+E Ubiquitin system KO
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Ubiquitin System - Cryptococcus deuterogattii
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C CNBG_3023 polyubiquitin K08770 UBC; ubiquitin C
C CNBG_0225 ubiquitin-40S ribosomal protein S27a K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C CNBG_0751 30S small subunit ribosomal protein S27Ae K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C CNBG_3480 ubiquitin-like protein Nedd8 K12158 NEDD8; ubiquitin-like protein Nedd8
C CNBG_1119 40S ribosomal protein S30 K02983 RP-S30e; small subunit ribosomal protein S30e
C CNBG_1122 microtubule binding protein K08341 GABARAP; GABA(A) receptor-associated protein
C CNBG_5369 ubiquitin-like protein ATG12 K08336 ATG12; ubiquitin-like protein ATG12
C CNBG_4601 uncharacterized protein K12161 URM1; ubiquitin related modifier 1
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C CNBG_0422 ubiquitin-activating enzyme E1 K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C CNBG_5113 SUMO activating enzyme K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C CNBG_1651 ubiquitin-like 1-activating enzyme E1 B K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C CNBG_3237 ubiquitin-activating enzyme E1 C K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C CNBG_4921 amyloid beta protein binding protein 1 K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C CNBG_0566 adenylyltransferase and sulfurtransferase K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C CNBG_2532 ubiquitin-like modifier-activating enzyme ATG7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C CNBG_1114 ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C CNBG_1843 ubiquitin-conjugating enzyme E2-16 kDa K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C CNBG_1969 ubiquitin-conjugating enzyme E2 G1 K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C CNBG_5379 ubiquitin-conjugating enzyme E2 G2 K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C CNBG_1039 ubiquitin-conjugating enzyme E2-24 kDa K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C CNBG_5354 uncharacterized protein K10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
C CNBG_1779 ubiquitin-conjugating enzyme E2 J2 K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C CNBG_3550 ubiquitin-conjugating enzyme E2 1 K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C CNBG_5296 ubiquitin-conjugating enzyme E2 13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C CNBG_1695 ubiquitin-conjugating enzyme E2 O K10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]
C CNBG_0848 ubiquitin-conjugating enzyme E2 S K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C CNBG_5261 ubiquitin-conjugating enzyme E2 W K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
B UBL-conjugating enzymes
C CNBG_2724 ubiquitin-conjugating enzyme E2 I K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C CNBG_0987 NEDD8-conjugating enzyme UBC12 K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C CNBG_3760 uncharacterized protein K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
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AUbiquitin ligases (E3)
B HECT type E3
C CNBG_0935 ubiquitin-protein ligase E3 C K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C CNBG_3787 uncharacterized protein K20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]
C CNBG_0817 E3 ubiquitin-protein ligase TRIP12 K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C CNBG_2503 uncharacterized protein K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C CNBG_2632 uncharacterized protein K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C CNBG_4503 ubiquitin-conjugation factor E4 B K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C CNBG_1065 peptidyl-prolyl cis-trans isomerase-like 2 K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C CNBG_3272 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D CNBG_2749 E3 ubiquitin-protein ligase BRE1 K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
D CNBG_1926 E3 ubiquitin-protein ligase MARCH6 K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
C NFX1 proteins
D CNBG_3613 transcriptional repressor NF-X1 K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D CNBG_4308 peroxin-10 K13346 PEX10; peroxin-10
D CNBG_4734 peroxin-12 K13345 PEX12; peroxin-12
D CNBG_0388 peroxin-2 K06664 PEX2; peroxin-2
C RBR proteins
D CNBG_2884 ariadne-1 K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D CNBG_3283 E3 ubiquitin-protein ligase RNF14 K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D CNBG_0013 uncharacterized protein K20804 RNF34; E3 ubiquitin-protein ligase RNF34 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
D CNBG_5316 ubiquitin-protein ligase K10625 UBR1; E3 ubiquitin-protein ligase UBR1 [EC:2.3.2.27]
