+F Repair protein KO
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DNA Repair and Recombination Proteins - Chlamydotis macqueenii (Macqueen's bustard)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 104476014 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 104474710 ALKBH2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 104483325 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 104481838 ASCC3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 104481318 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 104474166 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 104484881 TDG; G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 104483024 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 104481751 MUTYH; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 104481433 MBD4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 104475836 NEIL1; endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 104481720 NEIL2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 104473209 NEIL3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 104480409 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
F 104478392 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 104474197 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 104474207 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 104474542 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104485416 FEN1; LOW QUALITY PROTEIN: flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 104473790 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 104487781 LIG3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 104485145 TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 104483870 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 104479224 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 104483248 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 104487546 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 104487477 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 104484034 PARP3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 104485226 PARP4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 104479590 XPC; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 104485097 RAD23B; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 104487086 centrin-2-like K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 104473319 CUL4A; cullin-4A K10609 CUL4; cullin 4
F 104485202 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 104487473 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 104480689 DDB2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 104473433 POLR2B; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 104485281 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 104475042 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 104487154 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 104482344 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 104481864 POLR2G; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 104474884 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 104473570 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 104480559 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 104473319 CUL4A; cullin-4A K10609 CUL4; cullin 4
F 104485202 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 104487473 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 104483609 ERCC8; DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 104481452 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 104481701 UVSSA; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
D TFIIH complex
E 104483317 ERCC3; TFIIH basal transcription factor complex helicase XPB subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 104476991 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 104473183 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 104474219 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 104475564 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 104476934 cyclin-dependent kinase 7-like K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 104477706 CCNH; cyclin-H K06634 CCNH; cyclin H
E 104473080 MNAT1; LOW QUALITY PROTEIN: CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 104476180 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 104474103 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 104473982 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 104479066 XPA; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 104485437 ERCC4; LOW QUALITY PROTEIN: DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 104473371 ERCC5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 104484781 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 104473469 CUL3; cullin-3 K03869 CUL3; cullin 3
E 104476006 CUL5; cullin-5 K10612 CUL5; cullin 5
E 104475166 TCEB1; transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E 104478332 TCEB2; transcription elongation factor B polypeptide 2 K03873 ELOB; elongin-B
E 104483551 transcription elongation factor B polypeptide 3-like K15076 ELOA; elongin-A
E 104485393 TCEB3; transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 104473205 ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 104480827 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 104485646 MSH6; DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 104487174 PMS1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 104484620 MLH1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 104473693 LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
E 104480009 MLH3; DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 104478392 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 104476180 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 104474103 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 104473982 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 104477910 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 104483459 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 104474526 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 104474157 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 104479244 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 104474542 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104482215 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 104483248 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 104474469 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 104485099 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 104473413 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 104481417 NBN; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 104480680 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104484508 BARD1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 104480680 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104487240 FAM175A; BRCA1-A complex subunit Abraxas K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 104477147 UIMC1; BRCA1-A complex subunit RAP80 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 104486700 BABAM1; LOW QUALITY PROTEIN: BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 104487251 BRCC3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 104480680 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104482409 BRIP1; LOW QUALITY PROTEIN: Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 104475231 DNA topoisomerase 2-binding protein 1-like K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 104480680 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104486166 RBBP8; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 104485099 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 104473413 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 104481417 NBN; nibrin K10867 NBN; nibrin
D BRCA complex
E 104480680 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104487441 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 104486967 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 104482566 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 104482566 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 104473022 RAD51B; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 104486632 RAD51C; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 104482194 RAD51D; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 104487105 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 104485816 XRCC3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 104481641 RAD52; DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 104473491 RDM1; RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 104473538 RAD54L; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104482161 RAD54L2; LOW QUALITY PROTEIN: helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 104478238 RAD54B; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 104474072 RECQL; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 104478948 WRN; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 104486296 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104484364 RECQL5; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 104486296 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104473649 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104480937 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104486461 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 104476180 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 104474103 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 104473982 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 104485988 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 104473541 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 104482572 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 104473917 SMEK1; serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 104474395 SMEK2; serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 104486563 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 104475514 AP5M1; LOW QUALITY PROTEIN: AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 104482800 AP5Z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 104475908 SMC5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 104477801 SMC6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 104485806 protein FAM84A-like K22805 FAM84A; protein FAM84A
E 104474338 NSMCE1; LOW QUALITY PROTEIN: non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 104481826 NSMCE2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 104473941 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 104480473 ANKRD32; ankyrin repeat domain-containing protein 32 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 104476092 protein FAM178A-like K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 104477714 EME1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 104487324 LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 104482907 EXD2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 104473354 SWI5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 104480749 SFR1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 104481979 SLX4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 104481585 GEN1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 104481756 SPG11; LOW QUALITY PROTEIN: spatacsin K19026 SPG11; spatacsin
