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Mitochondrial Biogenesis - Cyanidioschyzon merolae
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AMitochondrial DNA transcription, translation, and replication factors
B Mitochondrial DNA-encoded proteins
C Mitochondrial respiratory chain complex I
C Mitochondrial respiratory chain complex III
C Cytochrome c oxidase
C F-type ATPase
B Mitochondrial transcription and translation factors
C Mitochondrial RNA polymerase
D CYME_CMJ257C single subunit mitochondrial RNA polymerase K10908 POLRMT; DNA-directed RNA polymerase, mitochondrial [EC:2.7.7.6]
C Mitochondrial transcription factors
C Mitochondrial translation factors
D CYME_CMK228C mitochondrial translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D CYME_CMB051C mitochondrial translation elongation factor Ts K02357 tsf; elongation factor Ts
D CYME_CMS502C mitochondrial translation elongation factor Tu K02358 tuf; elongation factor Tu
D CymeCp164 tufA; elongation factor Tu K02358 tuf; elongation factor Tu
D CYME_CMG196C mitochondrial translation elongation factor G1 K02355 fusA; elongation factor G
D CYME_CMK150C chloroplast translation elongation factor G K02355 fusA; elongation factor G
D CYME_CMO140C mitochondrial translation elongation factor G2 K02355 fusA; elongation factor G
D CYME_CMT470C hypothetical protein K15031 MTERF; mitochondrial transcription termination factor family protein
C RNase MRP
D CYME_CMR143C ribonuclease P protein subunit POP1 K01164 POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
D CYME_CMG096C ribonuclease P protein subunit POP4 K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D CYME_CMO008C ribonuclease P protein subunit POP5 K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D CYME_CMM152C ribonuclease P protein subunit P30 K03539 RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
C Mitochondrial ribonuclease P
C Other mitochondrial DNA transcription and translation factors
D CYME_CMN222C hypothetical protein K17710 PTCD1; pentatricopeptide repeat domain-containing protein 1
D CYME_CMS388C hypothetical protein K17662 CBP3; cytochrome b pre-mRNA-processing protein 3
D CYME_CMJ050C lactation elevated 1 K18798 AFG1; peroxisome-assembly ATPase [EC:3.6.4.7]
D CYME_CMA132C unknown metallopeptidase K18156 ATP23; mitochondrial inner membrane protease ATP23 [EC:3.4.24.-]
D CYME_CMP140C probable mitochondrial ATP-dependent RNA helicase Suv3 K17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1/SUV3 [EC:5.6.2.6]
D CYME_CMN084C ADP/ATP translocase K05863 SLC25A4S; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
D CYME_CMR162C similar to mitochondrial carrier protein K15113 SLC25A28_37; solute carrier family 25 (mitochondrial iron transporter), member 28/37
D CYME_CMR309C probable mitochondrial iron transporter Mrs3 K15113 SLC25A28_37; solute carrier family 25 (mitochondrial iron transporter), member 28/37
D CYME_CMN201C GTP-binding protein of Era family K03595 era; GTPase
D CYME_CMJ139C tyrosine--tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D CYME_CMQ275C tyrosine--tRNA ligase, mitochondrial or chloroplast K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D CYME_CMP205C leucine--tRNA ligase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D CYME_CMQ336C leucyl--tRNA ligase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D CYME_CMK087C aspartate--tRNA ligase, mitochondrial and chloroplast? K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D CYME_CMC037C glycine--tRNA ligase, class II K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D CYME_CMN177C arginine--tRNA ligase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D CYME_CMF178C glutamyl-tRNA amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D CYME_CME151C GTP-binding protein of Nug1 family K19828 MTG1; mitochondrial GTPase 1
D CYME_CMT118C similar to bacterial peptide chain release factor K23498 COXPD7; peptide chain release factor
D CYME_CMS088C hypothetical protein K25877 MYG1; MYG1 exonuclease [EC:3.1.-.-]
B Mitochondrial DNA replication factors
C Mitochondrial DNA polymerase
D CYME_CMN185C hypothetical protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Mitochondrial DNA maintenance factors
D CYME_CMT452C mitochondrial DNA helicase Twinkle K17680 PEO1; twinkle protein [EC:5.6.2.3]