D CNBG_0100 E3 ubiquitin-protein ligase UBR7 K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D CNBG_2435 BRCA1-associated protein K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D CNBG_9147 CCR4-NOT transcription complex subunit 4 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D CNBG_5356 uncharacterized protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D CNBG_4334 DNA repair protein rad18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D CNBG_5359 uncharacterized protein K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D CNBG_9293 U4/U6.U5 tri-snRNP-associated protein 1 K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D CNBG_0597 E3 ubiquitin-protein ligase SHPRH K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D CNBG_4588 uncharacterized protein K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D CNBG_4393 E3 ubiquitin-protein ligase synoviolin K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D CNBG_1253 uncharacterized protein K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
D CNBG_2087 cytoplasmic protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D CNBG_1088 ligase K23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
D CNBG_2230 cytoplasmic protein K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
B Atypical E3
C CNBG_2509 uncharacterized protein K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
B UBL E3 ligases
C CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C CNBG_4925 E3 SUMO-protein ligase PIAS1 K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
C CNBG_0711 uncharacterized protein K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
C CNBG_4698 uncharacterized protein K25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]
C CNBG_5959 defective in Cullin neddylation protein 1 K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E CNBG_5070 Cullin 1 K03347 CUL1; cullin 1
D Adaptor protein
E CNBG_1109 E3 ubiquitin ligase complex SCF subunit sconC K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E CNBG_9559 beta-transducin repeat containing protein K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E CNBG_1771 F-box and WD-40 domain-containing protein MET30 K10259 MET30; F-box and WD-40 domain protein MET30
E CNBG_1236 F-box and WD-40 domain-containing protein CDC4 K03361 CDC4; F-box and WD-40 domain protein CDC4
E CNBG_5717 uncharacterized protein K03361 CDC4; F-box and WD-40 domain protein CDC4
E CNBG_4973 uncharacterized protein K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E CNBG_2082 JmjC domain-containing histone demethylation protein 1 K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E CNBG_5705 F-box and leucine-rich repeat protein GRR1 K03360 GRR1; F-box and leucine-rich repeat protein GRR1
E CNBG_2601 F-box protein 9 K10295 FBXO9; F-box protein 9
E CNBG_2689 recyclin-1 K15071 RCY1; recyclin-1
E CNBG_5582 SCF-associated factor 1 K15072 SAF1; SCF-associated factor 1
C Cul2 complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E CNBG_0317 transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E CNBG_2478 Cullin 3 K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
C Cul4 complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E CNBG_2445 ubiquitin-protein ligase K10609 CUL4; cullin 4
D Adoptor protein
E CNBG_2411 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E CNBG_5701 uncharacterized protein K11790 DTL; denticleless
E CNBG_5702 uncharacterized protein K11790 DTL; denticleless
E CNBG_1419 WD-repeat protein 21A K11799 DCAF4; DDB1- and CUL4-associated factor 4
E CNBG_1721 WD-repeat protein 68 K11805 DCAF7; DDB1- and CUL4-associated factor 7
E CNBG_2920 uncharacterized protein K11807 WDTC1; WD and tetratricopeptide repeats protein 1
E CNBG_1388 WD-repeat protein 23 K11801 DCAF11; DDB1- and CUL4-associated factor 11
E CNBG_1315 WD repeat and SOF domain-containing protein 1 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E CNBG_1316 WD repeat and SOF domain-containing protein 1 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E CNBG_9441 WD-repeat protein K22382 WDR26; WD repeat-containing protein 26
E CNBG_6047 transcription factor K24752 WDR70; WD repeat-containing protein 70
E CNBG_2874 WD repeat-containing protein K24755 WDR76; WD repeat-containing protein 76
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E CNBG_0317 transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E CNBG_1109 E3 ubiquitin ligase complex SCF subunit sconC K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E CNBG_1541 RING-box protein 1b K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E CNBG_1472 anaphase-promoting complex subunit 11 K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E CNBG_4961 anaphase-promoting complex subunit 2 K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E CNBG_2922 cell division control protein K03363 CDC20; cell division cycle 20, cofactor of APC complex
E CNBG_2394 uncharacterized protein K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E CNBG_5327 anaphase-promoting complex subunit 1 K03348 APC1; anaphase-promoting complex subunit 1
