+E Replication protein KO
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DNA Replication Proteins - Cucurbita maxima (winter squash)
%
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 111472568 origin of replication complex subunit 1B-like isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 111495969 origin of replication complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 111491354 origin of replication complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 111492031 origin of replication complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 111499245 origin of replication complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 111471366 origin of replication complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 111490341 CDT1-like protein a, chloroplastic K10727 CDT1; chromatin licensing and DNA replication factor 1
D 111466932 CDT1-like protein b K10727 CDT1; chromatin licensing and DNA replication factor 1
D 111484463 cell division control protein 6 homolog B-like K02213 CDC6; cell division control protein 6
D 111470849 DNA replication licensing factor MCM2-like K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 111481534 DNA replication licensing factor MCM2-like isoform X1 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 111497175 DNA replication licensing factor MCM3 homolog 1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 111468442 DNA replication licensing factor MCM4 isoform X1 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 111496758 DNA replication licensing factor MCM4-like K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 111465447 DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 111497108 DNA replication licensing factor MCM6 isoform X1 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 111488244 DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
D 111497769 DNA replication licensing factor MCM7-like K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 111497583 cyclin-A2-4-like K06627 CCNA; cyclin-A
D 111470981 G2/mitotic-specific cyclin C13-1-like K06627 CCNA; cyclin-A
D 111487831 cyclin-A1-1-like K06627 CCNA; cyclin-A
D 111496542 putative cyclin-A3-1 K06627 CCNA; cyclin-A
D 111480485 cyclin-A2-2-like K06627 CCNA; cyclin-A
D 111492410 putative cyclin-A3-1 K06627 CCNA; cyclin-A
D 111477235 putative cyclin-A3-1 K06627 CCNA; cyclin-A
D 111486057 cyclin-A3-1-like K06627 CCNA; cyclin-A
D 111496207 cyclin-A2-1-like K06627 CCNA; cyclin-A
D 111476627 cyclin-A2-2-like K06627 CCNA; cyclin-A
D 111488618 cyclin-A2-3 K06627 CCNA; cyclin-A
D 111489746 cyclin-A1-1-like K06627 CCNA; cyclin-A
D 111481124 putative cyclin-A3-1 isoform X1 K06627 CCNA; cyclin-A
D 111467752 cell division control protein 2 homolog A-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 111486635 cell division control protein 2 homolog A K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 111472476 uncharacterized protein LOC111472476 isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 111497968 uncharacterized protein LOC111497968 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 111494653 probable DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 111466105 DNA replication complex GINS protein PSF2 isoform X1 K10733 GINS2; GINS complex subunit 2
D 111487145 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 111480093 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 111488182 BRCT domain-containing protein At4g02110 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 111477010 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 111466352 ATP-dependent DNA helicase Q-like 5 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 111497995 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 111488363 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 111498277 probable DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 111470623 probable DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 111484408 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 111499673 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 111466380 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 111472037 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 111497616 probable DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 111491125 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 111492993 DNA polymerase epsilon subunit B K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 111490783 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 111497123 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 111481642 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D 111481028 uncharacterized protein LOC111481028 K03504 POLD3; DNA polymerase delta subunit 3
D 111491182 uncharacterized protein LOC111491182 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
D 111493656 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
D 111498272 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
D 111465201 LOW QUALITY PROTEIN: replication protein A 70 kDa DNA-binding subunit A-like K07466 RFA1; replication factor A1
D 111470404 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
D 111485578 replication protein A 32 kDa subunit B K10739 RFA2; replication factor A2
D 111476648 replication protein A 32 kDa subunit A-like K10739 RFA2; replication factor A2
D 111480784 replication protein A 32 kDa subunit A-like K10739 RFA2; replication factor A2
D 111499646 replication protein A 32 kDa subunit B-like K10739 RFA2; replication factor A2
D 111498639 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
D 111481797 replication protein A 14 kDa subunit B-like K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 111490698 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 111465064 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 111480296 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 111489762 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 111497446 uncharacterized protein LOC111497446 K10756 RFC3_5; replication factor C subunit 3/5
D 111478265 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 111487024 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 111472711 uncharacterized protein LOC111472711 K10756 RFC3_5; replication factor C subunit 3/5
D 111474906 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 111479443 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 111491930 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 111495695 uncharacterized protein C12B10.15c K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 111491393 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 111500022 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 111484515 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111479647 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 111468704 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 111490394 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 111495297 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 111485093 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 111483595 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 111480233 uncharacterized protein LOC111480233 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 111489794 DNA (cytosine-5)-methyltransferase 1B-like isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 111498655 putative DNA (cytosine-5)-methyltransferase CMT1 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 111485397 DNA (cytosine-5)-methyltransferase CMT3-like isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 111466330 DNA (cytosine-5)-methyltransferase CMT3 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 