
E        142088372 RAD51; (RefSeq) DNA repair protein RAD51 homolog 1	K04482 RAD51; DNA repair protein RAD51 
E        142090499 RAD51C; (RefSeq) DNA repair protein RAD51 homolog 3 isoform X1	K10870 RAD51L2; RAD51-like protein 2 
E        142089346 TELO2; (RefSeq) telomere length regulation protein TEL2 homolog isoform X1	K11137 TELO2; telomere length regulation protein 
E        142084721 USP1; (RefSeq) ubiquitin carboxyl-terminal hydrolase 1	K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] 
E        142079654 WDR48; (RefSeq) WD repeat-containing protein 48 isoform X1	K15361 WDR48; WD repeat-containing protein 48 
C    Other DSBR factors
D      Protein phosphatase 6
E        142091503 PPP6C; (RefSeq) serine/threonine-protein phosphatase 6 catalytic subunit isoform X1	K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] 
E        142078503 PPP6R2; (RefSeq) serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1	K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 
E        142088032 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        142088034 PPP6R3; (RefSeq) serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        142079375 ANKRD28; (RefSeq) serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1	K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 
E        142083727 ANKRD44; (RefSeq) serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1	K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 
E        142073577 ANKRD52; (RefSeq) serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C	K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 
D      Ubiquitin ligases
E        142080783 RNF8; (RefSeq) E3 ubiquitin-protein ligase RNF8 isoform X1	K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27] 
E        142085689 RNF168; (RefSeq) E3 ubiquitin-protein ligase RNF168	K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31] 
E        142077977 RNF169; (RefSeq) E3 ubiquitin-protein ligase RNF169 isoform X1	K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31] 
E        142074259 HERC2; (RefSeq) E3 ubiquitin-protein ligase HERC2 isoform X1	K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] 
D      Others
E        142074441 WRAP53; (RefSeq) LOW QUALITY PROTEIN: telomerase Cajal body protein 1	K23314 WRAP53; telomerase Cajal body protein 1 
E        142091360 TPRN; (RefSeq) taperin	K24164 TPRN; taperin 
E        142075014 LOW QUALITY PROTEIN: WD repeat-containing protein 70-like	K24752 WDR70; WD repeat-containing protein 70 
E        142075352 WDR70; (RefSeq) WD repeat-containing protein 70	K24752 WDR70; WD repeat-containing protein 70 
E        142086541 WDR76; (RefSeq) WD repeat-containing protein 76	K24755 WDR76; WD repeat-containing protein 76 
E        142086217 HMCES; (RefSeq) abasic site processing protein HMCES	K28434 HMCES; abasic site processing protein HMCES 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      142080758 POLH; (RefSeq) DNA polymerase eta	K03509 POLH; DNA polymerase eta [EC:2.7.7.7] 
D      142074920 DNA polymerase iota-like isoform X1	K03510 POLI; DNA polymerase iota [EC:2.7.7.7] 
D      142075695 DNA polymerase iota-like	K03510 POLI; DNA polymerase iota [EC:2.7.7.7] 
D      142075436 POLK; (RefSeq) DNA polymerase kappa isoform X1	K03511 POLK; DNA polymerase kappa [EC:2.7.7.7] 
D      142074688 REV1; (RefSeq) DNA repair protein REV1 isoform X1	K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] 
C    B-family DNA polymerases
D      142080383 REV3L; (RefSeq) DNA polymerase zeta catalytic subunit isoform X1	K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7] 
C    A-family DNA polymerase
D      142081682 POLN; (RefSeq) DNA polymerase nu	K16618 POLN; DNA polymerase nu [EC:2.7.7.7] 
C    Rad6 epistasis group
D      142087756 UBE2A; (RefSeq) ubiquitin-conjugating enzyme E2 A isoform X1	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      142088832 UBE2B; (RefSeq) ubiquitin-conjugating enzyme E2 B isoform X1	K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23] 
D      142086068 RAD18; (RefSeq) E3 ubiquitin-protein ligase RAD18 isoform X1	K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27] 
D      142085539 HLTF; (RefSeq) helicase-like transcription factor isoform X1	K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27] 
