+E Replication protein KO
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DNA Replication Proteins - Coturnix japonica (Japanese quail)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 107317640 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 107316520 ORC2; origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 107311954 ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 107317054 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 107325026 ORC5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 107319281 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 107319489 CDT1; chromatin licensing and DNA replication factor 1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 107325289 CDC6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 107319813 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 107312427 MCM3; DNA replication licensing factor MCM3 isoform X1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 107310154 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 107314341 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 107316873 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 107307417 MCM7; DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 107308220 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 107313565 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 107310377 CCNE2; G1/S-specific cyclin-E2 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 107319346 CCNE1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 107325763 CDK2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 107317548 CDC7; cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 107309012 DBF4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 107325024 DBF4B; protein DBF4 homolog B isoform X1 K06629 DBF4; protein DBF4
C GINS complex
D 107310929 GINS1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 107319426 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 107319208 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 107323754 GINS4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 107309347 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 107310609 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 107321035 CDC45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 107310940 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 107311833 MCM9; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 107317863 MCM10; protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 107310647 HELB; DNA helicase B K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 107315278 CINP; cyclin-dependent kinase 2-interacting protein isoform X2 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 107310494 MTBP; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 107318804 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 107325213 POLA1; LOW QUALITY PROTEIN: DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 107325864 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 107312102 PRIM2; DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 107321357 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 107315495 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 107321601 POLE3; DNA polymerase epsilon subunit 3 isoform X1 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 107325669 POLE4; DNA polymerase epsilon subunit 4 isoform X1 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 107323665 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 107308624 POLD3; LOW QUALITY PROTEIN: DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D 107314195 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 107318822 POLG; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 107322007 POLG2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 107322528 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 107323930 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 107309108 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 107313815 RFC1; LOW QUALITY PROTEIN: replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 107318176 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 107322486 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 107308273 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 107321464 RFC5; replication factor C subunit 5 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 107312176 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 107307175 RNASEH2A; ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 107308176 RNASEH2B; ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 107307499 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 107323623 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 107315722 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 107314208 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 107311317 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 107316881 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 107325897 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 107322028 ATAD5; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 107312403 DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 107323238 DNMT3B; DNA (cytosine-5)-methyltransferase 3B K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 107306795 geminin-like K10749 GMNN; geminin
D 107309908 GMNN; LOW QUALITY PROTEIN: geminin K10749 GMNN; geminin
D 107305982 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 107318514 CCNB2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 107312631 CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 107315682 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 107308941 POT1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 107310275 TERF1; telomeric repeat-binding factor 1 isoform X1 K11110 TERF1; telomeric repeat-binding factor 1
E 107319477 TERF2; telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 107319089 ACD; adrenocortical dysplasia protein homolog isoform X1 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 107319334 TERB1; telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 107321263 MAJIN; membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 107319488 CTC1; CST complex subunit CTC1 isoform X1 K23311 CTC1; CST complex subunit CTC1
E 107316019 STN1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 107322026 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 107322464 SMG6; telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 107324339 SMG5; protein SMG5 K11125 SMG5; protein SMG5
D 107309452 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 107313598 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 107312551 DKC1; H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 107309452 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 107323119 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 107309380 SNRPD1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 107321426 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 107324680 SNRPE; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 107311805 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 107323695 SNRPG; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 107318176 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 107322486 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 107308273 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 107321464 RFC5; replication factor C subunit 5 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 107308433 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 107320089 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 107310359 NBN; nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 107308373 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 107313186 WRN; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 107318949 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 107310139 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 107320532 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 107310981 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 107315940 TNKS2; poly [ADP-ribose] polymerase tankyrase-2 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 107313436 TNKS; poly [ADP-ribose] polymerase tankyrase-1 isoform X2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 107312402 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 107323122 RTEL1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 107320918 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 107307172 TRIR; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 107316940 RIF1; telomere-associated protein RIF1 isoform X2 K11138 RIF1; telomere-associated protein RIF1
D 107317404 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 107320324 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 107313197 PURG; purine-rich element-binding protein gamma isoform X2 K21800 PURG; purine-rich element-binding protein gamma
D 107306988 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 107311029 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 107323095 RTF2; replication termination factor 2 isoform X1 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 107322894 TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 107310626 TOP1MT; DNA topoisomerase I, mitochondrial isoform X6 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 107309329 DNA topoisomerase 2-beta-like isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107309267 DNA topoisomerase 2-beta isoform X2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107325246 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107321033 TOP3B; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 107320577 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 107315859 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 107312176 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 107312176 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 107315722 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 107314208 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 107325897 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022