C Other Mitochondrial DNA replication factors
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AMitochondrial protein import machinery
B Endoplasmic reticulum membrane and cytosol
C ER-mitochondria encounter structure (ERMES) complex
C Other ER-memrane and cytosol factors
D CYME_CML030C DnaJ homolog, subfamily A K09503 DNAJA2; DnaJ homolog subfamily A member 2
D CYME_CMJ069C mitochondrial Rho GTP-binding protein Miro K07870 RHOT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-]
D CYME_CMP145C heat shock protein Hsp70, cytosolic K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
B Outer membrane
C Transporter outer membrane (TOM) complex
D CYME_CMF062C mitochondrial general import pore subunit Tom40 K11518 TOM40; mitochondrial import receptor subunit TOM40
D CYME_CMG115C hypothetical protein K17769 TOM22; mitochondrial import receptor subunit TOM22
C TOB/SAM complex
D CYME_CMO061C hypothetical protein K07277 SAM50; outer membrane protein insertion porin family
C Porin
D CYME_CMO111C outer mitochondrial membrane protein porin K15040 VDAC2; voltage-dependent anion channel protein 2
C ERMES complex
C Other outer membrane factor
B Inter membrane space
C Transporter inner membrane (TIM) 9/10 complex
D CYME_CMR213C mitochondrial intermembrane space complex subunit Tim9 K17777 TIM9; mitochondrial import inner membrane translocase subunit TIM9
D CYME_CMG033C mitochondrial intermembrane space complex subunit Tim10 K17778 TIM10; mitochondrial import inner membrane translocase subunit TIM10
C TIM8/13 complex
D CYME_CMI216C probable mitochondrial intermembrane space complex subunit Tim8 K17780 TIM8; mitochondrial import inner membrane translocase subunit TIM8
D CYME_CMB148C probable mitochondrial intermembrane space complex subunit Tim13 K17781 TIM13; mitochondrial import inner membrane translocase subunit TIM13
C Mitochondrial intermembrane space assembly (MIA) complex
D CYME_CMJ294C hypothetical protein K17782 MIA40; mitochondrial intermembrane space import and assembly protein 40
D CYME_CMT484C probable flavin-linked sulfhydryl oxidase ERV1 K17783 ERV1; mitochondrial FAD-linked sulfhydryl oxidase [EC:1.8.3.2]
B Inner mambrane
C MICOS complex
D CYME_CMN291C hypothetical protein K17784 MICOS10; MICOS complex subunit MIC10
D CYME_CMN265C hypothetical protein K17785 IMMT; MICOS complex subunit MIC60
C MICOS complex (yeast)
D CYME_CMN291C hypothetical protein K17784 MICOS10; MICOS complex subunit MIC10
D CYME_CMN265C hypothetical protein K17785 IMMT; MICOS complex subunit MIC60
C TIM22 complex
D CYME_CMS209C mitochondrial inner membrane insertion complex subunit Tim22 K17790 TIM22; mitochondrial import inner membrane translocase subunit TIM22
C TIM23 complex
D CYME_CMO311C similar to mitochondrial presequence translocase subunit Tim23 K17794 TIM23; mitochondrial import inner membrane translocase subunit TIM23
D CYME_CMS471C mitochondrial presequence translocase subunit Tim17 K17795 TIM17; mitochondrial import inner membrane translocase subunit TIM17
D CYME_CMN179C mitochondrial presequence translocase subunit Tim50 K17496 TIM50; mitochondrial import inner membrane translocase subunit TIM50
C Mitochondrial calcium uniporter complex
D CYME_CMK267C hypothetical protein K22137 MCUR1; mitochondrial calcium uniporter regulator 1
C Other inner membrane factors
D CYME_CMN072C similar to mitochondrial distribution and morphology mutant Mdm38 K17800 LETM1; LETM1 and EF-hand domain-containing protein 1, mitochondrial
D CYME_CMS218C similar to mitochondrial distribution and morphology; Mdm38p K17800 LETM1; LETM1 and EF-hand domain-containing protein 1, mitochondrial
D CYME_CMB077C similar to mitochondrial inner membrane protease IMP1 K09647 IMP1; mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-]
D CYME_CMR326C similar to inner mitochondrial membrane peptidase Imp2p K09648 IMP2; mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-]
D CYME_CMR333C similar to inner mitochondrial membrane peptidase Imp2p K09648 IMP2; mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-]
D CYME_CMA004C hypothetical protein K22138 MPC1; mitochondrial pyruvate carrier 1
D CYME_CMB099C hypothetical protein K22139 MPC2; mitochondrial pyruvate carrier 2
B Matrix
C MMC/PAM proteins