D      142078785 UBE2V2; (RefSeq) ubiquitin-conjugating enzyme E2 variant 2 isoform X1	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      142082753 UBE2N; (RefSeq) ubiquitin-conjugating enzyme E2 N	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
C    Other TLS factors
D      142093583 PCNA; (RefSeq) proliferating cell nuclear antigen	K04802 PCNA; proliferating cell nuclear antigen 
D      142085453 PARPBP; (RefSeq) PCNA-interacting partner isoform X1	K27412 PARPBP; PCNA-interacting partner 
D      142080645 SPRTN; (RefSeq) DNA-dependent metalloprotease SPRTN isoform X1	K24051 SPRTN; SprT-like domain-contaning protein Spartan 
D      142087683 GCNA; (RefSeq) germ cell nuclear acidic protein	K26957 GCNA; germ cell nuclear acidic protein 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
D      142088272 RAD9A; (RefSeq) cell cycle checkpoint control protein RAD9A	K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] 
D      142090183 RAD9B; (RefSeq) cell cycle checkpoint control protein RAD9B isoform X1	K10995 RAD9B; cell cycle checkpoint control protein RAD9B 
D      142079173 HUS1; (RefSeq) checkpoint protein HUS1 isoform X1	K10903 HUS1; HUS1 checkpoint protein 
D      142074977 LOW QUALITY PROTEIN: cell cycle checkpoint protein RAD1-like	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
D      142075599 RAD1; (RefSeq) cell cycle checkpoint protein RAD1 isoform X1	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    HRAD17(Rad24)-RFC complex
D      142075653 RAD17; (RefSeq) cell cycle checkpoint protein RAD17 isoform X1	K06662 HRAD17; cell cycle checkpoint protein 
D      142085408 RFC4; (RefSeq) replication factor C subunit 4 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
D      142090693 RFC2; (RefSeq) replication factor C subunit 2 isoform X1	K10755 RFC2_4; replication factor C subunit 2/4 
D      142077737 RFC3; (RefSeq) replication factor C subunit 3 isoform X1	K10756 RFC3_5; replication factor C subunit 3/5 
D      142090016 RFC5; (RefSeq) replication factor C subunit 5	K10756 RFC3_5; replication factor C subunit 3/5 
C    Rad17-Mec3-Ddc1 complex
D      142074977 LOW QUALITY PROTEIN: cell cycle checkpoint protein RAD1-like	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
D      142075599 RAD1; (RefSeq) cell cycle checkpoint protein RAD1 isoform X1	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    FPC (fork protection complex)
D      142073785 TIMELESS; (RefSeq) protein timeless homolog isoform X1	K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 
D      142086583 TIPIN; (RefSeq) TIMELESS-interacting protein isoform X1	K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 
D      142092755 CLSPN; (RefSeq) claspin isoform X1	K25773 CLSPN; claspin 
C    Triple T complex
D      142089346 TELO2; (RefSeq) telomere length regulation protein TEL2 homolog isoform X1	K11137 TELO2; telomere length regulation protein 
D      142089870 TTI1; (RefSeq) TELO2-interacting protein 1 homolog isoform X1	K20403 TTI1; TELO2-interacting protein 1 
D      142093620 TTI2; (RefSeq) TELO2-interacting protein 2	K23115 TTI2; TELO2-interacting protein 2 
C    BAG6-UBL4A-GET4 complex
D      142089157 GET4; (RefSeq) Golgi to ER traffic protein 4 homolog isoform X1	K23387 GET4; golgi to ER traffic protein 4 
C    Other check point factors
D      142085849 ATR; (RefSeq) serine/threonine-protein kinase ATR isoform X1	K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] 
D      142086350 ATRIP; (RefSeq) LOW QUALITY PROTEIN: ATR-interacting protein	K10905 ATRIP; ATR interacting protein 
D      142077826 ATM; (RefSeq) serine-protein kinase ATM isoform X1	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      142092727 CHEK1; (RefSeq) serine/threonine-protein kinase Chk1 isoform X1	K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] 
D      142090101 CHEK2; (RefSeq) serine/threonine-protein kinase Chk2 isoform X1	K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] 
D      142079716 CDC25A; (RefSeq) M-phase inducer phosphatase 1 isoform X1	K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48] 
D      142081590 CDC25B; (RefSeq) M-phase inducer phosphatase 2 isoform X1	K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48] 