E 104483407 ZFYVE26; zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 104482218 RAD51AP1; RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 104484669 MORF4L1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 104485941 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 104487778 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 104487713 SPIDR; LOW QUALITY PROTEIN: DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 104474353 FAM84B; protein FAM84B K22810 FAM84B; protein FAM84B
E 104483021 BRAT1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 104486867 protein C21orf2 K23456 CFAP410; cilla- and flagella-associated protein
E 104485230 hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 104481972 ZSWIM7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 104479010 protein EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 104483451 HSF2BP; LOW QUALITY PROTEIN: heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 104482722 LOW QUALITY PROTEIN: protein MMS22-like K26125 MMS22L; protein MMS22-like
E 104480663 BOD1L1; LOW QUALITY PROTEIN: biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 104477297 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 104482168 XRCC6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 104472985 XRCC5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 104478885 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 104485099 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 104473413 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 104473073 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 104485826 XRCC4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 104487546 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 104486491 DNTT; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 104473790 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 104483870 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 104479224 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 104473023 DCLRE1C; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 104483757 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 104486911 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 104473280 PWWP domain-containing protein MUM1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 104475434 uncharacterized protein C20orf196 homolog K26128 SHLD1; shieldin complex subunit 1
E 104480740 FAM35A; protein FAM35A K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 104477208 FANCA; Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 104481842 FANCB; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 104473761 FANCC; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 104482011 FANCE; LOW QUALITY PROTEIN: Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 104473189 FANCG; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 104478887 FANCL; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 104476185 Fanconi anemia group M protein-like K10896 FANCM; fanconi anemia group M protein
E 104473930 Fanconi anemia-associated protein of 24 kDa K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 104480657 LOW QUALITY PROTEIN: transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 104474421 APITD1; centromere protein S K11511 APITD1; centromere protein S
E 104482751 UBE2T; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 104486296 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 104473649 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104480937 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104486461 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 104481476 FANCD2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 104473340 FANCI; LOW QUALITY PROTEIN: Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 104480680 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104487441 breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 104482409 BRIP1; LOW QUALITY PROTEIN: Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 104486967 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 104483535 FAN1; LOW QUALITY PROTEIN: fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 104482566 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 104486632 RAD51C; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 104482177 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 104477030 USP1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 104478049 WDR48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 104474393 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 104484451 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 104473802 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 104483064 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 104484117 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
D Ubiquitin ligases
E 104484685 RNF8; E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 104486885 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 104479387 RNF169; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 104479154 HERC2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 104482850 WDR70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 104474469 WDR76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 104475642 POLH; LOW QUALITY PROTEIN: DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 104479882 POLI; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 104473382 POLK; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
C B-family DNA polymerases
D 104473001 REV3L; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 104486993 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 104484788 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 104474900 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 104484029 RAD18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 104474098 HLTF; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 104483423 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104481677 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104484183 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 104474542 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 104477297 PCNA-interacting partner-like K27412 PARPBP; PCNA-interacting partner
D 104473814 SPRTN; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 104479650 ACRC; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 104478160 LOW QUALITY PROTEIN: cell cycle checkpoint control protein RAD9B-like K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 104480388 HUS1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 104477103 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 104480754 RAD17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 104483459 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104474526 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 104474157 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 104479244 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 104477103 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 104473401 TIPIN; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 104476169 CLSPN; LOW QUALITY PROTEIN: claspin K25773 CLSPN; claspin
C Triple T complex
D 104482177 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 104486629 TTI1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 104475375 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 104477559 GET4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 104479604 ATR; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 104474669 ATRIP; LOW QUALITY PROTEIN: ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 104478527 ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 104476199 CHEK2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 104484842 CDC25A; M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 104479837 SFN; 14-3-3 protein sigma K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104477094 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104474714 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104479727 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 104481889 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 104485745 YWHAE; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 104477556 LOW QUALITY PROTEIN: neuron navigator 2-like K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 104480122 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 104477049 WEE1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 104473770 period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 104479211 PER3; period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 104478555 PLS3; plastin-3 isoform X1 K17336 PLS3; plastin-3
D 104480367 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 104473636 PLK3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 104474809 serine/threonine-protein kinase Nek5-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104481395 NEK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104477802 NEK1; serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104485743 NEK10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 104478577 serine/threonine-protein kinase Nek11-like K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 104477592 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 104484977 KANK4; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 104486121 KANK1; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 104475268 vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 104482023 ZFYVE19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 104484481 SDE2; protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 104478477 POLQ; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 104480189 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 104477234 PRIMPOL; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 104480775 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 104480851 ENDOV; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 104475868 ZRANB3; LOW QUALITY PROTEIN: DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
C Helicases
D 104483755 HELQ; helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 104476505 DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 104480998 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 104473238 BCAS2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 104473760 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 104483418 NUDT1; LOW QUALITY PROTEIN: 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 104487130 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 104480954 RRM1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 104474154 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 104476108 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 104476014 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 104481318 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 104474166 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 104483024 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 104481751 MUTYH; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 104480409 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 104484129 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 104484129 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 104487130 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024