D CYME_CMJ253C similar to mitochondrial presequence translocase subunit Tim44 K17804 TIM44; mitochondrial import inner membrane translocase subunit TIM44
D CYME_CML205C DnaK-type molecular chaperone, mitochondrial precursor K04043 dnaK; molecular chaperone DnaK
D CYME_CML088C similar to chaperone GrpE K03687 GRPE; molecular chaperone GrpE
D CYME_CMT423C chloroplast molecular chaperone GrpE K03687 GRPE; molecular chaperone GrpE
D CYME_CMP334C DnaJ homolog, subfamily D K09539 DNAJC19; DnaJ homolog subfamily C member 19
D CYME_CMK200C hypothetical protein K17805 PAM16; mitochondrial import inner membrane translocase subunit TIM16
C Other matrix factors
D CYME_CMK260C probable mitochondrial processing peptidase alpha subunit K01412 PMPCA; mitochondrial-processing peptidase subunit alpha [EC:3.4.24.64]
D CYME_CMM104C mitochondrial processing peptidase beta subunit, precursor K17732 PMPCB; mitochondrial-processing peptidase subunit beta [EC:3.4.24.64]
D CYME_CMS132C mitochondrial intermediate peptidase K01410 MIPEP; mitochondrial intermediate peptidase [EC:3.4.24.59]
D CYME_CMB021C chroloplast chaperonin CPN60, precursor K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D CYME_CMQ270C mitochondrial chaperonin hsp60, precursor K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D CYME_CMF129C mitochondrial chaperonin hsp10, precursor K04078 groES; chaperonin GroES
D CYME_CMS188C probable chloroplast chaperonin CPN21, precursor K04078 groES; chaperonin GroES
D CYME_CML293C probable chaperone protein DnaJ K03686 dnaJ; molecular chaperone DnaJ
D CYME_CMR298C heat shock protein DnaJ K03686 dnaJ; molecular chaperone DnaJ
D CYME_CMR095C similar to proline transport helper PTH1 K17807 TAM41; mitochondrial translocator assembly and maintenance protein 41
D CYME_CMT595C hypothetical protein K17808 ZIM17; mitochondrial protein import protein ZIM17
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AMitochondrial quality control factors
B Regulator of mitochondrial biogenesis
C Ubiquitas transcription factors
D CYME_CMG196C mitochondrial translation elongation factor G1 K02355 fusA; elongation factor G
D CYME_CMK150C chloroplast translation elongation factor G K02355 fusA; elongation factor G
D CYME_CMO140C mitochondrial translation elongation factor G2 K02355 fusA; elongation factor G
C Nuclear respiratory factors
C Coactivators
C Proteins involved in Fe-S cluster biogenesis
D CYME_CMT234C cysteine desulfurase IscS, mitochondrial precursor K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D CYME_CMR318C similar to NifU-like iron-sulfur cluster protein Isu1 K22068 ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial
D CYME_CMN136C hypothetical protein K22069 LYRM4; LYR motif-containing protein 4
D CYME_CMK051C similar to frataxin K19054 FXN; frataxin [EC:1.16.3.1]
D CYME_CMO141C probable adrenodoxin K22071 FDX2; ferredoxin-2, mitochondrial
D CYME_CMM294C probable ferredoxin--NADP reductase K18914 FDXR; adrenodoxin-NADP+ reductase [EC:1.18.1.6]
D CYME_CML205C DnaK-type molecular chaperone, mitochondrial precursor K04043 dnaK; molecular chaperone DnaK
D CYME_CMP355C similar to J-type co-chaperone HSC20 K04082 hscB; molecular chaperone HscB
D CYME_CMM250C hypothetical protein K07390 grxD; monothiol glutaredoxin
D CYME_CMT264C probable iron-sulfur cluster assembly protein IscA K22063 ISCA1; iron-sulfur cluster assembly 1
D CYME_CMF122C similar to nitrogen fixation associated protein HesB K22072 ISCA2; iron-sulfur cluster assembly 2
D CYME_CMJ205C probable iron-sulfur cluster scaffold protein K22074 NFU1; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
D CYME_CMC085C hypothetical protein K22066 BOLA1; BolA-like protein 1
D CYME_CML011C transcriptional regulator BolA K22066 BOLA1; BolA-like protein 1
D CYME_CMR275C transcriptional regulator BolA K22066 BOLA1; BolA-like protein 1
D CYME_CMS131C unknown protein for iron-sulfur cluster formation SufE K22066 BOLA1; BolA-like protein 1
C Other regulator of mitochondrial biogenesis
D CYME_CMF139C serine/threonine protein kinase SNF1 K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
D CYME_CMQ097C probable ATP-dependent protease Lon K08675 PRSS15; ATP-dependent Lon protease [EC:3.4.21.53]
D CYME_CMT600C NAD-dependent deacetylase sirtuin 1 K11411 SIRT1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