E CNBG_0251 anaphase-promoting complex subunit 3 K03350 APC3; anaphase-promoting complex subunit 3
E CNBG_2815 uncharacterized protein K03351 APC4; anaphase-promoting complex subunit 4
E CNBG_10089 uncharacterized protein K03352 APC5; anaphase-promoting complex subunit 5
E CNBG_5301 anaphase-promoting complex subunit 6 K03353 APC6; anaphase-promoting complex subunit 6
E CNBG_3605 anaphase-promoting complex subunit 8 K03355 APC8; anaphase-promoting complex subunit 8
E CNBG_1800 anaphase-promoting complex subunit 10 K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D CNBG_2331 breast cancer 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
D CNBG_1208 DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
D CNBG_3575 uncharacterized protein K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D CNBG_0914 uncharacterized protein K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D CNBG_5729 uncharacterized protein K23334 RANBP9_10; Ran-binding protein 9/10
D CNBG_6007 endosome protein K23334 RANBP9_10; Ran-binding protein 9/10
D CNBG_0378 macrophage erythroblast attacher isoform 1 K18624 MAEA; macrophage erythroblast attacher
D CNBG_4442 uncharacterized protein K23335 GID4; glucose-induced degradation protein 4
D CNBG_3677 uncharacterized protein K23338 GID8; glucose-induced degradation protein 8
D CNBG_9441 WD-repeat protein K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
D CNBG_0044 uncharacterized protein K25216 UBAC2; ubiquitin-associated domain-containing protein 2
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D CNBG_3159 tip120-family protein K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D CNBG_0379 ubiquitin carboxyl-terminal hydrolase L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D CNBG_0569 ubiquitin carboxyl-terminal hydrolase L5 K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D CNBG_9230 ubiquitin carboxyl-terminal hydrolase 4/11/15 K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D CNBG_1832 ubiquitin carboxyl-terminal hydrolase 5/13 K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D CNBG_6153 ubiquitin carboxyl-terminal hydrolase 7 K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D CNBG_1173 ubiquitin carboxyl-terminal hydrolase 8 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D CNBG_9422 ubiquitin carboxyl-terminal hydrolase 10 K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D CNBG_2473 ubiquitin carboxyl-terminal hydrolase 14 K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D CNBG_1928 ubiquitin carboxyl-terminal hydrolase 22/27/51 K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D CNBG_0350 ubiquitin carboxyl-terminal hydrolase 25/28 K11849 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
D CNBG_1456 ubiquitin carboxyl-terminal hydrolase Ubp16 K11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.4.19.12]
D CNBG_2575 uncharacterized protein K11858 USP48; ubiquitin carboxyl-terminal hydrolase 48 [EC:3.4.19.12]
D CNBG_0374 ubiquitin carboxyl-terminal hydrolase 1 K11870 UBP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D CNBG_4100 ubiquitin carboxyl-terminal hydrolase 9/13 K11872 UBP9_13; ubiquitin carboxyl-terminal hydrolase 9/13 [EC:3.4.19.12]
C OTU
D CNBG_2798 ubiquitin thioesterase OTUB1 K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D CNBG_3299 uncharacterized protein K13717 OTUD3; OTU domain-containing protein 3 [EC:3.4.19.12]
D CNBG_2950 OTU domain-containing protein 6B K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
D CNBG_2836 ataxin-3 K11863 ATXN3; Ataxin-3 [EC:3.4.22.-]
C MINDY
C JAMM
D CNBG_0342 26S proteasome non-ATPase regulatory subunit 14 K03030 PSMD14; 26S proteasome regulatory subunit N11
C PPPDE
C ZUFSP
C BRISC complex
B UBL-specific proteases (ULPs)
C CNBG_5760 sentrin/sumo-specific protease K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C CNBG_0379 ubiquitin carboxyl-terminal hydrolase L3 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C CNBG_3116 uncharacterized protein K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C COP9 signalosome (CSN) complex
D CNBG_4212 COP9 signalosome complex subunit 1 K12175 GPS1; COP9 signalosome complex subunit 1
D CNBG_0633 COP9 signalosome complex subunit 2 K12176 COPS2; COP9 signalosome complex subunit 2
D CNBG_9672 COP9 signalosome complex subunit 3 K12177 COPS3; COP9 signalosome complex subunit 3
D CNBG_2433 COP9 signalosome complex subunit 4 K12178 COPS4; COP9 signalosome complex subunit 4
D CNBG_5645 COP9 signalosome complex subunit 5 K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D CNBG_1888 COP9 signalosome complex subunit 6 K12179 COPS6; COP9 signalosome complex subunit 6
D CNBG_2867 uncharacterized protein K12180 COPS7; COP9 signalosome complex subunit 7
D CNBG_9084 COP9 signalosome complex subunit 12 K24364 CSN12; COP9 signalosome complex subunit 12
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 3, 2024