D      142078597 YWHAZ; (RefSeq) 14-3-3 protein zeta/delta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      142080148 YWHAQ; (RefSeq) 14-3-3 protein theta	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      142089684 YWHAB; (RefSeq) 14-3-3 protein beta/alpha isoform X1	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      142090088 YWHAH; (RefSeq) 14-3-3 protein eta	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      142090655 YWHAG; (RefSeq) 14-3-3 protein gamma	K16198 YWHAG_H; 14-3-3 protein gamma/eta 
D      142090612 YWHAE; (RefSeq) 14-3-3 protein epsilon isoform X1	K06630 YWHAE; 14-3-3 protein epsilon 
D      142088219 NAV2; (RefSeq) neuron navigator 2 isoform X1	K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] 
D      142085799 wee1-like protein kinase 2 isoform X1	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      142088141 WEE1; (RefSeq) wee1-like protein kinase isoform X1	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      142085792 PER2; (RefSeq) period circadian protein homolog 2 isoform X1	K02633 PER2; period circadian protein 2 
D      142092295 PER3; (RefSeq) period circadian protein homolog 3 isoform X1	K21945 PER3; period circadian protein 3 
D      142074214 MDC1; (RefSeq) mediator of DNA damage checkpoint protein 1 isoform X1	K20780 MDC1; mediator of DNA damage checkpoint protein 1 
D      142087654 PLS3; (RefSeq) plastin-3	K17336 PLS3; plastin-3 
D      142086642 AEN; (RefSeq) apoptosis-enhancing nuclease	K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-] 
D      142085256 PLK3; (RefSeq) serine/threonine-protein kinase PLK3	K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21] 
D      142077702 NEK5; (RefSeq) serine/threonine-protein kinase Nek5	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      142081946 NEK1; (RefSeq) serine/threonine-protein kinase Nek1 isoform X1	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      142086294 NEK4; (RefSeq) serine/threonine-protein kinase Nek4 isoform X1	K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1] 
D      142079346 NEK10; (RefSeq) serine/threonine-protein kinase Nek10	K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1] 
D      142079309 NEK11; (RefSeq) serine/threonine-protein kinase Nek11	K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1] 
D      142092215 DONSON; (RefSeq) protein downstream neighbor of Son	K22422 DONSON; protein downstream neighbor of Son 
D      142075281 KANK1; (RefSeq) KN motif and ankyrin repeat domain-containing protein 1 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      142084722 KANK4; (RefSeq) KN motif and ankyrin repeat domain-containing protein 4	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      142093818 KANK3; (RefSeq) KN motif and ankyrin repeat domain-containing protein 3 isoform X1	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      142090643 schlafen family member 13-like	K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-] 
D      142090729 BCL7B; (RefSeq) B-cell CLL/lymphoma 7 protein family member B isoform X1	K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-] 
D      142078681 CHMP4C; (RefSeq) charged multivesicular body protein 4c	K24782 CHMP4C; charged multivesicular body protein 4C 
D      142079045 VPS4B; (RefSeq) vacuolar protein sorting-associated protein 4B isoform X1	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      142087431 VPS4A; (RefSeq) vacuolar protein sorting-associated protein 4A	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      142083083 ZFYVE19; (RefSeq) abscission/NoCut checkpoint regulator	K24778 ZFYVE19; abscission/NoCut checkpoint regulator 
D      142080943 SDE2; (RefSeq) splicing regulator SDE2 isoform X1	K25059 SDE2; replication stress response regulator SDE2 
B  Other factors with a suspected DNA repair function
C    DNA polymerases
D      142089615 POLQ; (RefSeq) DNA polymerase theta	K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] 
D      142090690 MYBBP1A; (RefSeq) myb-binding protein 1A isoform X1	K02331 POL5; DNA polymerase phi [EC:2.7.7.7] 
D      142081899 PRIMPOL; (RefSeq) DNA-directed primase/polymerase protein isoform X1	K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] 
C    Nucleases
D      142084410 DCLRE1A; (RefSeq) DNA cross-link repair 1A protein	K15340 DCLRE1A; DNA cross-link repair 1A protein 
