+E Replication protein KO
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DNA Replication Proteins - Cyclopterus lumpus (lumpfish)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 117729771 orc1; origin recognition complex subunit 1 isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 117747008 orc2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 117751658 orc3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 117740977 orc4; origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 117726468 orc5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 117744461 cdt1; DNA replication factor Cdt1 isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 117732744 cdc6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 117731055 mcm2; DNA replication licensing factor MCM2 isoform X1 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 117727592 mcm3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 117746842 mcm4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 117735274 mcm5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 117746197 mcm6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 117737765 mcm7; DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 117742791 ccna1; cyclin-A1 K06627 CCNA; cyclin-A
D 117737854 ccna2; cyclin-A2 K06627 CCNA; cyclin-A
D 117748979 ccne1; G1/S-specific cyclin-E1 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 117745136 ccne2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 117739024 G1/S-specific cyclin-E2-like K06626 CCNE; G1/S-specific cyclin-E1
D 117731176 cdk2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 117746765 cdc7; cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 117749096 dbf4b; uncharacterized protein dbf4b K06629 DBF4; protein DBF4
D 117745319 dbf4; protein DBF4 homolog A K06629 DBF4; protein DBF4
C GINS complex
D 117743895 gins1; DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 117725921 gins2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 117731746 gins3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 117736960 gins4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 117749668 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 117739154 recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 117736873 cdc45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 117744033 mcm8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 117727288 mcm9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 117726432 mcm10; protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 117748090 protein FAM111A-like K24274 FAM111A; protein FAM111A
D 117751324 cinp; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 117745841 mtbp; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 117731807 ticrr; treslin isoform X1 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 117749539 pola1; DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 117737504 pola2; DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 117733469 prim1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
C DNA polymerase epsilon complex
D 117736298 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 117751628 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 117727673 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 117729606 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 117735332 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 117736081 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 117747095 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 117738233 pold4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 117732185 polg; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 117738522 polg2; DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 117742361 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
D 117741412 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 117745052 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 117739261 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
D 117738902 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 117736065 rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 117733058 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 117730118 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 117736566 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 117743171 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 117727805 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 117735622 rnaseh2a; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 117750366 rnaseh2b; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 117737533 rnaseh2c; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 117736700 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 117728717 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 117749581 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 117746642 zgc:110269; probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 117744357 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 117744624 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 117746413 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 117735079 atad5a; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 117734997 dnmt1; DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 117727236 DNA (cytosine-5)-methyltransferase 3A-like isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 117751478 dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 117733281 DNA (cytosine-5)-methyltransferase 3B-like isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 117733414 dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 117733920 uncharacterized protein LOC117733920 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 117738642 gmnn; geminin K10749 GMNN; geminin
D 117736934 multicilin K26119 MCIDAS; multicilin
D 117740880 ccnb1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 117728654 G2/mitotic-specific cyclin-B2-like isoform X1 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 117728839 G2/mitotic-specific cyclin-B2-like isoform X1 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 117741719 ccnp; cyclin N-terminal domain-containing protein 2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 117748048 ccnb3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 117744214 cdk1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 117731864 pot1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 117749826 terf1; telomeric repeat-binding factor 1 isoform X1 K11110 TERF1; telomeric repeat-binding factor 1
E 117747853 terfa; telomeric repeat binding factor a K11111 TERF2; telomeric repeat-binding factor 2
E 117747471 tinf2; uncharacterized protein tinf2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 117731386 terf2ip; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 117731711 acd; adrenocortical dysplasia protein homolog K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 117732287 terb1; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 117728469 terb2; telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 117748001 membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 117747811 ctc1; CST complex subunit CTC1 isoform X1 K23311 CTC1; CST complex subunit CTC1
E 117736905 stn1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 117747074 ten1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 117742391 smg6; telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 117728034 smg5; protein SMG5 K11125 SMG5; protein SMG5
D 117738740 tert; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 117746115 tep1; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 117737431 gar1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 117743258 nhp2; H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 117747601 nop10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 117751389 dkc1; H/ACA ribonucleoprotein complex subunit DKC1 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 117738740 tert; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 117730436 snrpb; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 117739423 snrpd1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 117741974 snrpd2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 117740431 snrpd3l; small nuclear ribonucleoprotein D3 polypeptide, like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 117731419 snrpe; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 117726129 snrpf; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 117733544 snrpg; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 117733058 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 117730118 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 117736566 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 117743171 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 117741300 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 117742876 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 117745643 nbn; nibrin K10867 NBN; nibrin
C Other termination factors
D 117741262 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 117732752 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 117749370 prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 117749171 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 117727663 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 117731382 parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 117750123 parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 117746860 parp2; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 117736271 poly [ADP-ribose] polymerase tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 117740264 tnksa; poly [ADP-ribose] polymerase tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 117727480 pinx1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 117733415 rtel1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 117748582 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 117734580 trir; telomerase RNA component interacting RNase isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 117750878 rif1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 117746542 pif1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 117742967 puraa; purine-rich element binding protein Aa K21772 PURA; transcriptional activator protein Pur-alpha
D 117737700 purab; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 117740544 purg; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 117747933 wrap53; LOW QUALITY PROTEIN: telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 117729906 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 117730260 rtf2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 117730787 top1l; DNA topoisomerase I, like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 117732794 zgc:173742; DNA topoisomerase I, mitochondrial K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 117733720 DNA topoisomerase 1-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 117748323 top2a; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 117738584 top2b; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 117736526 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 117735267 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 117726016 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 117727805 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 117727805 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 117728717 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 117749581 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 117746642 zgc:110269; probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 117746413 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022