D CYME_CMP162C hypothetical protein K23504 SERAC1; protein SERAC1
D CYME_CMP169C similar to expression regulator of ATP synthase Nca2p K18158 NCA2; nuclear control of ATPase protein 2
B Mitochondrial respiratory chain complex assembly factors
C Complex-I assembly factors
D CYME_CMB006C similar to NADH dehydrogenase I alpha subcomplex assembly factor 1 K18159 NDUFAF1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1
D CYME_CMC088C hypothetical protein K18160 NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2
D CYME_CMM259C hypothetical protein K18162 NDUFAF5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [EC:2.1.1.-]
D CYME_CMQ116C similar to phytoene synthase K18163 NDUFAF6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 6
D CYME_CMR220C hypothetical protein K18164 NDUFAF7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 7
D CYME_CML231C similar to multidrug resistance protein K03593 mrp; ATP-binding protein involved in chromosome partitioning
C Complex-II assembly factors
C Complex-III assembly factors
D CYME_CMS388C hypothetical protein K17662 CBP3; cytochrome b pre-mRNA-processing protein 3
C Complex-IV assembly factors
D CYME_CMN287C hypothetical protein K18172 CMC2; COX assembly mitochondrial protein 2
D CYME_CMB145C hypothetical protein K18178 COA5; cytochrome c oxidase assembly factor 5
D CYME_CMT232C protoheme IX farnesyltransferase K02257 COX10; heme o synthase [EC:2.5.1.141]
D CYME_CMG064C cytochrome c oxidase assembly protein K02258 COX11; cytochrome c oxidase assembly protein subunit 11
D CYME_CMQ318C hypothetical protein K18182 COX16; cytochrome c oxidase assembly protein subunit 16
D CYME_CMS431C cytochrome c oxidase assembly protein K02260 COX17; cytochrome c oxidase assembly protein subunit 17
D CYME_CMN204C hypothetical protein K18183 COX19; cytochrome c oxidase assembly protein subunit 19
D CYME_CMC118C similar to mitochondrial inner membrane protein OXA1 K03217 yidC; YidC/Oxa1 family membrane protein insertase
D CYME_CMT063C chloroplast membrane protein ALBINO3 or ARTEMIS K03217 yidC; YidC/Oxa1 family membrane protein insertase
D CYME_CMH063C similar to Surfeit 1, a protein involved in cytochrome c oxidase assembly K14998 SURF1; surfeit locus 1 family protein
D CYME_CMO244C inner mitochondrial membrane protein Sco1p K07152 SCO1; protein SCO1
C Complex-V assembly factors
D CYME_CME118C hypothetical protein K07555 ATPeAF1; ATP synthase mitochondrial F1 complex assembly factor 1
D CYME_CMO239C hypothetical protein K07556 ATPeAF2; ATP synthase mitochondrial F1 complex assembly factor 2
B Mitochondrial dynamics
C Fission and Fusion factors
D CYME_CMP210C hypothetical protein K09650 PARL; rhomboid-like protein [EC:3.4.21.105]
D CYME_CME019C dynamin-related protein involved in mitochondrial division CmDnm1/DRP3 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D CYME_CMQ197C similar to mitochondrial division protein Fis1p K17969 FIS1; mitochondrial fission 1 protein
C Actin cytoskeleton organization
D CYME_CML218C similar to N-terminal acetyltransferase complex ARD1 subunit K17972 NAA20; N-terminal acetyltransferase B complex catalytic subunit [EC:2.3.1.254]
C Mitochondrial movement
D CYME_CMJ078C probable prohibitin K17080 PHB1; prohibitin 1
D CYME_CMD067C probable prohibitin protein K17081 PHB2; prohibitin 2
C Retention of mitochondria
D CYME_CME019C dynamin-related protein involved in mitochondrial division CmDnm1/DRP3 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C Morphogenesis factors
D CYME_CMJ069C mitochondrial Rho GTP-binding protein Miro K07870 RHOT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-]
D CYME_CMN265C hypothetical protein K17785 IMMT; MICOS complex subunit MIC60
D CYME_CMS040C hypothetical protein K17408 DAP3; small subunit ribosomal protein S29
B Mitophagy factors
C Autophagy-related proteins
C Parkin-dependent mechanism factors
D CYME_CMP210C hypothetical protein K09650 PARL; rhomboid-like protein [EC:3.4.21.105]
C Parkin-independent mechanism factors
D CYME_CMQ224C heat shock protein of Hsp90 family K04079 HSP90A; molecular chaperone HtpG
C Other mitophagy factors
D CYME_CMF139C serine/threonine protein kinase SNF1 K07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 30, 2025