D      142093259 DCLRE1B; (RefSeq) 5' exonuclease Apollo	K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-] 
D      142090875 ENDOV; (RefSeq) endonuclease V isoform X1	K21813 ENDOV; endonuclease V [EC:3.1.26.-] 
D      142083394 ZRANB3; (RefSeq) DNA annealing helicase and endonuclease ZRANB3 isoform X1	K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-] 
D      142093696 ANKLE1; (RefSeq) ankyrin repeat and LEM domain-containing protein 1	K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 
C    Helicases
D      142077578 helicase POLQ-like isoform X1	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
D      142082149 HELQ; (RefSeq) helicase POLQ-like isoform X1	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
D      142075763 ERCC6L2; (RefSeq) DNA excision repair protein ERCC-6-like 2 isoform X1	K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-] 
C    PSO4 complex
D      142088289 PRPF19; (RefSeq) pre-mRNA-processing factor 19	K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] 
D      142080065 CDC5L; (RefSeq) cell division cycle 5-like protein	K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 
D      142093291 BCAS2; (RefSeq) pre-mRNA-splicing factor SPF27 isoform X1	K12861 BCAS2; pre-mRNA-splicing factor SPF27 
D      142081992 PLRG1; (RefSeq) pleiotropic regulator 1	K12862 PLRG1; pleiotropic regulator 1 
C    Modulation of nucleotide pools
D      142077666 NUDT15; (RefSeq) nucleotide triphosphate diphosphatase NUDT15 isoform X1	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      142089181 NUDT1; (RefSeq) oxidized purine nucleoside triphosphate hydrolase	K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56] 
D      142093616 NUDT18; (RefSeq) 8-oxo-dGDP phosphatase NUDT18 isoform X1	K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 
D      142086710 DUT; (RefSeq) deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      142078014 RRM1; (RefSeq) ribonucleoside-diphosphate reductase large subunit isoform X1	K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] 
D      142078592 RRM2B; (RefSeq) ribonucleoside-diphosphate reductase subunit M2 B isoform X1	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
D      142080142 RRM2; (RefSeq) ribonucleoside-diphosphate reductase subunit M2	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
#
A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      142084496 MGMT; (RefSeq) methylated-DNA--protein-cysteine methyltransferase isoform X1	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      142085356 deoxyribodipyrimidine photo-lyase-like	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        142090135 UNG; (RefSeq) uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        142073584 SMUG1; (RefSeq) LOW QUALITY PROTEIN: single-strand selective monofunctional uracil DNA glycosylase	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        142089440 MPG; (RefSeq) DNA-3-methyladenine glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        142084844 LOW QUALITY PROTEIN: uncharacterized protein LOC142084844	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        142089280 NTHL1; (RefSeq) endonuclease III-like protein 1 isoform X1	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      RecJ
D      DNA ligase
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      Molecular matchmaker
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
D      Other MMR factors
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
D      RecFOR pathway proteins
D      AddAB pathway proteins
D      Other HR factor
D      Archaeal homologous recombinant proteins
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
E        Facilitator
E        Supressor
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    Other SOS response factors
B  Other factors with a suspected DNA repair function
C    DNA polymerase
C    DNA helicases
C    Modulation of nucleotide pools
D      142077666 NUDT15; (RefSeq) nucleotide triphosphate diphosphatase NUDT15 isoform X1	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      142086710 DUT; (RefSeq) deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
C    Others
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#<hr>
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#Last updated: July 29, 2025