111493532 uncharacterized protein LOC111493532 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 111465898 G2/mitotic-specific cyclin S13-7-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111465899 G2/mitotic-specific cyclin S13-7-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111465902 G2/mitotic-specific cyclin S13-7-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111480929 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-2-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111468451 putative cyclin-B3-1 isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111487160 cyclin-SDS-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111476814 cyclin-B2-3-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111490741 G2/mitotic-specific cyclin S13-7 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111466277 G2/mitotic-specific cyclin S13-7-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111477661 G2/mitotic-specific cyclin-2-like isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111490875 cyclin-SDS-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 111497345 G2/mitotic-specific cyclin-2-like K21777 CCNB; G2/mitotic-specific cyclin-B, other
C Telomere proteins
D Shelterin complex
E 111499729 uncharacterized protein LOC111499729 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 111484457 uncharacterized protein LOC111484457 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
E 111466921 CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 111465725 CST complex subunit TEN1-like K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 111481922 telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 111466108 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 111478321 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 111490234 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 111495237 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 111467025 H/ACA ribonucleoprotein complex subunit 3-like protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 111491467 H/ACA ribonucleoprotein complex subunit 3-like protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 111481852 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 111470135 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 111481922 telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 111477902 small nuclear ribonucleoprotein-associated protein B'-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 111496768 small nuclear ribonucleoprotein-associated protein B'-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 111469600 small nuclear ribonucleoprotein SmD1b-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 111491270 small nuclear ribonucleoprotein SmD1b K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 111467008 small nuclear ribonucleoprotein SmD1a K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 111482063 small nuclear ribonucleoprotein Sm D2-like K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 111483160 small nuclear ribonucleoprotein Sm D2-like K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 111480932 small nuclear ribonucleoprotein SmD3b-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 111473626 small nuclear ribonucleoprotein SmD3b-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 111471407 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 111485738 small nuclear ribonucleoprotein E-like isoform X1 K11097 SNRPE; small nuclear ribonucleoprotein E
E 111470751 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 111496373 probable small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 111491861 probable small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 111477789 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 111471160 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 111465064 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 111480296 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 111489762 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 111497446 uncharacterized protein LOC111497446 K10756 RFC3_5; replication factor C subunit 3/5
D 111478265 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 111487024 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 111472711 uncharacterized protein LOC111472711 K10756 RFC3_5; replication factor C subunit 3/5
D 111474906 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 111476838 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D 111479648 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 111493152 nijmegen breakage syndrome 1 protein isoform X1 K10867 NBN; nibrin
C Other termination factors
D 111497793 serine/threonine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 111465434 ATP-dependent DNA helicase Q-like SIM K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 111483078 ATP-dependent DNA helicase Q-like 4A K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 111465781 ATP-dependent DNA helicase Q-like 3 isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 111491052 DNA repair endonuclease UVH1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 111466943 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 111490703 poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 111497777 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 111487939 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 111491233 PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 111488529 regulator of telomere elongation helicase 1 homolog isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 111495136 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 111485102 uncharacterized protein LOC111485102 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 111467262 transcription factor Pur-alpha 1-like K21772 PURA; transcriptional activator protein Pur-alpha
D 111484871 transcription factor Pur-alpha 1-like K21772 PURA; transcriptional activator protein Pur-alpha
D 111495498 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 111498131 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 111488625 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 111498815 protein RTF2 homolog isoform X1 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 111498332 DNA topoisomerase 1 beta-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 111500229 DNA topoisomerase 1 beta-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 111481402 DNA topoisomerase 2 isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 111479340 DNA topoisomerase 3-beta isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 111481572 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 111495086 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
D Other elongation factors
E 111476616 DNA polymerase I A, chloroplastic/mitochondrial-like K02335 polA; DNA polymerase I [EC:2.7.7.7]
E 111483260 DNA polymerase I A, chloroplastic/mitochondrial isoform X1 K02335 polA; DNA polymerase I [EC:2.7.7.7]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
D RFC (replication factor C)
D Other elongation factors
E 111479647 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 111468704 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 111483595 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
C 111492096 DNA gyrase subunit A, chloroplastic/mitochondrial K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C 111467169 DNA gyrase subunit B, chloroplastic/mitochondrial-like K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C 111490712 DNA topoisomerase 6 subunit B isoform X1 K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022